169 results on '"Guozhen Xu"'
Search Results
2. Induction TPF followed by concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone in locally advanced hypopharyngeal cancer: a preliminary analysis of a randomized phase 2 trial
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Xi Luo, Xiaodong Huang, Jingwei Luo, Jianping Xiao, Kai Wang, Yuan Qu, Xuesong Chen, Ye Zhang, Runye Wu, Jingbo Wang, Jianghu Zhang, Guozhen Xu, Li Gao, Shaoyan Liu, Xiaolei Wang, Xiaohui He, Dehong Luo, and Junlin Yi
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Hypopharyngeal cancer ,Concurrent chemoradiotherapy ,Induction chemotherapy ,Multi-disciplinary treatment ,Laryngeal preservation ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Purpose Concurrent chemoradiotherapy (CCRT) is a standard treatment choice for locally advanced hypopharyngeal carcinoma. The aim of this study was to investigate whether induction chemotherapy (IC) followed by CCRT is superior to CCRT alone to treat locally advanced hypopharyngeal carcinoma. Methods and materials Patients (n = 142) were randomized to receive two cycles of paclitaxel/cisplatin/5-fluorouracil (TPF) IC followed by CCRT or CCRT alone. The primary end point was overall survival (OS). The secondary end points included the larynx-preservation rate, progression-free survival (PFS), distant metastasis-free survival (DMFS), and toxicities. Results Ultimately, 113 of the 142 patients were analyzed. With a median follow-up of 45.6 months (interquartile range 26.8–57.8 months), the 3-year OS was 53.1% in the IC + CCRT group compared with 54.8% in the CCRT group (hazard ratio, 1.004; 95% confidence interval, 0.573–1.761; P = 0.988). There were no statistically significant differences in PFS, DMFS, and the larynx-preservation rate between the two groups. The incidence of grade 3–4 hematological toxicity was much higher in the IC+ CCRT group than in the CCRT group (54.7% vs. 10%, P
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- 2022
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3. Pretreatment systemic immune-inflammation index predicts survival for non-metastatic nasopharyngeal carcinoma: two independent institutional studies
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Fengge Zhou, Liting Liu, Xiaodong Huang, Shiran Sun, Xuesong Chen, Qiuyan Chen, Linquan Tang, Haiqiang Mai, Kai Wang, Yuan Qu, Runye Wu, Ye Zhang, Qingfeng Liu, Jianghu Zhang, Jingwei Luo, Jianping Xiao, Li Gao, Guozhen Xu, Jingbo Wang, and Junlin Yi
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Nasopharyngeal carcinoma ,Non-metastatic cancer ,Systemic immune-inflammation index ,Prognostic risk stratification ,Validation ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Objective: This study aimed to evaluate the prognostic value of the pretreatment systemic immune-inflammation index (SII) in non-metastatic nasopharyngeal carcinoma (NPC). Methods: We retrospectively analyzed the data of 839 patients with non-metastatic NPC recruited from two independent institutions. The training-set cohort and the external validation-set cohort was comprised of 459 and 380 patients from each institution, respectively. The optimal cut-off value of SII was determined, and a prognostic risk stratification model was developed based on the training cohort and further assessed in the validation cohort. The propensity score matching (PSM) method was applied to minimize the confounding effects of unbalanced covariables. Results: The optimal cut-off value of the SII in the training cohort was 686, which was confirmed using the validation cohort. Multivariate analysis showed that both before and after PSM, SII values > 686 were independently associated with worse progression-free survival (PFS) ratio in both cohorts (before PSM, P = 0.008 and P = 0.008; after PSM, P = 0.008 and P = 0.007, respectively). Based on the analysis of independent prognostic factors of SII and N stage, we developed a categorical risk stratification model, which achieved significant discrimination among risk indexes associated with PFS and distant metastasis-free survival (DMFS) in the training cohort. There was no significant difference in PFS between RT alone and combined therapies within the low- and intermediate-risk groups (5-year PFS, 77.5% vs. 75.3%, P = 0.275). Patients in the high-risk group who received concurrent chemoradiotherapy experienced superior PFS compared with those who received other therapies (5-year PFS, 64.9% vs. 40.3%, P = 0.003). Conclusion: Pretreatment SII predicts PFS of patients with non-metastatic NPC. Prognostic risk stratification incorporating SII is instructive for selecting individualized treatment.
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- 2022
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4. Evaluation of the prevalence of metachronous second primary malignancies in hypopharyngeal carcinoma and their effect on outcomes
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Xi Luo, Xiaodong Huang, Shaoyan Liu, Xiaolei Wang, Jingwei Luo, Jianping Xiao, Kai Wang, Yuan Qu, Xuesong Chen, Ye Zhang, Jingbo Wang, Jianghu Zhang, Guozhen Xu, Li Gao, Runye Wu, and Junlin Yi
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hypopharyngeal cancer ,incidence ,metachronous second primary neoplasm ,second primary neoplasm ,survival analysis ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background To investigate the clinical characteristics of metachronous second primary malignancies (Met‐SPMs) and its impact on prognosis in hypopharyngeal carcinoma (HPC). Methods We reviewed 593 newly diagnosed HPC patients without invasive synchronous SPMs (Syn‐SPMs) who were treated in our cancer center between 2009 and 2019. According to the status during follow‐up, patients were classified into three groups: (a) without SPMs (No‐SPMs, n = 440), (b) with tumors in situ in the esophagus or stomach (Tis, n = 80), or (c) with Met‐SPMs (n = 73). Results The median follow‐up time for entire cohort (n = 593) was 66.7 months. Met‐SPMs were present in 12.3% of the cohort (73/593). The predominant site of SPMs was esophagus, followed by lung, oral cavity, thyroid, stomach, and oropharynx. In Met‐SPMs group, both index tumor and SPMs were the main causes of death. Tis group exhibited comparable 5‐year overall survival (OS) and disease‐specific survival (DSS) with that of No‐SPMs group. The Met‐SPMs group had similar 5‐year OS rate and better 5‐year DSS rate of 47.3% versus 43.6% (odds ratio [OR], 0.931; 95% confidence interval [CI], 0.681–1.274, p = 0.657) and 66.3% vs. 46.2% (OR, 0.600; 95% CI, 0.402–0.896, p = 0.012), respectively, compared with the No‐SPMs group. Conclusion The overall incidence of Met‐SPMs in HPC was 12.3%. The occurrence of Met‐SPMs does not jeopardize the survival outcome of HPC. Routine surveillance of Met‐SPMs was requisite for patients with HPC.
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- 2022
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5. Intensified continental chemical weathering and carbon-cycle perturbations linked to volcanism during the Triassic–Jurassic transition
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Jun Shen, Runsheng Yin, Shuang Zhang, Thomas J. Algeo, David J. Bottjer, Jianxin Yu, Guozhen Xu, Donald Penman, Yongdong Wang, Liqin Li, Xiao Shi, Noah J. Planavsky, Qinglai Feng, and Shucheng Xie
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Science - Abstract
The work shows that volcanic-related elevated continental chemical weathering could have played a significant role in global environmental perturbations during the Triassic-Jurassic mass extinction.
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- 2022
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6. Irradiation-induced nasopharyngeal necrosis (INN) in newly diagnosed nasopharyngeal carcinoma treated by intensity-modulated radiation therapy: clinical characteristics and the influence of treatment strategies
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Yi Xu, Yang Liu, Zekun Wang, Jingbo Wang, Jianghu Zhang, Xuesong Chen, Runye Wu, Qingfeng Liu, Yuan Qu, Kai Wang, Xiaodong Huang, Jingwei Luo, Li Gao, Guozhen Xu, Ye Zhang, and Junlin Yi
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Irradiation-induced nasopharyngeal necrosis ,Primary nasopharyngeal carcinoma ,Intensity-modulated radiation therapy ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Purpose To define the clinical characteristics of irradiation-induced nasopharyngeal necrosis (INN) after intensity-modulated radiotherapy (IMRT) and identify the influence of treatment strategies on INN in primary nasopharyngeal carcinoma (NPC) patients. Patients and methods From 2008 to 2019, NPC patients pathologically diagnosed with INN after primary IMRT were reviewed. Those patients were matched with propensity scores for patients without INN in our center. The impact of treatment strategies on INN occurrence was assessed using univariate and multivariate logistic regression analysis. Results The incidence rate of INN was 1.9% among the primary NPC population, and 53 patients with INN were enrolled. Headache and foul odor were the main symptoms, and 71.7% of cases had pseudomembrane during or at the end of radiotherapy. All patients were in early or middle stage INN, and no one presented with skull-based osteoradionecrosis. Then 212 non-INN patients were included based on propensity scores match. Overall survival (p = 0.248) and progression-free survival (p = 0.266) curves were similar between the INN and non-INN groups. Treatment strategies including combining chemotherapy or molecular targeted therapy with radiotherapy were not associated with INN occurrence, while boost dose (OR 7.360; 95% CI 2.301–23.547; p = 0.001) was a predictor factor for it. However, the optimal threshold for an accumulated dose to predict INN's occurrence was failed to determine. Conclusion In the IMRT era, the severity of INN in primary NPC patients is lessened. This study showed that treatment strategies contributed little to develop INN, while the accumulated dose of radiation may relate to its occurrence.
