133 results on '"Guven T"'
Search Results
2. Attitude towards seeking psychological help regarding psychiatric symptoms and stigma in patients with fibromyalgia.
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BULU, A., ONALAN, E., KORKMAZ, S., YAKAR, B., KARATAS, T. K., GUVEN, T., KARATAS, A., KOCA, S. S., ATLI, H., and DONDER, E.
- Abstract
OBJECTIVE: The current study aimed to examine the psychiatric symptoms that can be seen in fibromyalgia (FM) patients, their attitudes toward seeking psychological help, and their concerns about stigma. Besides, it was investigated whether the stigma concerns that they may experience about receiving psychiatric treatment constitute an obstacle for patients to receive psychiatric treatment. SUBJECTS AND METHODS: This cross-sectional descriptive study was conducted between February and July 2020. Various seeking help were measured with Attitude Towards Seeking Psychological Help Scale-Short Form (ATSPPHSF), Self-Stigma in the Process of Seeking Psychological Help Scale (SSPSPHS), Intention to Seek Psychological Help Inventory (ISPHI), and Social Stigma Due to Seeking Psychological Help Scale (SSDSPHS). FM symptoms of patients were measured with The Symptom Screening Questionnaire, Revised 90 Items (SCL-90-R). Quality-of-life parameters were measured with Fibromyalgia Impact Questionnaire (FIQ). RESULTS: Fibromyalgia patients had higher somatization (p=0.001), psychotism (p=0.045) and phobic anxiety (p=0.015) scores than controls. The ATSPPH-SF (p=0.002) and SSPSPHS (p=0.043) scale scores of the FM patients were higher than the controls. There was a significant positive correlation between FIQ and SSPSPHS (r=0.288, p=0.043) and SCL-90 overall (r=0.602, p<0.001) and all subscales scores. Patients with high active psychotic symptom levels had higher FM exposure scale scores and SCL-90 overall scores than those with low active psychotic symptom levels (p<0.001). CONCLUSIONS: The findings of this study showed that fibromyalgia patients have more somatization symptoms than healthy individuals, and as psychiatric symptoms increase in these individuals, their level of being affected by FM increases. [ABSTRACT FROM AUTHOR]
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- 2023
3. Evaluation of tularaemia courses: a multicentre study from Turkey
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Erdem, H., Ozturk-Engin, D., Yesilyurt, M., Karabay, O., Elaldi, N., Celebi, G., Korkmaz, N., Guven, T., Sumer, S., Tulek, N., Ural, O., Yilmaz, G., Erdinc, S., Nayman-Alpat, S., Sehmen, E., Kader, C., Sari, N., Engin, A., Cicek-Senturk, G., Ertem-Tuncer, G., Gulen, G., Duygu, F., Ogutlu, A., Ayaslioglu, E., Karadenizli, A., Meric, M., Ulug, M., Ataman-Hatipoglu, C., Sirmatel, F., Cesur, S., Comoglu, S., Kadanali, A., Karakas, A., Asan, A., Gonen, I., Kurtoglu-Gul, Y., Altin, N., Ozkanli, S., Yilmaz-Karadag, F., Cabalak, M., Gencer, S., Umut Pekok, A., Yildirim, D., Seyman, D., Teker, B., Yilmaz, H., Yasar, K., Inanc Balkan, I., Turan, H., Uguz, M., Kilic, S., Akkoyunlu, Y., Kaya, S., Erdem, A., Inan, A., Cag, Y., Bolukcu, S., Ulu-Kilic, A., Ozgunes, N., Gorenek, L., Batirel, A., and Agalar, C.
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- 2014
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4. Genitourinary brucellosis: results of a multicentric study
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Erdem, H., Elaldi, N., Ak, O., Gulsun, S., Tekin, R., Ulug, M., Duygu, F., Sunnetcioglu, M., Tulek, N., Guler, S., Cag, Y., Kaya, S., Turker, N., Parlak, E., Demirdal, T., Ataman Hatipoglu, C., Avci, A., Bulut, C., Avci, M., Pekok, A., Savasci, U., Sozen, H., Tasbakan, M., Guven, T., Bolukcu, S., Cesur, S., Sahin-Horasan, E., Kazak, E., Denk, A., Gonen, I., Karagoz, G., Haykir Solay, A., Alici, O., Kader, C., Senturk, G., Tosun, S., Turan, H., Baran, A.I., Ozturk-Engin, D., Bozkurt, F., Deveci, O., Inan, A., Kadanali, A., Sayar, M.S., Cetin, B., Yemisen, M., Naz, H., Gorenek, L., and Agalar, C.
