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2. Supplementary Figure S6. NK-cells redistribute towards tumors and draining lymph nodes after treatment with trastuzumab-coding oncolytic virus from Oncolytic Adenovirus Expressing Monoclonal Antibody Trastuzumab for Treatment of HER2-Positive Cancer

Author

Liikanen, Ilkka, primary, Tähtinen, Siri, primary, Guse, Kilian, primary, Gutmann, Theresia, primary, Savola, Paula, primary, Oksanen, Minna, primary, Kanerva, Anna, primary, and Hemminki, Akseli, primary

Published
2023
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5. Supplementary Figure S1. Trastuzumab-coding oncolytic adenovirus mediates cytotoxicity in several HER2-positive and negative cancer cell lines from Oncolytic Adenovirus Expressing Monoclonal Antibody Trastuzumab for Treatment of HER2-Positive Cancer

Author

Liikanen, Ilkka, primary, Tähtinen, Siri, primary, Guse, Kilian, primary, Gutmann, Theresia, primary, Savola, Paula, primary, Oksanen, Minna, primary, Kanerva, Anna, primary, and Hemminki, Akseli, primary

Published
2023
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8. Supplementary Figure S2. Oncolytic adenovirus coding for trastuzumab shows superior cell killing efficacy when dosed according to functional titers from Oncolytic Adenovirus Expressing Monoclonal Antibody Trastuzumab for Treatment of HER2-Positive Cancer

Author

Liikanen, Ilkka, primary, Tähtinen, Siri, primary, Guse, Kilian, primary, Gutmann, Theresia, primary, Savola, Paula, primary, Oksanen, Minna, primary, Kanerva, Anna, primary, and Hemminki, Akseli, primary

Published
2023
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9. Supplementary Figure S4. Oncolytic adenoviruses inhibit tumor growth, while trastuzumab transgene does not add to efficacy against HER2-negative breast cancer in vivo from Oncolytic Adenovirus Expressing Monoclonal Antibody Trastuzumab for Treatment of HER2-Positive Cancer

Author

Liikanen, Ilkka, primary, Tähtinen, Siri, primary, Guse, Kilian, primary, Gutmann, Theresia, primary, Savola, Paula, primary, Oksanen, Minna, primary, Kanerva, Anna, primary, and Hemminki, Akseli, primary

Published
2023
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10. Supplementary Data from Oncolytic Adenovirus ICOVIR-7 in Patients with Advanced and Refractory Solid Tumors

Author

Nokisalmi, Petri, primary, Pesonen, Sari, primary, Escutenaire, Sophie, primary, Särkioja, Merja, primary, Raki, Mari, primary, Cerullo, Vincenzo, primary, Laasonen, Leena, primary, Alemany, Ramon, primary, Rojas, Juan, primary, Cascallo, Manel, primary, Guse, Kilian, primary, Rajecki, Maria, primary, Kangasniemi, Lotta, primary, Haavisto, Elina, primary, Karioja-Kallio, Aila, primary, Hannuksela, Päivi, primary, Oksanen, Minna, primary, Kanerva, Anna, primary, Joensuu, Timo, primary, Ahtiainen, Laura, primary, and Hemminki, Akseli, primary

Published
2023
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11. Supplementary Data from Targeted Chemotherapy for Head and Neck Cancer with a Chimeric Oncolytic Adenovirus Coding for Bifunctional Suicide Protein FCU1

Author

Dias, João D., primary, Liikanen, Ilkka, primary, Guse, Kilian, primary, Foloppe, Johann, primary, Sloniecka, Marta, primary, Diaconu, Iulia, primary, Rantanen, Ville, primary, Eriksson, Minna, primary, Hakkarainen, Tanja, primary, Lusky, Monika, primary, Erbs, Philippe, primary, Escutenaire, Sophie, primary, Kanerva, Anna, primary, Pesonen, Sari, primary, Cerullo, Vincenzo, primary, and Hemminki, Akseli, primary

Published
2023
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12. Data from Oncolytic Adenovirus Coding for Granulocyte Macrophage Colony-Stimulating Factor Induces Antitumoral Immunity in Cancer Patients

