Search

Your search keyword '"Gutenberger, Sylvia"' showing total 19 results
Start Over Author "Gutenberger, Sylvia"
19 results on '"Gutenberger, Sylvia"'

1. Interferon-Driven Immune Dysregulation in Common Variable Immunodeficiency–Associated Villous Atrophy and Norovirus Infection

Author

Strohmeier, Valentina, Andrieux, Geoffroy, Unger, Susanne, Pascual-Reguant, Anna, Klocperk, Adam, Seidl, Maximilian, Marques, Otavio Cabral, Eckert, Marleen, Gräwe, Katja, Shabani, Michelle, von Spee-Mayer, Caroline, Friedmann, David, Harder, Ina, Gutenberger, Sylvia, Keller, Baerbel, Proietti, Michele, Bulashevska, Alla, Grimbacher, Bodo, Provaznik, Jan, Benes, Vladimir, Goldacker, Sigune, Schell, Christoph, Hauser, Anja E., Boerries, Melanie, Hasselblatt, Peter, and Warnatz, Klaus

Published
2023
Full Text
View/download PDF

3. Interferon-Driven Immune Dysregulation in Common Variable Immunodeficiency–Associated Villous Atrophy and Norovirus Infection

Author

Strohmeier, Valentina, primary, Andrieux, Geoffroy, additional, Unger, Susanne, additional, Pascual-Reguant, Anna, additional, Klocperk, Adam, additional, Seidl, Maximilian, additional, Marques, Otavio Cabral, additional, Eckert, Marleen, additional, Gräwe, Katja, additional, Shabani, Michelle, additional, von Spee-Mayer, Caroline, additional, Friedmann, David, additional, Harder, Ina, additional, Gutenberger, Sylvia, additional, Keller, Baerbel, additional, Proietti, Michele, additional, Bulashevska, Alla, additional, Grimbacher, Bodo, additional, Provaznik, Jan, additional, Benes, Vladimir, additional, Goldacker, Sigune, additional, Schell, Christoph, additional, Hauser, Anja E., additional, Boerries, Melanie, additional, Hasselblatt, Peter, additional, and Warnatz, Klaus, additional

Published
2022
Full Text
View/download PDF

6. Circulating ${\rm{CD21}}^{\operatorname{low} } $ B Cells in Common Variable Immunodeficiency Resemble Tissue Homing, Innate-Like B Cells

Author

Rakhmanov, Mirzokhid, Keller, Baerbel, Gutenberger, Sylvia, Foerster, Christian, Hoenig, Manfred, Driessen, Gertjan, van der Burg, Mirjam, van Dongen, Jacques J., Wiech, Elisabeth, Visentini, Marcella, Quinti, Isabella, Prasse, Antje, Voelxen, Nadine, Salzer, Ulrich, Goldacker, Sigune, Fisch, Paul, Eibel, Hermann, Schwarz, Klaus, Peter, Hans-Hartmut, Warnatz, Klaus, and Carson, Dennis A.

Published
2009
Full Text
View/download PDF

7. The EUROclass trial: defining subgroups in common variable immunodeficiency

Author

Wehr, Claudia, Kivioja, Teemu, Schmitt, Christian, Ferry, Berne, Witte, Torsten, Eren, Efrem, Vlkova, Marcela, Hernandez, Manuel, Detkova, Drahomira, Bos, Philip R., Poerksen, Gonke, von Bernuth, Horst, Baumann, Ulrich, Goldacker, Sigune, Gutenberger, Sylvia, Schlesier, Michael, Bergeron-van der Cruyssen, Florence, Le Garff, Magali, Debré, Patrice, Jacobs, Roland, Jones, John, Bateman, Elizabeth, Litzman, Jiri, van Hagen, P. Martin, Plebani, Alessandro, Schmidt, Reinhold E., Thon, Vojtech, Quinti, Isabella, Espanol, Teresa, Webster, A. David, Chapel, Helen, Vihinen, Mauno, Oksenhendler, Eric, Peter, Hans Hartmut, and Warnatz, Klaus

Published
2008
Full Text
View/download PDF

8. Circulating [CD21.sup.low] B cells in common variable immunodeficiency resemble tissue homing, innate-like B cells

Author

Rakhmanov, Mirzokhid, Keller, Baerbel, Gutenberger, Sylvia, Foerster, Christian, Hoenig, Manfred, Driessen, Gertjan, van der Burg, Mirjam, van Dongen, Jacques J., Wiech, Elisabeth, Visentini, Marcella, Quinti, Isabella, Prasse, Antje, Voelxen, Nadine, Salzer, Ulrich, Goldacker, Sigune, Fisch, Paul, Eibel, Hermann, Schwarz, Klaus, Peter, Hans-Hartmut, and Warnatz, Klaus

Subjects
Gene expression -- Research, B cells -- Health aspects, B cells -- Research, Cell differentiation -- Physiological aspects, Cell differentiation -- Research, Immunological deficiency syndromes -- Prevention, Immunological deficiency syndromes -- Research, Science and technology
Abstract

