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Esophageal squamous cell carcinoma (ESCC) is a prevalent gastrointestinal cancer characterized by high mortality and an unfavorable prognosis. While combination therapies involving surgery, chemotherapy, and radiation therapy are advancing, targeted therapy for ESCC remains underdeveloped. As a result, the overall five‐year survival rate for ESCC is still below 20%. Herein, ESCC‐specific DNA aptamers and an innovative aptamer‐modified nano‐system is introduced for targeted drug and gene delivery to effectively inhibit ESCC. The EA1 ssDNA aptamer, which binds robustly to ESCC cells with high specificity and affinity, is identified using cell‐based systematic evolution of ligands by exponential enrichment (cell‐SELEX). An EA1‐modified nano‐system is developed using a natural egg yolk lipid nanovector (EA1‐EYLNs‐PTX/siEFNA1) that concurrently loads paclitaxel (PTX) and a small interfering RNA of Ephrin A1 (EFNA1). This combination counters ESCC's proliferation, migration, invasion, and lung metastasis. Notably, EFNA1 is overexpressed in ESCC tumors with lung metastasis and has an inverse correlation with ESCC patient prognosis. The EA1‐EYLNs‐PTX/siEFNA1 nano‐system offers effective drug delivery and tumor targeting, resulting in significantly improved therapeutic efficacy against ESCC tumors. These insights suggest that aptamer‐modified nano‐systems can deliver drugs and genes with superior tumor‐targeting, potentially revolutionizing targeted therapy in ESCC. [ABSTRACT FROM AUTHOR]

Shelter-recruited adolescents are known to have high rates of substance abuse and co-occurring internalizing and externalizing problem behaviors. Many studies have documented these mental health concerns, but only a small number of studies have tested interventions that may be useful for ameliorating these vulnerabilities. The current study compared three empirically supported psychotherapy interventions, Motivational Interviewing (MI), the Community Reinforcement Approach (CRA), and Ecologically-Based Family Therapy (EBFT) with 179 substance abusing runaway adolescents (47% female, 74% minority) and their primary caretaker recruited through a Midwestern runaway crisis shelter. Examining both child and primary caretaker reports, each treatment was associated with significant reductions in internalizing and externalizing behaviors to 24 months post-baseline. However, the trajectory of change differed among the treatments. Adolescents receiving MI showed a quicker reduction in internalizing and externalizing behaviors but also a quicker increase in these behaviors compared to adolescents receiving EBFT, who continued to evidence improvements to 24 months. The findings provide support for continued evaluation of these treatments for use with this vulnerable population of adolescents.

This study examined the relation between maternal depressive symptoms and adolescents' problem behaviors, moderated by adolescent gender, as well as the association between maternal depressive symptoms and the family environment characteristics above and beyond child variables. Data were collected from 137 mothers of runaway adolescents with alcohol and/or substance abuse problems. Results showed that both internalizing and externalizing problem behaviors of adolescent girls, as opposed to problem behaviors of boys, were significantly associated with maternal depressive symptoms. In addition, higher family cohesion was significantly related to lower maternal depressive symptoms even after controlling for adolescent problem behaviors. However, no significant relationship was found between family conflict and maternal depressive symptoms. These findings indicate that both adolescents' problem behaviors and mothers' perceptions of the family environment are associated with maternal depressive symptoms, highlighting the potential utility of the family systems theoretical framework for understanding and intervening mothers' emotional problems in the family context. (Contains 2 figures, 4 tables, and 1 footnote.)

Objectives: Depressive symptoms and life satisfaction are closely related among the older adults. However, investigation of the dyadic influence of depressive symptoms and life satisfaction among Chinese older married couples is limited. The current study aimed to investigate the reciprocal effects of life satisfaction and depressive symptoms longitudinally among a sample of Chinese older married couples. Method: The current sample consisted of 1,877 older married couples from the China Family Panel Studies (CFPS). Depressive symptoms and life satisfaction were measured at the 2010 baseline and the 2014 assessment. Age, income, education, physical health, and length of marriage measured at baseline were included as the controlled variables. Data was analyzed with the longitudinal actor-partner interdependence models. Results: One's life satisfaction and depressive symptoms were significantly associated with his/her own life satisfaction and depressive symptoms longitudinally. In addition, higher levels of wives' depressive symptoms in 2010 were associated with higher levels of depressive symptoms and lower levels of life satisfaction among their husbands in 2014. Higher levels of husbands' life satisfaction in 2010 were associated with higher levels of wives' life satisfaction in 2014. Conclusion: The current study found both actor and partner effects in the long-term association between depressive symptoms and life satisfaction. Among these older married couples, husbands were the 'receivers' of their wives' depressive symptoms and the 'senders' of life satisfaction. Practitioners aiming to promote the well-beings of older married adults need to consider the dyadic influences given the significant partner effects found in the current study. [ABSTRACT FROM AUTHOR]

