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285 results on '"Guo Shifeng"'

1. Identification of serum miR-378 and miR-575 as diagnostic indicators and predicting surgical prognosis in human epilepsy

Author

Li Xiuxiu, Gao Zhiqing, Ma Mei Ling, Li Li, and Guo Shifeng

Subjects
mir-378, mir-575, human epilepsy, serum biomarkers, Biochemistry, QD415-436
Abstract

Background: Epilepsy (EP) is a common neurological disorder which is characterized by excessive abnormal synchronization of neuronal discharges in the brain due to chronic recurrent seizures of multiple etiologies. Variety of microRNAs have been associated with the occurrence and development of EP. This study aimed to determine the aberrant expression of miR-378 and miR-575 in EP patients to validate their potential to distinguish EP from healthy patients. Methods: RT-qPCR was used to determine the expressions of miR-378 and miR-575 from serum specimens of 106 EP and 103 control individuals. Clinical indicators between EP patients and controls were assessed. Based on surgical outcome, EP patients were further divided into Engel I-IV EP. The potentials of miR-378 and miR-575 in discriminating EP from healthy participants and predicting surgical prognosis were calculated by receiver operating characteristic (ROC) analysis. Results: We found the miR-378 and miR-575 were significantly declined (P

Published
2022
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2. Ring Artifacts Removal Based on Implicit Neural Representation of Sinogram Data

Author

Shi, Ligen, Jiang, Xu, Liu, YunZe, Liu, Chang, Yang, Ping, Guo, Shifeng, and Zhao, Xing

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, 68U05, 65D18, I.4.5, I.4.10
Abstract

Inconsistent responses of X-ray detector elements lead to stripe artifacts in the sinogram data, which manifest as ring artifacts in the reconstructed CT images, severely degrading image quality. This paper proposes a method for correcting stripe artifacts in the sinogram data. The proposed method leverages implicit neural representation (INR) to correct defective pixel response values using implicit continuous functions and simultaneously learns stripe features in the angular direction of the sinogram data. These two components are combined within an optimization constraint framework, achieving unsupervised iterative correction of stripe artifacts in the projection domain. Experimental results demonstrate that the proposed method significantly outperforms current state-of-the-art techniques in removing ring artifacts while maintaining the clarity of CT images., Comment: 10 pages, 11 figures

Published
2024

20. Insights into the Molecular Mechanisms of Purine Compounds Synergistically Inducing Larval Settlement in Mytilopsis sallei Using Multi-Group Comparative Transcriptomic Analysis.

Author

He, Jian, Hao, Huanhuan, Pan, Huakang, Yao, Shanshan, Zhao, Yiran, Guo, Shifeng, Huang, Jianfang, and Feng, Danqing

Subjects
LIFE cycles (Biology), MARINE biology, MARINE invertebrates, FOULING organisms, FOCAL adhesions, LARVAL dispersal
Abstract

Simple Summary: The life cycle of marine benthic invertebrates includes a planktonic larval stage and a benthic adult stage, with larval settlement being the critical transition from a planktonic to a benthic lifestyle. Since adult mobility is limited or completely lost in the benthic environment, larval settlement directly affects population distribution, growth, and reproduction. Although larval settlement induced by natural chemical cues is widespread among marine invertebrates, the molecular mechanisms underlying this process remain unclear. Mytilopsis sallei, a typical marine fouling mussel, releases three purine compounds—adenosine, inosine, and hypoxanthine—that synergistically induce larval settlement. In this study, transcriptomic sequencing was employed to identify differentially expressed genes and signaling pathways associated with purine-compound-induced larval settlement. This research not only provides new insights into the molecular mechanisms of larval settlement in marine benthic invertebrates, but also offers a scientific basis and theoretical foundation for the ecological control of marine fouling organisms. The settlement of marine benthic invertebrate larvae is a crucial stage in their life cycle, directly influencing their population distribution, growth, and reproduction. It is generally believed that multiple chemical inducers in the environment synergistically affect larval settlement, though the underlying molecular mechanisms remain unclear. Our previous study has established that three purine compounds (adenosine, inosine, and hypoxanthine) released by adults of the mussel Mytilopsis sallei synergistically induced larval settlement. In this study, we performed transcriptomic sequencing analysis on larvae exposed to individual purine compounds and those exposed to a combination of three purine compounds. A total of 21,850 differentially expressed genes (DEGs) were identified. KEGG enrichment analysis of these DEGs revealed that the AMPK signaling pathway, FoxO signaling pathway, extracellular matrix (ECM)-receptor interaction, focal adhesion, and the thyroid hormone signaling pathway play key roles in the settlement of M. sallei larvae. Moreover, in larvae exposed to the combined action of three purines, the expression of relevant signaling pathways and metabolic processes was more significant. This research provides important information for understanding the molecular mechanisms underlying the induction of larval settlement in M. sallei by purine compounds in natural environments. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Generating Airy surface acoustic waves with dislocated interdigital transducers.

Author

Ma, Zongjun, Kong, Delai, Cai, Wenfeng, Wang, Zhenming, Cheng, Ming, Wu, Zixuan, Zhao, Xueqian, Cen, Mengjia, Dai, Haitao, Guo, Shifeng, and Liu, Yan Jun

Subjects
ACOUSTIC surface waves, INTERDIGITAL transducers, PHASE modulation, SAWS
Abstract

We propose an innovative design for interdigital transducers (IDTs), enabling phase modulation of surface acoustic waves (SAWs) with a dislocated electrode structure. By designing the size and arrangement of these dislocated IDTs, a novel type of Airy SAWs can be generated, exhibiting self-accelerating, self-bending, and self-healing characteristics. The acceleration of the generated Airy SAW is 0.081 cm−1. Furthermore, particles and bubbles can be precisely manipulated using the generated Airy SAW. The proposed dislocated IDTs could be used for generation of many other types of SAWs, hence holding great promise for applications including SAW shaping, particle manipulation/sorting, and acoustic sensing/detection. [ABSTRACT FROM AUTHOR]

Published
2024
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