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24 results on '"Guo, Xiuhai"'

3. Differential Features of Culprit Intracranial Atherosclerotic Lesions: A Whole‐Brain Vessel Wall Imaging Study in Patients With Acute Ischemic Stroke

Author

Wu, Fang, Ma, Qingfeng, Song, Haiqing, Guo, Xiuhai, Diniz, Marcio A, Song, Shlee S, Gonzalez, Nestor R, Bi, Xiaoming, Ji, Xunming, Li, Debiao, Yang, Qi, Fan, Zhaoyang, and Investigators, the WISP

Subjects
Neurosciences, Aging, Brain Disorders, Atherosclerosis, Stroke, Biomedical Imaging, Clinical Research, Detection, screening and diagnosis, 4.2 Evaluation of markers and technologies, Acute Disease, Brain, Brain Ischemia, Cerebral Arteries, Female, Humans, Imaging, Three-Dimensional, Intracranial Arteriosclerosis, Magnetic Resonance Angiography, Male, Middle Aged, Reproducibility of Results, Retrospective Studies, high-resolution magnetic resonance imaging, intracranial atherosclerosis, stroke, vessel wall imaging, WISP Investigators, high‐resolution magnetic resonance imaging, Cardiorespiratory Medicine and Haematology
Abstract

Intracranial atherosclerotic disease tends to affect multiple arterial segments. Using whole-brain vessel wall imaging, we sought to study the differences in plaque features among various types of plaques in patients with a recent unilateral anterior circulation ischemic stroke. Sixty-one patients with unilateral anterior circulation ischemic stroke were referred to undergo whole-brain vessel wall imaging (before and after contrast) within 1 month of symptom onset for intracranial atherosclerotic disease evaluations. Each plaque was classified as a culprit, probably culprit, or nonculprit lesion, according to its likelihood of causing the stroke. The associations between plaque features (thickening pattern, plaque-wall contrast ratio, high signal on T1-weighted images, plaque contrast enhancement ratio, enhancement grade, and enhancement pattern) and culprit lesions were estimated using mixed multivariable logistic regression after adjustment for maximum wall thickness. In 52 patients without motion corruption in whole-brain vessel wall imaging, a total of 178 intracranial plaques in the anterior circulation were identified, including 52 culprit lesions (29.2%), 51 probably culprit lesions (28.7%), and 75 nonculprit lesions (42.1%). High signal on T1-weighted images (adjusted odds ratio, 9.1; 95% confidence interval, 1.9-44.1; P=0.006), grade 2 (enhancement ratio of plaque ≥ enhancement ratio of pituitary) contrast enhancement (adjusted odds ratio, 17.4; 95% confidence interval, 1.8-164.9; P=0.013), and type 2 (≥50% cross-sectional wall involvement) enhancement pattern (adjusted odds ratio, 10.1; 95% confidence interval, 1.3-82.2; P=0.030) were independently associated with culprit lesions. High signal on T1-weighted images, grade 2 contrast enhancement, and type 2 enhancement pattern are associated with cerebrovascular ischemic events, which may provide valuable insights into risk stratification.

Published
2018

12. Abstract WMP48: 3D MR Vessel Wall Imaging Reveals Plaque-Specific Responses to Medical Therapy in Patients With Symptomatic Intracranial Atherosclerotic Disease: Initial Experience

Author

Xiao, Jiayu, primary, Miao, Huijuan, additional, Shlee, Song, additional, Schlick, Konrad, additional, Jiang, Tao, additional, Xia, Shuang, additional, Han, Tong, additional, Maya, Marcel, additional, Lyden, Patrick, additional, Li, Debiao, additional, Guo, Xiuhai, additional, Yang, Qi, additional, and Fan, Zhaoyang, additional

Published
2020
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15. Hyperintense Plaque on Intracranial Vessel Wall Magnetic Resonance Imaging as a Predictor of Artery-to-Artery Embolic Infarction

Author

Wu, Fang, primary, Song, Haiqing, additional, Ma, Qingfeng, additional, Xiao, Jiayu, additional, Jiang, Tao, additional, Huang, Xiaoqin, additional, Bi, Xiaoming, additional, Guo, Xiuhai, additional, Li, Debiao, additional, Yang, Qi, additional, Ji, Xunming, additional, Fan, Zhaoyang, additional, Yu, Huan, additional, Cui, Bin, additional, Sun, Jiayu, additional, Sun, Bin, additional, Xia, Shuang, additional, Han, Tong, additional, and Cheng, Jingliang, additional

Published
2018
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16. Abstract WP134: Quantitatively Monitoring Regression or Progression in Intracranial Atherosclerotic Plaques Using 3D Vessel Wall Imaging and Deep-learning-based Vessel Wall Analysis

