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17 results on '"Guruceaga, Elisabeth"'

1. The bone marrow niche regulates redox and energy balance in MLL::AF9 leukemia stem cells

Author

Viñado, Ana C., Calvo, Isabel A., Cenzano, Itziar, Olaverri, Danel, Cocera, Miguel, San Martin-Uriz, Patxi, Romero, Juan P., Vilas-Zornoza, Amaia, Vera, Laura, Gomez-Cebrian, Nuria, Puchades-Carrasco, Leonor, Lisi-Vega, Livia E., Apaolaza, Iñigo, Valera, Pablo, Guruceaga, Elisabeth, Granero-Molto, Froilan, Ripalda-Cemborain, Purificacion, Luck, Tamara J., Bullinger, Lars, Planes, Francisco J., Rifon, José J., Méndez-Ferrer, Simón, Yusuf, Rushdia Z., Pardo-Saganta, Ana, Prosper, Felipe, and Saez, Borja

Published
2022
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2. Characterization of complete lncRNAs transcriptome reveals the functional and clinical impact of lncRNAs in multiple myeloma

Author

Carrasco-Leon, Arantxa, Ezponda, Teresa, Meydan, Cem, Valcárcel, Luis V., Ordoñez, Raquel, Kulis, Marta, Garate, Leire, Miranda, Estíbaliz, Segura, Victor, Guruceaga, Elisabeth, Vilas-Zornoza, Amaia, Alignani, Diego, Pascual, Marién, Amundarain, Ane, Castro-Labrador, Laura, Martín-Uriz, Patxi San, El-Omri, Halima, Taha, Ruba Y., Calasanz, Maria J., Planes, Francisco J., Paiva, Bruno, Mason, Christopher E., San Miguel, Jesús F., Martin-Subero, José I., Melnick, Ari, Prosper, Felipe, and Agirre, Xabier

Published
2021
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3. Supplementary Figure 3 from Inhibitor of Differentiation-1 Sustains Mutant KRAS-Driven Progression, Maintenance, and Metastasis of Lung Adenocarcinoma via Regulation of a FOSL1 Network

Author

Román, Marta, primary, López, Inés, primary, Guruceaga, Elisabeth, primary, Baraibar, Iosune, primary, Ecay, Margarita, primary, Collantes, María, primary, Nadal, Ernest, primary, Vallejo, Adrián, primary, Cadenas, Silvia, primary, Miguel, Marta Echavarri-de, primary, Jang, Jae Hwi, primary, Martin-Uriz, Patxi San, primary, Castro-Labrador, Laura, primary, Vilas-Zornoza, Amaia, primary, Lara-Astiaso, David, primary, Ponz-Sarvise, Mariano, primary, Rolfo, Christian, primary, Santos, Edgardo S., primary, Raez, Luis E., primary, Taverna, Simona, primary, Behrens, Carmen, primary, Weder, Walter, primary, Wistuba, Ignacio I., primary, Vicent, Silvestre, primary, and Gil-Bazo, Ignacio, primary

Published
2023
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4. Supplementary Figure 1 from Inhibitor of Differentiation-1 Sustains Mutant KRAS-Driven Progression, Maintenance, and Metastasis of Lung Adenocarcinoma via Regulation of a FOSL1 Network

Author

Román, Marta, primary, López, Inés, primary, Guruceaga, Elisabeth, primary, Baraibar, Iosune, primary, Ecay, Margarita, primary, Collantes, María, primary, Nadal, Ernest, primary, Vallejo, Adrián, primary, Cadenas, Silvia, primary, Miguel, Marta Echavarri-de, primary, Jang, Jae Hwi, primary, Martin-Uriz, Patxi San, primary, Castro-Labrador, Laura, primary, Vilas-Zornoza, Amaia, primary, Lara-Astiaso, David, primary, Ponz-Sarvise, Mariano, primary, Rolfo, Christian, primary, Santos, Edgardo S., primary, Raez, Luis E., primary, Taverna, Simona, primary, Behrens, Carmen, primary, Weder, Walter, primary, Wistuba, Ignacio I., primary, Vicent, Silvestre, primary, and Gil-Bazo, Ignacio, primary