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- 2014
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5. Spread of carbapenem-resistant international clones of Acinetobacter baumannii in Turkey and Azerbaijan: a collaborative study
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Ahmed, S. S., Alp, E., Ulu-Kilic, A., Dinc, G., Aktas, Z., Ada, B., Bagirova, F., Baran, I., Ersoy, Y., Esen, S., Guven, T. G., Hopman, J., Hosoglu, S., Koksal, F., Parlak, E., Yalcin, A. N., Yilmaz, G., Voss, A., and Melchers, W.
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- 2016
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6. Ethical evaluation of the website-based promotion and advertisements for in vitro fertilisation services in Turkey
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Karatas, M, Sehiralti, M, Gorkey, S, and Guven, T
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- 2011
7. Comparison of colistin–carbapenem, colistin–sulbactam, and colistin plus other antibacterial agents for the treatment of extremely drug-resistant Acinetobacter baumannii bloodstream infections
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Batirel, A., Balkan, I. I., Karabay, O., Agalar, C., Akalin, S., Alici, O., Alp, E., Altay, F. A., Altin, N., Arslan, F., Aslan, T., Bekiroglu, N., Cesur, S., Celik, A. D., Dogan, M., Durdu, B., Duygu, F., Engin, A., Engin, D. O., Gonen, I., Guclu, E., Guven, T., Hatipoglu, C. A., Hosoglu, S., Karahocagil, M. K., Kilic, A. U., Ormen, B., Ozdemir, D., Ozer, S., Oztoprak, N., Sezak, N., Turhan, V., Turker, N., and Yilmaz, H.
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- 2014
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8. Liver involvement in patients with brucellosis: results of the Marmara study
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Ozturk-Engin, D., Erdem, H., Gencer, S., Kaya, S., Baran, A. I., Batirel, A., Tekin, R., Celen, M. K., Denk, A., Guler, S., Ulug, M., Turan, H., Pekok, A. U., Mermut, G., Kaya, S., Tasbakan, M., Tulek, N., Cag, Y., Inan, A., Yalci, A., Ataman-Hatipoglu, C., Gonen, I., Dogan-Celik, A., Bozkurt, F., Gulsun, S., Sunnetcioglu, M., Guven, T., Duygu, F., Parlak, E., Sozen, H., Tosun, S., Demirdal, T., Guclu, E., Karabay, O., Uzun, N., Gunal, O., Diktas, H., Haykir-Solay, A., Erbay, A., Kader, C., Aydin, O., Erdem, A., Elaldi, N., Kadanali, A., Yulugkural, Z., Gorenek, L., Altındis, M., Bolukcu, S., Agalar, C., and Ormeci, N.
