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Objective To investigate the association between whole blood iron, copper and their interaction with cardiovascular diseases (CVD). Methods A cohort-based case control study was conducted. Cases were 93 males with CVD in the Kailuan cohort who participated in the follow-up in 3 hospitals in 2017-2018. During the same period, 372 males with non-CVD who were 1∶4 individual matched by age and labor type were selected as controls. The concentration of blood iron and copper was determined by inductively coupled plasma mass spectrometry. Conditional logistic regression models were used to estimate the association between blood iron and copper and CVD, respectively and elastic-Net regression models to estimates interaction between the two metals and CVD. Results The whole blood iron concentration in the cases was significantly higher than the controls, while blood copper concentration was lower than the controls (both P＜0.001). After adjusting for age, smoking, drinking, overweight, hypertension, diabetes, anemia, hyperlipidemia, and high sensitivity C-reactive protein, the participants with higher iron increase 3.17 times (OR=4.17, 95% CI: 2.23-7.79, P＜0.001) risk of CVD than those with lower iron, and those with lower copper increase 3.26 times (OR=4.26, 95% CI: 1.73-10.45, P＜0.01) risk than those with the higher copper. Adaptive Elastic-net regression analysis showed that it under the simultaneous exposure of higher iron and lower copper, the risk of CVD with environment risk score ＞0.232 was 8.96 times (OR=8.96, 95% CI: 4.47-17.95, P＜0.001) than the score ≤0.232. Conclusions Higher iron and copper deficiency may be independent risk factors for CVD. Environment risk score could be a good indicator of simultaneous exposure of blood iron and copper, which should have a better predictive value of CVD.

A body shape index (ABSI) has been proven to be related to a population's CVD incidence. However, the application of this indicator has produced different results. This study aimed to evaluate the applicability of the ABSI in predicting the incidence of CVD in rural Xinjiang, China, and compare it with waist circumference (WC), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), and body mass index (BMI). 5375 people aged 18 years or older were included in the study. We used the Cox proportional hazard model to evaluate the relationship between WC, WHR, WHtR, BMI, and ABSI and the incidence of CVD, the area under the curve (AUC) to evaluate the predictive power of each anthropometric index for the incidence of CVD, and restricted cubic splines are used to analyse the trend relationship between anthropometric indicators and the incidence of CVD. After multivariate adjustment, standardised WC, WHR, WHtR, BMI, and ABSI all positively correlated with the incidence of CVD. WC had the highest HR (95% CI) value, 1.64 (1.51–1.78), and AUC (95% CI) value, 0.7743 (0.7537–0.7949). ABSI had the lowest HR (95% CI) value, 1.21(1.10–1.32), and AUC (95% CI) value, 0.7419 (0.7208–0.7630). In the sex-specific sensitivity analysis, the predictive ability of traditional anthropometric indicators for the incidence of CVD is higher than that of ABSI. In the rural areas of Xinjiang, the traditional anthropometric indicators of WC had better ability to predict the incidence of CVD than ABSI. [ABSTRACT FROM AUTHOR]

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On the basic of describes the space signal interface control document of the Beidou satellite navigation system about the quadrature phase shift keying (QPSK) modulated signals and ranging codes published recently, for the direct sequence spread spectrum (DSSS) communication system used by the navigation system, analysis the performance of system in the presence of narrowband interference, and simulate the result. The result shows that, in the presence of narrowband interference, related the performance of the navigation signals with jamming position, characteristics of the spreading code and modulation styles, and for improving the performance of the navigation signal, it's necessary to consider factors above mentioned. [ABSTRACT FROM AUTHOR]