Published
2023
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5. Supplementary Figure 2 from Inhibitor of Differentiation-1 Sustains Mutant KRAS-Driven Progression, Maintenance, and Metastasis of Lung Adenocarcinoma via Regulation of a FOSL1 Network

Author

Román, Marta, primary, López, Inés, primary, Guruceaga, Elisabeth, primary, Baraibar, Iosune, primary, Ecay, Margarita, primary, Collantes, María, primary, Nadal, Ernest, primary, Vallejo, Adrián, primary, Cadenas, Silvia, primary, Miguel, Marta Echavarri-de, primary, Jang, Jae Hwi, primary, Martin-Uriz, Patxi San, primary, Castro-Labrador, Laura, primary, Vilas-Zornoza, Amaia, primary, Lara-Astiaso, David, primary, Ponz-Sarvise, Mariano, primary, Rolfo, Christian, primary, Santos, Edgardo S., primary, Raez, Luis E., primary, Taverna, Simona, primary, Behrens, Carmen, primary, Weder, Walter, primary, Wistuba, Ignacio I., primary, Vicent, Silvestre, primary, and Gil-Bazo, Ignacio, primary

Published
2023
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6. Supplementary Figure 4 from Inhibitor of Differentiation-1 Sustains Mutant KRAS-Driven Progression, Maintenance, and Metastasis of Lung Adenocarcinoma via Regulation of a FOSL1 Network

Author

Román, Marta, primary, López, Inés, primary, Guruceaga, Elisabeth, primary, Baraibar, Iosune, primary, Ecay, Margarita, primary, Collantes, María, primary, Nadal, Ernest, primary, Vallejo, Adrián, primary, Cadenas, Silvia, primary, Miguel, Marta Echavarri-de, primary, Jang, Jae Hwi, primary, Martin-Uriz, Patxi San, primary, Castro-Labrador, Laura, primary, Vilas-Zornoza, Amaia, primary, Lara-Astiaso, David, primary, Ponz-Sarvise, Mariano, primary, Rolfo, Christian, primary, Santos, Edgardo S., primary, Raez, Luis E., primary, Taverna, Simona, primary, Behrens, Carmen, primary, Weder, Walter, primary, Wistuba, Ignacio I., primary, Vicent, Silvestre, primary, and Gil-Bazo, Ignacio, primary

Published
2023
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7. Data from Inhibitor of Differentiation-1 Sustains Mutant KRAS-Driven Progression, Maintenance, and Metastasis of Lung Adenocarcinoma via Regulation of a FOSL1 Network

Author

Román, Marta, primary, López, Inés, primary, Guruceaga, Elisabeth, primary, Baraibar, Iosune, primary, Ecay, Margarita, primary, Collantes, María, primary, Nadal, Ernest, primary, Vallejo, Adrián, primary, Cadenas, Silvia, primary, Miguel, Marta Echavarri-de, primary, Jang, Jae Hwi, primary, Martin-Uriz, Patxi San, primary, Castro-Labrador, Laura, primary, Vilas-Zornoza, Amaia, primary, Lara-Astiaso, David, primary, Ponz-Sarvise, Mariano, primary, Rolfo, Christian, primary, Santos, Edgardo S., primary, Raez, Luis E., primary, Taverna, Simona, primary, Behrens, Carmen, primary, Weder, Walter, primary, Wistuba, Ignacio I., primary, Vicent, Silvestre, primary, and Gil-Bazo, Ignacio, primary

Published
2023
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8. Supplementary Information from Inhibitor of Differentiation-1 Sustains Mutant KRAS-Driven Progression, Maintenance, and Metastasis of Lung Adenocarcinoma via Regulation of a FOSL1 Network