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- 2014
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9. PROKR2 Mutations in Patients with Short Stature Who Have Isolated Growth Hormone Deficiency and Multiple Pituitary Hormone Deficiency
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Aslı Derya Kardelen, Adam Najaflı, Firdevs Baş, Birsen Karaman, Güven Toksoy, Şükran Poyrazoğlu, Şahin Avcı, Umut Altunoğlu, Zehra Yavaş Abalı, Ayşe Pınar Öztürk, Esin Karakılıç Özturan, Seher Başaran, Feyza Darendeliler, and Z. Oya Uyguner
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growth hormone deficiency ,multiple pituitary hormone deficiency ,prokr2 ,short stature ,Pediatrics ,RJ1-570 ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
INTRODUCTION: Recent reports have indicated the role of the prokineticin receptor 2 gene (PROKR2) in the etiology of pituitary hormone deficiencies, suggesting a potential role for the PROK2 pathway in pituitary development, in addition to its role in gonadotropin releasing hormone-expressing neuron development. Here, we present the clinical and molecular findings of four patients with PROKR2 mutations. METHODS: Next-generation targeted sequencing was used to screen 25 genes in 59 unrelated patients with multiple pituitary hormone deficiency (MPHD), isolated growth hormone (GH) deficiency, or idiopathic short stature. RESULTS: Two different, very rare PROKR2 missense alterations classified as pathogenic (NM_144773.4: c.518T>G; NP_658986.1: p. (Leu173Arg)) and likely pathogenic (NM_144773.4: c.254G>A; NP_658986.1: p.(Arg85His)) were identified in four patients in heterozygous form. Patient 1 and Patient 2 presented with short stature and were diagnosed as GH deficiency. Patient 3 and Patient 4 presented with central hypothyroidism and cryptorchidism and were diagnosed as MPHD. No other pathogenic alterations were detected in the remaining 24 genes related to short stature, MPHD, and hypogonadotropic hypogonadism. Segregation analysis revealed asymptomatic or mildly affected carriers in the families. DISCUSSION AND CONCLUSION: PROKR2 dominance should be kept in mind as a very rare cause of GH deficiency and MPHD. Expressional variation or lack of penetrance may imply oligogenic inheritance or other environmental modifiers in individuals who are heterozygous carriers.
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- 2023
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10. Comparison of immunological, histological and oxidative effects of felbamate and levetiracetam in traumatic brain injury
- Author
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Bayhan, I, TURTAY, MUHAMMET GÖKHAN, ÇİFTÇİ, OSMAN, ÇETİN, AYMELEK, Basak, N., ÖZTANIR, MUSTAFA NAMIK, OĞUZTÜRK, HAKAN, GÜRBÜZ, ŞÜKRÜ, Guven, T., and ÖZTANIR, MUSTAFA NAMIK
- Abstract
OBJECTIVE: We aimed to compare immunological, histological and oxidative effects of antiepileptic agents; felbamate and levetiracetam on head trauma in rats.
- Published
- 2020
11. Clinical and microbiological efficacy and toxicity of different dosages of colistin in critically patients: O411
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Yilmaz, G. R., Guner, R., Guven, T., Gulen, Aslan T., Kalem, Kaya A., and Tasyaran, M. A.
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- 2012
12. Characteristics of 117 malaria cases in Turkey
- Author
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Celikbas, A., Ergonul, O., Eren, S., Baykam, N., Guven, T., and Dokuzoguz, B.
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- 2004
13. Central nervous system infections in the absence of cerebrospinal fluid pleocytosis
- Author
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Erdem, H., Ozturk-Engin, D., Cag, Y., Senbayrak, S., Inan, A., Kazak, E., Savasci, U., Elaldi, N., Vahaboglu, H., Hasbun, R., Nechifor, M., Tireli, H., Kilicoglu, G., Defres, S., Gulsun, S., Ceran, N., Crisan, A., Johansen, I.S., Namiduru, M., Dayan, S., Kayabas, U., Parlak, E., Khalifa, A., Kursun, E., Sipahi, O.R., Yemisen, M., Akbulut, A., Bitirgen, M., Popovic, N., Kandemir, B., Luca, C., Parlak, M., Stahl, J.P., Pehlivanoglu, F., Simeon, S., Ulu-Kilic, A., Yasar, K., Yilmaz, G., Yilmaz, E., Beovic, B., Catroux, M., Lakatos, B., Sunbul, M., Oncul, O., Alabay, S., Sahin-Horasan, E., Kose, S