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Your search keyword '"Guo, Ruiyan"' showing total 22 results
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22 results on '"Guo, Ruiyan"'

2. Suction Piles

Author

Wang, Yi, Guo, Ruiyan, An, Hongwei, Section editor, Griffiths, Terry, Section editor, Duan, Menglan, Section editor, Cui, Weicheng, editor, Fu, Shixiao, editor, and Hu, Zhiqiang, editor

Published
2022
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4. Conservation Challenges: Climate and Land Use/Land Cover Changes Increasing Habitat Overlap Among Endangered Crested Ibis and Sympatric Egret‎/‎Heron Species

Author

Tuohetahong, Yilamujiang, primary, Lu, Ruyue, additional, Guo, Ruiyan, additional, Gan, Feng, additional, Zhao, Fuyue, additional, Ding, Sheng, additional, Jin, Saisai, additional, Cui, Huifang, additional, Niu, Kesheng, additional, Wang, Chao, additional, Duan, Wenbing, additional, Ye, Xinping, additional, and Yu, Xiaoping, additional

Published
2024
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10. Development of a Single-Molecule Nanobalance Ratiometric Electrochemical DNA Biosensor Using a Triblock Poly-Adenine Probe

Author

Li, Lanying, primary, Guo, Ruiyan, additional, Wang, Lele, additional, Tao, Qing, additional, Luo, Ming, additional, Ding, Min, additional, Li, Yan, additional, Yang, Liu, additional, Chen, Lizhen, additional, Yan, Juan, additional, Cao, Chengming, additional, Chang, Jinxue, additional, Chen, Ying, additional, Gong, Feiyan, additional, Wen, Yanli, additional, and Liu, Gang, additional

Published
2023
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12. Framework Nucleic Acids as Blood-Retinal-Barrier-Penetrable Nanocarrier for Periocular Administration

Author

Wang, Ruobing, primary, Liu, Yanhan, additional, Xiao, Wenjuan, additional, Yi, Qiuxue, additional, Jiang, Mengmeng, additional, Guo, Ruiyan, additional, Song, Lu, additional, Li, Min, additional, Li, Fan, additional, Shi, Danli, additional, Zhao, Lingyi, additional, Huang, Weiyi, additional, Zuo, Xiaolei, additional, and Mao, Xiuhai, additional

Published
2022
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17. DNA origami nanocalipers for pH sensing at the nanoscale

Author

Zhang, Xinyue, primary, Pan, Li, additional, Guo, Ruiyan, additional, Zhang, Yueyue, additional, Li, Fan, additional, Li, Min, additional, Li, Jiang, additional, Shi, Jiye, additional, Qu, Fengli, additional, Zuo, Xiaolei, additional, and Mao, Xiuhai, additional

Published
2022
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21. Construction of an Enzyme Cascade Based on the Accurate Adjacent Arrangement of Coupled Enzymes Using a Triblock PolyA DNA Probe

Author

Wang, Lele, Guo, Ruiyan, Li, Lanying, Tao, Qing, Xu, Qin, Yang, Xue, Liu, Xue, Li, Jiang, Wang, Lihua, Chang, Jinxue, Cao, Chengming, Wen, Yanli, Song, Shiping, and Liu, Gang

Abstract

Intracellular enzyme cascades are essential for various biological processes, and mimicking their functions in artificial systems has attracted significant research attention. However, achieving convenient and efficient spatial organization of enzymes on interfaces remains a critical challenge. In this work, we designed a simple single-DNA scaffold using triblock polyA single-stranded DNA for the arrangement of coupled enzymes. The scaffold was assembled onto a gold electrode through the affinity of polyA-Au, and two enzymes (glucose oxidase and horseradish peroxidase) were captured through hybridization. The molecular distance between the enzymes was regulated by changing the length of the polyA fragment. As a proof of concept, a glucose biosensor was constructed based on the enzyme cascade amplification. The biosensor exhibited excellent detection capability for glucose in human serum samples with a limit of detection of 1.6 μM. Additionally, a trienzyme cascade reaction was successfully activated, demonstrating the potential scalability of our approach for multienzyme reactions. This study provides a promising platform for the development of easy-to-operate, highly efficient, and versatile enzyme cascade systems using DNA scaffolds.

Published
2023
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22. Framework Nucleic Acids as Blood-Retinal-Barrier-Penetrable Nanocarrier for Periocular Administration.

Author

Wang R, Liu Y, Xiao W, Yi Q, Jiang M, Guo R, Song L, Li M, Li F, Shi D, Zhao L, Huang W, Zuo X, and Mao X

Subjects
Rats, Animals, Tissue Distribution, Retina, Drug Delivery Systems methods, Blood-Retinal Barrier, Nucleic Acids
Abstract

Designing an ocular drugs delivery system that can permeate the outer blood-retinal barrier (oBRB) is crucial for the microinvasive or noninvasive treatment of ocular fundus diseases. However, due to the lack of a nanocarrier that can maintain structure and composition at the oBRB, only intravitreal injection at the eyeball can deliver therapeutics directly to the ocular fundus via paracellular and intercellular routes, despite the intraocular operations risks. Here, we demonstrated tetrahedral framework nucleic acids (tFNAs) can penetrate the oBRB and deliver therapeutic nucleic acids to the retina of the rat eye in vivo following subconjunctival injection. We also discovered that tFNAs were transported via a paracellular route across the intercellular tight junctions at the oBRB. The histology analysis for ocular layers indicated that individual and aptamer/doxorubicin-loaded tFNAs penetrated all layers of the posterior segment of the eyeball to reach the innermost retina and persisted for over 3 days with minimal systemic biodistribution. We expect that the programmability and penetrability of tFNAs will provide a promising method for drug delivery across oBRB and long-term sustenance at the target site via periocular administration to various tissues.

Published
2023
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