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BackgroundStroke is the leading cause of mortality in China, with limited evidence of in-hospital burden obtained from nationwide surveys. We aimed to monitor and track the temporal trends and rural–urban disparities in cerebrovascular risk factors, management and outcomes from 2005 to 2015.MethodsWe used a two-stage random sampling survey to create a nationally representative sample of patients admitted for ischaemic stroke in 2005, 2010 and 2015. We sampled participating hospitals with an economic-geographical region-stratified random-sampling approach first and then obtained patients with a systematic sampling approach. We weighed our survey data to estimate the national-level results and assess changes from 2005 to 2015.ResultsWe analysed 28 277 ischaemic stroke admissions from 189 participating hospitals. From 2005 to 2015, the estimated national hospital admission rate for ischaemic stroke per 100 000 people increased (from 75.9 to 402.7, Ptrendtrendtrendtrend=0.046), and decreases in in-hospital mortality (0.7% in 2015 vs 1.8% in 2005; adjusted OR (aOR) 0.52; 95% CI 0.32 to 0.85) and the composite outcome of in-hospital mortality or DAMA (8.4% in 2015 vs 13.9% in 2005; aOR 0.65; 95% CI 0.47 to 0.89) were observed. Disparities between rural and urban hospitals narrowed; however, disparities persisted in in-hospital management (brain MRI: rural–urban difference from −14.4% to −11.2%; cerebrovascular assessment: from −20.3% to −16.7%; clopidogrel: from −2.1% to −10.3%; anticoagulant for atrial fibrillation: from −10.9% to −8.2%) and in-hospital outcomes (DAMA: from 2.7% to 5.0%; composite outcome of in-hospital mortality or DAMA: from 2.4% to 4.6%).ConclusionsFrom 2005 to 2015, improvements in hospital admission and in-hospital management for ischaemic stroke in China were found. A temporal improvement in DAMA and improvements in in-hospital mortality and the composite outcome of in-hospital mortality or DAMA were observed. Disparities between rural and urban hospitals generally narrowed but persisted.

Introduction: Breast cancer (BC) is a complex heterogenous disease and is a leading cause of death in women. Following primary BC therapy ~40% of patients will develop metastatic BC (MBC) and 60-70% of the recurrent disease will occur at distant sites. Median survival of MBC patients with distant recurrence is ~2-3 yr. While the early detection and monitoring of BC progression are essential to improve prognosis and reduce BC-related mortality, there is a lack of surveillance strategies for monitoring patients for distant recurrence of MBC. The aim of our study was to identify urinary biomarkers for detection and monitoring of MBC. Method: We have conducted a comparative label-free LC-MS/MS analysis of the urinary proteome of patients with MBC and healthy age-matched controls (HC). A hybrid quadrupole time of flight (Q-Tof™) mass spectrometer was used for urine analysis via liquid chromatography (LC) with tandem mass spectrometry (MS/MS). Three different database search algorithms were used for peptide identification including MASCOT, Protein Lynx Global Server and Ion Accounting software. Only peptides detected in at least two out of three replicated LC-MS experiments were counted towards protein identification. Identified candidate biomarkers were validated via ELISA assays. Results: Using this approach, we identified ~400 urinary proteins of which ~104 and 89 were unique to the MBC and HC groups, respectively. Upregulated proteins in the MBC cohort were associated with angiogenesis, apoptosis, proteolysis, ECM regulation, and cell adhesion pathways. Using bioinformatic and in silico approaches, we identified a specific metastasis signature comprised of CALB1, S100A8, ZAG, VTN and TN. Diagnostic accuracies of these candidate markers were validated using independent training and validation sets according to the REMARK criteria. Urinary VTN (uVTN) and uTN levels correlated significantly with disease status in MBC patients when compared to patients with locally invasive BC and HC. Interestingly, a small subset of patients with bone metastasis also had significantly higher uVTN levels. A multiplexed marker panel of uVTN and uTN could discriminate between HC and MBC groups (AUC=0.831, P1018 ng/ml) could discriminate (AUC=0.782, P Conclusions: Our findings suggest that uVTN and uTN have the potential to serve as biomarkers for the detection of MBC. While validation in larger cohorts is necessary, these results may be useful in the development of noninvasive diagnostic tests for monitoring BC progression and recurrence. [Supported by: the Advanced Medical Research Foundation, the Jo Ann Webb Fund for Angiogenesis Research and the S. Elizabeth O’Brien Trust] Citation Format: Roopali Roy, Elisa Schunkert, Petra Olivova, Martin Gilar, Scott Geromanos, Guo-Zhong Li, John Gebler, Adelle Dagher, Andrew El-Hayek, Rama Aldakhlallah, David Zurakowski, Susan Pories, Marsha A. Moses. Global proteomic analysis of urine using a label-free LC-MS/MS approach identifies potential biomarkers of metastatic breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 3433.

