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21 results on '"Gupta, Meera R."'

8. Preventing asthma in high risk kids (PARK) with omalizumab: Design, rationale, methods, lessons learned and adaptation

Author

Phipatanakul, Wanda, primary, Mauger, David T., additional, Guilbert, Theresa W., additional, Bacharier, Leonard B., additional, Durrani, Sandy, additional, Jackson, Daniel J., additional, Martinez, Fernando D., additional, Fitzpatrick, Anne M., additional, Cunningham, Amparito, additional, Kunselman, Susan, additional, Wheatley, Lisa M., additional, Bauer, Cindy, additional, Davis, Carla M., additional, Geng, Bob, additional, Kloepfer, Kirsten M., additional, Lapin, Craig, additional, Liu, Andrew H., additional, Pongracic, Jacqueline A., additional, Teach, Stephen J., additional, Chmiel, James, additional, Gaffin, Jonathan M., additional, Greenhawt, Matthew, additional, Gupta, Meera R., additional, Lai, Peggy S., additional, Lemanske, Robert F., additional, Morgan, Wayne J., additional, Sheehan, William J., additional, Stokes, Jeffrey, additional, Thorne, Peter S., additional, Oettgen, Hans C., additional, Israel, Elliot, additional, Bartnikas, Lisa, additional, Kantor, David, additional, Permaul, Perdita, additional, Akar-Ghibril, Nicole, additional, Haktanir-Abul, Mehtap, additional, Gunnalaugsson, Sigfus, additional, Esty, Brittany, additional, Crestani, Elena, additional, Maciag, Michelle, additional, Hauptman, Marissa, additional, Baxi, Sachin N., additional, Burke-Roberts, Elizabeth, additional, Louisias, Margee, additional, Banzon, Tina, additional, Habiballah, Saddiq, additional, Nguyen, Alan, additional, Simoneau, Tregony, additional, Minnicozzi, Samantha, additional, Treffeisen, Elsa, additional, LaBere, Brenna, additional, Chandler, Mia, additional, Fanny, Manoussa, additional, Vasquez-Muniz, Anna Cristina, additional, Konzelman, Vanessa, additional, Garcia, Giselle, additional, Waskosky, Sullivan, additional, Ramsey, Anna, additional, Ansel-Kelly, Ethan, additional, Fitzpatrick, Elizabeth, additional, Bairaktaris, Vaia, additional, Fernandez, Jesse, additional, Hollister, Brianna, additional, Lewis, Owen, additional, McIntosh, Masai, additional, Almeida, Sigrid, additional, Kercsmar, Carolyn, additional, McDowell, Karen, additional, Shipp, Cassie, additional, Ward, Stephanie (Logsdon), additional, Lin, Nancy, additional, George, Alisha, additional, Simpson, Ryne, additional, St. Onge, Ina, additional, Corwin, Will, additional, Geigle, Grant, additional, Hartmann, Alisha, additional, Broderick, John, additional, Szefler, Stanley, additional, Miyazawa, Naomi, additional, Tippin, Brooke, additional, Anderson, Darci, additional, Belimezova, Sonya, additional, Navanandan, Nidhya, additional, Watson, Tanya, additional, Olson, Michelle, additional, Caldwell, Wanda, additional, Horner, Caroline, additional, Kertz, Lila, additional, Norris, Tina, additional, Rivera-Spoljaric, Katherine, additional, Coverstone, Andrea, additional, McDowell, Molly, additional, Laughlin, Sarah, additional, Laury, Gina, additional, Donato, Rosanne, additional, Beckett-Firmage, Elizabeth, additional, Cornidez, Elia A., additional, Lopez, Silvia, additional, Simon, Michele, additional, Skeps, Raymond, additional, Vasquez, Monica, additional, Gage, Rob, additional, Shearer, Heather, additional, Pecak, Melissa, additional, Winters, Sandi, additional, Rukasin, Christine, additional, McNally, Bernadette, additional, Johnson, Darcy, additional, Vickery, Brian, additional, Grunwell, Jocelyn, additional, Nicholls, Morgan, additional, El-Hussein, Taqwa, additional, Patel, Shilpa, additional, Pillai, Dinsesh, additional, Makhija, Melanie, additional, Robison, Rachel, additional, Bosworth, Jennifer, additional, Catalano, Michelle, additional, Cassin, Kathleen, additional, DeLeon, Laura Bamaca, additional, Titus, Nicole, additional, Leibel, Sydney, additional, Aceves, Seema, additional, Mortazavi, Diba, additional, Loop, Lauren, additional, Anvari, Sara, additional, Anagnostou, Aikaterini, additional, Pitts, Kathy, additional, Sebutra, Sopar, additional, Tran, Daisy, additional, McMullen-Jackson, Chivon, additional, Jin, Jay, additional, Krupp, Nadia, additional, Ren, Clement, additional, Vitalpur, Girish, additional, Shively, Lori, additional, Campbell, Patrick, additional, Bendy, Lisa, additional, France, Lisa, additional, Jara, Sylvia, additional, Cichy, Sarah, additional, Engle, Linda, additional, Merchlinski, Aimee, additional, Payton, Melanie, additional, Ramsey, Pam, additional, Schmidt, James, additional, Tekely, Dan, additional, Updegrave, Angela, additional, Weber, Rachel, additional, Zimmerman, Ronald, additional, Metwali, Nervana, additional, Jing, Xuefang, additional, Walker, Melissa, additional, Sigelman, Steven S., additional, Li, Ling, additional, and Hamrah, Sanaz, additional