GNSS anti-jamming receiver indoor wireless anti-jamming test has the advantages of low cost, good controllability, strong repeatability etc, so it is used widely. Under the current indoor wireless anti-jamming test method, satellite signals use a single antenna output form and interference signals use the static interference simulation. The satellites' space position and the real interference scene can't be simulated, so the performance of GNSS anti-jamming receiver cannot be tested accurately. In order to solve the problem, a large field angle test method based on the microwave chamber is proposed, which achieves the satellite signals using multiple antenna output and the interference signals using dynamic interference simulation by expanding the range of the analog signals of viewing angle. According to comparing digital simulations with test results, the effectiveness and reasonability of the proposed method is verified, and the influence on the anti-jamming receiver performance test brought by the simulation error of signals is also analyzed. [ABSTRACT FROM AUTHOR]

Objective: To explore the efficacy and safety of haploidentical hematopoietic stem cell transplantation combined with umbilical cord blood infusion for the treatment of aplastic anaemia in children., Methods: Nine cases of children with aplastic anaemia treated with umbilical cord blood combined with haploidentical hematopoietic stem cell transplantation at the People's Hospital of Henan University of Chinese Medicine from January 1, 2021 to September 15, 2023 with a median age of 11(2-13) years and a median follow up of 18(7.5-21) months were included, and the clinical data were retrospectively analyzed. Hematopoiesis reconstitution, the incidence of graft-versus-host disease(GVHD), infections and survival of the patients were analyzed., Results: All 9 children were successfully implanted. The median time to neutrophil and platelet implantation was 11.11±1.27 d and 12.44±3.36 d, respectively. One case developed acute gastrointestinal GVHD of degree I, which was improved after treatment, and the patient developed superficial gastritis and chronic gastrointestinal GVHD at a later stage, which is currently under clinical follow-up. Acute GVHD of II-IV degree was 0%. Hemorrhagic cystitis in 3 cases, CMV infection in 5 cases and bacterial and fungal infections in 5 cases improved with symptomatic treatment.All 9 children demonstrated complete donor chimerism within 1 month after transplantation, at two years of follow-up, all nine children survived without recurrence or development of grade II-IV GVHD, and there were no children with transplant-related deaths., Conclusion: Haploidentical hematopoietic stem cell transplantation combined with umbilical cord blood transfusion for aplastic anaemia in children has a low incidence and mild degree of GVHD, with significant efficacy, and can be used as a therapeutic option for children without an HLA full donor chimeric match.

Objective: To investigate the correlation of peripheral blood platelet/lymphocyte ratio (PLR) with Treg and Th17 and its influence on prognosis in newly diagnosed multiple myeloma (MM)., Methods: One hundred thirty-five newly diagnosed multiple myeloma patients admitted to the Department of Hematology of Zhengzhou People's Hospital from June 2015 to October 2022 were selected as MM group. Clinical data included sex, age, immune typing, ISS stage, blood calcium (Ca), albumin (ALB), hemoglobin (Hb), PLR, LDH, β 2 microglobulin (β 2 -MG), Treg and Th17 levels. Sixty healthy volunteers who underwent physical examination in our hospital during the same period were selected as the control group. PLR, Treg and Th17 levels in MM group and control group were compared. Pearson was used to analyze the correlation between PLR and Treg, Th17. The relationship between MM patients with different PLR and clinical features and prognosis was analyzed., Results: The PLR and Th17 of MM patients were significantly higher than that of control group, and Treg was significantly lower than that of control group ( P <0.05). In MM patients, PLR was negatively correlated with Treg ( r =-0.616), and PLR was positively correlated with Th17 ( r =0.555). Using mean PLR=132.72 as the boundary, 135 MM patients were divided into high PLR group ( n =54) and low PLR group ( n =81). In MM patients with high PLR, ISS stage, ALB and Treg were significantly higher than those in low PLR group, while Th17 was significantly lower than those in low PLR group ( P <0.05). By univariate and COX regression analysis, PLR was an independent prognostic risk factor for newly diagnosed MM patients ( P <0.05). MM patients with high PLR had better PFS and OS, and the difference was statistically significant compared with MM patients with low PLR ( P <0.05). 65 patients admitted from June 2015 to December 2018 were used as the training set, and 70 patients admitted from January 2019 to October 2022 were used as the validation set. The OS of MM patients with different PLR were compared respectively. The results showed that the conclusions of the training set and the validation set were consistent. PLR with high expression had higher OS ( P <0.01)., Conclusion: PLR is correlated with Treg and Th17 in newly diagnosed MM patients, and high PLR has better prognosis. PLR can be used to evaluate the prognosis of MM patients.