Alzheimer's disease (AD) is a major neurodegenerative disorder. The functions of lncRNA RMRP have been characterized mainly in various human cancers. However, the functional network of RMRP in AD progression remains unknown.Human serum samples, AD transgenic (Tg) mice as well as SH-SY5Y cells were used in this study. The RNA expression patterns of RMRP, miR-3142 and TRIB3 were assessed by quantitative real-time PCR (qRT-PCR). Levels of apoptosis- or autophagy-associated biomarkers and TRIB3 level were evaluated using immunohistochemistry (IHC), western blotting or immunofluorescence assays, respectively. Bioinformatics methods and luciferase assays were used to predict and validate the interactions among RMRP, miR-3142, and TRIB3. Flow cytometry, TUNEL staining and EdU assays were used to examine the apoptosis and proliferation of neurons, respectively.The elevated RMRP and TRIB3 expressions and activation of autophagy were observed in AD. Knockdown of RMRP restrained neuronal apoptosis and autophagy activation in vitro and in vivo. Interestingly, TRIB3 overexpression reversed the biological effects of RMRP silencing on AβThese data illustrated that knockdown of RMRP inhibited autophagy and apoptosis via regulating miR-3142/TRIB3 axis in AD, suggesting that inhibition of RMRP maybe a therapeutic strategy for AD.

BACKGROUND It is well documented that the Blood-Brain barrier (BBB) can be damaged by matrix metalloproteases (MMPs) after intracerebral hemorrhage (ICH), but little is known about the mechanism of this effect. MATERIAL AND METHODS We established an ICH model in rats by injecting collagenase VII into the striatum. Afterwards, intraperitoneal injection of these rats with 40 mg/kg GM6001 (a MMPs inhibitor). The effects of GM6001 on ICH were investigated by neurological severity score, brain water content, Evans blue staining, hematoxylin-eosin staining, immunohistochemical staining, and Western blot assays. RESULTS We demonstrated that the neurological damage caused by ICH was relieved at 5 and 7 days following administration of GM6001. The impaired BBB induced by ICH was improved in response to GM6001 treatment at around 3 days, as evidenced by alleviated cerebral edema, decreased Evans blue extravasation, and a reduction in inflammatory cellular infiltration. Mechanism analysis revealed that ICH induced the generation of β-dystroglycan cleavage, which could be suppressed by GM6001 treatment. Furthermore, we found that recombinant MMP2 and MMP9 triggered the cleavage of β-dystroglycan in vitro, and this action could be inhibited by GM6001 administration. CONCLUSIONS Taken together, our results suggest that MMPs-mediated cleavage on β-dystroglycan may play an important role in BBB after ICH.

The aim of the present study is to confirm the correlation between fibrinogen and the severity of cerebral white matter hyperintensities (WMHs) among nondiabetic patients with noncardiogenic acute ischemic stroke.A cross-sectional study of 170 consecutive patients with noncardiogenic acute ischemic stroke who underwent magnetic resonance imaging and vascular imaging was conducted. WMHs were classified into periventricular hyperintensity (PVH) and deep and subcortical WMH (DSWMH) using Fazekas rating scale. After adjustment for fibrinogen and other vascular risk factors, we determined which factors were independent of WMHs.After adjustment for the vascular risk factors, prior ischemic stroke (odds ratio [OR] 4.153, 95% confidence interval [CI] 1.077-16.020, P = .039), fibrinogen level (OR 2.114, 95% CI 1.034-4.322, P = .040), and glycosylated hemoglobin A1c (OR .633, 95% CI .423-.947, P = .026) were independently and positively associated with PVH (P .05); prior ischemic stroke (OR 2.841, 95% CI 1.469-5.493, P = .002), lipoprotein(a) (OR 1.002, 95% CI 1.000-1.005, P = .047), and fibrinogen levels (OR 1.788, 95% CI 1.170-2.732, P = .007) were independently and positively associated with DSWMH (P .05).Our study demonstrated that prior ischemic stroke and higher fibrinogen are associated with WMHs, regardless of PVH and DSWMH, in nondiabetic patients with noncardiogenic acute ischemic stroke. In addition, lipoprotein(a) might be an independent predictor of DSWMH in patients with noncardiogenic acute ischemic stroke.

