1. Anti-inflammatory principles from Lindera aggregata
- Author
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Sio Hong Lam, Ping Chung Kuo, Liang Mou Kuo, Daih Huang Kuo, Tian Shung Wu, Hsin Yi Hung, Yi Hung Wu, Tsong-Long Hwang, and Guo Hao Ma
- Subjects
Neutrophils ,medicine.drug_class ,Stereochemistry ,Clinical Biochemistry ,Anti-Inflammatory Agents ,Pharmaceutical Science ,Sesquiterpene ,01 natural sciences ,Biochemistry ,Anti-inflammatory ,Lindera aggregata ,chemistry.chemical_compound ,Superoxides ,Drug Discovery ,medicine ,Ic50 values ,Humans ,Molecular Biology ,chemistry.chemical_classification ,Molecular Structure ,Pancreatic Elastase ,biology ,010405 organic chemistry ,Superoxide ,Alkaloid ,Organic Chemistry ,Glycoside ,biology.organism_classification ,Lindera ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,chemistry ,Natural source ,Molecular Medicine ,Sesquiterpenes - Abstract
Four new sesquiterpenes (1–4), one new alkaloid (5), and one new benzenoid glycoside (6) were characterized from Lindera aggregata, and their structures were elucidated according to their spectrometric analytical data. Among these isolates, 3 and 4 were constructed as possessing unprecedented carbon skeletons from the natural source. Some of these purified constituents were examined for their anti-inflammatory bioactivity. Among the tested compounds, linderaggredin C (3), (+)-N-methyllaurotetanine, and (+)-isoboldine displayed the significant inhibition of superoxide anion generation in human neutrophils with IC50 values of 7.45 ± 0.74, 8.36 ± 0.11, and 5.81 ± 0.59 μM, respectively.
- Published
- 2020
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