Search

Your search keyword '"Gupta, KL"' showing total 372 results
Start Over Author "Gupta, KL"
372 results on '"Gupta, KL"'

5. Establishing surrogate kidney endpoints for lupus nephritis clinical trials: development and validation of a novel approach to predict future kidney outcomes

Author

Mackay, M, Dall’Era, M, Fishbein, J, Kalunian, K, Lesser, M, Sanchez Guerrero, J, Levy, DM, Silverman, E, Petri, M, Arriens, C, Lewis, EJ, Korbet, SM, Conti, F, Tesar, V, Hruskova, Z, Borba, EF, Bonfa, E, Mao Chan, T, Rathi, M, Gupta, KL, Jha, V, Hasni, S, West, MR, Solomons, N, Houssiau, FA, Romera Diaz, J, Mejia-Vilet, J, and Rovin, BH

Subjects
Adult, Male, Nephrology, medicine.medical_specialty, Databases, Factual, medicine.medical_treatment, Immunology, Lupus nephritis, urologic and male genital diseases, Severity of Illness Index, Rheumatology, Predictive Value of Tests, Internal medicine, Humans, Immunology and Allergy, Medicine, Longitudinal Studies, Renal replacement therapy, Renal Insufficiency, Chronic, Proportional Hazards Models, Clinical Trials as Topic, Proteinuria, business.industry, Proportional hazards model, Age Factors, Reproducibility of Results, Acute Kidney Injury, Middle Aged, medicine.disease, Lupus Nephritis, female genital diseases and pregnancy complications, Renal Replacement Therapy, Clinical trial, Creatinine, Multivariate Analysis, Cohort, Female, medicine.symptom, business, Biomarkers, Kidney disease
Abstract

Objective End points currently used in lupus nephritis (LN) clinical trials lack uniformity and questionably reflect long-term kidney survival. This study was undertaken to identify short-term end points that predict long-term kidney outcomes for use in clinical trials. Methods A database of 944 patients with LN was assembled from 3 clinical trials and 12 longitudinal cohorts. Variables from the first 12 months of treatment after diagnosis of active LN (prediction period) were assessed as potential predictors of long-term outcomes in a 36-month follow-up period. The long-term outcomes examined were new or progressive chronic kidney disease (CKD), severe kidney injury (SKI), and the need for permanent renal replacement therapy (RRT). To predict the risk for each outcome, hazard index tools (HITs) were derived using multivariable analysis with Cox proportional hazards regression. Results Among 550 eligible subjects, 54 CKD, 55 SKI, and 22 RRT events occurred. Variables in the final CKD HIT were prediction-period CKD status, 12-month proteinuria, and 12-month serum creatinine level. The SKI HIT variables included prediction-period CKD status, International Society of Nephrology (ISN)/Renal Pathology Society (RPS) class, 12-month proteinuria, 12-month serum creatinine level, race, and an interaction between ISN/RPS class and 12-month proteinuria. The RRT HIT included age at diagnosis, 12-month proteinuria, and 12-month serum creatinine level. Each HIT validated well internally (c-indices 0.84-0.92) and in an independent LN cohort (c-indices 0.89-0.92). Conclusion HITs, derived from short-term kidney responses to treatment, correlate with long-term kidney outcomes, and now must be validated as surrogate end points for LN clinical trials.

Published
2018

6. Haemodialysis vascular access: current practices amongst Indian nephrologists

Author

Bansal, D, Kher, V, Gupta, KL, Banerjee, D, and Jha, V

Abstract

INTRODUCTION: Despite the growing number of haemodialysis (HD) patients in India, little is known about vascular access practice. We investigated the use and cost of different vascular accesses by Indian nephrologists. METHODS: An online survey was emailed to 920 Indian nephrologists and 388 (42.1%) responded; 98.5% of whom were responsible for managing dialysis patients, 98% in hospitals. RESULTS: Sixty-four percent of patients initiated renal replacement therapy with HD, 7% with peritoneal dialysis, 10% kidney transplantation and 19% conservative care. Forty-eight percent of patients were self-paying, 26% had employee reimbursement and 23% had insurance. According to 59% of responders, more than three-quarters of patients started dialysis with uncuffed catheter, less than one-quarter started dialysis with fistula; and very few used grafts or tunnelled catheters. Among prevalent HD patients, over half were dialysing with fistula (79% nephrologists), rather than uncuffed catheters (15% nephrologists) or grafts (

Published
2018

10. The effect of vitamin D supplementation on bone metabolic markers in chronic kidney disease

Author

Yadav, AK, Kumar, V, Banerjee, D, Gupta, KL, and Jha, V

Abstract

Use of active forms of vitamin D is advocated in CKD patients for treatment of mineral bone disease because of the presumption that native forms of vitamin D would not undergo significant activation to calcitriol, the most active biological form of vitamin D. We present secondary analysis looking at bone turnover in subjects who completed the randomized, double blind, placebo controlled trial investigating the effect of cholecalciferol supplementation on vascular function in non-diabetic CKD stage G3-4 and vitamin D ≤20ng/ml [CTRI/2013/05/003648]. Patients were randomized (1:1) to receive either two directly observed oral doses of 300,000 IU of cholecalciferol or matching placebo at baseline and 8 weeks. Of the 120 subjects enrolled, 58 in the cholecalciferol group and 59 in the placebo group completed the study. At 16 weeks, the serum 25(OH)D and 1,25(OH)2D levels increased in the cholecalciferol group but not in the placebo group [between-group difference in mean change: 23.40 ng/ml; 95% CI: 19.76 to 27.06; p

Published
2017

11. Non-Communicable Diseases and their determinants: A Cross-sectional State-Wide STEPS Survey, Haryana, North India

Author

Thakur, JS, primary, Jeet, Gursimer, additional, Nangia, Ria, additional, Singh, Divya, additional, Grover, Sandeep, additional, Lyngdoh, Tanica, additional, Pal, Arnab, additional, Verma, Ramesh, additional, Aggarwal, Ramnika, additional, Khan, Mohd. Haroon, additional, Saran, Rajiv, additional, Jain, Sanjay, additional, Gupta, KL, additional, and Kumar, Vivek, additional

Published
2018
Full Text
View/download PDF

45. Should salt restriction be advised for every patient with hypertension?

Author

Gupta Kl and Gupta

Subjects
medicine.medical_specialty, Endocrinology, business.industry, Internal medicine, Hypertension, medicine, Salt restriction, Humans, Diet, Sodium-Restricted, Cardiology and Cardiovascular Medicine, business, Bioinformatics, Life Style
Published
2002

Catalog

Books, media, physical & digital resources
See catalog results