SummaryIntroduction Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most prevalent cause of familial and sporadic Parkinson's disease (PD). Because most pathogenic LRRK2 mutations result in enhanced kinase activity, it suggests that LRRK2 inhibitors may serve as a potential treatment for PD. To evaluate whether LRRK2 inhibitors are effective therapies for PD, it is crucial to know whether LRRK2 inhibitors will affect dopaminergic (DAergic) neurotransmission. However, to date, there is no study to investigate the impact of LRRK2 inhibitors on DAergic neurotransmission. Aims To address this gap in knowledge, we examined the effects of three types of LRRK2 inhibitors (LRRK2-IN-1, GSK2578215A, and GNE-7915) on dopamine (DA) release in the dorsal striatum using fast-scan cyclic voltammetry and DA neuron firing in the substantia nigra pars compacta (SNpc) using patch clamp in mouse brain slices. Results We found that LRRK2-IN-1 at a concentration higher than 1 μM causes off-target effects and decreases DA release, whereas GSK2578215A and GNE-7915 do not. All three inhibitors at 1 μM have no effect on DA release and DA neuron firing rate. We have further assessed the effects of the inhibitors in two preclinical LRRK2 mouse models (i.e., BAC transgenic hG2019S and hR1441G) and demonstrated that GNE-7915 enhances DA release and synaptic vesicle mobilization/recycling. Conclusion GNE-7915 can be validated for further therapeutic development for PD.

Detecting building changes via aerial images acquired at different times is important in the urban planning and geographic information updating. Deep learning solutions have high potential in improving detection performance as compared with traditional methods. However, existing methods usually carry out detection for whole images. Non-building interferences involved may result in an increase of false alarm rate, a decrease in accuracy rate, and a heavy computational load. In addition, they mostly utilize supervised deep learning networks dependent highly on massive labeled samples. In this study, we present an unsupervised deep learning solution with detection only on segmented building areas. We first employ a masking technique based on building segmentation to remove non-building interferences. We then use a classification model combing an unsupervised deep learning network PCANet and linear SVM to realize building change detection. Experimental results show that our method achieves 34.96% higher accuracy rate, 45.18% lower missed detection rate, 37.92% lower false alarm rate, and 50.12% lesser computational time than the whole-image detection method without building segmentation.

As one of the significant structural materials used in safe and arming system of MEMS fuze, the research on micro-electroforming process technologies and micro-electroforming nickel's properties have been a popular field for MEMS area. This paper surveys present domestic and overseas research status of mechanical characterization of electroformed nickel, summarizes and analyzes that changes of the microstructure led by parameters of micro-electroforming process and the external environment make great effects. © (2015) Trans Tech Publications, Switzerland.

MEMS nickel material is commonly used for structural material in micro devices. In order to study the effect of environmental temperature on its mechanical properties,this paper has built up a experimental system which can measure the temperature-related static mechanical parameters of the UV-LIGA nickel material. By using the system for uniaxial tensile experiments of the micro specimen under different temperature, the stress-strain curves of the micro specimen under different temperature were obtained; the mechanical parameters of the micro specimen such as elastic modulus, yield stress and failure stress under different temperature were also calculated out;Finally, the relationship between temperature and mechanical parameters including elastic modulus, yield stress and failure stress was analyzed.

Lightweight aggregates glazed hollow bead, cement, foaming agent, foam stabilizer and waterproofing agents as the main raw material, produce foamed thermal insulation materials by vibration shaping. By adding emulsified stearic acid and methyl stearate alcohol organosilicon waterproofing agent, the effects of two types of waterproofing agent on quality of water absorption of foamed thermal insulation materials were studied, and the related mechanisms were discussed. Results show that the waterproofing effect of organosilicon waterproofing agents is superior to emulsified stearic acid, when the content of emulsified stearic acid and organosilicon waterproofing agent are 7% and 4% respectively, 2h,24h water absorption rate of samples are 18.34%, 45.45% and 14.45%, 32.83%.

Using the desulfurization gypsum as raw material and the atmospheric acidification method, prepared desulfurization gypsum whisker, Studied water gypsum ratio, crystallization agent on properties of gypsum whiskers. Researchs show that, when the water gypsum ratio is 57.14%, the average ratio of length to diameter reaches the maximum value is 41.1; when using calcium chloride and Magnesium sulfate (the quality of various additives in the desulfurization gypsum quality accounted for 2%), the best effect, the ratio of length to diameter is 42.9.

The fluorine gypsum was used as research object in this paper. In order to recognize the basic properties of fluorine gypsum fully, the physical and chemical properties were analyzed through different testing means. The chemical modification (additive A, sodium sulfate, quick lime) on the activity of fluorine gypsum excitation effect were studied. The best way to compound modification was determined and the mechanism of the admixture was analyzed. On this basis, the fluorine gypsum base self-leveling mortar materials was prepared and its performances were tested. Research shows that, the optimal ratio of: additive A content 2.0% (mixed), sodium sulfate content 0.8%, quick lime content 1.5%, the fluorine gypsum self-leveling material initial setting time is 2.4h, the final setting time is 5.3h, 24h flexural strength of 2.60MPa, compressive strength of 6.05MPa, the dry flexural strength of 7.68MPa, compressive strength of 22.89MPa, the performance indicators have reached the JC/T1023-2007《Gypsum based self-leveling mortar》 requirements.