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- 2022
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7. Relative Localization within a Quadcopter Unmanned Aerial Vehicle Swarm Based on Airborne Monocular Vision
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Xiaokun Si, Guozhen Xu, Mingxing Ke, Haiyan Zhang, Kaixiang Tong, and Feng Qi
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UAV swarm ,relative localization ,Perspective-n-Point ,GNSS-denied environments ,YOLO ,keypoint detection ,Motor vehicles. Aeronautics. Astronautics ,TL1-4050 - Abstract
Swarming is one of the important trends in the development of small multi-rotor UAVs. The stable operation of UAV swarms and air-to-ground cooperative operations depend on precise relative position information within the swarm. Existing relative localization solutions mainly rely on passively received external information or expensive and complex sensors, which are not applicable to the application scenarios of small-rotor UAV swarms. Therefore, we develop a relative localization solution based on airborne monocular sensing data to directly realize real-time relative localization among UAVs. First, we apply the lightweight YOLOv8-pose target detection algorithm to realize the real-time detection of quadcopter UAVs and their rotor motors. Then, to improve the computational efficiency, we make full use of the geometric properties of UAVs to derive a more adaptable algorithm for solving the P3P problem. In order to solve the multi-solution problem when less than four motors are detected, we analytically propose a positive solution determination scheme based on reasonable attitude information. We also introduce the maximum weight of the motor-detection confidence into the calculation of relative localization position to further improve the accuracy. Finally, we conducted simulations and practical experiments on an experimental UAV. The experimental results verify the feasibility of the proposed scheme, in which the performance of the core algorithm is significantly improved over the classical algorithm. Our research provides viable solutions to free UAV swarms from external information dependence, apply them to complex environments, improve autonomous collaboration, and reduce costs.
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- 2023
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8. Investigating the Performance of IGS Real-Time Global Ionospheric Maps under Different Solar Conditions
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Hang Liu, Xiaodong Ren, and Guozhen Xu
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global navigation satellite system (GNSS) ,ionosphere ,real-time (RT) ,global ionospheric map (GIM) ,total electron content (TEC) ,Science - Abstract
In recent years, real-time global ionospheric map (RT-GIM) products have been actively developed by the international global navigation satellite system (GNSS) service (IGS) and its ionosphere associate analysis centers (IAACs) along with the increase of RT-GNSS multi-frequency and multi-constellation observations. In this study, the accuracy and consistency of three RT-GIM products from the Chinese Academy of Sciences (CAS), Wuhan University (WHU), and IGS are evaluated and analyzed utilizing three validation methods, namely, comparison with JASON-3 vertical total electron content (VTEC), the difference of slant total electron content (dSTEC), and IGS combined final GIM (IGSG) data. The test period was from 1 January 2019 to 31 December 2022, including the different solar activities. First, the comparison with JASON-3 data illustrates that the quality of the three RT-GIM products over oceans is in great consistency with that of the IGSG during different levels of solar activity and the daily mean bias (MEAN) values in low and high solar activities are approximately 5 and 10 TECU, respectively. The root mean square (RMS) values under low and high solar activities can be up to 7 and 12 TECU. Furthermore, the dSTEC validation results present that the MEAN values of RT-GIM products from different IAACs at high- and mid-latitude stations are about 0.5 TECU, which is smaller than those at low-latitude stations at about 1 TECU over continental regions. The standard deviation (STD) and RMS values for various RT-GIM products are within 3 and 4 TECU at low latitudes, respectively. In terms of the comparison with IGSG, the result shows that IGS combined RT-GIM (IRTG) presents better consistency than CAS RT-GIM (CRTG) and WHU RT-GIM (WRTG) in 2021 and 2022, with average annual STD and RMS values of 2.56 and 2.78 TECU, respectively. The daily biases of the RT-GIM products relative to IGSG can reach 4 TECU in high solar activities and the daily STD and RMS values are mainly within the 5 to 6 TECU range, respectively.
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- 2023
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9. Stage‐dependent conditional survival and failure hazard of non‐metastatic nasopharyngeal carcinoma after intensity‐modulated radiation therapy: Clinical implications for treatment strategies and surveillance
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Jingbo Wang, Xiaodong Huang, Shiran Sun, Kai Wang, Yuan Qu, Xuesong Chen, Runye Wu, Ye Zhang, Qingfeng Liu, Jianghu Zhang, Jingwei Luo, Jianping Xiao, Li Gao, Guozhen Xu, Chen Hu, Ye‐Xiong Li, and Junlin Yi
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conditional survival ,hazard analysis ,intensity‐modulated radiotherapy ,nasopharyngeal neoplasms ,survival analyses ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Purpose Conditional survival (CS) and failure hazard estimations can provide important dynamic prognostic information for clinical decision‐making and surveillance counseling. The current study aimed to investigate the CS and dynamic failure hazard in non‐metastatic nasopharyngeal carcinoma (NPC) treated with intensity‐modulated radiotherapy (IMRT). Methods Conditional overall survival (COS) and progression‐free survival (CPFS) estimates adjusted for age and gender against each AJCC 8th stage were calculated. Multivariable Cox regression (MCR) models were fitted in the entire population at baseline and subsequently separate MCR models were fitted in patients who have maintained event‐free time of 1 to 10 years to generate respective hazard ratio (HR). Annual hazard rates of death and progression over 10 years for each stage were also estimated. Results A total of 1993 patients were eligible for analysis. The estimated 5‐year OS and PFS for entire cohort were 79.0% and 70.7% at initial diagnosis. After 5 years of event‐free follow‐up, additional 5‐year COS and CPFS increased to 85.9% and 85.5%, respectively. Stage I/II maintained dramatically favorable CS and low hazard (< 5%) of death and progression over time. Relative to stage I/II, stage III manifested non‐significantly higher failure hazard for the first 3 years of survivorship and approached to similar level of stage I/II afterwards. Stage IVA presented most impressive improvement in terms of both COS (∆=9.8%) and CPFS (∆ = 16.8%) whereas still drastically inferior to that of stage I‐III across all conditional time points. After 4 years of follow‐up, progression hazard of stage IVA became relatively steady of approximate 6%. Conclusions Survival prospect of non‐metastatic NPC improves over years with distinct dynamic patterns across stages, providing important implications for personalized decision‐making in terms of both clinical management and surveillance counseling. Stage‐dependent and hazard‐adapted clinical management and surveillance are warranted.
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- 2021
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10. Lymph Node Metastasis Spread Patterns and the Effectiveness of Prophylactic Neck Irradiation in Sinonasal Squamous Cell Carcinoma (SNSCC)
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Qian Liu, Yuan Qu, Kai Wang, Runye Wu, Ye Zhang, Xiaodong Huang, Jianghu Zhang, Xuesong Chen, Jingbo Wang, Jianping Xiao, Junlin Yi, Guozhen Xu, and Jingwei Luo
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lymph node spread pattern ,lymph node metastasis ,sinonasal malignancies ,elective neck irradiation ,node-negative neck ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
ObjectivesTo analyze the incidence and spread of lymph node metastasis (LNM) and the effectiveness of prophylactic neck irradiation in patients with SNSCC.MethodsA total of 255 patients with SNSCC were retrospectively reviewed. The LNM spread pattern was revealed. The clinical parameters related to LNM, and the prognostic value of elective neck irradiation (ENI) were assessed. A 1:1 matching with propensity scores was performed between ENI group and observation (OBS) group.ResultsThe initial LNM rate was 20.8%, and the regional recurrence (RR) rate was 7.5%. Lymphatic spreading in SNSCC followed the common trajectories: a. level Ib ➔ level II ➔ level Va/level III/IV lymph nodes (LNs); b. retropharyngeal lymph nodes (RPLNs) ➔ level II LNs. The most frequently involved site was level II LNs (16.1%), followed by level Ib LNs (10.2%), RPLNs (4.7%), level III LNs (3.2%), level Va LNs (1.6%), level IVa LNs (1.4%) and level VIII LNs (0.8%). The median follow-up time was 105 months. The 5-year overall survival (OS) was 55.7% for N0 patients and 38.5% for patients with initial N+ or N- relapse (p = 0.009). After PSM, the 5-year regional recurrence-free survival was 71.6% and 94.7% (p = 0.046) in OBS and ENI group, respectively. The multivariate analysis showed that ENI (p = 0.013) and absence of nasopharynx involvement (p = 0.026) were associated with a significantly lower RR rate.ConclusionsPatients with LNM had poorer survival than those who never experienced LNM. Lymphatic spread in SNSCC followed predictable patterns. ENI effectively reduced the RR rate in patients at high risk.