., Shehata, G., Andre, K., Dragovac, G., Gul, H.C., Karakas, A., Chadapaud, S., Hansmann, Y., Harxhi, A., Kirova, V., Masse-Chabredier, I., Oncu, S., Sener, A., Tekin, R., Deveci, O., Ozkaya, H.D., Karabay, O., Agalar, C., Gencer, S., Karahocagil, M.K., Karsen, H., Kaya, S., Pekok, A.U., Celen, M.K., Deniz, S., Ulug, M., Demirdal, T., Guven, T., Bolukcu, S., Avci, M., Nayman-Alpat, S., Yaşar, K., Pehlivanoʇlu, F., Ates-Guler, S., Mutlu-Yilmaz, E., Tosun, S., Sirmatel, F., Batirel, A., Öztoprak, N., Kadanali, A., Turgut, H., Baran, A.I., Karaahmetoglu, G., Sunnetcioglu, M., Haykir-Solay, A., Denk, A., Ayaz, C., Gorenek, L., Larsen, L., Poljak, M., Barsic, B., Argemi, X., Sørensen, S.M., Bohr, A.L., Tattevin, P., Gunst, J.D., Baštáková, L., Jereb, M., Chehri, M., Beraud, G., Del Vecchio, R.F., Maresca, M., Yilmaz, H., Sharif-Yakan, A., Kanj, S.S., Korkmaz, F., Komur, S., Coskuner, S.A., Ince, N., Akkoyunlu, Y., Halac, G., Nemli, S.A., Ak, O., Gunduz, A., Gozel, M.G., Hatipoglu, M., Cicek-Senturk, G., Akcam, F.Z., Inkaya, A.C., Sagmak-Tartar, A., Ersoy, Y., Tuncer-Ertem, G., Balkan, I.I., Cetin, B., Ersoz, G., Ozgunes, N., Yesilkaya, A., Erturk, A., Gundes, S., Turhan, V., Yalci, A., Aydin, E., Diktas, H., Ulcay, A., Seyman, D., and Leblebicioglu, H.
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protein cerebrospinal fluid level ,Male ,pleocytosis ,Meningitis, Pneumococcal ,Leukocytosis ,herpes simplex encephalitis ,CSF ,Leukocyte ,brucella meningitis ,Article ,cerebrospinal fluid ,clinical feature ,female ,Central Nervous System Infections ,tuberculous meningitis ,Tuberculosis, Meningeal ,central nervous system infection ,middle aged ,neurosyphilis ,Encephalitis ,Humans ,pathology ,Meningitis ,human ,pneumococcal meningitis - Abstract
Previous multicenter/multinational studies were evaluated to determine the frequency of the absence of cerebrospinal fluid pleocytosis in patients with central nervous system infections, as well as the clinical impact of this condition. It was found that 18% of neurosyphilis, 7.9% of herpetic meningoencephalitis, 3% of tuberculous meningitis, 1.7% of Brucella meningitis, and 0.2% of pneumococcal meningitis cases did not display cerebrospinal fluid pleocytosis. Most patients were not immunosuppressed. Patients without pleocytosis had a high rate of unfavorable outcomes and thus this condition should not be underestimated. © 2017 The Author(s)
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- 2017
14. Comparison of immunological, histological and oxidative effects of felbamate and levetiracetam in traumatic brain injury.
- Author
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BAYHAN, I., TURTAY, M. G., CIFTCI, O., CETIN, A., BASAK, N., OZTANIR, M. NAMIK, OGUZTURK, H., GURBUZ, S., and GUVEN, T.
- Abstract
OBJECTIVE: We aimed to compare immunological, histological and oxidative effects of antiepileptic agents; felbamate and levetiracetam on head trauma in rats. MATERIALS AND METHODS: In this study, 32 Sprague-Dawley genus male rats were used. A closed head trauma mechanism was constituted in order to perform head trauma in rats. Rats were divided into 4 groups, and each group had 8 rats. Following head trauma, Group 1 (Control); normal saline was administered, Group 2; levetiracetam 50 mg/kg was administered, Group 3; felbamate 100 mg/kg was administered, and Group 4; levetiracetam 50 mg/kg and felbamate 100 mg/kg were administered with a combination. Injections were administered intraperitoneally once a day for 20 days. The rats were decapitated at the end of the 20th day. Blood and tissue samples were collected and analyzed for biochemical, immunohistochemical and histological parameters. RESULTS: Serum cytokine levels in Group 2, 3 and 4 were lower when compared to the control group. In Group 4, in which combined therapy was performed, cytokine levels were found to be the lowest. In Groups 2 and 3, a significant decrease in vascular congestion, mononuclear cell infiltration, hemorrhage, and neural degeneration was noticed in the pia mater. In Group 2, a decrease in vascular congestion and Purkinje cell degeneration was obtained in the cerebellum. However, the best outcomes were determined in Group 4. CONCLUSIONS: We determined that levetiracetam and felbamate alone are useful with respect to immunological, oxidative and histological alterations. However, their utility is better when used in a combination. [ABSTRACT FROM AUTHOR]