Author

Cerullo, Vincenzo, primary, Pesonen, Sari, primary, Diaconu, Iulia, primary, Escutenaire, Sophie, primary, Arstila, Petteri T., primary, Ugolini, Matteo, primary, Nokisalmi, Petri, primary, Raki, Mari, primary, Laasonen, Leena, primary, Särkioja, Merja, primary, Rajecki, Maria, primary, Kangasniemi, Lotta, primary, Guse, Kilian, primary, Helminen, Andreas, primary, Ahtiainen, Laura, primary, Ristimäki, Ari, primary, Räisänen-Sokolowski, Anne, primary, Haavisto, Elina, primary, Oksanen, Minna, primary, Karli, Eerika, primary, Karioja-Kallio, Aila, primary, Holm, Sirkka-Liisa, primary, Kouri, Mauri, primary, Joensuu, Timo, primary, Kanerva, Anna, primary, and Hemminki, Akseli, primary

Published
2023
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13. Supplementary Figures 1-6, Tables 1-3 from Oncolytic Adenovirus Coding for Granulocyte Macrophage Colony-Stimulating Factor Induces Antitumoral Immunity in Cancer Patients

Author

Cerullo, Vincenzo, primary, Pesonen, Sari, primary, Diaconu, Iulia, primary, Escutenaire, Sophie, primary, Arstila, Petteri T., primary, Ugolini, Matteo, primary, Nokisalmi, Petri, primary, Raki, Mari, primary, Laasonen, Leena, primary, Särkioja, Merja, primary, Rajecki, Maria, primary, Kangasniemi, Lotta, primary, Guse, Kilian, primary, Helminen, Andreas, primary, Ahtiainen, Laura, primary, Ristimäki, Ari, primary, Räisänen-Sokolowski, Anne, primary, Haavisto, Elina, primary, Oksanen, Minna, primary, Karli, Eerika, primary, Karioja-Kallio, Aila, primary, Holm, Sirkka-Liisa, primary, Kouri, Mauri, primary, Joensuu, Timo, primary, Kanerva, Anna, primary, and Hemminki, Akseli, primary

Published
2023
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15. List of Contributors

Author

Ackert-Bicknell, Cheryl, primary, Agarwal, Sunita K., additional, Albagha, Omar M.E., additional, Allen, Robyn S., additional, Arnold, Andrew, additional, Bassett, J.H. Duncan, additional, Bateman, John F., additional, Bellido, Teresita, additional, Bonewald, Lynda, additional, Boudin, Eveline, additional, Bouxsein, Mary L., additional, Boyce, Brendan F., additional, Brewer, Niambi S., additional, Brewster, Stephanie J., additional, Briggs, Mike, additional, Brown, Edward M., additional, Brown, Matthew A., additional, Bushinsky, David A., additional, Cabral, Wayne A., additional, Collins, Michael T., additional, Convente, Michael R., additional, Costa-Guda, Jessica, additional, Deng, Hong-Wen, additional, Devuyst, Olivier, additional, Drezner, Marc K., additional, Duncan, Emma L., additional, Egbuna, Ogo I., additional, Eisman, John A., additional, Farber, Charles R., additional, Feldman, David, additional, Ferreira, Carlos R., additional, Gahl, William A., additional, Gorvin, Caroline M., additional, Grol, Matthew W., additional, Guo, Yan, additional, Guse, Kilian, additional, Hannan, Fadil M., additional, Hao, Ruo-Han, additional, Holm, Ingrid A., additional, Igarashi, Takashi, additional, Jacobsen, Christina, additional, Johannesdottir, Fjola, additional, Jüppner, Harald, additional, Kaplan, Frederick S., additional, Karsenty, Gerard, additional, Kovacs, Christopher S., additional, Kuiper, John J., additional, Lee, Brendan H., additional, Loots, Gabriela G., additional, Lories, Rik J., additional, Luyten, Frank P., additional, Malloy, Peter J., additional, Mannstadt, Michael, additional, Marini, Joan C., additional, John Martin, T., additional, Miller, Walter L., additional, Moe, Orson W., additional, Newey, Paul J., additional, Nguyen, Tuan V., additional, Okamoto, Kazuo, additional, Pajevic, Paola D., additional, Papasian, Christopher J., additional, Piret, Siân E., additional, Ralston, Stuart H., additional, Rivadeneira, Fernando, additional, Robey, Pamela G., additional, Rosen, Clifford J., additional, Ruan, Merry Z.C., additional, Scheinman, Steven J., additional, Schurman, Scott J., additional, Sebastian, Aimy, additional, Shen, Yiping, additional, Shore, Eileen M., additional, Silve, Caroline, additional, Sims, Natalie A., additional, Stanley, Alexandra K., additional, Stone, Adrianne, additional, Takayanagi, Hiroshi, additional, Thakker, Rajesh V., additional, Towler, O. Will, additional, Uitterlinden, André G., additional, Valdes, Ana M., additional, van der Eerden, Bram C.J., additional, Van Hul, Wim, additional, Wei, Jianwen, additional, Wein, Marc N., additional, Weinstein, Lee S., additional, Whyte, Michael P., additional, Williams, Graham R., additional, Xing, Lianping, additional, Yang, Tie-Lin, additional, Zankl, Andreas, additional, Ziegler, Shira G., additional, and Zuscik, Michael J., additional