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- 2022
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11. Long-term analysis of multimodality treatment outcomes and prognosis of esthesioneuroblastomas: a single center results of 138 patients
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Meng Sun, Kai Wang, Yuan Qu, Jianghu Zhang, Shiping Zhang, Xuesong Chen, Jingbo Wang, Runye Wu, Ye Zhang, Junlin Yi, Jianping Xiao, Guozhen Xu, Xiaodong Huang, and Jingwei Luo
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Esthesioneuroblastoma ,Treatment strategy ,Survival outcomes ,Prognostic factors ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background The aim of this study is to evaluate the efficacy of different treatment strategies and the potential prognostic factors of esthesioneuroblastoma (ENB). Materials and methods Between April 1984 and December 2018, 138 patients with non-metastatic ENB were retrospectively analyzed. The treatment modalities mainly included surgery alone (n = 7), radiotherapy alone (n = 33), concurrent chemoradiotherapy (n = 17), surgery combined with current chemoradiotherapy (n = 32), and surgery plus radiotherapy (n = 49). Results The median follow-up time for the entire cohort was 61 months (range, 4–231 months). The 5-year overall survival (OS), locoregional failure-free survival (LRFFS), and distant metastasis-free survival (DMFS) rate were 69.6, 78.0 and 73.9%, respectively. Surgery combined with radiotherapy elicited superior survival results, and the combination of surgery and current chemoradiotherapy achieved the best prognoses for all patients, patients with advanced Kadish disease, patients receiving intensity modulated radiation therapy and those with positive surgical margin. Univariate analysis identified orbital invasion and treatment modalities were predictors for OS, LRFFS and DMFS. Lymph node metastasis was associated with OS and DMFS, but not LRFFS. Intracranial invasion, advanced Kadish stage and not receiving concurrent chemotherapy were also predictive of lower OS. Multivariate analyses indicated that lymph node metastasis was an independent prognostic factor affecting DMFS, whereas treatment modalities was independent prognostic factors for OS and LRFFS. Conclusion Orbital invasion, intracranial invasion, lymph node metastasis and advanced Kadish disease at initial diagnosis were significantly associated with inferior prognosis. Regarding the treatment modality, the optimal strategy remined surgery with radiotherapy-based multimodality treatment. The concurrent chemoradiotherapy may play a more beneficial role.
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- 2020
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12. Prognostic impact of pathological complete remission after preoperative irradiation in patients with locally advanced head and neck squamous cell carcinoma: re-analysis of a phase 3 clinical study
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Kai Wang, Junlin Yi, Xiaodong Huang, Yuan Qu, Jingwei Luo, Jianping Xiao, Shiping Zhang, Yuan Tang, Weixin Liu, Guozhen Xu, Li Gao, Zhengang Xu, Shaoyan Liu, and Xiaolei Wang
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Head and neck squamous cell carcinoma ,Preoperative radiotherapy ,Concurrent chemoradiotherapy ,Pathological complete remission ,Prognosis ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Purpose The purpose of this study was to determine the associations between pathological complete remission (pCR) and clinical outcomes in patients with locally advanced head and neck squamous cell carcinoma (HNSCC) who received preoperative radiotherapy or chemoradiotherapy in a phase 3 clinical study. Methods A total of 222 newly diagnostic stage III/IVM0 HNSCC patients were randomly assigned to a preoperative concurrent chemoradiotherapy group (n = 104) or preoperative radiotherapy alone group (n = 118). Over a mean follow-up of 59 months, 72 patients were defined as non-responders to preoperative therapy and subsequently underwent resection of the primary lesion with or without neck dissection. The relationship between the pathological tumor response of the primary lesion and treatment prognosis was analyzed. Kaplan–Meier and Cox regression multivariate analyses were performed to evaluate the impact of pCR on local control (LC), overall survival (OS), progression-free survival (PFS), and distant metastasis-free survival (DMFS). Results Among the 72 non-responders, 25 patients, 10 in the chemotherapy group and 15 in the radiotherapy group, achieved pCR. The 5-year LC, OS, PFS, and DMFS of pCR patients and non-pCR patients were 93.2% vs. 67.7% (p = 0.007), 83.3% vs. 39.7% (p = 0.0006), 76.1% vs. 44.0% (p = 0.009), and 90.4% vs. 56.3% (p = 0.005), respectively. In multivariate analysis, pCR is also an independent prognostic factor in prognosis, with statistically significant differences. Conclusion pCR after preoperative radiotherapy or concurrent chemoradiotherapy is a good prognostic factor in locally advanced HNSCC. Trial registration Number:ChiCTR-TRC-114004322 Date:05 Mar, 2014
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- 2019
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13. Sinonasal Inverted Papilloma–Associated and De Novo Squamous Cell Carcinoma: A Tale of Two Cities or Not
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Zekun Wang, Ye Zhang, Jianghu Zhang, Xuesong Chen, Jingbo Wang, Runye Wu, Kai Wang, Yuan Qu, Xiaodong Huang, Jingwei Luo, Li Gao, Guozhen Xu, Shaoyan Liu, Ye-Xiong Li, and Junlin Yi
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sinonasal squamous cell carcinoma ,inverted papilloma ,de novo ,survival outcome ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Background: Sinonasal squamous cell carcinoma (SNSCC) can arise as either inverted papilloma–associated SCC (IP-SCC) or as de novo SCC (DN-SCC). It is controversial as to whether survival differences between IP-SCC and DN-SCC exist. Methods: Between January 2000 and December 2016, 234 patients with SNSCC were analyzed retrospectively, including 68 with IP-SCC and 166 with DN-SCC. Propensity score matching (PSM) was performed to balance baseline characteristics. The Kaplan–Meier method and Cox proportional hazard model were used to determine risk factors on survival outcomes. Results: The median follow-up time was 98.4 months. Before PSM, lymph node metastasis was noted to be lower in patients with IP-SCC. After PSM, the 5-year DFS, DSS and OS between IP-SCC and DN-SCC were 43.0% vs. 44.5% (p = 0.701), 49.2% vs. 56.2% (p = 0.753), and 48.2% vs. 52.9% (p = 0.978). The annual hazards of local failure, respectively, peaked at 28.4% and 27.8% for IP-SCC and DN-SCC within 12 months after treatment. Afterward, the hazards gradually decreased and the hazard for IP-SCC was always higher before approaching null. Conclusions: This study provides novel evidence to support the clinical utility of improved distinction between IP-SCC and DN-SCC. Further studies are necessary to validate these findings before considering escalation of IP-SCC.
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- 2022
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14. The Oxidation Process and Methods for Improving Reactivity of Al
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Deqi Wang, Guozhen Xu, Tianyu Tan, Shishuo Liu, Wei Dong, Fengsheng Li, and Jie Liu
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aluminum ,oxidation process ,reaction mechanism ,modification method ,development trend ,Crystallography ,QD901-999 - Abstract
Aluminum (Al) has been widely used in micro-electromechanical systems (MEMS), polymer bonded explosives (PBXs) and solid propellants. Its typical core-shell structure (the inside active Al core and the external alumina (Al2O3) shell) determines its oxidation process, which is mainly influenced by oxidant diffusion, Al2O3 crystal transformation and melt-dispersion of the inside active Al. Consequently, the properties of Al can be controlled by changing these factors. Metastable intermixed composites (MICs), flake Al and nano Al can improve the properties of Al by increasing the diffusion efficiency of the oxidant. Fluorine, Titanium carbide (TiC), and alloy can crack the Al2O3 shell to improve the properties of Al. Furthermore, those materials with good thermal conductivity can increase the heat transferred to the internal active Al, which can also improve the reactivity of Al. Now, the integration of different modification methods is employed to further improve the properties of Al. With the ever-increasing demands on the performance of MEMS, PBXs and solid propellants, Al-based composite materials with high stability during storage and transportation, and high reactivity for usage will become a new research focus in the future.
