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228 results on '"Guru, Santosh Kumar"'

20. Formulation of inclusion complex of Abiraterone acetate with 2-Hydroxypropyl-Beta-Cyclodextrin: physiochemical characterization, molecular docking and bioavailability evaluation

Author

Tamizhmathy, M., Gupta, Ujala, Shettiwar, Arti, Kumar, Gogikar Shiva, Daravath, Sandeep, Aalhate, Mayur, Mahajan, Srushti, Maji, Indrani, Sriram, Anitha, Modak, Chandrima, Rajalakshmi, A.N., Dikundwar, Amol G., Doijad, Nandkumar, Guru, Santosh Kumar, and Singh, Pankaj Kumar

Published
2023
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23. Unveiling the healing properties of 2,3-dehydrosilychristin: a potential silymarin-derived flavonolignan from Vitex negundo

Author

Tripathi, Nancy, primary, Naik, Aliva, additional, Kumar, Dulla Naveen, additional, Bhardwaj, Nivedita, additional, Goel, Bharat, additional, Kumar, Sanjay, additional, Chakrabarty, Sanheeta, additional, Ranjan, Amit, additional, Guru, Santosh Kumar, additional, Kumar, Sanjeev, additional, Agrawal, Ashish, additional, and Jain, Shreyans K., additional

Published
2024
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25. Emerging In Vitro and In Vivo Models: Hope for the Better Understanding of Cancer Progression and Treatment.

Author

Yadav, Rachana, Mahajan, Srushti, Singh, Hoshiyar, Mehra, Neelesh Kumar, Madan, Jitender, Doijad, Nandkumar, Singh, Pankaj Kumar, and Guru, Santosh Kumar

Subjects
CANCER invasiveness, CANCER treatment, SEXUAL cycle, MEDICAL research, TUMOR growth
Abstract

Various cancer models have been developed to aid the understanding of the underlying mechanisms of tumor development and evaluate the effectiveness of various anticancer drugs in preclinical studies. These models accurately reproduce the critical stages of tumor initiation and development to mimic the tumor microenvironment better. Using these models for target validation, tumor response evaluation, resistance modeling, and toxicity comprehension can significantly enhance the drug development process. Herein, various in vivo or animal models are presented, typically consisting of several mice and in vitro models ranging in complexity from transwell models to spheroids and CRISPR‐Cas9 technologies. While in vitro models have been used for decades and dominate the early stages of drug development, they are still limited primary to simplistic tests based on testing on a single cell type cultivated in Petri dishes. Recent advancements in developing new cancer therapies necessitate the generation of complicated animal models that accurately mimic the tumor's complexity and microenvironment. Mice make effective tumor models as they are affordable, have a short reproductive cycle, exhibit rapid tumor growth, and are simple to manipulate genetically. Human cancer mouse models are crucial to understanding the neoplastic process and basic and clinical research improvements. The following review summarizes different in vitro and in vivo metastasis models, their advantages and disadvantages, and their ability to serve as a model for cancer research. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Isolation of a new cytotoxic colchinoid from Gloriosa superba roots.

Author

Goel, Bharat, Reddy, Harichander, Cholkar, Anjali, Kumar, Sanjeev, Guru, Santosh Kumar, and Jain, Shreyans K.

Subjects
CYTOTOXINS, CELL lines, CANCER cells
Abstract

A new colchinoid compound, identified as N-deacetyl-N-formylcornigerine (1), named glorigerine was isolated from the roots of Gloriosa superba, along with two known compounds. The structures of isolated compounds were elucidated by 1 D and 2 D NMR and HRMS experiments. Glorigerine (1) differed from cornigerine (6) by the presence of an N-formyl group instead of the N-acetyl group. Glorigerine (1) was found to have moderate cytotoxicity when tested against four human cancer cell lines. [ABSTRACT FROM AUTHOR]

Published
2023
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36. Data from Secalonic Acid-D Represses HIF1α/VEGF-Mediated Angiogenesis by Regulating the Akt/mTOR/p70S6K Signaling Cascade