The crude divorce rate has been increasing steadily for over a decade in China. Consequently, more and more children have to face the challenge of growing up in single parent families. The current study investigated the mediating effects of problem-oriented and emotion-oriented coping on the relationship between parental attachment and psychological resilience among a sample of Chinese adolescents from single parent families and intact families. Participants were 975 high school students (44.30% males; aged 15–19 years, M = 16.32 years, SD = 0.74), 871 from intact families and 104 from single parent families. Structural equation modeling showed that security in maternal attachment was positively associated with resilience through the indirect effect of reduced emotion-oriented coping among adolescents from single parent families. Among adolescents from intact families, security in maternal attachment was both directly associated with resilience and indirectly through enhanced problem-oriented and reduced emotion-oriented coping. Security in paternal attachment was associated with resilience both directly and indirectly through enhanced problem-oriented coping as well among those from intact families. Female adolescents exhibited significantly lower levels of resilience than male adolescents did regardless of the marital status of their parents. Limitations and suggestions for future research are discussed. [ABSTRACT FROM AUTHOR]

The current study examined the mediating role of both mother and child interactive behaviors, which granted or undermined autonomy and relatedness, on the bidirectional and longitudinal association between maternal depressive symptoms and child internalizing behaviors, as well as the association between maternal substance use and child externalizing behaviors. Child's sex and mother's drug of choice were explored as potential moderators of the mediation relationship. Data were collected from 183 dyads including treatment-seeking substance using mothers and their children (95 males, aged between 8 and 16 years old). Structural equation modeling analysis showed girls' internalizing and externalizing behaviors at the 3-month follow-up were negatively associated with the same behaviors at the 12-month follow-up through increased relatedness undermining behaviors from their mothers at the 6-month follow-up. Among mothers with opioids as their drug of choice (DOC), children's externalizing behaviors at the 3-month follow-up were positively associated with mothers' substance use at the 12-month follow-up through the elevated levels of mothers' relatedness undermining behaviors at the 6-month follow-up. Among mothers with alcohol as their DOC, maternal depressive symptoms at the 3-month follow-up were positively related to children's internalizing behaviors at the 12-month follow-up through reduced relatedness undermining behaviors exhibited by mothers at the 6-month follow-up. To our knowledge, this is one of the first studies to attempt to unravel these longitudinal and bidirectional influences as well as the moderated mediation pathways among families with a substance using mothers. [ABSTRACT FROM AUTHOR]

Eligible adolescents (12-17 years old) were recruited from a short-term crisis shelter for runaway adolescents in a large Midwestern city. Adolescents (N = 179) were randomly assigned to Ecologically-Based Family Therapy (EBFT, n = 61), the Community Reinforcement Approach (CRA, n = 57), or brief Motivational Enhancement Therapy (MET, n = 61) with the primary focus on substance abuse. A significant increase in perceived family cohesion and a significant reduction in perceived family conflict were found among all treatment conditions from baseline to the 24-month follow-up. Adolescents who received EBFT demonstrated more improvement in family cohesion after treatment than those who received CRA or MET, and more reduction in family conflict during treatment than those who received MET. [ABSTRACT FROM AUTHOR]

This study examined the degree of disagreement between runaway adolescents and their primary caretakers, defined as informant discrepancies, on their view of their family. How these discrepancies changed over time and whether family therapy or individual therapy could impact that change were also explored. The current sample ( N = 179 dyads) included adolescent substance abusers residing in a runaway shelter and their primary caretakers. Adolescent gender was examined as a correlate of change, and treatment attendance was controlled. The intraclass correlation coefficient was used to measure discrepancies between the individuals within a dyad. Results showed that among those receiving family therapy, but not individual therapy, informant discrepancies decreased significantly over time. Additionally, dyads with a male adolescent showed a significantly slower rate of improvement in discrepancy scores across time compared with dyads with a female adolescent. Previous research indicates that lower levels of discrepant perceptions are associated with better individual and relationship functioning. Therefore, this study's findings support family therapy as superior to individual therapy for addressing parent-child discrepancies--possibly through its focus on improving family communication, perspective taking, and understanding. [ABSTRACT FROM AUTHOR]