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- 2022
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15. Patterns of Cervical Lymph Node Metastasis in Locally Advanced Supraglottic Squamous Cell Carcinoma: Implications for Neck CTV Delineation
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Yi Xu, Ye Zhang, Zhengang Xu, Shaoyan Liu, Guozhen Xu, Li Gao, Jingwei Luo, Xiaodong Huang, Kai Wang, Yuan Qu, Shiping Zhang, Qingfeng Liu, Runye Wu, Xuesong Chen, and Junlin Yi
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locally advanced ,supraglottic squamous cell carcinoma ,lymph node metastasis ,clinical target volume ,delineation ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
ObjectiveTo investigate the prevalence and distribution of cervical lymph node metastasis (LNM) in locally advanced supraglottic squamous cell carcinoma (LASCC) and guide the delineation of clinical lymph node target volumes.Materials and MethodsWe reviewed patients defined as LASCC from January 2000 to December 2017 in our hospital. The primary tumor was operated on using partial or total laryngectomy, and all patients underwent bilateral neck dissection (levels II–IV at least). Univariate and multivariate logistic regressions were used to find risk factors associated with LNM.ResultsA total of 206 patients were enrolled. In the whole group, the rate of ipsilateral metastasis (IM) was 60.9% (67 patients), whereas contralateral metastasis was 25.5% (28 patients). Only positive ipsilateral lymph nodes contributed to contralateral metastasis (p = 0.001). Seventy-six cases were diagnosed with clinical positive lymph nodes (cN+). IM of primary lesions mainly located within the unilateral sites (n = 49 patients) was detected in levels II, III, and IV with lymph node metastasis ratios of 73.5% (36 patients), 63.3% (31 patients), and 20.4% (10 patients), respectively, and contralateral metastasis of 36.7% (18 patients), 16.3% (8 patients), and 6.1% (3 patients), respectively. Involvement of level II or III was associated with metastasis of level IV. No one developed contralateral level IV involvement without metastasis of contralateral levels II and III. A total of 130 cases had clinically negative neck lymph nodes (cN0). The prevalence of occult metastasis (OM) was 35.4%. Among 62 patients with unilateral lesions, the rates of OM to ipsilateral neck levels II, III, and IV were 21, 11.1, and 1.6%, respectively, whereas contralateral neck levels were 6.3, 4.8, and 0%, respectively. In terms of the risk factors, histopathological differentiation was related to OM (p = 0.003). Two of 25 people were with level VIb metastasis, and both of them were with subglottic involvement.ConclusionNeck levels II to IV are most frequently involved and should be included in clinical target volume (CTV) in cN+ patients. Contralateral IV may be omitted when contralateral levels II and III are negative. In cN0 patients, ipsilateral levels II and III are suggested to be included in the CTV, whereas whether contralateral levels II and III should be included needs further research.
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- 2020
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16. Adding Concurrent Chemotherapy to Intensity-Modulated Radiotherapy Does Not Improve Treatment Outcomes for Stage II Nasopharyngeal Carcinoma: A Phase 2 Multicenter Clinical Trial
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Xiaodong Huang, Xiaozhong Chen, Chong Zhao, Jingbo Wang, Kai Wang, Lin Wang, Jingjing Miao, Caineng Cao, Ting Jin, Ye Zhang, Yuan Qu, Xuesong Chen, Qingfeng Liu, Shiping Zhang, Jianghu Zhang, Jingwei Luo, Jianping Xiao, Guozhen Xu, Li Gao, and Junlin Yi
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nasopharyngeal carcinoma ,intensity-modulated radiotherapy ,concurrent chemoradiotherapy ,stage II ,treatment outcomes ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Purpose: To explore the efficacy of concomitant chemotherapy in intensity-modulated radiotherapy (IMRT) to treat stage II nasopharyngeal carcinoma (NPC).Methods and Materials: In this randomized phase 2 study [registered with ClinicalTrials.gov (NCT01187238)], eligible patients with stage II (2010 UICC/AJCC) NPC were randomly assigned to either IMRT alone (RT group) or IMRT combined with concurrent cisplatin (40 mg/m2, weekly) (CCRT group). The primary endpoint was overall survival (OS). The second endpoints included local failure-free survival (LFFS), regional failure-free survival (RFFS), disease-free survival (DFS), distant metastasis-free survival (DMFS), and acute toxicities.Results: Between May 2010 to July 2012, 84 patients who met the criteria were randomized to the RT group (n = 43) or the CCRT group (n = 41). The median follow-up time was 75 months. The OS, LFFS, RFFS, DFS, and DMFS for the RT group and CCRT group were 100% vs. 94.0% (p = 0.25), 93.0% vs. 89.3% (p = 0.79), 97.7% vs. 95.1% (p = 0.54), 90.4% vs. 86.6% (p = 0.72), and 95.2% vs. 94.5% (p = 0.77), respectively. A total of 14 patients experienced disease failure, 7 patients in each group. The incidence of grade 2 to 4 leukopenia was higher in the CCRT group (p = 0.022). No significant differences in liver, renal, skin, or mucosal toxicity was observed between the two groups.Conclusion: For patients with stage II NPC, concomitant chemotherapy with IMRT did not improve survival or disease control but had a detrimental effect on bone marrow function.
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- 2020
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17. Outage-Constrained Beamforming for Two-Tier Massive MIMO Downlink with Pilot Reuse
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Guozhen Xu, An Liu, Wei Jiang, Haige Xiang, and Wu Luo
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Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 ,Cellular telephone services industry. Wireless telephone industry ,HE9713-9715 - Abstract
Massive multiple-input multiple-output (MIMO) systems and small cell networks are both regarded as promising candidates to meet the exponential growth of mobile data traffic for the next generation (5G) wireless communications. Hence, a new kind of multitier networks which combine massive MIMO macro cells with a secondary tier of small cells is proposed to resolve the contradiction of large network coverage and high data rate. In such multitier networks, it is inevitable to allocate nonorthogonal uplink pilot sequences to user equipment (UE) due to the large number of users. We propose a pilot reuse scheme by exploiting the unique architecture of this networks and analyse the special mixed channel state information (CSI) yielded by the pilot reuse scheme. Based on the mixed CSI, we formulate a downlink transmit beamforming problem of minimizing the total power consumption while satisfying the quality of service (QoS) requirements with outage constraints. After decomposing the original problem into simpler subproblems, we provide an efficient algorithm to combine these subproblems and solve them iteratively for generating the beamforming vectors. Monte Carlo simulations show that the average power consumption of the proposed pilot reuse scheme and its associated beamforming algorithm is close to that of the perfect CSI case.
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- 2015
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18. Precious Localization Based on Carrier Phase and Range Measurements in Wireless Networks.
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Mingxing Ke, Huaijin Chen 0003, Feng Qi, Haiyan Zhang, Guozhen Xu, and Xiaokun Si
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- 2023
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19. Decentralized Automatic Modulation Classification Method Based on Lightweight Neural Network.
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Biao Dong, Guozhen Xu, Xue Fu, Heng Dong, Guan Gui 0001, Haris Gacanin, and Fumiyuki Adachi
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- 2022
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20. A Robust CSI- Based Passive Perception Method Using CNN and Attention-Based Bi-Directional LSTM.
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Zhengran He, Guozhen Xu, Siyuan Xu, Yu Wang 0078, Guan Gui 0001, Haris Gacanin, and Fumiyuki Adachi
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- 2022
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21. Method and Validation of Real-Time Global Ionosphere Modeling Constraint by Multi-Source GNSS/LEO Data.