Author

Fan, Zhaoyang, primary, Yang, Qi, additional, Shi, Feng, additional, Miao, Huijuan, additional, Yang, Yujiao, additional, Schlick, Konrad, additional, Gonzalez, Nestor, additional, Maya, Marcel, additional, Song, Haiqing, additional, Li, Debiao, additional, Guo, Xiuhai, additional, and Song, Shlee, additional

Published
2018
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17. Lipoprotein-Associated Phospholipase A2 and Risk of Carotid Atherosclerosis and Cardiovascular Events in Community-Based Older Adults in China

Author

Wang, Chunxiu, primary, Fang, Xianghua, additional, Hua, Yang, additional, Liu, Yutong, additional, Zhang, Zhongying, additional, Gu, Xiang, additional, Wu, Xiaoguang, additional, Tang, Zhe, additional, Guan, Shaochen, additional, Liu, Hongjun, additional, Liu, Beibei, additional, Guo, Xiuhai, additional, and Ji, Xunming, additional

Published
2017
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23. Mutations of sodium channel alpha-subunit genes in Chinese patients with normokalemic periodic paralysis

Author

Zhu Ke, Wang Hongbin, Guo Xiuhai, MaoYanling, Wu Weiping, and Si Yiling

Subjects
Adult, Genetic Markers, Male, China, Adolescent, Sequence analysis, DNA Mutational Analysis, Muscle Fibers, Skeletal, Biology, medicine.disease_cause, Sodium Channels, Denaturing high performance liquid chromatography, Paralyses, Familial Periodic, Cellular and Molecular Neuroscience, Exon, Asian People, medicine, Humans, Genetic Predisposition to Disease, Amino Acid Sequence, Genetic Testing, NAV1.4 Voltage-Gated Sodium Channel, Child, Muscle, Skeletal, Gene, Genetics, Mutation, Muscle biopsy, medicine.diagnostic_test, Cell Biology, General Medicine, Middle Aged, Molecular biology, genomic DNA, Amino Acid Substitution, Child, Preschool, Female, Heteroduplex
Abstract

In this study, we aim to investigate the clinical features and Mutations of sodium channel alpha-subunit (SCN4A) genes in Chinese patients with normokalemic periodic paralysis (normoKPP).Six unrelated Chinese families with normoKPP were analyzed in clinical features. Genomic DNA was extracted from peripheral blood leukocytes and amplified with PCR. We screened all 24 exons of SCN4A gene with denaturing high performance liquid chromatography (DHPLC) technology, and then sequence analysis was performed in those who showed heteroduplex as compared with unaffected controls.The laboratory tests were within normal ranges. Electromyograms and electrocardiograms were normal. One muscle biopsy was performed with the patient in family 4 after a brief attack of normoKPP. Examination of light microscopy showed no changes, but electronic microscopy showed occasionally degenerating myofibers. The mutations of SCN4A genes were as follows: (1) Met1592Val occurred in family 1. (2) Val-781-Ile occurred with the patient and her father in family 4. (3) Both the patients had a novel mutation g2101a predicting the amino acid exchange Arg675Gln in family 5, which may be a disease-causing mutation.In addition to Val-781-Ile and Met1592Val, the mutation g2101a (Arg675Gln) may be the novel mutation of SCN4A genes in Chinese patients with normoKPP.

Published
2007

24. Mutations of Sodium Channel α-Subunit Genes in Chinese Patients with Normokalemic Periodic Paralysis.

Author

Guo Xiuhai, Wu Weiping, Zhu Ke, Wang Hongbin, Si Yiling, and MaoYanling

Subjects
*GENES, *HEREDITY, *SODIUM channels, *PHYSIOLOGICAL transport of sodium
Abstract

Abstract Objective  In this study, we aim to investigate the clinical features and Mutations of sodium channel α-subunit (SCN4A) genes in Chinese patients with normokalemic periodic paralysis (normoKPP). Methods  Six unrelated Chinese families with normoKPP were analyzed in clinical features. Genomic DNA was extracted from peripheral blood leukocytes and amplified with PCR. We screened all 24 exons of SCN4A gene with denaturing high performance liquid chromatography (DHPLC) technology, and then sequence analysis was performed in those who showed heteroduplex as compared with unaffected controls. Results  The laboratory tests were within normal ranges. Electromyograms and electrocardiograms were normal. One muscle biopsy was performed with the patient in family 4 after a brief attack of normoKPP. Examination of light microscopy showed no changes, but electronic microscopy showed occasionally degenerating myofibers. The mutations of SCN4A genes were as follows: ➀ Met1592Val occurred in family 1. ➁ Val-781-Ile occurred with the patient and her father in family 4. ➂ Both the patients had a novel mutation g2101a predicting the amino acid exchange Arg675Gln in family 5, which may be a disease-causing mutation. Conclusions  In addition to Val-781-Ile and Met1592Val, the mutation g2101a (Arg675Gln) may be the novel mutation of SCN4A genes in Chinese patients with normoKPP. [ABSTRACT FROM AUTHOR]

Published
2008
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