Published
2021
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10. Intralesional Corticosteroids as Adjunctive Therapy for Refractory Cutaneous Lesions in Chronic Granulomatous Disease

Author

Joseph, Michelle, primary, Chew, Wai-Tim, additional, Seeborg, Filiz, additional, Satter, Lisa Forbes, additional, Anvari, Sara, additional, Chinn, Ivan K., additional, Davis, Carla M., additional, Gupta, Meera R., additional, Nicholas, Sarah, additional, Noroski, Lenora M., additional, James, Mansi, additional, Deniskin, Roman, additional, Diaz, Veronica C., additional, Lowe, Juliette, additional, Lee, Grace L., additional, Craddock, Megan F., additional, Chan, Audrey J., additional, and Rider, Nicholas L., additional

Published
2020
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13. Grand rounds review: Managing Atopic Dermatitis in Patients with Skin of Color

Author

Davis, Carla, Flohr, Carsten, Gupta, Meera R., and Koplin, Jennifer J

Abstract

Managing atopic dermatitis (AD) in patients with skin of color presents unique challenges for the clinician. There is increasing evidence that atopic dermatitis has higher prevalence, persistence, and severity among skin of color populations. This is likely to be partly related to differences in living conditions and exposure to irritants and allergens, among other factors. Assessment of AD severity in patients with darker skin can be challenging, in particular the assessment of erythema, leading to the potential for underscoring AD severity. Variations in disease have also been described, with the potential for a greater risk of inflammation-induced nodularity and hyper- or hypopigmentation. Management challenges include variable adherence to treatment, potential disparities in access to healthcare, and differences in the metabolism of cyclosporine. Optimal management of atopic dermatitis in patients with skin of color requires a tailored approach. Here we review approaches to diagnosing AD, evaluating extent and severity with subjective and objective measures, treatment options for patients with skin of color, and highlight areas for improvement in AD care for skin of color populations.

Published
2023
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20. Paramyxovirus Infection Regulates T Cell Responses by BDCA-1+ and BDCA-3+ Myeloid Dendritic Cells.

Author

Gupta, Meera R., Kolli, Deepthi, Molteni, Claudio, Casola, Antonella, and Garofalo, Roberto P.