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Jun Chen, Xiaodong Ren, Guozhen Xu, Pengxin Yang, Hang Liu, and Xiaohong Zhang
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LOW earth orbit satellites ,GLOBAL Positioning System ,IONOSPHERE ,ROOT-mean-squares ,AMBIGUITY ,KALMAN filtering - Abstract
This study applies the zero-differenced integer ambiguity method, named PPP-Fixed, to extract real-time ionospheric data and eliminate the latencies of rapid/final Global Ionosphere Maps (GIMs). The PPP-Fixed method is also used to derive ionospheric data for post-processed GIM generation, named SGG Post- GIM, combined with low earth orbit satellite data. The obtained hardware delays are applied to revise real-time ionospheric data. Meanwhile, the estimated multi-source ionospheric model is regarded as historical data to estimate an ionospheric prediction model for constraint using the semi-parameter model. Then, the Kalman filter is employed to estimate the parameters to generate real-time GIM. Finally, the accuracy of estimated real-time GIM, named SGG RT-GIM, and SGG Post-GIM is assessed. During the experimental period, the mean differences of SGG Post-GIM and SGG RT-GIM relative to GIMs provided by the international Global Navigation Satellite System service, named IGSG, are _ 0.46 and _ 0.57 Total Electron Content Unit (TECU), respectively. The corresponding Root Mean Square (RMS) values are 1.64 and 3.08 TECU. Over the test period, the mean positioning errors of the single-frequency precise point positioning corrected by IGSG, SGG Post- GIM, SGG RT-GIM, and Klobuchar model are 0.14, 0.19, 0.21, and 0.25 m in the horizontal direction, respectively, while the corresponding errors are 0.36, 0.33, 0.38, and 0.64 m in the up direction. Further, the mean biases of experimental days for the self-consistency assessment are 0.06, _ 0.01, and _ 0.07 TECU for IGSG, SGG Post-GIM, and SGG RT-GIM, respectively. The corresponding RMS values are 1.19, 1.15, and 1.57 TECU. [ABSTRACT FROM AUTHOR]
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- 2024
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22. Characterization of protein isolates from green wheat: structure, thermal and rheological properties
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Qingyu Wen, Kangyi Zhang, Yu Zhang, Benguo Liu, Guozhen Xu, Dongxian Sun, Tianqi Li, and Di Zhao
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General Chemical Engineering ,Safety, Risk, Reliability and Quality ,Industrial and Manufacturing Engineering ,Food Science - Published
- 2023
23. Dual-core–shell structure B@LiF@AP with multi-effect synergies to improve processibility and energy release characteristics of B
- Author
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Deqi Wang, Jie Liu, Tianyu Tan, Shishuo Liu, Guozhen Xu, Zhimiao Zhang, Yang Qin, and Fengsheng Li
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Renewable Energy, Sustainability and the Environment ,General Materials Science ,General Chemistry - Abstract
A dual-core–shell structure, B@LiF@AP, B embedded with LiF as core and AP as shell, with multi-effect synergies, has been designed and successfully prepared to improve processibility, ignition and combustion of B.
- Published
- 2023
24. Evaluation and validation of various rapid GNSS global ionospheric maps over one solar cycle
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Hang Liu, Dengkui Mei, Guozhen Xu, Pengxin Yang, Xiaodong Ren, and Xiaohong Zhang
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Atmospheric Science ,Geophysics ,Space and Planetary Science ,Aerospace Engineering ,General Earth and Planetary Sciences ,Astronomy and Astrophysics - Published
- 2022
25. An automatic quantitative measurement method for performance assessment of retina image registration algorithms.
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Ee Ping Ong, Jimmy Addison Lee, Guozhen Xu, Beng Hai Lee, and Damon Wing Kee Wong
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- 2016
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26. On amorphous nature of ultra dense networks.
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Guozhen Xu, Sen Wang 0005, and Chih-Lin I
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- 2016
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27. A low-dimensional step pattern analysis algorithm with application to multimodal retinal image registration.
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Jimmy Addison Lee, Jun Cheng 0003, Beng Hai Lee, Ee Ping Ong, Guozhen Xu, Damon Wing Kee Wong, Jiang Liu 0001, Augustinus Laude, and Tock Han Lim
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- 2015
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28. An augmented reality assistance platform for eye laser surgery.
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Ee Ping Ong, Jimmy Addison Lee, Jun Cheng 0003, Beng Hai Lee, Guozhen Xu, Augustinus Laude, Stephen Teoh, Tock Han Lim, Damon Wing Kee Wong, and Jiang Liu 0001
- Published
- 2015
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- View/download PDF
29. Registration of Color and OCT Fundus Images Using Low-dimensional Step Pattern Analysis.
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Jimmy Addison Lee, Jun Cheng 0003, Guozhen Xu, Ee Ping Ong, Beng Hai Lee, Damon Wing Kee Wong, and Jiang Liu 0001
- Published
- 2015
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30. A Robust Outlier Elimination Approach for Multimodal Retina Image Registration.
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Ee Ping Ong, Jimmy Addison Lee, Jun Cheng 0003, Guozhen Xu, Beng Hai Lee, Augustinus Laude, Stephen Teoh, Tock Han Lim, Damon Wing Kee Wong, and Jiang Liu 0001
- Published
- 2015
- Full Text
- View/download PDF
31. Global Ionospheric TEC Forecasting for Geomagnetic Storm Time Using a Deep Learning‐Based Multi‐Model Ensemble Method
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Xiaodong Ren, Pengxin Yang, Dengkui Mei, Hang Liu, Guozhen Xu, and Yue Dong
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Atmospheric Science - Published
- 2023
32. Geometric corner extraction in retinal fundus images.
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Jimmy Addison Lee, Beng Hai Lee, Guozhen Xu, Ee Ping Ong, Damon Wing Kee Wong, Jiang Liu 0001, and Tock Han Lim
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- 2014
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33. Construction of Military Knowledge Graph Based on Neo4j and MongoDB
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Yun He, Xile Zhang, Feng Oi, Guozhen Xu, and Guan Gui
- Published
- 2022
34. T4b Sinonasal Squamous Cell Carcinoma: Surgery Plus Radiotherapy May Contribute to Prolonged Survival
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Zekun Wang, Jianghu Zhang, Bining Yang, Ye Zhang, Xuesong Chen, Jingbo Wang, Runye Wu, Kai Wang, Yuan Qu, Xiaodong Huang, Jingwei Luo, Li Gao, Guozhen Xu, Ye‐Xiong Li, and Junlin Yi
- Subjects
Otorhinolaryngology - Abstract
To determine oncologic outcomes for patients with T4b sinonasal squamous cell carcinoma (SNSCC) treated with either surgery plus radiotherapy or definitive radiotherapy.Between January 1999 and December 2016, 85 patients with T4b SNSCC were analyzed retrospectively, there were 54 who received surgery plus radiotherapy (S + RT group) ± chemotherapy and 31 with definitive radiotherapy (RT group) ± chemotherapy. A 1: 2 propensity score matching (PSM) was performed to balance clinical factors and match patients. Kaplan-Meier method and Cox proportional hazard model were used to determine risk factors on survival outcomes.The median follow-up time was 76.7 months. The cumulative rates of locoregional control (LRC), distant metastasis-free survival (DMFS), cancer-specific survival (CSS), and overall survival (OS) at 5 years for entire cohort were 44.6%, 33.1%, 38.8%, and 33.9% respectively. After PSM, a total of 50 patients in S + RT group and 25 patients in RT group were analyzed. The 5-year LRC, DMFS, CSS, and OS between S + RT and RT group were 58.6% versus 27.5% (p = 0.035), 42.8% versus 20.0% (p = 0.006), 50.3% versus 22.0% (p = 0.005), 44.5% veruss 20.0% (p = 0.004). The 5-year survival rates with orbital retention between groups were 32.7% and 15.0%, p = 0.080. Multivariate Cox analysis revealed non-surgical therapy (HR = 3.678, 95%CI 1.951-6.933) and invasion of cranial nerves (other than maxillary division of trigeminal nerves) (HR = 2.596, 95%CI 1.217-5.535) were associated with decreased OS.The inclusion of surgery in the multimodal management of T4b SNSCC might confer a survival benefit. Further prospective studies comparing the oncologic outcomes of S + RT with RT are warranted.III Laryngoscope, 2022.