Through to join in processing of titanium gypsum naphthalene series water reducing agent and sodium sulfate, study the effect of admixtures on the physical properties of titanium gypsum and mechanism analysis, and to determine the optimum content of admixtures. Research shows that when the content of naphthalene series water reducing agent was 3% water reducing effect is best, the titanium gypsum sample standard consistency water consumption is 126%,2h flexural strength was 1.06MPa, 2h compressive strength was 1.97MPa, absolutely dry flexural strength was 2.21MPa and absolutely dry compressive strength was 2.76 MPa. When the dosage of sodium sulfate is 1.5%, titanium gypsum physical performance is best,initial setting time and final setting time of 8 min and 10 min respectively,2h flexural strength was 1.35MPa, 2h compressive strength was 2.42MPa, absolutely dry flexural strength was 2.43MPa and absolutely dry compressive strength was 3.32 MPa.

Hydrogen peroxide was used as the foaming agent to reduce the density and thermal conductivity of composite insulation materials, and glass fibers were adopted to reinforce the performance of foamed composite insulation materials. Meanwhile, the mechanical properties of foamed composite insulation materials is studied, and the internal micro-morphology of samples were observed by SEM. The strengthening mechanism of fiber was analyzed. The results indicated that mixing foaming agent significantly decrease the density and thermal conductivity of samples, when the content of foaming agent was 4%, the minimum rate of thermal conductivity was 0.051W/(m•K). Wrapped VAE emulsion on the surface of glass fiber, glass fiber after surface modification could improve the strength of samples. The flexural and compressive strength of samples that adding glass fiber after surface modification were increased by 18.75% and 6.98% compared with samples that adding unmodified glass fiber.

Polystyrene granules (EPS) for lightweight aggregate and cement for cementing material, while adding a variety of additives, were used to prepare cement-based composite thermal insulation materials by the method of vibration molding. The effects of different waterproof agent on water absorption and strength of cement-based composite thermal insulation materials were studied contrastively by adding emulsified stearic acid and emulsified composite waterproofing agent, and the related mechanisms were analyzed. Results showed that the waterproofing effect and strengthen effect of emulsified composite waterproofing agent is superior to emulsified stearic acid, when the content of emulsified stearic acid and emulsified composite waterproofing agent are 5% and 5%, respectively, the 2h, 24h water absorption of samples are 20.59%, 47.64% and 15.53%, 34.53%, the flexural and compressive strength of samples are 0.32MPa, 0.42MPa and 0.35MPa, 0.47MPa.

In this article, the influence of the churning technology on the average diameter of xonotlite particle and the micro-structure of xonotlite particle during the hydrothermal synthesis progress of the heat insulating material of xonotlite were researched. The influence of fiber adding process on the strength and density of calcium silicate insulation material was studied. The complexity and the macro mechanical properties of the fiber dispersed in the matrix with different fiber adding way were discussed. The microstructure of xonotlite was observed and analyzed by scanning electron microscope and the related mechanisms were studied.

In this paper, desulfurization gypsum was made of cementing materials and expanded perlite as light aggregate, by adding the right amount of fly ash and other admixture, in the pouring forming preparation of desulfurization gypsum heat preservation material. Expanded perlite is porous surface, made its hydrophobic, lower water absorption, by emulsion coated surface of expanded perlite. In the waterproof property research, different emulsion composite waterproof contents on the influence of the bibulous rate of the product volumetric had been studied, and emulsion composite waterproof agent was chosen as the last agent with the dosage of 4%. SEM test for analyzing the microcosmic structure of desulfurization gypsum products were taken to research and analyze each combination, and discuss the waterproof and thermal insulation mechanism. The optimal parameters of the desulfurization gypsum of insulation products obtained by the experiments were: desulfurization gypsum of 90%, fly ash of 10%, and fiber of 0.5%, emulsion composite waterproof agent of 4%.

This paper studies the different calcination temperature on the properties of titanium gypsum physical effects, and the mechanism of the effects are discussed in this paper. Research has shown that with the increase of calcination temperature, the mechanical properties of titanium gypsum present a trend of after rising first down. When the calcination temperature is 180 °C, titanium gypsum calcined product mainly for the half water gypsum phase, the mechanical strength of samples of titanium gypsum achieve maximum at this time, The mechanical properties of titanium gypsum samples: 2h flexural strength was 0.94MPa, 2h compressive strength was 1.87MPa, absolutely dry flexural strength was 1.54 MPa and absolutely dry compressive strength was 2.52 MPa.