Author

Román, Marta, primary, López, Inés, primary, Guruceaga, Elisabeth, primary, Baraibar, Iosune, primary, Ecay, Margarita, primary, Collantes, María, primary, Nadal, Ernest, primary, Vallejo, Adrián, primary, Cadenas, Silvia, primary, Miguel, Marta Echavarri-de, primary, Jang, Jae Hwi, primary, Martin-Uriz, Patxi San, primary, Castro-Labrador, Laura, primary, Vilas-Zornoza, Amaia, primary, Lara-Astiaso, David, primary, Ponz-Sarvise, Mariano, primary, Rolfo, Christian, primary, Santos, Edgardo S., primary, Raez, Luis E., primary, Taverna, Simona, primary, Behrens, Carmen, primary, Weder, Walter, primary, Wistuba, Ignacio I., primary, Vicent, Silvestre, primary, and Gil-Bazo, Ignacio, primary

Published
2023
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9. Exploiting 4-1BB immune checkpoint to enhance the efficacy of oncolytic virotherapy for diffuse intrinsic pontine gliomas

Author

Laspidea, Virginia, primary, Puigdelloses, Montserrat, additional, Labiano, Sara, additional, Marrodán, Lucía, additional, Garcia-Moure, Marc, additional, Zalacain, Marta, additional, Gonzalez-Huarriz, Marisol, additional, Martínez-Vélez, Naiara, additional, Ausejo-Mauleon, Iker, additional, de la Nava, Daniel, additional, Herrador-Cañete, Guillermo, additional, Marco-Sanz, Javier, additional, Guruceaga, Elisabeth, additional, de Andrea, Carlos E., additional, Villalba, María, additional, Becher, Oren, additional, Squatrito, Massimo, additional, Matía, Verónica, additional, Gállego Pérez-Larraya, Jaime, additional, Patiño-García, Ana, additional, Gupta, Sumit, additional, Gomez-Manzano, Candelaria, additional, Fueyo, Juan, additional, and Alonso, Marta M., additional

Published
2022
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10. Id1 and PD-1 Combined Blockade Impairs Tumor Growth and Survival of KRAS-mutant Lung Cancer by Stimulating PD-L1 Expression and Tumor Infiltrating CD8+ T Cells

Author

Baraibar, Iosune, primary, Roman, Marta, additional, Rodríguez-Remírez, María, additional, López, Inés, additional, Vilalta, Anna, additional, Guruceaga, Elisabeth, additional, Ecay, Margarita, additional, Collantes, María, additional, Lozano, Teresa, additional, Alignani, Diego, additional, Puyalto, Ander, additional, Oliver, Ana, additional, Ortiz-Espinosa, Sergio, additional, Moreno, Haritz, additional, Torregrosa, María, additional, Rolfo, Christian, additional, Caglevic, Christian, additional, García-Ros, David, additional, Villalba-Esparza, María, additional, De Andrea, Carlos, additional, Vicent, Silvestre, additional, Pío, Rubén, additional, Lasarte, Juan José, additional, Calvo, Alfonso, additional, Ajona, Daniel, additional, and Gil-Bazo, Ignacio, additional

Published
2020
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11. Role of lncRNAs as prognostic factor and potential therapeutic target in Multiple Myeloma

Author

Carrasco-Leon, Arantxa, primary, Ezponda, Teresa, additional, Meydan, Cem, additional, Valcárcel, Luis Vítores, additional, Ordoñez, Raquel, additional, Kulis, Marta, additional, Garate, Leire, additional, Miranda, Estíbaliz, additional, Segura, Víctor, additional, Guruceaga, Elisabeth, additional, Vilas-Zornoza, Amaia, additional, Alignani, Diego, additional, Castro-Labrador, Laura, additional, Pascual, Marién, additional, Amundarain, Ane, additional, El Omri, Halima, additional, Taba, Ruba Y., additional, Calasanz, Maria-Jose, additional, Planes, Francisco, additional, Paiva, Bruno, additional, Mason, Christopher E., additional, San-Miguel, Jesus, additional, Martín-Subero, José I., additional, Melnick, Ari, additional, Agirre, Xabier, additional, and Prosper, Felipe, additional