- Published
- 2022
35. Synchronous Second Primary Cancers of Hypopharyngeal Carcinoma in the Image‐Enhanced Endoscopy Era
- Author
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Xi Luo, Xiaodong Huang, Shaoyan Liu, Xiaolei Wang, Jingwei Luo, Jianping Xiao, Kai Wang, Yuan Qu, Xuesong Chen, Ye Zhang, Jingbo Wang, Jianghu Zhang, Guozhen Xu, Li Gao, Runye Wu, and Junlin Yi
- Subjects
Otorhinolaryngology - Abstract
To explore the prevalence of hypopharyngeal carcinoma (HPC) with synchronous second primary malignancies (Syn-SPMs), their impact on clinical outcomes, and associated risk factors in the image-enhanced endoscopy era.We retrospectively analyzed 673 patients newly diagnosed with HPC at our cancer center between 2009 and 2019. The patients were divided into three groups: (a) no second primary malignancies (N-SPMs, n = 533); (b) synchronous carcinoma in situ (Syn-Tis, n = 60); (c) synchronous invasive tumors (Syn-invasive, n = 80). Propensity score matching was conducted to balance the N-SPMs and Syn-invasive groups at a 3:1 ratio.Most (96.1%) underwent pretreatment esophagogastroduodenoscopy evaluation with image-enhanced endoscopy. The incidence rates were: Syn-SPMs, 20.8%; Syn-Tis, 8.9%; Syn-invasive, 11.9%. At a median follow-up of 66.7 months, the Syn-Tis and N-SPMs groups had a similar 5-year overall survival (OS; 45.6% vs. 44.5%; hazard ratio [HR], 0.956; 95% confidence interval [CI], 0.660-1.385; p = 0.806). Compared to the N-SPMs group, the Syn-invasive group had poorer 5-year OS (27.0% vs. 52.9%; HR, 2.059; 95% CI, 1.494-2.839; p 0.001). Alcohol consumption was significantly associated with Syn-SPMs occurrence (odds ratio, 2.055, 2.414, and 3.807 for light, intermediate, and heavy drinkers, respectively).The prevalence of Syn-SPMs among patients with HPC was high. Syn-invasive SPMs decreased the survival of patients with HPC. Routine screening with image-enhanced endoscopy should be recommended to detect early-stage SPMs, especially for heavy alcohol drinkers.III Laryngoscope, 2022.
- Published
- 2022
36. Optimal Feedback Bits Allocation for Two-Cell Massive MIMO Downlink.
- Author
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Guozhen Xu, Wei Jiang 0003, An Liu 0001, Haige Xiang, and Wu Luo
- Published
- 2013
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37. Case-Based Reasoning for Data Verification with Data Structure in M&S.
- Author
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Guozhen Xu, Peng Jiao, and Yabing Zha
- Published
- 2011
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38. Zernike Sub-pixel Edge Detection Method Based on Ramer-Turkey-Fitzgibbon
- Author
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Guozhen Xu, Kelin Li, Yuchao Yang, Yixuan Song, and Haiyan Zhang
- Published
- 2022
39. Feature-Specific Sliding Window-Based Sub-pixel Edge Detection Algorithm
- Author
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Weilin Hu, Haiyan Zhang, Bo Hu, Han Wang, and Guozhen Xu
- Published
- 2022
40. Construction of a linear unbiased diffeomorphic probabilistic liver atlas from CT images.
- Author
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Wei Xiong 0001, S. H. Ong 0001, Qi Tian 0002, Guozhen Xu, Jiayin Zhou, Jiang Liu 0001, and Sudhakar K. Venkatesh
- Published
- 2009
- Full Text
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41. Stage‐dependent conditional survival and failure hazard of non‐metastatic nasopharyngeal carcinoma after intensity‐modulated radiation therapy: Clinical implications for treatment strategies and surveillance
- Author
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Guozhen Xu, Chen Hu, Ye Zhang, Qingfeng Liu, Jingwei Luo, Li Gao, Kai Wang, Jingbo Wang, Junlin Yi, Jianghu Zhang, Jianping Xiao, Xuesong Chen, S. Sun, Xiaodong Huang, Ye Xiong Li, Runye Wu, and Yuan Qu
- Subjects
Male ,0301 basic medicine ,Oncology ,Cancer Research ,survival analyses ,Hazard analysis ,0302 clinical medicine ,Medicine ,Stage (cooking) ,Child ,RC254-282 ,Original Research ,Aged, 80 and over ,Nasopharyngeal Carcinoma ,conditional survival ,Hazard ratio ,Age Factors ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,nasopharyngeal neoplasms ,Middle Aged ,Prognosis ,Progression-Free Survival ,Child, Preschool ,030220 oncology & carcinogenesis ,Cohort ,Female ,Adult ,medicine.medical_specialty ,Adolescent ,Nasopharyngeal neoplasm ,Young Adult ,03 medical and health sciences ,Sex Factors ,Internal medicine ,Survivorship curve ,Confidence Intervals ,Humans ,Radiology, Nuclear Medicine and imaging ,intensity‐modulated radiotherapy ,Aged ,Neoplasm Staging ,Proportional Hazards Models ,hazard analysis ,business.industry ,Proportional hazards model ,Clinical Cancer Research ,medicine.disease ,030104 developmental biology ,Nasopharyngeal carcinoma ,Radiotherapy, Intensity-Modulated ,business - Abstract
Purpose Conditional survival (CS) and failure hazard estimations can provide important dynamic prognostic information for clinical decision‐making and surveillance counseling. The current study aimed to investigate the CS and dynamic failure hazard in non‐metastatic nasopharyngeal carcinoma (NPC) treated with intensity‐modulated radiotherapy (IMRT). Methods Conditional overall survival (COS) and progression‐free survival (CPFS) estimates adjusted for age and gender against each AJCC 8th stage were calculated. Multivariable Cox regression (MCR) models were fitted in the entire population at baseline and subsequently separate MCR models were fitted in patients who have maintained event‐free time of 1 to 10 years to generate respective hazard ratio (HR). Annual hazard rates of death and progression over 10 years for each stage were also estimated. Results A total of 1993 patients were eligible for analysis. The estimated 5‐year OS and PFS for entire cohort were 79.0% and 70.7% at initial diagnosis. After 5 years of event‐free follow‐up, additional 5‐year COS and CPFS increased to 85.9% and 85.5%, respectively. Stage I/II maintained dramatically favorable CS and low hazard (< 5%) of death and progression over time. Relative to stage I/II, stage III manifested non‐significantly higher failure hazard for the first 3 years of survivorship and approached to similar level of stage I/II afterwards. Stage IVA presented most impressive improvement in terms of both COS (∆=9.8%) and CPFS (∆ = 16.8%) whereas still drastically inferior to that of stage I‐III across all conditional time points. After 4 years of follow‐up, progression hazard of stage IVA became relatively steady of approximate 6%. Conclusions Survival prospect of non‐metastatic NPC improves over years with distinct dynamic patterns across stages, providing important implications for personalized decision‐making in terms of both clinical management and surveillance counseling. Stage‐dependent and hazard‐adapted clinical management and surveillance are warranted., This study aimed to investigate the conditional survival (CS) and dynamic failure hazard in non‐metastatic nasopharyngeal carcinoma (NPC) treated with intensity‐modulated radiotherapy (IMRT). Survival prospect of non‐metastatic NPC improved over years with distinct dynamic patterns across stage, providing important implications for personalized decision‐making in terms of both clinical management and surveillance counseling. Stage‐dependent and hazard‐adapted clinical management and surveillance are warranted.
- Published
- 2021
42. Sinonasal mucosal melanoma: is there a need for elective neck irradiation?
- Author
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Shiran Sun, Ye Zhang, Xiaodong Huang, Kai Wang, Yuan Qu, Runye Wu, Xuesong Chen, Jingbo Wang, Jianghu Zhang, Jingwei Luo, Guozhen Xu, Ye-Xiong Li, and Junlin Yi
- Subjects
Oncology ,Radiology, Nuclear Medicine and imaging ,Hematology - Published
- 2023
43. Mercury fluxes record regional volcanism in the South China craton prior to the end-Permian mass extinction
- Author
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Jun Shen, Shucheng Xie, Jiubin Chen, Yi-Gang Xu, Qinglai Feng, Guozhen Xu, Yong Lei, Jianxin Yu, Thomas J. Algeo, and Noah J. Planavsky
- Subjects
geography ,South china ,geography.geographical_feature_category ,010504 meteorology & atmospheric sciences ,Geochemistry ,chemistry.chemical_element ,Geology ,Volcanism ,010502 geochemistry & geophysics ,01 natural sciences ,Mercury (element) ,Craton ,chemistry ,Permian–Triassic extinction event ,0105 earth and related environmental sciences - Abstract
Enhanced regional subduction-related volcanism in the South China craton concurrent with Siberian Traps large igneous province magmatism was a likely contributor to major biotic and environmental stresses associated with the Permian-Triassic boundary (ca. 252 Ma) mass extinction. However, the timing, intensity, and duration of this regional volcanic activity remain uncertain. We analyzed mercury (Hg) concentrations in three widely separated marine sections in the South China craton (Shangsi, Ganxi, and Chaohu) as well as Hg isotopic compositions in one section (Shangsi) from the Upper Permian (Changhsingian) through the lowermost Triassic (Induan) in order to track volcanic inputs. Four mercury enrichment (ME) intervals, dating to the lowermost Changhsingian (ME1), mid–Clarkina changxingensis zone (ME2), upper C. changxingensis to lower C. yini zones (ME3), and latest Permian mass extinction (LPME) interval (ME4), were recognized on the basis of elevated Hg/total organic carbon ratios. These records provide evidence of strong volcanism in the Tethyan region starting ∼2 m.y. before the LPME, whereas only the ME4 event is recorded in extra-Tethyan sections. Mercury isotopes support the inference that pre-LPME Hg peaks were related to regional subduction-related volcanism, and that Hg emissions at the LPME were the result of Siberian Traps large igneous province intrusions into organic-rich sediments. This study demonstrates the feasibility of distinguishing flood-basalt from subduction-related volcanic inputs on the basis of marine sedimentary Hg records.
