1. High infiltration of CD20 + B lymphocytes in extranodal natural killer/T‐cell lymphoma is associated with better prognosis
- Author
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Min‐Min Chen, Guo‐Peng Zeng, Jing Li, Jun‐Hong Fu, Ya‐Yi Long, Jie‐Ying Pan, Lin‐Zhi Wei, Jie‐Ying Guan, Ying‐Xi Lin, Hua You, Cheng Si, Wen‐Xing Li, Yi‐Jun Liang, Da‐Hai Liu, and Fang Liu
- Subjects
CD20 ,biology ,business.industry ,Hematology ,medicine.disease ,Natural killer T cell ,Phenotype ,Lymphoma ,03 medical and health sciences ,0302 clinical medicine ,Immune system ,030220 oncology & carcinogenesis ,medicine ,Cancer research ,biology.protein ,Immunohistochemistry ,Clinical significance ,business ,Infiltration (medical) ,030215 immunology - Abstract
Immune cells have an uncertain function during the progression of extranodal natural killer/T-cell lymphoma (ENKTL). The present study determined the distribution, phenotype, and clinical significance of B lymphocytes in ENKTL. Immunohistochemistry indicated high infiltration of CD20+ B lymphocytes in the tumour tissues of 40% of the patients, and that a high infiltration correlated with better overall survival. Moreover, B lymphocytes had an active mature phenotype in situ and suppressed the proliferation of ENKTL cells in vitro. These results suggest that tumour infiltration of CD20+ B lymphocytes may be a new prognostic indicator for patients with ENKTL.
- Published
- 2020
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