Objective: To investigate the expression and correlation of miR-211, miR-155, and C-myc in acute T lymphocytic leukemia (T-ALL), aiming to provide evidence for the diagnosis and treatment., Methods: A total of 96 T-ALL patients who were diagnosed and treated in People's Hospital of Zhengzhou from June 2014 to June 2017 were selected, and 69 healthy volunteers who had a physical examination were selected as control group in the same period. Real-time fluorescent quantitative PCR (RT-PCR) was used to determine the expression levels of miR-211, miR-155, and C-myc in peripheral blood mononuclear cells in each group. Kaplan-Meier was used to analyze the survival of T-ALL patients and correlation of miR-211, miR-155, and C-myc with prognosis. Pearson correlation analysis was used to evaluate the correlation of miR-211, miR-155, and C-myc with disease risk., Results: The expression levels of miR-211 mRNA, miR-155 mRNA, and C-myc mRNA in T-ALL group were higher than those in the control group (P<0.01), those in non-remission group were higher than those in remission group (P<0.01), and those in high-risk group were also higher than those in low-risk group and intermediate-risk group (P<0.01). The survival time of T-ALL patients with low miR-211 expression was longer than that with high miR-211 expression (P<0.01), that with low miR-155 expression was longer than that with high miR-155 expression (P<0.01), and that with low C-myc expression was also longer than that with high C-myc expression (P<0.01). The high expression of miR-211, miR-155, and C-myc was linearly positively correlated with high risk of disease (r=0.749, 0.781, 0.804)., Conclusion: The expressions of miR-211, miR-155, and C-myc are up-regulated in T-ALL patients, closely related to prognosis, and linearly positively correlated with disease risk.

Objective: To explore the hematological and clinical features of patients with malignant lymphoma (ML) combined with venous thromboembolism (VTE)., Methods: Sixty patients with ML combined with VTE in our hospital from May 2014 to May 2016 were enrolled in ML+VTE group, out of them 42 patients were males and 18 patients with females; another 60 patients with ML alone were enrolled in control group, out of them 43 patients were males and 17 patients females. The hematological, coagulation and clinical datas of all the patients were collected and then retrospectively analyzed., Results: About 81.54% of the patients in ML+VTE group were found in Stage ⅢB-Ⅳ tumor, and about 66.67% patients were found after ML was diagnosed; about 85.00% were with deep vein thrombosis (DVT), 10.00% were with pulmonary embolism (PE), and 5.00% were complicated with both DVT and PE. Common DVT locations in 56.67% cases were the upper limb and the neck vein(56.67%); The total effective rate of the cases with DVT was 49.02%, and the rate of cases with PE was 14.29%, and 0 in the cases with both DVT and PE, the difference was statistically significant (χ 2 =72.650, P<0.001). Compared with the patients of control group, the levels of platelet aggregation, D-dimer, high cut blood viscosity, low cut blood viscosity, plasma viscosity, hematocrit, assembly index of erythrocyte, and rigidity index of erythrocyte were higher in patients of ML+VTE group (P<0.05), and APTT, erythrocy tesed imentation rate, deformability index of erythrocyte, and average velocity of blood flow were reduced, the differences were statistically significant (P<0.05)., Conclusion: Hemaorheology and coagulation of patients with ML combined with VTE indicate changes in the sensitivity state of thromboembolism; DVT, which is commonly manifested in the upper limb and the neck vein, and it mainly observed in patients with end-stage.