- Published
- 2020
44. Research on Key Technologies of Conceptual Design and Verification of Electronic Countermeasure Based on Combat Simulation
- Author
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GuoZhen Xu, Feng Qi, and Yun He
- Published
- 2022
45. The Pattern of Cervical Lymph Node Metastasis and Risk Factors of Retropharyngeal Lymph Node Metastasis Based on Magnetic Resonance Imaging in Different Sites of Hypopharyngeal Carcinoma
- Author
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Kai Wang, Yuan Qu, Runye Wu, Xuesong Chen, Xiaodong Huang, Guozhen Xu, Shiping Zhang, Junlin Yi, Ye Zhang, Jingwei Luo, Li Gao, Jianping Xiao, Huili Wang, and Qingfeng Liu
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Metastasis ,Hypopharyngeal Carcinoma ,03 medical and health sciences ,0302 clinical medicine ,Retropharyngeal lymph nodes ,medicine ,retropharyngeal lymph node ,risk factors ,metastasis ,Lymph node ,Original Research ,medicine.diagnostic_test ,lymph node metastasis ,business.industry ,Magnetic resonance imaging ,medicine.disease ,Primary tumor ,Squamous carcinoma ,030104 developmental biology ,medicine.anatomical_structure ,Oncology ,Cancer Management and Research ,030220 oncology & carcinogenesis ,Cohort ,hypopharyngeal carcinoma ,Radiology ,business - Abstract
Huili Wang, Runye Wu, Xiaodong Huang, Yuan Qu, Kai Wang, Qingfeng Liu, Xuesong Chen, Ye Zhang, Shiping Zhang, Jianping Xiao, Junlin Yi, Guozhen Xu, Li Gao, Jingwei Luo National Cancer Center/National Cancer Clinical Medical Research Center/Chinese Academy of Medical Sciences, Peking Union Medical College, Cancer Hospital, Beijing, People’s Republic of ChinaCorrespondence: Jingwei LuoNational Cancer Center/National Cancer Clinical Medical Research Center/Chinese Academy of Medical Sciences, Peking Union Medical College, Cancer Hospital, Beijing, People’s Republic of ChinaTel +86 13601181202Email jingwei-luo@outlook.comBackground: This study was to determine the patterns of regional lymph node (LN) spread and the risk factors of retropharyngeal lymph node (RPLN) metastasis based on magnetic resonance imaging (MRI) in hypopharyngeal squamous carcinoma (HPC) to improve clinical target volume (CTV) delineation.Methods: A cohort of 326 consecutive patients of HPC in a single institute were retrospectively reviewed. All patients underwent MRI prior to initial treatment, and the diagnosis based on MRI of the LN metastasis was confirmed by all radiation oncologists in the head and neck group during twice weekly chat rounds. Statistical analysis of data was using chi-square test and multivariant logistic regression model in SPSS 22.0 software.Results: The LN metastasis rate of all patients in this cohort was 90.5% (295/326). Level IIa/b and level III were the most frequently involved regions followed by level IV and retropharyngeal region. Skip metastasis only occurred in 6.4% (19/295). Univariate and multivariate analysis demonstrated that primary tumor subsites were located in the posterior pharyngeal wall (P=0.002), bilateral cervical LN metastasis (P=0.020), larger volume of primary gross target (GTVp, P=0.003), and larger volume of LN gross target (GTVnd, P=0.023) were significantly associated with RPLN metastasis.Conclusion: The regional LN spread of HPC follows an ordered pattern as level II is the most frequently involved area followed by level III, level IV, and RPLN. RPLN metastasis is more likely to occur in patients with primary site of posterior pharyngeal wall, large tumor burden, or bilateral neck LN metastasis. Therefore, it is highly recommended that the RPLN should be included into CTV for patients who have these risk factors.Keywords: hypopharyngeal carcinoma, lymph node metastasis, risk factors, retropharyngeal lymph node, metastasis
- Published
- 2020
46. Antiemetic prophylaxis for chemoradiotherapy-induced nausea and vomiting in locally advanced head and neck squamous cell carcinoma: a prospective phase II trial
- Author
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Zekun Wang, Wenyang Liu, Jianghu Zhang, Xuesong Chen, Jingbo Wang, Kai Wang, Yuan Qu, Xiaodong Huang, Jingwei Luo, Jianping Xiao, Guozhen Xu, Li Gao, Junlin Yi, and Ye Zhang
- Subjects
Male ,Squamous Cell Carcinoma of Head and Neck ,Vomiting ,Nausea ,Chemoradiotherapy ,Middle Aged ,Ondansetron ,Dexamethasone ,Oncology ,Head and Neck Neoplasms ,Antiemetics ,Humans ,Radiology, Nuclear Medicine and imaging ,Drug Therapy, Combination ,Female ,Prospective Studies ,Cisplatin ,Aprepitant - Abstract
There is sparse research reporting effective interventions for preventing nausea and emesis caused by concurrent chemoradiotherapy (CCRT) in locally advanced head and neck squamous cell carcinoma (LA-HNSCC).Treatment-naïve LA-HNSCC patients received intensity-modulated radiotherapy with concomitant cisplatin 100 mg/mA total of 43 patients with LA-HNSCC were enrolled. The median age was 53 years, and 86.0% were male. All patients received radiotherapy and 86.0% of patients completed both cycles as planned. The overall CR rate was 86.0% (95% confidence interval [CI]: 72.1-94.7). The CR rates for cycles 1 and 2 were 88.4% (95% CI: 74.9-96.1) and 89.2% (95% CI: 74.6-97.0). The complete protection rate in the overall phase was 72.1% (95% CI: 56.3-84.7). The emesis-free and nausea-free responses in the overall phase were 88.4% (95% CI: 74.9-96.1) and 60.5% (95% CI: 44.4-75.0), respectively. The adverse events related to antiemetics were constipation (65.1%) and hiccups (16.3%), but both were grade 1-2. There was no grade 4 or 5 treatment-related toxicity with antiemetic usage.The addition of aprepitant into ondansetron and dexamethasone provided effective protection from nausea and emesis in patients with LA-HNSCC receiving radiotherapy and concomitant high-dose cisplatin chemotherapy.
- Published
- 2021
47. Evaluation of the prevalence of metachronous second primary malignancies in hypopharyngeal carcinoma and their effect on outcomes
- Author
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Xi Luo, Xiaodong Huang, Shaoyan Liu, Xiaolei Wang, Jingwei Luo, Jianping Xiao, Kai Wang, Yuan Qu, Xuesong Chen, Ye Zhang, Jingbo Wang, Jianghu Zhang, Guozhen Xu, Li Gao, Runye Wu, and Junlin Yi
- Subjects
Cancer Research ,Hypopharyngeal Neoplasms ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,metachronous second primary neoplasm ,second primary neoplasm ,Neoplasms, Second Primary ,Prognosis ,survival analysis ,Oncology ,incidence ,Carcinoma, Squamous Cell ,Prevalence ,Humans ,Radiology, Nuclear Medicine and imaging ,hypopharyngeal cancer ,RC254-282 ,Retrospective Studies - Abstract
Background To investigate the clinical characteristics of metachronous second primary malignancies (Met‐SPMs) and its impact on prognosis in hypopharyngeal carcinoma (HPC). Methods We reviewed 593 newly diagnosed HPC patients without invasive synchronous SPMs (Syn‐SPMs) who were treated in our cancer center between 2009 and 2019. According to the status during follow‐up, patients were classified into three groups: (a) without SPMs (No‐SPMs, n = 440), (b) with tumors in situ in the esophagus or stomach (Tis, n = 80), or (c) with Met‐SPMs (n = 73). Results The median follow‐up time for entire cohort (n = 593) was 66.7 months. Met‐SPMs were present in 12.3% of the cohort (73/593). The predominant site of SPMs was esophagus, followed by lung, oral cavity, thyroid, stomach, and oropharynx. In Met‐SPMs group, both index tumor and SPMs were the main causes of death. Tis group exhibited comparable 5‐year overall survival (OS) and disease‐specific survival (DSS) with that of No‐SPMs group. The Met‐SPMs group had similar 5‐year OS rate and better 5‐year DSS rate of 47.3% versus 43.6% (odds ratio [OR], 0.931; 95% confidence interval [CI], 0.681–1.274, p = 0.657) and 66.3% vs. 46.2% (OR, 0.600; 95% CI, 0.402–0.896, p = 0.012), respectively, compared with the No‐SPMs group. Conclusion The overall incidence of Met‐SPMs in HPC was 12.3%. The occurrence of Met‐SPMs does not jeopardize the survival outcome of HPC. Routine surveillance of Met‐SPMs was requisite for patients with HPC.
