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1,038 results on '"Gutiérrez B"'

1. Epidemiological support for genetic variability at hypothalamic–pituitary–adrenal axis and serotonergic system as risk factors for major depression

Author

Ching-López A, Cervilla J, Rivera M, Molina E, McKenney K, Ruiz-Perez I, Rodríguez-Barranco M, and Gutiérrez B

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract

Ana Ching-López,1 Jorge Cervilla,1–3 Margarita Rivera,1–3 Esther Molina,4 Kathryn McKenney,2 Isabel Ruiz-Perez,3,5,6 Miguel Rodríguez-Barranco,5 Blanca Gutiérrez1,21Department of Psychiatry, Institute of Neurosciences, School of Medicine, University of Granada, Granada, 2CIBER en Salud Mental (CIBERSAM), University of Granada, Granada, 3Instituto de Investigación Biosanitaria Ibs. Granada, Granada, 4Department of Nursing, University of Seville, Seville, 5Andalusian School of Public Health, Granada, 6CIBER de Epidemiología y Salud Pública (CIBERESP), Granada, SpainBackground: Major depressive disorder (MDD) is a serious, and common psychiatric disorder worldwide. By the year 2020, MDD will be the second cause of disability in the world. The Granad∑p study is the first, to the best of our knowledge, epidemiological study of mental disorders carried out in Andalusia (South Spain), being one of its main objectives to identify genetic and environmental risk factors for MDD and other major psychiatric disorders. In this study, we focused on the possible association of 91 candidate single nucleotide polymorphisms (SNPs) with MDD.Methods: A total of 711 community-based individuals participated in the Granad∑p study. All individuals were extensively assessed for clinical, psychological, sociodemographic, life style, and other environmental variables. A biological sample was also collected for subsequent genetic analyses in 91 candidate SNPs for MDD. DSM-IV diagnosis of MDD was used as the outcome variable. Logistic regression analysis assuming an additive genetic model was performed to test the association between MDD and the genetic data. The experiment-wide significance threshold adjusted with the SNP spectral decomposition method provided a maximum P-value (8×10-3) required to identify an association. Haplotype analyses were also performed.Results: One SNP (rs623580) located in the tryptophan hydroxylase 1 gene (TPH1; chromosome 11), one intergenic variant (rs9526236) upstream of the 5-hydroxytryptamine receptor 2A gene (HTR2A; chromosome 13), and five polymorphisms (rs17689966, rs173365, rs7209436, rs110402, and rs242924) located in the corticotropin-releasing hormone receptor 1 gene (CRHR1; chromosome 17), all showed suggestive trends for association with MDD (P

Published
2015

2. Different presence of Chlamydia pneumoniae, herpes simplex virus type 1, human herpes virus 6, and Toxoplasma gondii in schizophrenia: meta-analysis and analytical study

Author

Gutiérrez-Fernández J, Luna del Castillo JD, Mañanes-González S, Carrillo-Ávila JA, Gutiérrez B, Cervilla JA, and Sorlózano-Puerto A

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract

José Gutiérrez-Fernández,1 Juan de Dios Luna del Castillo,2 Sara Mañanes-González,1 José Antonio Carrillo-Ávila,1 Blanca Gutiérrez,3 Jorge A Cervilla,3 Antonio Sorlózano-Puerto1 1Department of Microbiology, 2Department of Statistics and Operation Research, 3Department of Psychiatry, Institute of Neurosciences and CIBERSAM, School of Medicine and Biohealth Research Institute (Instituto de Investigación Biosanitaria) IBS-Granada, University of Granada, Granada, Spain Abstract: In the present study we have performed both a meta-analysis and an analytical study exploring the presence of Chlamydia pneumoniae, herpes simplex virus type 1, human herpes virus 6, and Toxoplasma gondii antibodies in a sample of 143 schizophrenic patients and 143 control subjects. The meta-analysis was performed on papers published up to April 2014. The presence of serum immunoglobulin G and immunoglobulin A was performed by enzyme-linked immunosorbent assay test. The detection of microbial DNA in total peripheral blood was performed by nested polymerase chain reaction. The meta-analysis showed that: 1) C. pneumoniae DNA in blood and brain are more common in schizophrenic patients; 2) there is association with parasitism by T. gondii, despite the existence of publication bias; and 3) herpes viruses were not more common in schizophrenic patients. In our sample only anti-Toxoplasma immunoglobulin G was more prevalent and may be a risk factor related to schizophrenia, with potential value for prevention. Keywords: meta-analysis, analytical study, Chlamydia pneumoniae, herpes simplex virus type 1, human herpes virus 6, Toxoplasma gondii, schizophrenia

Published
2015

9. AB1451 NEW APPROACHES TO THE STUDY OF SOCIAL DETERMINANTS OF HEALTH: DISCOVERY, EXTRACTION AND CHARACTERISATION OF MUSCULOSKELETAL PATIENTS’ OCCUPATIONS IN THE ELECTRONICAL MEDICAL RECORD USING DEEP LEARNING AND PRE-TRAINED LANGUAGE MODELS