Published
2019
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12. Inhibitor of Differentiation-1 Sustains Mutant KRAS-Driven Progression, Maintenance, and Metastasis of Lung Adenocarcinoma via Regulation of a FOSL1 Network

Author

Román, Marta, primary, López, Inés, additional, Guruceaga, Elisabeth, additional, Baraibar, Iosune, additional, Ecay, Margarita, additional, Collantes, María, additional, Nadal, Ernest, additional, Vallejo, Adrián, additional, Cadenas, Silvia, additional, Miguel, Marta Echavarri-de, additional, Jang, Jae Hwi, additional, Martin-Uriz, Patxi San, additional, Castro-Labrador, Laura, additional, Vilas-Zornoza, Amaia, additional, Lara-Astiaso, David, additional, Ponz-Sarvise, Mariano, additional, Rolfo, Christian, additional, Santos, Edgardo S., additional, Raez, Luis E., additional, Taverna, Simona, additional, Behrens, Carmen, additional, Weder, Walter, additional, Wistuba, Ignacio I., additional, Vicent, Silvestre, additional, and Gil-Bazo, Ignacio, additional

Published
2019
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13. Epigenomic profiling of myelofibrosis reveals widespread DNA methylation changes in enhancer elements and ZFP36L1 as a potential tumor suppressor gene that is epigenetically regulated

Author

Martínez-Calle, Nicolás, primary, Pascual, Marien, additional, Ordoñez, Raquel, additional, Enériz, Edurne San José, additional, Kulis, Marta, additional, Miranda, Estíbaliz, additional, Guruceaga, Elisabeth, additional, Segura, Víctor, additional, Larráyoz, María José, additional, Bellosillo, Beatriz, additional, Calasanz, María José, additional, Besses, Carles, additional, Rifón, José, additional, Martín-Subero, José I., additional, Agirre, Xabier, additional, and Prosper, Felipe, additional

Published
2019
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15. Whole-epigenome analysis in multiple myeloma reveals DNA hypermethylation of B cell-specific enhancers

Author

Agirre, Xabier, primary, Castellano, Giancarlo, additional, Pascual, Marien, additional, Heath, Simon, additional, Kulis, Marta, additional, Segura, Victor, additional, Bergmann, Anke, additional, Esteve, Anna, additional, Merkel, Angelika, additional, Raineri, Emanuele, additional, Agueda, Lidia, additional, Blanc, Julie, additional, Richardson, David, additional, Clarke, Laura, additional, Datta, Avik, additional, Russiñol, Nuria, additional, Queirós, Ana C., additional, Beekman, Renée, additional, Rodríguez-Madoz, Juan R., additional, José-Enériz, Edurne San, additional, Fang, Fang, additional, Gutiérrez, Norma C., additional, García-Verdugo, José M., additional, Robson, Michael I., additional, Schirmer, Eric C., additional, Guruceaga, Elisabeth, additional, Martens, Joost H.A., additional, Gut, Marta, additional, Calasanz, Maria J., additional, Flicek, Paul, additional, Siebert, Reiner, additional, Campo, Elías, additional, Miguel, Jesús F. San, additional, Melnick, Ari, additional, Stunnenberg, Hendrik G., additional, Gut, Ivo G., additional, Prosper, Felipe, additional, and Martín-Subero, José I., additional

Published
2015
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16. Whole-Genome Epigenomic Analysis in Multiple Myeloma Reveals DNA Hypermethylation of B-Cell Specific Enhancers