Published
2018
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17. Nitric-Oxide Supplementation for Treatment of Long-Term Complications in Argininosuccinic Aciduria

Author

Nagamani, Sandesh C.S., Campeau, Philippe M., Shchelochkov, Oleg A., Premkumar, Muralidhar H., Guse, Kilian, Brunetti-Pierri, Nicola, Chen, Yuqing, Sun, Qin, Tang, Yaoping, Palmer, Donna, Reddy, Anilkumar K., Li, Li, Slesnick, Timothy C., Feig, Daniel I., Caudle, Susan, Harrison, David, Salviati, Leonardo, Marini, Juan C., Bryan, Nathan S., Erez, Ayelet, and Lee, Brendan

Published
2012
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18. Treatment of Cancer Patients With a Serotype 5/3 Chimeric Oncolytic Adenovirus Expressing GMCSF

Author

Koski, Anniina, Kangasniemi, Lotta, Escutenaire, Sophie, Pesonen, Sari, Cerullo, Vincenzo, Diaconu, Iulia, Nokisalmi, Petri, Raki, Mari, Rajecki, Maria, Guse, Kilian, Ranki, Tuuli, Oksanen, Minna, Holm, Sirkka-Liisa, Haavisto, Elina, Karioja-Kallio, Aila, Laasonen, Leena, Partanen, Kaarina, Ugolini, Matteo, Helminen, Andreas, Karli, Eerika, Hannuksela, Päivi, Pesonen, Saila, Joensuu, Timo, Kanerva, Anna, and Hemminki, Akseli

Published
2010
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23. List of Contributors

Author

Albagha, Omar M.E., primary, Arnold, Andrew, additional, Baldock, Paul, additional, Bouxsein, Mary L., additional, Boyce, Brendan F., additional, Brewster, Stephanie Jo, additional, Brown, Edward M., additional, Brown, Matthew A., additional, Bushinsky, David A., additional, Chakkalakal, Salin A., additional, Clifton-Bligh, Roderick, additional, Cole, William G., additional, Collins, Michael T., additional, Convente, Michael R., additional, Costa-Guda, Jessica, additional, Culbert, Andria L., additional, Deng, Hong-Wen, additional, Devuyst, Olivier, additional, Drezner, Marc K., additional, Duncan, Emma L., additional, Egbuna, Ogo I., additional, Eisman, John A., additional, Feldman, David, additional, Ferron, Mathieu, additional, Gild, Matti, additional, Guo, Yan, additional, Guse, Kilian, additional, Holm, Ingrid A., additional, Hudson, Bryan, additional, Igarashi, Takashi, additional, Jacobsen, Christina, additional, Jüppner, Harald, additional, Kaplan, Frederick S., additional, Karsenty, Gerard, additional, Kovacs, Christopher S., additional, Lee, Brendan, additional, Loots, Gabriela G., additional, Lories, Rik J., additional, Lounev, Vitali Y., additional, Luyten, Frank P., additional, Malloy, Peter J., additional, Marini, Joan C., additional, John Martin, T., additional, Miller, Walter L., additional, Moe, Orson W., additional, Nguyen, Tuan V., additional, Oury, Franck, additional, Papasian, Christopher J., additional, Patel, Dhruval, additional, Perdu, Bram, additional, Piret, Siân E., additional, Helen Rajpar, M., additional, Ralston, Stuart H, additional, Rivadeneira, Fernando, additional, Robinson, Bruce G, additional, Ruan, Merry ZC, additional, Scheinman, Steven J., additional, Schurman, Scott J., additional, Shen, Yiping, additional, Shore, Eileen M., additional, Silve, Caroline, additional, Sims, Natalie A., additional, Singh, Anil, additional, Spiegel, Allen M., additional, Thakker, Rajesh V., additional, Uitterlinden, André G., additional, Valdes, Ana M., additional, Van Hul, Wim, additional, Weinstein, Lee S., additional, Whyte, Michael P., additional, Xing, Lianping, additional, Yang, Tie-Lin, additional, and Zuscik, Michael J., additional