Author

Guru, Santosh Kumar, primary, Pathania, Anup Singh, primary, Kumar, Suresh, primary, Ramesh, Deshidi, primary, Kumar, Manjeet, primary, Rana, Satiander, primary, Kumar, Ajay, primary, Malik, Fayaz, primary, Sharma, P.R., primary, Chandan, B.K., primary, Jaglan, Sundeep, primary, Sharma, J.P., primary, Shah, Bhahwal Ali, primary, Tasduq, Sheikh Abdullah, primary, Lattoo, Surrinder K., primary, Faruk, Abdul, primary, Saxena, A.K., primary, Vishwakarma, R.A., primary, and Bhushan, Shashi, primary

Published
2023
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37. Supplementary Figure 2 from Secalonic Acid-D Represses HIF1α/VEGF-Mediated Angiogenesis by Regulating the Akt/mTOR/p70S6K Signaling Cascade

Author

Guru, Santosh Kumar, primary, Pathania, Anup Singh, primary, Kumar, Suresh, primary, Ramesh, Deshidi, primary, Kumar, Manjeet, primary, Rana, Satiander, primary, Kumar, Ajay, primary, Malik, Fayaz, primary, Sharma, P.R., primary, Chandan, B.K., primary, Jaglan, Sundeep, primary, Sharma, J.P., primary, Shah, Bhahwal Ali, primary, Tasduq, Sheikh Abdullah, primary, Lattoo, Surrinder K., primary, Faruk, Abdul, primary, Saxena, A.K., primary, Vishwakarma, R.A., primary, and Bhushan, Shashi, primary

Published
2023
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38. Supplementary Figure 1 from Secalonic Acid-D Represses HIF1α/VEGF-Mediated Angiogenesis by Regulating the Akt/mTOR/p70S6K Signaling Cascade

Author

Guru, Santosh Kumar, primary, Pathania, Anup Singh, primary, Kumar, Suresh, primary, Ramesh, Deshidi, primary, Kumar, Manjeet, primary, Rana, Satiander, primary, Kumar, Ajay, primary, Malik, Fayaz, primary, Sharma, P.R., primary, Chandan, B.K., primary, Jaglan, Sundeep, primary, Sharma, J.P., primary, Shah, Bhahwal Ali, primary, Tasduq, Sheikh Abdullah, primary, Lattoo, Surrinder K., primary, Faruk, Abdul, primary, Saxena, A.K., primary, Vishwakarma, R.A., primary, and Bhushan, Shashi, primary

Published
2023
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39. Supplementary Material 1 from Secalonic Acid-D Represses HIF1α/VEGF-Mediated Angiogenesis by Regulating the Akt/mTOR/p70S6K Signaling Cascade

Author

Guru, Santosh Kumar, primary, Pathania, Anup Singh, primary, Kumar, Suresh, primary, Ramesh, Deshidi, primary, Kumar, Manjeet, primary, Rana, Satiander, primary, Kumar, Ajay, primary, Malik, Fayaz, primary, Sharma, P.R., primary, Chandan, B.K., primary, Jaglan, Sundeep, primary, Sharma, J.P., primary, Shah, Bhahwal Ali, primary, Tasduq, Sheikh Abdullah, primary, Lattoo, Surrinder K., primary, Faruk, Abdul, primary, Saxena, A.K., primary, Vishwakarma, R.A., primary, and Bhushan, Shashi, primary

Published
2023
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40. Supplementary Material 2 from Secalonic Acid-D Represses HIF1α/VEGF-Mediated Angiogenesis by Regulating the Akt/mTOR/p70S6K Signaling Cascade

Author

Guru, Santosh Kumar, primary, Pathania, Anup Singh, primary, Kumar, Suresh, primary, Ramesh, Deshidi, primary, Kumar, Manjeet, primary, Rana, Satiander, primary, Kumar, Ajay, primary, Malik, Fayaz, primary, Sharma, P.R., primary, Chandan, B.K., primary, Jaglan, Sundeep, primary, Sharma, J.P., primary, Shah, Bhahwal Ali, primary, Tasduq, Sheikh Abdullah, primary, Lattoo, Surrinder K., primary, Faruk, Abdul, primary, Saxena, A.K., primary, Vishwakarma, R.A., primary, and Bhushan, Shashi, primary

Published
2023
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