The hard silicon calcium stone slurry were synthesized by dynamic hydrothermal synthesis in this article, the influence of water solid ratio and carbon fiber on the performance of the calcium silicate thermal insulation material was studied. The results showed that when the water-solid ratio of 40, sodium dodecyl benzene sulfonate cited as a foaming agent, the sphericity of spherical particles was well, and xonotlite fiber developed well. The added carbon fiber could significantly increase the flexural and compressive strength and coefficient of thermal conductivity of the material. The microstructure of calcium silicate insulation material was observed and analyzed by scanning electron microscope.

This meta-analysis aims to evaluate the relationships between serum vascular endothelial growth factor (VEGF) level and radiosensitivity in patients with nonsmall cell lung cancer (NSCLC) among Asians. We searched CISCOM, CINAHL, Web of Science, PubMed, Google Scholar, EBSCO, Cochrane Library, and CBM databases from their inception through October 1, 2013. Meta-analysis was performed using the STATA 12.0 software. Fourteen clinical studies were included in this meta-analysis, including five case-control studies and nine cohort studies. Our meta-analysis results revealed that levels of serum VEGF in NSCLC patients were higher than that of healthy controls. There was a significant difference in serum VEGF levels between before and after radiotherapy in NSCLC patients. Further, we found significant differences in serum VEGF levels between effective and noneffective clinical response groups pre- and postradiotherapy. Serum VEGF levels showed no significant associations with tumor-node-metastasis (TNM) stage and histologic grade in NSCLC patients. NSCLC patients with positive VEGF expression had shorter overall survival than those with negative VEGF expression. Our meta-analysis suggests that serum VEGF level may be a useful biomarker in predicting radiosensitivity and prognosis of NSCLC patients among Asians.

The effect of admixtures on the mechanical properties of recycled fine aggregate cement mortar was studied. The result indicated that compared with blank samples the 28d flexural strength, the compressive strength and osmotic pressure of cement mortar were increased by 15.6%, 35.5%, 41.1% respectively when adding silicone waterproofing agent 0.2wt%, naphdalin series water reducer 1.0wt%, polycarboxylate superplasticizer 0.8wt%. The micro-morphology and hydration products of mortar specimens was observed by SEM, XRD respectively.

The ordinary Portland cement was used to prepare foamed cement by the chemical foaming method. In this paper, the effect of superplasticizer on the water absorption and softening coefficient of foamed cement has been studied. The results show that the superplasticizer could improve foam structure, reduce the water absorption, and enhance the compressive strength and softening coefficient. The water resistance could be improved. When the dosage of superplasticizer was 0.3% (the quality of cement), compared with blank sample, the water absorption reduced 27.9%. When the softening coefficient was 0.68, softening coefficient increased 19.2%. The action mechanism of superplasticizer has been explored.

In this work, methods of introducing water-resistance to foamed gypsum were firstly adopted to investigate the influences of sulphoaluminate cement、redispersible latex powder and stearic acid emulsion on the mechanical strength、water absorption and softening coefficient. Scanning electron microscopy (SEM) was conducted to investigate microstructure of gypsum and phase composition of substances on plaster surface as well as the mechanisms. The result showed that sulphoaluminate cement reduced the water absorption of foamed gypsum, which decreases to 38.9% when dosage was 10%; Redispersible latex powder reduced the water absorption of foamed gypsum, which decreases to 35.6% when dosage was 5%; Stearic acid emulsion reduced the water absorption of foamed gypsum, which decreased to 30.1% when dosage was 3%; The combing use of sulphoaluminate cement、redispersible latex powder and stearic acid emulsion maked the water absorption decrease to 15.2% and the crystals became short and dense and a layer of organic hydrophobic membrane covered the surface of crystals and which makes gypsum less soluble and more suitable for use in humidity environment.

Desulfurization building gypsum was used as the main gelled material and fly ash was used as filler to prepare the new type desulfurization gypsum block. the mechanical properties of the new type desulfurization gypsum block was improved by adding compound excitation agent into the desulphurization gypsum-fly ash cementing material to stimulate its activity. The water resistant performance of the new type desulfurization gypsum block was improved through adding wax-alcohol compound waterproofing agent into it. Experimental results show that when the filling amount of fly ash was 20%(the quality of desulfurization gypsum), the impact on the strength of gypsum was minimal; when the dosage of compound excitation agent was 1.75%, the excitation effect of desulphurization gypsum-fly ash cementing material was best; when the dosage of wax-alcohol compound waterproofing agent was 0.4%, the water resistance of new desulfurization gypsum block was optimal.