Published
2013
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25. Integrin targeted oncolytic adenoviruses Ad5-D24-RGD and Ad5-RGD-D24-GMCSF for treatment of patients with advanced chemotherapy refractory solid tumors

Author

Pesonen, Sari, Diaconu, Iulia, Cerullo, Vincenzo, Escutenaire, Sophie, Raki, Mari, Kangasniemi, Lotta, Nokisalmi, Petri, Dotti, Gianpietro, Guse, Kilian, Laasonen, Leena, Partanen, Kaarina, Karli, Eerika, Haavisto, Elina, Oksanen, Minna, Karioja-Kallio, Aila, Hannuksela, Päivi, Holm, Sirkka-Liisa, Kauppinen, Satu, Joensuu, Timo, Kanerva, Anna, and Hemminki, Akseli

Published
2012
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26. Mitochondrial myopathy induces a starvation-like response

Author

Tyynismaa, Henna, Carroll, Christopher J., Raimundo, Nuno, Ahola-Erkkilä, Sofia, Wenz, Tina, Ruhanen, Heini, Guse, Kilian, Hemminki, Akseli, Peltola-Mjøsund, Katja E., Tulkki, Valtteri, Orešič, Matej, Moraes, Carlos T., Pietiläinen, Kirsi, Hovatta, Iiris, and Suomalainen, Anu

Published
2010
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27. Mre11 inhibition by oncolytic adenovirus associates with autophagy and underlies synergy with ionizing radiation

Author

Rajecki, Maria, Hällström, Taija af, Hakkarainen, Tanja, Nokisalmi, Petri, Hautaniemi, Sampsa, Nieminen, Anni I., Tenhunen, Mikko, Rantanen, Ville, Desmond, Reneé A., Chen, Dung-Tsa, Guse, Kilian, Stenman, Ulf-Håkan, Gargini, Ricardo, Kapanen, Mika, Klefström, Juha, Kanerva, Anna, Pesonen, Sari, Ahtiainen, Laura, and Hemminki, Akseli

Published
2009
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29. Disease-Modifying Osteoarthritis Treatment With Interleukin-1 Receptor Antagonist Gene Therapy in Small and Large Animal Models

Author

Nixon, Alan J., primary, Grol, Matthew W., additional, Lang, Hayley M., additional, Ruan, Merry Z. C., additional, Stone, Adrianne, additional, Begum, Laila, additional, Chen, Yuqing, additional, Dawson, Brian, additional, Gannon, Francis, additional, Plutizki, Stanislav, additional, Lee, Brendan H. L., additional, and Guse, Kilian, additional

Published
2018
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32. Incomplete but Infectious Vaccinia Virions Are Produced in the Absence of Oncolysis in Feline SCCF1 Cells