- Published
- 2021
48. Long-term Outcomes of Endoscopic Resection Versus Open Surgery for Locally Advanced Sinonasal Malignancies in Combination With Radiotherapy
- Author
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Jianghu Zhang, Guozhen Xu, Jingbo Wang, Runye Wu, Ye Zhang, Qian Liu, Kai Wang, Jianping Xiao, Xiaodong Huang, Yuan Qu, Junlin Yi, Xuesong Chen, and Jingwei Luo
- Subjects
Radiation therapy ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Open surgery ,Locally advanced ,Long term outcomes ,Medicine ,Endoscopic resection ,business ,Surgery - Abstract
Objective:To compare the long-term oncological outcomes of endoscopic resection versus open surgery in combination with radiotherapy for locally advanced sinonasal malignancies.Methods:Data for continuous patients with sinonasal epithelial tumors treated in our center between Jan 1999 and Dec 2016 were retrospectively reviewed. Those who received surgery (endoscopic or open surgery) combined with radiotherapy were identified, and 1:1 matching with propensity scores was performed. The primary endpoints of overall survival (OS) and progression-free survival (PFS) were evaluated using the Kaplan-Meier method and Cox proportional hazards modeling. The local recurrence rate (LRR) was assessed by competing risk analysis.Results:We identified 267 eligible patients, 90 of whom were included after matching: 45 patients in the endoscopy group and 45 in the open group. The median follow-up time was 87 months. In the endoscopic group, 84.4% of patients received intensity-modulated radiotherapy (IMRT), with a mean gross tumor volume (GTV) dose of 68.28 Gy; in the open surgery group, 64.4% of patients received IMRT, with a mean GTV dose of 64 Gy. The 5-year OS, PFS and LRR were 69.9%, 58.6%, and 24.5% in the endoscopic group and 64.6%, 54.4%, and 31.8% in the open surgery group, respectively. Multivariable regression analysis revealed that surgical approach was not associated with lower OS, PFS or LRR. Age, histopathology and stage were independent risk factors for OS.Conclusion:For patients with locally advanced sinonasal carcinoma, minimally invasive endoscopic resection, in combination with a higher radiation dose and new radiation techniques such as IMRT, yields survival outcomes similar to those of open surgery in combination with radiotherapy.
- Published
- 2021
49. Irradiation-Induced Nasopharyngeal Necrosis in Newly Diagnosed Nasopharyngeal Carcinoma Treated by Intensity-Modulated Radiation Therapy: Clinical Characteristics and the Influence of Treatment Strategies
- Author
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Jingwei Luo, Yi Xu, Junlin Yi, Li Gao, Jianghu Zhang, Runye Wu, Zekun Wang, Xiaodong Huang, Xuesong Chen, Yuan Qu, Guozhen Xu, Qingfeng Liu, Ye Zhang, Jingbo Wang, Kai Wang, and Yang Liu
- Subjects
medicine.medical_specialty ,Necrosis ,Nasopharyngeal carcinoma ,business.industry ,Medicine ,Treatment strategy ,Irradiation ,Newly diagnosed ,Radiology ,Intensity-modulated radiation therapy ,medicine.symptom ,business ,medicine.disease - Abstract
Purpose: To define the clinical characteristics of irradiation-induced nasopharyngeal necrosis (INN) after intensity-modulated radiotherapy (IMRT) and identify the influence of treatment strategies on INN in primary nasopharyngeal carcinoma (NPC) patients.Patients and methods: From 2008 to 2019, NPC patients pathologically diagnosed with INN after primary IMRT were reviewed. Those patients were matched with propensity scores for patients without INN in our center. The impact of treatment strategies on INN occurrence was assessed using univariate and multivariate logistic regression analysis. Results: The incidence rate of INN was 1.9% among the primary NPC population, and 53 patients with INN were enrolled. Headache and foul odor were the main symptoms, and 71.7% of cases had pseudomembrane during or at the end of radiotherapy. All patients were in early or middle stage INN, and no one presented with skull-based osteoradionecrosis. Then 212 non-INN patients were included based on propensity scores match. Overall survival (p=0.248) and progression-free survival (p=0.266) curves were similar between the INN and non-INN groups. Treatment strategies including combining chemotherapy or molecular targeted therapy with radiotherapy were not associated with INN occurrence, while boost dose (OR 7.360; 95% CI 2.301-23.547; P = 0.001) was a predictor factor for it. However, the optimal threshold for an accumulated dose to predict INN's occurrence was failed to determine.Conclusion: In the IMRT era, the severity of INN in primary NPC patients is lessened. This study showed that treatment strategies contributed little to develop INN, while the accumulated dose of radiation may relate to its occurrence.
- Published
- 2021
50. Irradiation-induced nasopharyngeal necrosis (INN) in newly diagnosed nasopharyngeal carcinoma treated by intensity-modulated radiation therapy: clinical characteristics and the influence of treatment strategies
- Author
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Yi Xu, Yang Liu, Zekun Wang, Jingbo Wang, Jianghu Zhang, Xuesong Chen, Runye Wu, Qingfeng Liu, Yuan Qu, Kai Wang, Xiaodong Huang, Jingwei Luo, Li Gao, Guozhen Xu, Ye Zhang, and Junlin Yi
- Subjects
Adult ,Male ,Intensity-modulated radiation therapy ,Nasopharyngeal Carcinoma ,Adolescent ,Research ,R895-920 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Nasopharyngeal Neoplasms ,Primary nasopharyngeal carcinoma ,Middle Aged ,Medical physics. Medical radiology. Nuclear medicine ,Necrosis ,Young Adult ,Oncology ,Nasopharynx ,Humans ,Radiology, Nuclear Medicine and imaging ,Female ,Radiotherapy, Intensity-Modulated ,Irradiation-induced nasopharyngeal necrosis ,Radiation Injuries ,RC254-282 ,Aged ,Retrospective Studies - Abstract
Purpose To define the clinical characteristics of irradiation-induced nasopharyngeal necrosis (INN) after intensity-modulated radiotherapy (IMRT) and identify the influence of treatment strategies on INN in primary nasopharyngeal carcinoma (NPC) patients. Patients and methods From 2008 to 2019, NPC patients pathologically diagnosed with INN after primary IMRT were reviewed. Those patients were matched with propensity scores for patients without INN in our center. The impact of treatment strategies on INN occurrence was assessed using univariate and multivariate logistic regression analysis. Results The incidence rate of INN was 1.9% among the primary NPC population, and 53 patients with INN were enrolled. Headache and foul odor were the main symptoms, and 71.7% of cases had pseudomembrane during or at the end of radiotherapy. All patients were in early or middle stage INN, and no one presented with skull-based osteoradionecrosis. Then 212 non-INN patients were included based on propensity scores match. Overall survival (p = 0.248) and progression-free survival (p = 0.266) curves were similar between the INN and non-INN groups. Treatment strategies including combining chemotherapy or molecular targeted therapy with radiotherapy were not associated with INN occurrence, while boost dose (OR 7.360; 95% CI 2.301–23.547; p = 0.001) was a predictor factor for it. However, the optimal threshold for an accumulated dose to predict INN's occurrence was failed to determine. Conclusion In the IMRT era, the severity of INN in primary NPC patients is lessened. This study showed that treatment strategies contributed little to develop INN, while the accumulated dose of radiation may relate to its occurrence.
- Published
- 2021
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