Author

Madrid García, A., primary, Pérez - Sancristóbal, I., additional, León, L., additional, Abasolo, L., additional, Rodríguez González, A., additional, Fernández-Gutiérrez, B., additional, Menasalvas Ruiz, E., additional, and Rodriguez Rodriguez, L., additional

Published
2024
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13. Is peritoneal dialysis suitable technique CKD patients over 65 years? A prospective multicenter study

Author

Tato, A., Molano, Bernal, Martín Cleary, C., Escribano, A., Vian, J., Sanz Ballesteros, S., Vega, A., Martínez, A., Campos, J., Bajo, M.A., Del Peso, G., Rodríguez Palomares, J.R., Carreño, A., Felipe, C., Perpén, A., Hernández, M.J., Moreno, F., Sánchez García, L., Rivera Gorrín, M., Burguera, A., Fernández-Reyes, M.J., Rodríguez, A., Hevia, C., Lorenzo, M., Paraíso, V., González Sanchidrián, S., Tornero, F., Hernández, E., Ortega, M., Campos Gutiérrez, B., Benito, J., Ortega, O., Herrero, J.C., Pizarro, M.S., Portolés, Jose, Vega, Almudena, Lacoba, Enrique, López-Sánchez, Paula, Botella, Mario, Yuste, Claudia, Martín Cleary, Catalina, Sanz Ballesteros, Sandra, González Sanchidrian, Silvia, Sánchez García, Luisa, Carreño, Agustín, Bajo, M. Auxiliadora, and Janeiro, Darío

Published
2021
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14. ¿Es adecuada la diálisis peritoneal para pacientes mayores de 65 años? Estudio multicéntrico prospectivo

Author

Tato, A., Molano, Bernal, Martín Cleary, C., Escribano, A., Vian, J., Sanz Ballesteros, S., Vega, A., Martínez, A., Campos, J., Bajo, M.A., Del Peso, G., Rodríguez Palomares, J.R., Carreño, A., Felipe, C., Perpén, A., Hernández, M.J., Moreno, F., Sánchez García, L., Rivera Gorrín, M., Burguera, A., Fernández-Reyes, M.J., Rodríguez, A., Hevia, C., Lorenzo, M., Paraíso, V., González Sanchidrián, S., Tornero, F., Hernández, E., Ortega, M., Campos Gutiérrez, B., Benito, J., Ortega, O., Herrero, J.C., Pizarro, M.S., Portolés, Jose, Vega, Almudena, Lacoba, Enrique, López-Sánchez, Paula, Botella, Mario, Yuste, Claudia, Martín Cleary, Catalina, Sanz Ballesteros, Sandra, González Sanchidrian, Silvia, Sánchez García, Luisa, Carreño, Agustín, Bajo, M. Auxiliadora, and Janeiro, Darío

Published
2021
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32. Mutational landscape of risk variants in comorbid depression and obesity: a next generation sequencing approach

Author

Pérez-Gutiérrez, A.M., primary, Carmona, R., additional, Loucera, C., additional, Cervilla, J.A., additional, Gutiérrez, B., additional, Molina, E., additional, López-López, D., additional, Pérez-Florido, J., additional, Zarza-Rebollo, J.A., additional, López-Isac, E., additional, Dopazo, J., additional, Martínez-González, L.J., additional, and Rivera, M., additional

Published
2023
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38. Preface

Author

Cristofaro, M, Palomino, Pr, Frondizi, R, Jiménez, E, Gutiérrez, B, Salvatore, S, and Antonucci, Fp

Subjects
Settore SECS-P/08
Published
2022

40. Origen y configuración de los procesos de capacitación dirigidos desde el IFED a partidos políticos y autoridades electas

Author

Gutiérrez Barboza. Jeniffer

Subjects
partidos políticos, capacitación electoral, gestión de conocimiento, proceso electoral, fortalecimiento de la democracia, Law, Law in general. Comparative and uniform law. Jurisprudence, K1-7720, Political science, Political science (General), JA1-92
Abstract

El artículo se circunscribe al periodo 2011-2023 y recupera los antecedentes que configuraron el origen de los servicios de capacitación que desde el IFED se brindaron a partidos políticos y autoridades electas, las principales características de la oferta de capacitación durante estos 12 años de gestión, la respuesta obtenida y las estrategias metodológicas implementadas. Sumado a este recuento histórico, se colocan algunas reflexiones que surgen del intercambio de saberes, pues la formación y capacitación han estado lejos de configurarse como un proceso vertical de enseñanza, más bien el acercamiento a los diferentes actores que participan en la vida de los partidos políticos ha proporcionado aprendizaje en doble vía.