Author

University of Helsinki, Haartman Institute, University of Helsinki, Department of Equine and Small Animal Medicine, University of Helsinki, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Research Programs Unit, University of Helsinki, Faculty of Pharmacy, University of Helsinki, Medicum, Parviainen, Suvi, Autio, Karoliina, Vähä-Koskela, Markus, Guse, Kilian, Pesonen, Sari, Rosol, Thomas J., Zhao, Fang, Hemminki, Akseli, University of Helsinki, Haartman Institute, University of Helsinki, Department of Equine and Small Animal Medicine, University of Helsinki, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Research Programs Unit, University of Helsinki, Faculty of Pharmacy, University of Helsinki, Medicum, Parviainen, Suvi, Autio, Karoliina, Vähä-Koskela, Markus, Guse, Kilian, Pesonen, Sari, Rosol, Thomas J., Zhao, Fang, and Hemminki, Akseli

Abstract

Vaccinia virus is a large, enveloped virus of the poxvirus family. It has broad tropism and typically virus replication culminates in accumulation and lytic release of intracellular mature virus (IMV), the most abundant form of infectious virus, as well as release by budding of extracellular enveloped virus (EEV). Vaccinia viruses have been modified to replicate selectively in cancer cells and clinically tested as oncolytic agents. During preclinical screening of relevant cancer targets for a recombinant Western Reserve strain deleted for both copies of the thymidine kinase and vaccinia growth factor genes, we noticed that confluent monolayers of SCCF1 cat squamous carcinoma cells were not destroyed even after prolonged infection. Interestingly, although SCCF1 cells were not killed, they continuously secreted virus into the cell culture supernatant. To investigate this finding further, we performed detailed studies by electron microscopy. Both intracellular and secreted virions showed morphological abnormalities on ultrastructural inspection, suggesting compromised maturation and morphogenesis of vaccinia virus in SCCF1 cells. Our data suggest that SCCF1 cells produce a morphologically abnormal virus which is nevertheless infective, providing new information on the virus-host cell interactions and intracellular biology of vaccinia virus.

Published
2015

33. 71. Boosting the Immunogenicity of an Oncolytic Vaccinia Virus By Expression of DAI Can Enhance Anti-Tumor Immunity in Humanized Mice

Author

Hirvinen, Mari, primary, Capasso, Cristian, additional, Guse, Kilian, additional, Garofalo, Mariangela, additional, Vitale, Andrea, additional, Ahonen, Marko, additional, Kuryk, Lukasz, additional, Vähä-Koskela, Markus, additional, Hemminki, Akseli, additional, Greco, Dario, additional, and Cerullo, Vincenzo, additional

Published
2015
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35. Genetically Engineered Oncolytic Adenoviruses for the Treatment of Kidney and Breast Cancer

Author

Guse, Kilian, University of Helsinki, Faculty of Medicine, Haartman Institute, Cancer Gene Therapy Group, Molecular Cancer Biology Program, Transplantation Laboratory, Finnish Institute for Molecular Medicine, HUSLAB, Helsingin yliopisto, lääketieteellinen tiedekunta, kliinisteoreettinen laitos, Helsingfors universitet, medicinska fakulteten, Haartman institutet, Sutter, Gerd, and Hemminki, Akseli

Subjects
syöpägenetiikka
Abstract

Metastatic kidney and breast cancer are devastating diseases currently lacking efficient treatment options. One promising developmental approach in cancer treatment are oncolytic adenoviruses, which have demonstrated excellent safety in many clinical trials. However, antitumor efficacy needs to be improved in order to make oncolytic viruses a viable treatment alternative. To be able to follow oncolytic virus replication in vivo, we set up a non-invasive imaging system based on coinjection of a replication deficient luciferase expressing virus and a replication competent virus. The system was validated in vitro and in vivo and used in other projects of the thesis. In another study we showed that capsid modifications on adenoviruses result in enhanced gene transfer and increased oncolytic effect on renal cancer cells in vitro. Moreover, capsid modified oncolytic adenoviruses demonstrated significantly improved antitumor efficacy in murine kidney cancer models. To transcriptionally target kidney cancer tissue we evaluated two hypoxia response elements for their usability as tissue specific promoters using a novel dual luciferase imaging system. Based on the results of the promoter evaluation and the studies on capsid modifications, we constructed a transcriptionally and transductionally targeted oncolytic adenovirus armed with an antiangiogenic transgene for enhanced renal cell cancer specificity and improved antitumor efficacy. This virus exhibited kidney cancer specific replication and significantly improved antitumor effect in a murine model of intraperitoneal disseminated renal cell cancer. Cancer stem cells are thought to be resistant to conventional cancer drugs and might play an important role in breast cancer relapse and the formation of metastasis. Therefore, we examined if capsid modified oncolytic adenoviruses are able to kill these cells proposed to be breast cancer initiating. Efficient oncolytic effect and significant antitumor efficacy on tumors established with breast cancer initiating cells was observed, suggesting that oncolytic adenoviruses might be able to prevent breast cancer relapse and could be used in the treatment of metastatic disease. In conclusion, the results presented in this thesis suggest that genetically engineered oncolytic adenoviruses have great potential in the treatment of metastatic kidney and breast cancer. Julkaistaan myöhemmin

