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The aim of the study was to investigate the value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and intravoxel incoherent motion (IVIM) in differentiating TP53-mutant from wild type, low-risk from non-low-risk early-stage endometrial carcinoma (EC).

Objective: The influence of vaspin on vascular health had been investigated, yielding conflicting results. This study is intended to investigate the relation between vaspin and stroke severity and stroke outcome in a cohort Chinese patient with acute ischemic stroke (AIS). Methods: This was a prospective single-center observational study in Xinxiang, China. From 1 July 2017 to 30 November 2019, all patients with first-ever AIS were consecutively included. Serum levels of vaspin, stroke severity at (assessed by NIHSS score) admission and functional outcome (assessed by modified Rankin Scale (mRS)) at discharge were recorded. Multivariate analyses were assessed using logistic regression models. Results: Finally, 340 patients with AIS were included. The median age of those patients was 65 (interquartile range [IQR], 56–74) years and 61.8% were men. At admission, 88 patients (25.9%) experienced severe stroke (NIHSS>10) and serum levels of vaspin (median [IQR]: 0.72[0.48–0.90]ng/ml) in those patients were significantly lower than in those mild(0.92[0.70–1.19]ng/ml) and moderate stroke (0.93[0.63–1.21]ng/ml). At discharge, 113 patients (33.2%) experienced poor functional outcome (mRS >2) and vaspin serum levels in those patients were lower as compared with patients who experienced good outcome (0.71[0.45–0.98] vs. 0.91[0.71–1.19]ng/ml). In multivariate analyses, lower level of vaspin (< median) was associated with a 2.5-fold (odds ratio [OR] 2.46; 95% confidence interval [CI]: 1.75–4.45) increased risk for severe stroke and a 2.1-fold (2.03; 1.42–3.58) increased risk for poor outcome. Conclusion: In conclusion, reduced serum levels of vaspin at admission are significantly related to stroke severity and prognosis, which illustrates a predictive role of reduced vaspin in ischemic stroke. [ABSTRACT FROM AUTHOR]

Abstract: The phase transitions that take place in Sr1 + x Co0.8Fe0.2O3− δ (−0.2≤ x ≤0.1) oxides are reported here. Thermogravimetric analysis (TGA) showed that the oxides with −0.2≤ x ≤0 were prone to undergo oxygen-vacancy disorder–order phase transitions, while others with x =0.05, 0.1 had more stable crystal structures during oxygen-desorption processes in nitrogen. These results were further confirmed by high-temperature in-situ X-ray techniques. The changes in activation energies of three typical oxides, Sr1 + x Co0.8Fe0.2O3− δ (x =−0.2, 0, 0.1), used as oxygen-permeable membranes were investigated. The phase transitions in Sr1 + x Co0.8Fe0.2O3− δ (x =−0.2, 0) have also been detected in differential scanning calorimetry (DSC) profiles. [Copyright &y& Elsevier]

Objective: To investigate the changes in CT perfusion between symptomatic and asymptomatic patients with unilateral middle cerebral artery severe stenosis or occlusion., Methods: A total of 64 consecutive patients with unilateral middle cerebral artery severe stenosis or occlusion admitted to the First Affiliated Hospital of Xinxiang Medical College from January 2019 to March 2022 were retrospectively analyzed and divided into the symptomatic group (n = 33), and the asymptomatic group (n = 31). Clinical data of the two groups were collected. Multivariate logistic regression analysis was performed to analyze the factors of symptomatic and asymptomatic MCA stenosis. A t -test was performed to compare the differences in cerebral perfusion parameters between the two groups., Results: Multivariate logistic regression analysis indicated that glycosylated hemoglobin levels and high-density lipoprotein cholesterol levels were associated with the development of asymptomatic MCA severe stenosis or occlusion (odds ratio = 1.591 and 0.04, respectively). There were significant differences in CBV, MTT, and TTP between symptomatic and asymptomatic groups ( p < 0.05). The CBF of the affected side in the symptomatic group was lower than that of the unaffected side ( p < 0.05), whereas the asymptomatic group in CBF was not. Compared with the asymptomatic group, the CBF, MTT, and TTP of the affected side were significantly different ( p < 0.05). In contrast, the cerebral perfusion parameters of the unaffected side were not significantly different ( p > 0.05)., Conclusion: The use of CT perfusion imaging to analyze the alterations in cerebral perfusion parameters in patients with symptomatic and asymptomatic MCA severe stenosis or occlusion was helpful in clinical diagnosis and selecting treatment strategies and judging the development of the disease., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)

Objective: To investigate the neuroprotective effects of umbilical cord-derived mesenchymal stem cells (UC-MSCs) on radiation-induced brain injury (RIBI)., Methods: Thirty female C57BL/6 mice were randomly divided into three groups: control (CON), whole brain irradiation (WBI), and the cell therapy (MSC) group. Mice in the WBI and MSC groups received a single, whole brain irradiation treatment with 15 Gy of 60 Co. Learning and memory were evaluated in the mice using the step-down avoidance test. The neuronal changes in the hippocampal cornu ammonis (CA) 1 region were observed using hematoxylin eosin (H&E) staining. The changes in astrocytes were visualized with glial fibrillary acidic protein immunohistochemistry, and the expression of TNF-α, IL-6, and IL-10 was detected by quantitative polymerase chain reaction (qPCR) along with Enzyme linked immunosorbent assay (ELISA)., Results: Compared with mice in the WBI group, learning and memory in the MSC mice were significantly increased (P<0.05), neuronal degeneration and necrosis were significantly decreased ( P <0.05), and the number of astrocytes was significantly increased ( P <0.05). The levels of the in˙ammatory cytokines, TNF-α and IL-6, were significantly decreased ( P <0.05), however, the inhibitory factor IL-10 was significantly increased ( P <0.05)., Conclusions: UC-MSCs play a neuroprotective role by inhibiting brain cell injury and neuroinflammation., (© 2020 by the Association of Clinical Scientists, Inc.)