Subjects
*PARAMYXOVIRUSES, *T cell differentiation, *THROMBOMODULIN, *DENDRITIC cells, *RESPIRATORY syncytial virus infections, *ANTIVIRAL agents, *IMMUNE response
Abstract

Respiratory syncytial virus (RSV) and human Metapneumovirus (hMPV), viruses belonging to the family Paramyxoviridae, are the most important causes of lower respiratory tract infection in young children. Infections with RSV and hMPV are clinically indistinguishable, and both RSV and hMPV infection have been associated with aberrant adaptive immune responses. Myeloid Dendritic cells (mDCs) play a pivotal role in shaping adaptive immune responses during infection; however, few studies have examined how interactions of RSV and hMPV with individual mDC subsets (BDCA-1+ and BDCA-3+ mDCs) affect the outcome of anti-viral responses. To determine whether RSV and hMPV induce virus-specific responses from each subset, we examined co-stimulatory molecules and cytokines expressed by BDCA-1+ and BDCA-3+ mDCs isolated from peripheral blood after infection with hMPV and RSV, and examined their ability to stimulate T cell proliferation and differentiation. Our data show that RSV and hMPV induce virus-specific and subset-specific patterns of co-stimulatory molecule and cytokine expression. RSV, but not hMPV, impaired the capacity of infected mDCs to stimulate T cell proliferation. Whereas hMPV-infected BDCA-1+ and BDCA-3+ mDCs induced expansion of Th17 cells, in response to RSV, BDCA-1+ mDCs induced expansion of Th1 cells and BDCA-3+ mDCs induced expansion of Th2 cells and Tregs. These results demonstrate a virus-specific and subset-specific effect of RSV and hMPV infection on mDC function, suggesting that these viruses may induce different adaptive immune responses. [ABSTRACT FROM AUTHOR]

Published
2014
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21. Differential response of BDCA-1+ and BDCA-3+ myeloid dendritic cells to respiratory syncytial virus infection.

Author

Gupta, Meera R., Kolli, Deepthi, and Garofalo, Roberto P.

Subjects
*RESPIRATORY syncytial virus infections, *DENDRITIC cells, *IMMUNE response, *CHEMOKINES, *CELL proliferation
Abstract

Background: Respiratory syncytial virus (RSV) is the leading cause of respiratory infections in children, elderly, and immunocompromised individuals. Severe infection is associated with short- and long-term morbidity including pneumonia, recurrent wheezing, and abnormal pulmonary function, and several lines of evidence indicate that impaired adaptive immune responses during infection are critical in the pathophysiology of RSV-mediated disease. Myeloid Dendritic cells (mDCs) play a pivotal role in shaping antiviral immune responses in the respiratory tract; however, few studies have examined the interactions between RSV and individual mDC subsets. In this study, we examined the effect of RSV on the functional response of primary mDC subsets (BDCA-1+ and BDCA-3+) isolated from peripheral blood. Methods: BDCA-1+ and BDCA-3+ mDCs were isolated from the peripheral blood of healthy adults using FACS sorting. Donor-matched BDCA-1+ and BDCA-3+ mDCs were infected with RSV at a multiplicity of infection (MOI) of 5 for 40 hours. After infection, cells were analyzed for the expression of costimulatory molecules (CD86, CD80, and PD-L1), cytokine production, and the ability to stimulate allogenic CD4+ T cell proliferation. Results: Both BDCA-1+ and BDCA-3+ mDCs were susceptible to infection with RSV and demonstrated enhanced expression of CD86, and the inhibitory costimulatory molecules CD80 and PD-L1. Compared to BDCA-3+ mDCs, RSV-infected BDCA-1+ mDC produced a profile of cytokines and chemokines predominantly associated with pro-inflammatory responses (IL-1β, IL-6, IL-12, MIP-1α, and TNF-α), and both BDCA-1+ and BDCA-3+ mDCs were found to produce IL-10. Compared to uninfected mDCs, RSV-infected BDCA-1+ and BDCA-3+ mDCs demonstrated a reduced capacity to stimulate T cell proliferation. Conclusions: RSV infection induces a distinct pattern of costimulatory molecule expression and cytokine production by BDCA-1+ and BDCA-3+ mDCs, and impairs their ability to stimulate T cell proliferation. The differential expression of CD86 and pro-inflammatory cytokines by highly purified mDC subsets in response to RSV provides further evidence that BDCA-1` and BDCA-3+ mDCs have distinct roles in coordinating the host immune response during RSV infection. Findings of differential expression of PD-L1 and IL-10 by infected mDCs, suggests possible mechanisms by which RSV is able to impair adaptive immune responses. [ABSTRACT FROM AUTHOR]

Published
2013
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