Published
2009

36. Oncolytic adenovirus and doxorubicin-based chemotherapy results in synergistic antitumor activity against soft-tissue sarcoma

Author

Siurala, Mikko, primary, Bramante, Simona, additional, Vassilev, Lotta, additional, Hirvinen, Mari, additional, Parviainen, Suvi, additional, Tähtinen, Siri, additional, Guse, Kilian, additional, Cerullo, Vincenzo, additional, Kanerva, Anna, additional, Kipar, Anja, additional, Vähä-Koskela, Markus, additional, and Hemminki, Akseli, additional

Published
2014
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38. Capsid-Modified Adenoviral Vectors for Improved Muscle-Directed Gene Therapy

Author

Guse, Kilian, primary, Suzuki, Masataka, additional, Sule, Gautam, additional, Bertin, Terry K., additional, Tyynismaa, Henna, additional, Ahola-Erkkilä, Sofia, additional, Palmer, Donna, additional, Suomalainen, Anu, additional, Ng, Philip, additional, Cerullo, Vincenzo, additional, Hemminki, Akseli, additional, and Lee, Brendan, additional

Published
2012
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40. Integrin targeted oncolytic adenoviruses Ad5-D24-RGD and Ad5-RGD-D24-GMCSF for treatment of patients with advanced chemotherapy refractory solid tumors

Author

Pesonen, Sari, primary, Diaconu, Iulia, additional, Cerullo, Vincenzo, additional, Escutenaire, Sophie, additional, Raki, Mari, additional, Kangasniemi, Lotta, additional, Nokisalmi, Petri, additional, Dotti, Gianpietro, additional, Guse, Kilian, additional, Laasonen, Leena, additional, Partanen, Kaarina, additional, Karli, Eerika, additional, Haavisto, Elina, additional, Oksanen, Minna, additional, Karioja-Kallio, Aila, additional, Hannuksela, Päivi, additional, Holm, Sirkka-Liisa, additional, Kauppinen, Satu, additional, Joensuu, Timo, additional, Kanerva, Anna, additional, and Hemminki, Akseli, additional

Published
2011
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42. Oncolytic Adenovirus Coding for Granulocyte Macrophage Colony-Stimulating Factor Induces Antitumoral Immunity in Cancer Patients

Author

Cerullo, Vincenzo, primary, Pesonen, Sari, additional, Diaconu, Iulia, additional, Escutenaire, Sophie, additional, Arstila, Petteri T., additional, Ugolini, Matteo, additional, Nokisalmi, Petri, additional, Raki, Mari, additional, Laasonen, Leena, additional, Särkioja, Merja, additional, Rajecki, Maria, additional, Kangasniemi, Lotta, additional, Guse, Kilian, additional, Helminen, Andreas, additional, Ahtiainen, Laura, additional, Ristimäki, Ari, additional, Räisänen-Sokolowski, Anne, additional, Haavisto, Elina, additional, Oksanen, Minna, additional, Karli, Eerika, additional, Karioja-Kallio, Aila, additional, Holm, Sirkka-Liisa, additional, Kouri, Mauri, additional, Joensuu, Timo, additional, Kanerva, Anna, additional, and Hemminki, Akseli, additional

Published
2010
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43. Oncolytic Adenovirus ICOVIR-7 in Patients with Advanced and Refractory Solid Tumors

