Search

Your search keyword '"Gutiérrez-Ruíz, María Concepción"' showing total 24 results
Start Over Author "Gutiérrez-Ruíz, María Concepción"
24 results on '"Gutiérrez-Ruíz, María Concepción"'

5. Impact of the gene-gene interactions related to the HIF-1α signaling pathway with the knee osteoarthritis development

Author

Fernández-Torres, Javier, Martínez-Nava, Gabriela Angélica, Zamudio-Cuevas, Yessica, Martínez-Flores, Karina, Gutiérrez-Ruíz, María Concepción, Gómez-Quiroz, Luis Enrique, Garrido-Rodríguez, Daniela, Muñoz-Valle, José Francisco, Oregón-Romero, Edith, Lozada, Carlos, Cornejo, Denise Clavijo, Pineda, Carlos, and López-Reyes, Alberto

Published
2019
Full Text
View/download PDF

19. Oxidative stress as a damage mechanism in porcine cumulus-oocyte complexes exposed to malathion during in vitro maturation

Author

Flores, Diana, primary, Souza, Verónica, additional, Betancourt, Miguel, additional, Teteltitla, Mario, additional, González-Márquez, Humberto, additional, Casas, Eduardo, additional, Bonilla, Edmundo, additional, Ramírez-Noguera, Patricia, additional, Gutiérrez-Ruíz, María Concepción, additional, and Ducolomb, Yvonne, additional

Published
2017
Full Text
View/download PDF

22. Animal model of acute gout reproduces the inflammatory and ultrasonographic joint changes of human gout.

Author

Pineda, Carlos, Fuentes-Gómez, Arturo J., Hernández-Díaz, Cristina, Zamudio-Cuevas, Yessica, Fernández-Torres, Javier, López-Macay, Ambar, Alba-Sánchez, Ismael, Camacho-Galindo, Javier, Ventura, Lucio, Gómez-Quiróz, Luis E., Gutiérrez-Ruíz, María Concepción, García-Vázquez, Francisco, Reginato, Anthony M., Gutiérrez, Marwin, and López-Reyes, Alberto

Published
2015
Full Text
View/download PDF

23. Role of Hypoxia Inducible Factor-1α signaling pathway in osteoarthritis: a systematic review

Author

Fernández-Torres, Javier, Martínez-Nava, Gabriela Angélica, Gutiérrez-Ruíz, María Concepción, Gómez-Quiroz, Luis Enrique, and Gutiérrez, Marwin

Subjects
Fator induzível por hipóxia 1-α, Osteoarthritis, HIF-1α signaling pathway, Via de sinalização do HIF-1α, Polimorfismos genéticos, Genetic polymorphisms, Osteoartrite, Hypoxia inducible factor-1α
Abstract

Osteoarthritis is the most common form of arthritis and is frequently diagnosed and managed in primary care; it is characterized by loss of articular hyaline cartilage, which is a unique connective tissue that physiologically lacks blood vessels. Articular cartilage survives in a microenvironment devoid of oxygen, which is regulated by hypoxia inducible factor (HIF-1α). HIF-1α is considered the main transcriptional regulator of cellular and developmental response to hypoxia. To date, the relevance of HIF-1α in the assessment of cartilage has increased since its participation is essential in the homeostasis of this tissue. Taking into account the new emerging insights of HIF-1α in the scientific literature in the last years, we focused the present review on the potential role of HIF-1α signaling pathway in osteoarthritis development, especially in how some genetic factors may influence the maintenance or breakdown of articular cartilage.

Full Text
View/download PDF

24. PM10 impairs the antioxidant defense system and exacerbates oxidative stress driven cell death

Author

Chirino, Yolanda I., Sánchez-Pérez, Yesennia, Osornio-Vargas, Álvaro R., Morales-Bárcenas, Rocío, Gutiérrez-Ruíz, María Concepción, Segura-García, Yazmin, Rosas, Irma, Pedraza-Chaverri, José, and García-Cuellar, Claudia M.

Subjects
*PARTICULATE matter, *ANTIOXIDANTS, *CELL death, *OXIDATIVE stress, *OXYGEN in the body, *CELL lines, *GLUTATHIONE, *CATALASE, *METABOLIC detoxification
Abstract

Abstract: The aim of this study was to investigate the effect of airborne particulate matter with a mean aerodynamic diameter of ≤10μm (PM10) on oxidative stress markers and antioxidant enzymatic activity and its relevance in the face of acute oxidative challenge in a human lung epithelial cell line (A549). PM10-induced reactive oxygen species (ROS) generation and oxidative damage with no changes in cellular viability. In addition, PM10 decreased glutathione (GSH) levels (54.9%) and the activity of the antioxidant enzymes superoxide dismutase (65%), catalase (31.2%), glutathione reductase (61.5%) and glutathione-S-transferase (42.39%). Trolox, a scavenger of reactive species, prevented the increase of ROS generation and the decrease in GSH levels but partially prevented PM10-induced oxidative damage. Interestingly, it was unable to avoid the decrease in the activity of antioxidant enzymes. Finally, the survival of the cells previously exposed to PM10 and challenged with hydrogen peroxide was significantly lower. We conclude that the impairment in the antioxidant defense system induced by PM10 weaken ROS detoxification which exacerbates cell death when these cells are exposed to an acute oxidative challenge. [Copyright &y& Elsevier]

Published
2010
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results