Published
2024
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45. Body mass index interacts with a genetic-risk score for depression increasing the risk of the disease in high-susceptibility individuals

Author

Anguita-Ruiz A, Zarza-Rebollo JA, Pérez-Gutiérrez AM, Molina E, Gutiérrez B, Bellón JÁ, Moreno-Peral P, Conejo-Cerón S, Aiarzagüena JM, Ballesta-Rodríguez MI, Fernández A, Fernández-Alonso C, Martín-Pérez C, Montón-Franco C, Rodríguez-Bayón A, Torres-Martos Á, López-Isac E, Cervilla J, and Rivera M

Abstract

Depression is strongly associated with obesity among other chronic physical diseases. The latest mega- and meta-analysis of genome-wide association studies have identified multiple risk loci robustly associated with depression. In this study, we aimed to investigate whether a genetic-risk score (GRS) combining multiple depression risk single nucleotide polymorphisms (SNPs) might have utility in the prediction of this disorder in individuals with obesity. A total of 30 depression-associated SNPs were included in a GRS to predict the risk of depression in a large case-control sample from the Spanish PredictD-CCRT study, a national multicentre, randomized controlled trial, which included 104 cases of depression and 1546 controls. An unweighted GRS was calculated as a summation of the number of risk alleles for depression and incorporated into several logistic regression models with depression status as the main outcome. Constructed models were trained and evaluated in the whole recruited sample. Non-genetic-risk factors were combined with the GRS in several ways across the five predictive models in order to improve predictive ability. An enrichment functional analysis was finally conducted with the aim of providing a general understanding of the biological pathways mapped by analyzed SNPs. We found that an unweighted GRS based on 30 risk loci was significantly associated with a higher risk of depression. Although the GRS itself explained a small amount of variance of depression, we found a significant improvement in the prediction of depression after including some non-genetic-risk factors into the models. The highest predictive ability for depression was achieved when the model included an interaction term between the GRS and the body mass index (BMI), apart from the inclusion of classical demographic information as marginal terms (AUC = 0.71, 95% CI = [0.65, 0.76]). Functional analyses on the 30 SNPs composing the GRS revealed an over-representation of the mapped genes in signaling pathways involved in processes such as extracellular remodeling, proinflammatory regulatory mechanisms, and circadian rhythm alterations. Although the GRS on its own explained a small amount of variance of depression, a significant novel feature of this study is that including non-genetic-risk factors such as BMI together with a GRS came close to the conventional threshold for clinical utility used in ROC analysis and improves the prediction of depression. In this study, the highest predictive ability was achieved by the model combining the GRS and the BMI under an interaction term. Particularly, BMI was identified as a trigger-like risk factor for depression acting in a concerted way with the GRS component. This is an interesting finding since it suggests the existence of a risk overlap between both diseases, and the need for individual depression genetics-risk evaluation in subjects with obesity. This research has therefore potential clinical implications and set the basis for future research directions in exploring the link between depression and obesity-associated disorders. While it is likely that future genome-wide studies with large samples will detect novel genetic variants associated with depression, it seems clear that a combination of genetics and non-genetic information (such is the case of obesity status and other depression comorbidities) will still be needed for the optimization prediction of depression in high-susceptibility individuals.

Published
2022

46. First detection of SARS-CoV-2 variant B.1.1.529 (Omicron) in Ecuador

Author

Carrazco-Montalvo, A., primary, Armendáriz-Castillo, I., additional, Tello, C.L., additional, Morales, D., additional, Armas-Gonzalez, R., additional, Guizado-Herrera, D., additional, León-Sosa, A., additional, Ramos-Sarmiento, D., additional, Fuertes, B., additional, Patino, L., additional, Cárdenas, P., additional, Márquez, S., additional, Prado-Vivar, B., additional, Guadalupe, J.J., additional, Gutiérrez, B., additional, Wong, M.B., additional, Grunauer, M., additional, Trueba, G., additional, Rojas-Silva, P., additional, and Barragán, V., additional

Published
2022
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47. La inercia terapéutica de la Atención Primaria

Author

Tranche Iparraguirre, S., primary, Fernández, M., additional, Galindo, G., additional, Arroyo, A., additional, Carbajo, L., additional, Martin, R., additional, Quevedo, J.A., additional, Bartolomé, C., additional, Párraga, I., additional, Bueno, J.M., additional, Fernández, A., additional, Gutiérrez, B., additional, and Ruiz, A., additional

Published
2021
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48. Espasmo hemifacial: experiencia en un centro terciario

Author

Neumann R.,Eduard D., Gutiérrez B.,Alfons, De-Juan B.,Julia, Pujol O.,Albert, del Prado-Venegas P.,María, and Orús D.,César

Subjects
nervio facial, espasmo hemifacial, trastorno movimiento, conflicto neurovascular
Abstract

Resumen El espasmo hemifacial consiste en un infrecuente trastorno del movimiento que afecta a la musculatura inervada por el nervio facial, en especial la de la hemicara superior. Existen dos formas clínicas, una primaria en la que la causa subyacente está representada por un conflicto neurovascular, y una secundaria, en la que la alteración del nervio facial es producida por algún tipo de lesión ocupante de espacio. Resulta de especial interés para el otorrinolaringólogo conocer esta entidad y ser capaz de diferenciar ambas formas clínicas dado el diferente enfoque terapéutico que pueden requerir. Aportamos una visión general de esta patología repasando su epidemiología y fisiopatología, además, de nuestra experiencia en forma de una serie de cuatro casos que ilustran las variadas formas de presentación de esta entidad, así como los signos y síntomas de alarma que pueden ayudar a realizar un correcto diagnóstico y manejo.

Published
2021

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