This paper studied the impact of borax, citric acid, carboxymethyl cellulose and gelatin on retarded time and mechanical properties of gypsum foamed materials. Scanning electron microscopy (SEM) was conducted to investigate microstructure of gypsum and phase composition of substances on plaster surface as well as the retardation mechanisms. The result showed that when the content of citric acid reached 0.2%-0.3%, the setting time of sample significantly prolonged, but the strength of samples significantly reduced and had defoaming effect. When the content of borax was more than 0.5%, retarding effect was obvious, but flexural strength of samples reduced to 1.22 MPa, it could not meet the requirement of the national standards on the properties of building gypsum. When the content of carboxymethy cellulose was 0.3%, the retarding effect was obvious, but the strength loss was serious, and the consistency of gypsum slurry significantly increased. When the content of gelatin was 0.2%, the comprehensive retarding effect was good, the strength reduction was smaller, so choose gelatin as a retarder in this paper.

The microstructures of fine recycled concrete aggregate (FRCA) after modifications in cement mortar were studied. The result indicated that the modification of RFA could strengthen the enhancement effect on microstructure when modified by 20wt% silica fume (SF) grout, 10wt% Polyvinyl alcohol (PVA) solution. After modification by SF grout and PVA solution, the thickness of interfacial transition zone (ITZ) of RFA cement mortar was decreased by 50% compared with the unmodified samples. The ITZ between RFA and cement paste was studied and the surface microstructure and sectional morphology of RFA was observed by scanning electron microscopy (SEM). Analyzing the modification mechanism and Building the superficial micro-structure model of RFA in cement mortar was carried out.

The red mud lightweight insulation brick was prepared by the sintering process as red mud, fly ash, bentonite as the main raw material, adding a certain amount of pore forming agent and fluxing agent. The sintering heat preservation time of red mud insulation brick on the properties was studied. The red mud lightweight insulation brick damage fracture microstructure was analyzed using scanning electron microscope (SEM) and the sintering mechanism was discussed preliminarily. The results show that with sintering temperature of 1100°C heating for 180 minutes, the performance of thermal insulation brick is better. When the heat preservation time extends to continue, the performances of sample remain stable basically.

MEMS processing technology can manufacture any complex structures in a plane, using this point, a variable stiffness design idea for the planar micro-spring is proposed. That is, using one type of structure named contact pairs to achieve stiffness change during the micro-spring’s stretching process. Using contact pairs, three types of variable stiffness springs are designed: stiffness increase spring, stiffness decrease spring and stiffness hump spring. Finally, the variable stiffness springs’ application for fuze setback arming device is discussed. When the three types of springs are used in setback arming device, the stiffness decrease spring is better than the other two springs from security analysis. Kinematic analysis shows that, if the variable stiffness spring’s design is reasonable, the setback arming device not only can effectively solve the safety and reliability issues for rocket fuze, but also applies in small caliber grenade fuze’s working environment without changing the setback arming device’s size and structure. Analysis result indicate that the setback arming device based on MEMS variable stiffness spring is universal for rocket fuze and small caliber grenade fuze.

In the experiment, polystyrene particles were used as lightweight aggregate to prepare lightweight composite insulation board which was mixed with fibers and waterproofing agent. The effect of water-cement ratio and volume ratio of polystyrene particles and cement on the density and mechanical properties of polystyrene insulation board was researched. And styrene-acrylic emulsion, stearic acid emulsion and composite emulsion waterproofing agent were used respectively to modify the waterproof of insulation board. Besides, the underlying action mechanism was explored. The results show that the optimum volume ratio was 5:1, and the optimum water-cement ratio was 0.45. And when the content of composite emulsion waterproofing agent was 8%, the 2h and 24h water absorption were 6.0% and 8.1% respectively.

Each component ratio of the ternary composite retarder was determined through orthogonal test and the effect of the ternary composite retarder on physical properties of FGD gypsum plaster material was studied. The results show that when the dosage of citric acid, admixture 1, admixture 2 were 0.05%, 0.4% and 0.3% respectively in the ternary composite retarder, the FGD gypsum plaster material had the best physical properties. The initial setting time was 118min and the final setting time was 132min respectively. The flexural and compressive strength were 3.15MPa and 6.46MPa, respectively. The microstructure of FGD gypsum hydration products was analyzed by SEM and the action mechanism of the ternary composite retarder was analyzed.

Red mud foam lightweight thermal insulation material was prepared by red mud, fly ash, cement as main raw materials, adding a certain amount of adhesive, through ingredients, mixing, molding, foam, sintering process. The influence of the ratio of red mud and fly ash on the properties of materials was studied and the mechanism of influence was analyzed. The test results show that performances of the samples were best when the ratio of red mud and fly ash is 5:4 and its flexural strength is 0.44MPa, compressive strength is 1.23MPa, density is 481kg/m3.

