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2 results on '"Guus Vissers"'

1. The risk of preterm birth in women with uterine fibroids: A systematic review and meta-analysis.

Author

Anadeijda J E M C Landman, Emma E Don, Guus Vissers, Hans C J Ket, Martijn A Oudijk, Christianne J M de Groot, Judith A F Huirne, and Marjon A de Boer

Subjects
Medicine, Science
Abstract

BackgroundFibroids have been identified as a possible risk factor for preterm birth, however, the magnitude of this risk is unclear. Our objective was to determine the risk of total, spontaneous, and medically indicated preterm birth in women with fibroids.MethodsA literature search was performed on 9 June 2021. We selected studies reporting on preterm birth in women with and without fibroids. Fibroids had to be diagnosed by routine ultrasound before or during pregnancy. Main outcomes were total preterm birth Main resultsThe search yielded 2078 unique articles of which 11 were included. Meta-analysis for preterm birth ConclusionsOur results suggest fibroids are associated with an increased risk of preterm birth, with a stronger risk at earlier gestational ages. We encourage further research to clarify the association between fibroids and preterm birth by systematic myometrial assessment in pregnancy.RegistrationProspero database [CRD42020186976].

Published
2022
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2. Uterine Fibroids Causing Preterm Birth: A New Pathophysiological Hypothesis on the Role of Fibroid Necrosis and Inflammation

Author

Emma E. Don, Anadeijda J. E. M. C. Landman, Guus Vissers, Ekaterina S. Jordanova, Emiel D. Post Uiterweer, Christianne J. M. de Groot, Marjon A. de Boer, Judith A. F. Huirne, Obstetrics and gynaecology, Amsterdam Reproduction & Development (AR&D), APH - Quality of Care, and APH - Societal Participation & Health

Subjects
Inflammation, Leiomyoma, Organic Chemistry, Infant, Newborn, General Medicine, Catalysis, Computer Science Applications, Inorganic Chemistry, Necrosis, Pregnancy, Uterine Neoplasms, Humans, Premature Birth, Female, Physical and Theoretical Chemistry, Molecular Biology, Spectroscopy
Abstract

According to recent studies and observations in clinical practice, uterine fibroids increase the risk of preterm birth. There are several theories on the pathogenesis of preterm birth in the presence of fibroids. One theory proclaims that fibroid necrosis leads to preterm birth, though pathophysiological mechanisms have not been described. Necrotic tissue secretes specific cytokines and proteins and we suggest these to be comparable to the inflammatory response leading to spontaneous preterm birth. We hypothesize that fibroid necrosis could induce preterm parturition through a similar inflammatory response. This new hypothesis generates novel perspectives for future research and the development of preventative strategies for preterm birth. Moreover, we emphasize the importance of the recognition of fibroids and especially fibroid necrosis by clinicians during pregnancy.

Published
2022
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