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Metabolic syndrome (MS) is a condition, which constitutes a group of risk factors that occur together and increase the risk for Coronary Artery Disease, Stroke and type 2 diabetes mellitus. This disorder is found prevalent in the industrialized societies of the world in epidemic proportions. Periodontitis is an oral disease of microbial origin characterized by loss of attachment apparatus of tooth, resulting in edentulism if untreated. Periodontitis has been attributed to produce a low grade systemic inflammatory condition. The link of periodontitis to various systemic disorders has led to the evolution of a new branch termed as “periodontal medicine.” Studies reviewed in the present paper have indicated a positive link between the MS and periodontitis and it is suggested that subjects displaying several components of MS should be submitted to periodontal examination. Present studies have displayed coherent relation between the two entities. This review will address the vicious association between MS and periodontitis, depicting the commonality of pathophysiological pathway between the two entities. Systematic reviews, meta-analysis addressing the concerned subject were screened. Whether the systematic periodontal therapy in individuals exhibiting MS has the potential to reduce the incidence of various adverse systemic complications remains a logical proposition. Further, longitudinal and controlled trials with a large population would be imperative to depict the robustness in the association between MS and periodontal disease in human subjects. [ABSTRACT FROM AUTHOR]

The purpose of this study was to evaluate the effectiveness of platelet rich fibrin (PRF) in periodontal regeneration in generalized aggressive periodontitis (GAgP) patients. Two patients diagnosed with GAgP were selected for this study. Baseline clinical and radiographic examination was performed and patients were treated by surgical periodontal therapy along with PRF. Post-surgical re-evaluation was carried out at regular intervals to evaluate clinical and radiographic changes. Surgical periodontal therapy accompanying the placement of PRF in angular defects of GAgP patients showed decreased probing pocket depth, increased attachment level and radiographic bone fill when baseline and 9 month follow-up data was compared. Surgical reconstructive therapy with placement of PRF in angular defects of GAgP patients can be an effective approach to enhance the periodontal regeneration. [ABSTRACT FROM AUTHOR]

Dental plaque which is formed on the teeth in absence of oral hygiene is a structurally and functionally organized biofilm. Plaque forms in an ordered way and has a diverse microbial composition. The biofilm undergoes maturation, and the resulting pathogenic bacterial complex can lead to periodontitis periodontitis. Inflammation of soft tissues around the teeth (see tooth). Poor dental hygiene leads to deposition of bacterial plaque on the teeth below the gum line, irritating and eroding nearby tissues. Periodontitis is an asymptomatic oral infection, resulting in loss of teeth if untreated. cardiovascular Atherosclerosis occurs in response to injury of the vascular endothelium and the nature of the process is largely inflammatory. An important hypothesis in the faculty of cardiology has been that chronic infections may contribute to atherogenesis. Periodontitis, a chronic infection, acting as a source of systemic inflammation would trigger the atherosclerosis process. Methods: Data sources for the following review include PubMed indexed articles, periodontal journals, bibliographies and review articles. Results: Periodontitis has been associated with an increased risk of cardiovascular events. Treatment of periodontitis is accompanied by a proportional decrease in cardiac events. Clinical Significance: The aim of this review article is to provide oral health care professionals and cardiologists a better understanding of the link between atherosclerotic CVD and periodontitis. This can lead to a systematic approach in reducing the risk for primary and secondary atherosclerotic CVD events in patients with periodontitis. [ABSTRACT FROM AUTHOR]

The purpose of this study was to evaluate the effectiveness of platelet rich fibrin (PRF) in periodontal regeneration in generalized aggressive periodontitis (GAgP) patients. Two patients diagnosed with GAgP were selected for this study. Baseline clinical and radiographic examination was performed and patients were treated by surgical periodontal therapy along with PRF. Post-surgical re-evaluation was carried out at regular intervals to evaluate clinical and radiographic changes. Surgical periodontal therapy accompanying the placement of PRF in angular defects of GAgP patients showed decreased probing pocket depth, increased attachment level and radiographic bone fill when baseline and 9 month follow-up data was compared. Surgical reconstructive therapy with placement of PRF in angular defects of GAgP patients can be an effective approach to enhance the periodontal regeneration.

Advanced glycation end products (AGEs) are synthesized via the non enzymaticglycation and oxidation of proteins, lipids and nucleic acids. The production of AGEs is particularly enhanced in chronic hyperglycemia, as in diabetes mellitus (DM). The formation of irreversible AGEs affects the tissues by compromising the physiologic and mechanical functions, as a result of defective constitution of the extracellular matrix (ECM) components. Periodontitis is an inflammatory disease of microbial origin, resulting in devastation of the tooth supporting apparatus. This disease condition has severe implicationsin subjects with DM, since the tooth supporting tissuescontain ECM targeted by AGE. There is miniscule literature regarding the contribution of AGE to periodontal disease in patients with DM. The purpose of this review is to address the prejudicial role of AGEs in relation to various tissue components. This paper is an attempt to elucidatethe possible link of AGEs between periodontitis and DM. The exploration of novel therapeutic strategies to target AGEs for the treatment of periodontitis in DM subjects is certainly intriguing.