A modification of using fly ash grout of different levels was adapted to treat the surface of recycled fine aggregate (RFA).The physical properties of RFA before and after modification and the effect on the mechanical performance of cement mortar was studied.The result indicated that the modification of RFA could strengthen the enhancement effect on mechanical performance when modified by 15wt% fly ash grout. After modification, water absorption of RFA was 6.12% and decreased by 47.5%. The 28d flexural strength was increased by 17.4% and compressive strength was increased by 24.2% of RFA cement mortar compared with the reference samples. The superficial microstructure and sectional morphology of RFA was observed by scanning electron microscopy (SEM). The modification mechanism was carried out.

Red mud lightweight baking-free brick was prepared by red mud, fly ash and cement, mixed with a certain amount of activator agent and foaming agent. The influence of foaming agent on properties of red mud lightweight baking-free brick was studied. The micro-structure of red mud lightweight baking-free brick was characterized by scanning electron microscopy (SEM). The results show that when the foaming agent content is 10ml, the sample with better performance obtained and the density is 423kg/m3, flexural strength is 0.49MPa and compressive strength is 1.87MPa.

In the experiment, the influence of water-cement ratio on the strength of composite material was studied, and the optimal water-cement ratio was 0.45. The influence of different dosages of foam stabilizer on the mechanical properties of composite material was studied, and the optimal dosage of foam stabilizer was 3%. And the influence of different dosages of polymer on the strength and water absorption of composite material was studied, and the optimal dosage of polymer was 1.5%. In this ratio, the compressive strength is 0.53 MPa, flexural strength is 0.39 MPa, 2h water absorption is 41.1%, 24h water absorption is 43.1% and thermal conductivity is 0.048 W/(m·K). Meanwhile, scanning electron microscopy is used to observe the internal morphology of the samples, and the related action mechanism is explored.

In this paper self-leveling floor material with flue gas desulfurization (FGD) gypsum was studied. Gypsum-based self-leveling materials was prepared with desulfurization gypsum as binder and added fly ashadmixture Aadmixture B and four kinds of water reducing agents. The result indicated that HC multi-carboxylic acid based super plasticizer demonstrates excellent workability and better compatibility with gypsum, when its content was 1.0%, the fluidity of slurry met the demands of 145mm±5mm. Adding re-dispersible polymer powder to enhance the strength of desulfurization gypsum, the results showed that when its content was 3%, the adhesive strength of sample was increased to 1.21MPa that could meet the performance requirements of self-leveling floor material.

This study investigated the roles of Ras, ERK, and Akt in the glucocorticoid-induced differentiation of growth hormone-producing pituitary cells in vitro. Pituicytes isolated from day-18 rat embryos were cultured with 50 mM dexamethasone in addition to specific inhibitors of Ras (manumycin; 0.5, 5, 50 nM), ERK (U0126, 10 μM), or Akt (LY294002, 25 μM). Differentiation was assessed using immunofluorescent staining of intracellular growth hormone. Radioimmunoassay and Western blot analyses were used to determine levels of secreted and intracellular growth hormone, respectively. Manumycin reduced the fraction of growth hormone-positive cells and dexamethasone-induced growth hormone secretion in a dose-dependent manner (both P < 0.001). In the absence of dexamethasone, LY294002 and U0126 did not alter the fraction of growth hormone-positive cells or intracellular growth hormone protein expression or secretion. Both LY294002 and U0126 alone significantly attenuated the fraction of dexamethasone-treated GH-positive cells and the secretion of GH compared to those of cells treated only with dexamethasone (50 nM for 44 h or 48 h) (all P < 0.05). Dexamethasone treatment alone did not change GH protein levels. Treatment of cells with a combination of LY294402 and U0126 significantly attenuated the fraction of dexamethasone-treated GH-positive cells, GH protein levels, and GH secretion compared to cells treated with dexamethasone alone (all P < 0.05). Moreover, dexamethasone-induced phosphorylation of GTP-Ras, ERK, and Akt was significantly attenuated by exposure to the respective inhibitors (P < 0.05). Taken together, our results indicate that Ras, ERK, and Akt are key effectors in the glucocorticoid-induced differentiation of growth hormone-secreting cells.

Used the desulfurization gypsum, foaming agent and fly ash for molding thermal insulation foamed desulfurization gypsum, and studied the influence of different content of foaming agent on its density, mechanical properties and thermal conductivity. The result showed that when the content of foaming agent was 5%,the thermal conductivity was 0.052W/(m·K) reaching minimum, and the density of foamed desulfurization gypsum was 225Kg/m3 .To use glass fiber as reinforcing material for studying the effect of the vary content of glass fiber on strength of the material. The result showed that when the content of glass fiber was 1.5%, the flexural strength and compressive strength of the sample was increased 41.67%5.66% than the blank sample.