The homeostasis of circulating B cell subsets in the peripheral blood of healthy adults is well regulated, but in disease it can be severely disturbed. Thus, a subgroup of patients with common variable immunodeficiency (CVID) presents with an extraordinary expansion of an unusual B cell population characterized by the low expression of CD21. CD[21.sup.low] B cells are polyclonal, unmutated Ig[M.sup.+]lg[D.sup.+] B cells but carry a highly distinct gene expression profile which differs from conventional naive B cells. Interestingly, while clearly not representing a memory population, they do share several features with the recently defined memory-like tissue, Fc receptor-like 4 positive B cell population in the tonsils of healthy donors. CD[21.sup.low] B cells show signs of previous activation and proliferation in vivo, while exhibiting defective calcium signaling and poor proliferation in response to B cell receptor stimulation. CD[21.sup.low] B cells express decreased amounts of homeostatic but increased levels of inflammatory chemokine receptors. This might explain their preferential homing to peripheral tissues like the bronchoalveolar space of CVID or the synovium of rheumatoid arthritis patients. Therefore, as a result of the close resemblance to the gene expression profile, phenotype, function and preferential tissue homing of murine B1 B cells, we suggest that CD[21.sup.low] B cells represent a human innate-like B cell population. B cell differentiation I CVID

Published
2009

9. Genetic CD21 deficiency is associated with hypogammaglobulinemia

Author

Thiel, Jens, Kimmig, Lucas, Salzer, Ulrich, Grudzien, Magdalena, Lebrecht, Dirk, Hagena, Tina, Draeger, Ruth, Völxen, Nadine, Bergbreiter, Astrid, Jennings, Stephanie, Gutenberger, Sylvia, Aichem, Annette, Illges, Harald, Hannan, Jonathan P., Kienzler, Anne-Kathrin, Rizzi, Marta, Eibel, Hermann, Peter, Hans-Hartmut, Warnatz, Klaus, Grimbacher, Bodo, Rump, Jörg-Andres, and Schlesier, Michael

Published
2012
Full Text
View/download PDF

12. B‐cell signaling in persistent polyclonal B lymphocytosis (PPBL)

Author

Voelxen, Nadine, primary, Wehr, Claudia, additional, Gutenberger, Sylvia, additional, Keller, Baerbel, additional, Erlacher, Miriam, additional, Dominguez‐Conde, Cecilia, additional, Bertele, Daniela, additional, Emmerich, Florian, additional, Pantic, Milena, additional, Jennings, Stefanie, additional, Rakhmanov, Mirzokhid, additional, Foerster, Christian, additional, Martens, Uwe M, additional, Platzbecker, Uwe, additional, Peter, Hans‐Hartmut, additional, Fisch, Paul, additional, Boztug, Kaan, additional, Eibel, Hermann, additional, Salzer, Ulrich, additional, and Warnatz, Klaus, additional

Published
2016
Full Text
View/download PDF

15. Circulating CD21lowB cells in common variable immunodeficiency resemble tissue homing, innate-like B cells

Author

Rakhmanov, Mirzokhid, primary, Keller, Baerbel, additional, Gutenberger, Sylvia, additional, Foerster, Christian, additional, Hoenig, Manfred, additional, Driessen, Gertjan, additional, van der Burg, Mirjam, additional, van Dongen, Jacques J., additional, Wiech, Elisabeth, additional, Visentini, Marcella, additional, Quinti, Isabella, additional, Prasse, Antje, additional, Voelxen, Nadine, additional, Salzer, Ulrich, additional, Goldacker, Sigune, additional, Fisch, Paul, additional, Eibel, Hermann, additional, Schwarz, Klaus, additional, Peter, Hans-Hartmut, additional, and Warnatz, Klaus, additional

Published
2009
Full Text
View/download PDF

18. Circulating CD21low B cells in common variable immunodeficiency resemble tissue homing, innate-like B cells.

Author

Rakhmanov, Mirzokhid, KeIIer, Baerbel, Gutenberger, Sylvia, Foerster, Christian, Hoenig, Manfred, Driessen, Gertjan, van der Burg, Mirjam, van Dongen, Jacques J., Wiech, Elisabeth, Visentini, Marcella, Quinti, Isabella, Prasse, Antje, VoeIxen, Nadine, Salzer, Ulrich, Goldacker, Sigune, Fisch, Paul, Eibel, Hermann, Schwarz, Klaus, Peter, Hans-Hartmut, and Warnatz, Klaus

Subjects
B cells, ANTIGEN presenting cells, LYMPHOCYTES, IMMUNODEFICIENCY, HOMEOSTASIS, PHYSIOLOGY, PHYSIOLOGICAL control systems
Abstract

The homeostasis of circulating B cell subsets in the peripheral blood of healthy adults is well regulated, but in disease it can be severely disturbed. Thus, a subgroup of patients with common variable immunodeficiency (CVID) presents with an extraordinary expansion of an unusual B cell population characterized by the low expression of CD21. CD21low B cells are polyclonal, unmutated IgM+IgD+ B cells but carry a highly distinct gene expression profile which differs from conventional naïve B cells. Interestingly, while clearly not representing a memory population, they do share several features with the recently defined memory-like tissue, Fc receptor-like 4 positive B cell population in the tonsils of healthy donors. CD21low B cells show signs of previous activation and proliferation in vivo, while exhibiting defective calcium signaling and poor proliferation in response to B cell receptor stimulation. CD21low B cells express decreased amounts of homeostatic but increased levels of inflammatory chemokine receptors. This might explain their preferential homing to peripheral tissues like the bronchoalveolar space of CVID or the synovium of rheumatoid arthritis patients. Therefore, as a result of the close resemblance to the gene expression profile, phenotype, function and preferential tissue homing of murine B1 B cells, we suggest that CD21low B cells represent a human innate-like B cell population. [ABSTRACT FROM AUTHOR]

Published
2009
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results