Author

Agirre, Xabier, primary, Castellano, Giancarlo, additional, Pascual, Marien, additional, Health, Simon, additional, Kulis, Marta, additional, Segura, Victor, additional, Bergmann, Anke, additional, Esteve, Anna, additional, Merkel, Angelika, additional, Raineri, Emanuele, additional, Agueda, Lidia, additional, Blanc, Julie, additional, Richardson, David, additional, Clarke, Laura, additional, Russiñol, Nuria, additional, Queirós, Ana C., additional, Beekman, Renée, additional, Rodriguez-Madoz, Juan R., additional, San José-Enériz, Edurne, additional, Fang, Fang, additional, Gutierrez, Norma Carmen, additional, García-Verdugo, José M, additional, Robson, Michael I., additional, Schirmer, Eric C., additional, Guruceaga, Elisabeth, additional, Martens, Joost H.A., additional, Gut, Marta, additional, Calasanz, María José, additional, Flicek, Paul, additional, Siebert, Reiner, additional, Campo, Elias, additional, San Miguel, Jesus F., additional, Melnick, Ari M, additional, Stunnenberg, Hendrik G., additional, Gut, Ivo G., additional, Prosper, Felipe, additional, and Martín-Subero, Jose Ignacio, additional

Published
2014
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17. Id1 and PD-1 Combined Blockade Impairs Tumor Growth and Survival of KRAS -mutant Lung Cancer by Stimulating PD-L1 Expression and Tumor Infiltrating CD8 + T Cells.

Author

Baraibar, Iosune, Roman, Marta, Rodríguez-Remírez, María, López, Inés, Vilalta, Anna, Guruceaga, Elisabeth, Ecay, Margarita, Collantes, María, Lozano, Teresa, Alignani, Diego, Puyalto, Ander, Oliver, Ana, Ortiz-Espinosa, Sergio, Moreno, Haritz, Torregrosa, María, Rolfo, Christian, Caglevic, Christian, García-Ros, David, Villalba-Esparza, María, and De Andrea, Carlos

Subjects
ANIMAL experimentation, BIOLOGICAL models, CELL lines, FLOW cytometry, GENE expression, LUNG tumors, GENETIC mutation, T cells, IN vitro studies, PROGRAMMED cell death 1 receptors
Abstract

Simple Summary: Lung adenocarcinoma is the most frequent lung cancer subtype. Many of those adenocarcinomas of the lung are driven by the KRAS gene. Although immunotherapy has significantly improved the clinical outcomes of patients with lung adenocarcinomas, many patients do not benefit from that therapeutic strategy. Id1 is a protein involved in immunosuppression. Here we aimed to test whether a combined blockade of Id1 and PD-1 is able to improve outcomes of mice models with KRAS-driven lung adenocarcinoma. The use of PD-1/PD-L1 checkpoint inhibitors in advanced NSCLC is associated with longer survival. However, many patients do not benefit from PD-1/PD-L1 blockade, largely because of immunosuppression. New immunotherapy-based combinations are under investigation in an attempt to improve outcomes. Id1 (inhibitor of differentiation 1) is involved in immunosuppression. In this study, we explored the potential synergistic effect of the combination of Id1 inhibition and pharmacological PD-L1 blockade in three different syngeneic murine KRAS-mutant lung adenocarcinoma models. TCGA analysis demonstrated a negative and statistically significant correlation between PD-L1 and Id1 expression levels. This observation was confirmed in vitro in human and murine KRAS-driven lung cancer cell lines. In vivo experiments in KRAS-mutant syngeneic and metastatic murine lung adenocarcinoma models showed that the combined blockade targeting Id1 and PD-1 was more effective than each treatment alone in terms of tumor growth impairment and overall survival improvement. Mechanistically, multiplex quantification of CD3+/CD4+/CD8+ T cells and flow cytometry analysis showed that combined therapy favors tumor infiltration by CD8+ T cells, whilst in vivo CD8+ T cell depletion led to tumor growth restoration. Co-culture assays using CD8+ cells and tumor cells showed that T cells present a higher antitumor effect when tumor cells lack Id1 expression. These findings highlight that Id1 blockade may contribute to a significant immune enhancement of antitumor efficacy of PD-1 inhibitors by increasing PD-L1 expression and harnessing tumor infiltration of CD8+ T lymphocytes. [ABSTRACT FROM AUTHOR]

Published
2020
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