The effect of some factors(dosage and grain size of recycled fine aggregate of construction waste, content of mineral admixture) on the properties of cement mortar was studied. The results indicated that when recycled fine aggregate particles gradation was areaⅡ, replacement percentage (sand) was 60%,dosage of mineral admixture was 36%, compared with blank sample, the 28d flexural strength and the compressive strength of cement mortar samples were increased by 30.7% and 37.2%, respectively. Micro-morphology of section on cement mortar was observed by SEM. Identifying the hydration products through XRD was carried out.

In the experiment, polystyrene particles, cement, fly ash, activator and fibers were used as raw material to prepare new cement-based composite insulation board by compression molding. Through the determination of best content of fly ash, the effects of fly ash on strength of composite insulation board were studied. Through the determination of the optimal content of activators, the effects of activators on the mechanical properties of composite insulation board were studied. Through the determination of the optimal dosage of fibers, the effects of fibers on performance of composite insulation board were studied. The morphology in the samples was observed by scanning electron microscopic, and the action mechanism of each component was studied.

The chemical modification of titanium gypsum was made by calcium lignosulfonate, naphthalene and polycarboxylate superplasticizer. The effect of different superplasticizer on the physical properties of titanium gypsum was studied. The test results show that the standard consistency water, setting time and mechanical strength of titanium gypsum had changed to different extent with the three types of superplasticizer added. Naphthalene superplasticizer had best modification effect on titanium gypsum and its optimum content was 3%. When the naphthalene superplasticizer dosage was 3%, the 2h flexural strength and the 2h compressive strength of sample were 1.15MPa and 2.37MPa. The micro structure of titanium gypsum hydration products was analysed by SEM and the action mechanism of superplasticizer was analysed.

The paper studied a compound desulphurization gypsum waterproof agent, which could modify the water-resistance performance of gypsum products on the basis of their microstructural properties. The waterproof mechanics were the synthesis results of superficial hydrophobic of hydrophobic emulsion, hindrance water of film forming matter and reducing the porosity in materials. The experiment results showed that the water-absorption rate of gypsum hardened body can be reduced to 3.5% and that the compressive strength reserve rate was 89.7% after 24h.

For the existing symmetry Z-tooth MEMS delay mechanisms can not play sports in place under the influence of centrifugal force, this paper presents an asymmetric Z-tooth delay mechanism which can works reliably by weak environmental forces. Working principle and the stress condition of the mechanism are analyzed. Based on the dynamic model, this paper makes a computational analysis and simulation about the kinetic characteristics of the asymmetric Z-tooth delay mechanism, and the results show that the improved mechanism can works reliably and meets the requirements.

Paraffin/expanded perlite composite phase change energy-storage material (PPCM) was prepared by vacuum adsorption method with expanded perlite as adsorption material and paraffin as phase change energy-storage material. The diffused-exudative circle method was used to determine that the best adsorption quantity of expanded perlite was 65%. The phase transition process and microstructure of PPCM with the best adsorption quantity were characterized by DSC and SEM. The results shown that the internal micropores of expanded perlite particles were almost completely filled with paraffin and the expanded perlite particles became close-grained particles. The phase change temperature of PPCM was basically similar with that of paraffin and its phase change latent heat was corresponded with that of paraffin in the PPCM.

In this paper, gypsum whiskers reinforced resin matrix composites were prepared with the desulfurization gypsum by the technology of atmospheric acidification. The influences of stabilization reagent on the stability of the gypsum whiskers were studied. Meanwhile, the enhanced effects of surface treatment and different contents of gypsum whiskers on the resin matrix composite were analyzed. Scanning electron microscopy, metallographic microscopy, X-ray diffraction test were taken to conduct analysis of the morphology and the aspect ratio of gypsum whiskers. Besides, the mechanical properties of gypsum whiskers reinforced resin matrix composites were tested, and cross-section scanning was used to analyze the strengthening mechanism.

FGD gypsum-fly ash plaster material was prepared by desulfurization gypsum plaster and fly ash as main materials, compound retarder A (composed of citric acid, sodium metaphosphate and borax), methylcellulose (MC) as super absorbent polymers (SAP) and water reducing agent of lignosulfonate. Mix proportion was determined through studying effects of the experimental factors, including fly ash mixing amount, retarders of citric acid, bone glue and compound retarder A, and SAP of MC and dextrin, on plaster material properties. Final mix proportion was followed as: FGD gypsum to fly ash mass ratio of 4.0, compound retarder of 0.2%, methylcellulose of 0.2% and lignosulfonate of 0.1%.