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968 results on '"Guo, Qinglong"'

6. The relationship between self-objectification and social avoidance among Chinese middle adolescent girls: The mediating role of appearance comparison and self-esteem

Author

Guo, Qinglong and Wu, Mingxia

Subjects
Self-esteem -- Influence -- Demographic aspects, Objectification theory -- Influence, Personal appearance -- Influence -- Demographic aspects, Avoidance (Psychology) -- Demographic aspects, Teenage girls -- Social aspects, Psychology and mental health
Abstract

Although previous studies have demonstrated that appearance plays an important role in the avoidance of social contact among adolescent girls, the reasons for this remain unclear. The purpose of the study was to investigate this issue from the perspective of objectification theory. We investigated self-objectification, appearance comparison, self-esteem, and social avoidance among 262 Chinese middle adolescent girls (M.sub.age = 15.97 years, ranging from 14 to 17) living in Guangdong province, China. The results showed a positive correlation between self-objectification and social avoidance, which was further mediated by appearance comparison and self-esteem. Moreover, girls with high levels of self-objectification were more likely to compare their appearance to others, which in turn, was linked to lower self-esteem, and subsequently correlated with greater social avoidance. These findings suggest that self-objectification may adversely influence adolescent girls' interpersonal well-being. Based on our results, interventions addressing social avoidance among adolescent girls may include reducing self-objectification, decreasing appearance comparison, and improving self-esteem. The findings of the present study provide a better understanding of the negative consequences of self-objectification by incorporating social avoidance., Author(s): Qinglong Guo [sup.1] [sup.2] [sup.3] , Mingxia Wu [sup.1] [sup.2] [sup.3] Author Affiliations: (1) grid.263906.8, 0000 0001 0362 4044, Faculty of Psychology, Southwest University, , 400715, Chongqing, People's Republic [...]

Published
2023
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17. YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity

Author

Wang, Lirui, Mazagova, Magdalena, Pan, Chuyue, Yang, Song, Brandl, Katharina, Liu, Jun, Reilly, Shannon M, Wang, Yanhan, Miao, Zhaorui, Loomba, Rohit, Lu, Na, Guo, Qinglong, Liu, Jihua, Yu, Ruth T, Downes, Michael, Evans, Ronald M, Brenner, David A, Saltiel, Alan R, Beutler, Bruce, and Schnabl, Bernd

Subjects
Biochemistry and Cell Biology, Biological Sciences, Chronic Liver Disease and Cirrhosis, Obesity, Nutrition, Digestive Diseases, Liver Disease, 2.1 Biological and endogenous factors, Aetiology, Metabolic and endocrine, Oral and gastrointestinal, Animals, Body Temperature, COP-Coated Vesicles, Diet, High-Fat, Endoplasmic Reticulum, Energy Metabolism, Fibroblast Growth Factors, Gene Expression Regulation, Hepatocytes, Humans, Lipolysis, Liver, Membrane Proteins, Metabolic Syndrome, Mice, Mice, Knockout, Non-alcoholic Fatty Liver Disease, Protein Binding, Signal Transduction, Thermogenesis, Vesicular Transport Proteins, obesity, YIPF6, FGF21, COPII vesicles, sorting receptor
Abstract

Fibroblast growth factor 21 (FGF21) is an endocrine hormone that regulates glucose, lipid, and energy homeostasis. While gene expression of FGF21 is regulated by the nuclear hormone receptor peroxisome proliferator-activated receptor alpha in the fasted state, little is known about the regulation of trafficking and secretion of FGF21. We show that mice with a mutation in the Yip1 domain family, member 6 gene (Klein-Zschocher [KLZ]; Yipf6KLZ/Y ) on a high-fat diet (HFD) have higher plasma levels of FGF21 than mice that do not carry this mutation (controls) and hepatocytes from Yipf6KLZ/Y mice secrete more FGF21 than hepatocytes from wild-type mice. Consequently, Yipf6KLZ/Y mice are resistant to HFD-induced features of the metabolic syndrome and have increased lipolysis, energy expenditure, and thermogenesis, with an increase in core body temperature. Yipf6KLZ/Y mice with hepatocyte-specific deletion of FGF21 were no longer protected from diet-induced obesity. We show that YIPF6 binds FGF21 in the endoplasmic reticulum to limit its secretion and specifies packaging of FGF21 into coat protein complex II (COPII) vesicles during development of obesity in mice. Levels of YIPF6 protein in human liver correlate with hepatic steatosis and correlate inversely with levels of FGF21 in serum from patients with nonalcoholic fatty liver disease (NAFLD). YIPF6 is therefore a newly identified regulator of FGF21 secretion during development of obesity and could be a target for treatment of obesity and NAFLD.

Published
2019

20. GL-V9 synergizes with oxaliplatin of colorectal cancer via Wee1 degradation mediated by HSP90 inhibition.

Author

Chen, Hongyu, Yang, Fan, Zhao, Qianying, Wang, Hongzheng, Zhu, Mengyuan, Li, Hui, Ge, Zheng, Zhang, Shuai, Guo, Qinglong, and Hui, Hui

Abstract

Objectives: GL-V9 exhibited anti-tumour effects on various types of tumours. This study aimed to verify if GL-V9 synergized with oxaliplatin in suppressing colorectal cancer (CRC) and to explore the synergistic mechanism. Methods: The synergy effect was tested by MTT assays and the mechanism was examined by comet assay, western blotting and immunohistochemistry (IHC). Xenograft model was constructed to substantiated the synergy effect and its mechanism in vivo. Results: GL-V9 was verified to enhance the DNA damage effect of oxaliplatin, so as to synergistically suppress colon cancer cells in vitro and in vivo. In HCT-116 cells, GL-V9 accelerated the degradation of Wee1 and induced the abrogation of cell cycle arrest and mis-entry into mitosis, bypassing the DNA damage response caused by oxaliplatin. Our findings suggested that GL-V9 binding to HSP90 was responsible for the degradation of Wee1 and the vulnerability of colon cancer cells to oxaliplatin. Functionally, overexpression of either HSP90 or WEE1 annulled the synergistic effect of GL-V9 and oxaliplatin. Conclusions: Collectively, our findings revealed that GL-V9 synergized with oxaliplatin to suppress CRC and displayed a promising strategy to improve the efficacy of oxaliplatin. Graphical Abstract [ABSTRACT FROM AUTHOR]

Published
2024
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