Author

Nokisalmi, Petri, primary, Pesonen, Sari, additional, Escutenaire, Sophie, additional, Särkioja, Merja, additional, Raki, Mari, additional, Cerullo, Vincenzo, additional, Laasonen, Leena, additional, Alemany, Ramon, additional, Rojas, Juan, additional, Cascallo, Manel, additional, Guse, Kilian, additional, Rajecki, Maria, additional, Kangasniemi, Lotta, additional, Haavisto, Elina, additional, Karioja-Kallio, Aila, additional, Hannuksela, Päivi, additional, Oksanen, Minna, additional, Kanerva, Anna, additional, Joensuu, Timo, additional, Ahtiainen, Laura, additional, and Hemminki, Akseli, additional

Published
2010
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44. Targeted Chemotherapy for Head and Neck Cancer with a Chimeric Oncolytic Adenovirus Coding for Bifunctional Suicide Protein FCU1

Author

Dias, João D., primary, Liikanen, Ilkka, additional, Guse, Kilian, additional, Foloppe, Johann, additional, Sloniecka, Marta, additional, Diaconu, Iulia, additional, Rantanen, Ville, additional, Eriksson, Minna, additional, Hakkarainen, Tanja, additional, Lusky, Monika, additional, Erbs, Philippe, additional, Escutenaire, Sophie, additional, Kanerva, Anna, additional, Pesonen, Sari, additional, Cerullo, Vincenzo, additional, and Hemminki, Akseli, additional

Published
2010
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45. Antiangiogenic Arming of an Oncolytic Vaccinia Virus Enhances Antitumor Efficacy in Renal Cell Cancer Models

Author

Guse, Kilian, primary, Sloniecka, Marta, additional, Diaconu, Iulia, additional, Ottolino-Perry, Kathryn, additional, Tang, Nan, additional, Ng, Calvin, additional, Le Boeuf, Fabrice, additional, Bell, John C., additional, McCart, J. Andrea, additional, Ristimäki, Ari, additional, Pesonen, Sari, additional, Cerullo, Vincenzo, additional, and Hemminki, Akseli, additional

Published
2010
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46. Oncolytic adenovirus treatment of a patient with refractory neuroblastoma

Author

Pesonen, Sari, primary, Helin, Heikki, additional, Nokisalmi, Petri, additional, Escutenaire, Sophie, additional, Ribacka, Camilla, additional, Sarkioja, Merja, additional, Cerullo, Vincenzo, additional, Guse, Kilian, additional, Bauerschmitz, Gerd, additional, Laasonen, Leena, additional, Kantola, Teemu, additional, Ristimaki, Ari, additional, Rajecki, Maria, additional, Oksanen, Minna, additional, Haavisto, Elina, additional, Kanerva, Anna, additional, Joensuu, Timo, additional, and Hemminki, Akseli, additional

Published
2010
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48. Serotype Chimeric and Fiber-Mutated Adenovirus Ad5/19p-HIT for Targeting Renal Cancer and Untargeting the Liver

Author

Diaconu, Iulia, primary, Denby, Laura, additional, Pesonen, Sari, additional, Cerullo, Vincenzo, additional, Bauerschmitz, Gerd J., additional, Guse, Kilian, additional, Rajecki, Maria, additional, Dias, João D., additional, Taari, Kimmo, additional, Kanerva, Anna, additional, Baker, Andrew H., additional, and Hemminki, Akseli, additional

Published
2009
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49. Oncolytic adenovirus treatment of a patient with refractory neuroblastoma

Author

Pesonen, Sari, primary, Helin, Heikki, additional, Nokisalmi, Petri, additional, Escutenaire, Sophie, additional, Ribacka, Camilla, additional, Sarkioja, Merja, additional, Cerullo, Vincenzo, additional, Guse, Kilian, additional, Bauerschmitz, Gerd, additional, Laasonen, Leena, additional, Kantola, Teemu, additional, Ristimaki, Ari, additional, Rajecki, Maria, additional, Oksanen, Minna, additional, Haavisto, Elina, additional, Kanerva, Anna, additional, Joensuu, Timo, additional, and Hemminki, Akseli, additional

Published
2009
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