- Published
- 2020
15. Effect of Screw Speed, Drawing Ratio and PET Concentration on the Properties of PET/PP Blends
- Author
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Gokgoz Erkoc, I., primary, Guven, T., additional, Yildirim, F., additional, Sözer, M., additional, and Güner, F., additional
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- 2018
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16. Clinical and bi-genomic DNA findings of patients suspected to have mitochondrial diseases
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Asuman Gedikbasi, Guven Toksoy, Meryem Karaca, Cagri Gulec, Mehmet Cihan Balci, Dilek Gunes, Seda Gunes, Ayca Dilruba Aslanger, Gokcen Unverengil, Birsen Karaman, Seher Basaran, Mubeccel Demirkol, Gulden Fatma Gokcay, and Zehra Oya Uyguner
- Subjects
mitochondrial diseases ,mtDNA ,bi-genomic sequencing ,exome sequencing ,differential diagnosis ,Genetics ,QH426-470 - Abstract
Background: Mitochondrial diseases are the most common group of inherited metabolic disorders, causing difficulties in definite diagnosis due to clinical and genetic heterogeneity. Clinical components are predominantly associated with pathogenic variants shown in nuclear or mitochondrial genomes that affect vital respiratory chain function. The development of high-throughput sequencing technologies has accelerated the elucidation of the genetic etiology of many genetic diseases that previously remained undiagnosed.Methods: Thirty affected patients from 24 unrelated families with clinical, radiological, biochemical, and histopathological evaluations considered for mitochondrial diseases were investigated. DNA isolated from the peripheral blood samples of probands was sequenced for nuclear exome and mitochondrial DNA (mtDNA) analyses. MtDNA sequencing was also performed from the muscle biopsy material in one patient. For segregation, Sanger sequencing is performed for pathogenic alterations in five other affected family members and healthy parents.Results: Exome sequencing revealed 14 different pathogenic variants in nine genes encoding mitochondrial function peptides (AARS2, EARS2, ECHS1, FBXL4, MICOS13, NDUFAF6, OXCT1, POLG, and TK2) in 12 patients from nine families and four variants in genes encoding important for muscle structure (CAPN3, DYSF, and TCAP) in six patients from four families. Three probands carried pathogenic mtDNA variations in two genes (MT-ATP6 and MT-TL1). Nine variants in five genes are reported for the first time with disease association: (AARS2: c.277C>T/p.(R93*), c.845C>G/p.(S282C); EARS2: c.319C>T/p.(R107C), c.1283delC/p.(P428Lfs*); ECHS1: c.161G>A/p.(R54His); c.202G>A/p.(E68Lys); NDUFAF6: c.479delA/p.(N162Ifs*27); and OXCT1: c.1370C>T/p.(T457I), c.1173-139G>T/p.(?).Conclusion: Bi-genomic DNA sequencing clarified genetic etiology in 67% (16/24) of the families. Diagnostic utility by mtDNA sequencing in 13% (3/24) and exome sequencing in 54% (13/24) of the families prioritized searching for nuclear genome pathologies for the first-tier test. Weakness and muscle wasting observed in 17% (4/24) of the families underlined that limb-girdle muscular dystrophy, similar to mitochondrial myopathy, is an essential point for differential diagnosis. The correct diagnosis is crucial for comprehensive genetic counseling of families. Also, it contributes to making treatment-helpful referrals, such as ensuring early access to medication for patients with mutations in the TK2 gene.
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- 2023
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17. Lu doping nickel oxide thin films using sol-gel spin coated and density functional theory: optoelectronic and magnetic properties
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Souraya Goumri-Said, Güven Turgut, and Mohammed Benali Kanoun
- Subjects
NiO ,Spin coating ,Lu-doping ,Electronic structure ,DFT+U ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
For the first time, sol-gel spin coating was used to fabricate thin films of NiO doped with lutetium. The films were characterized to determine their crystalline structure, surface morphology, and optical properties as a function of Lu doping concentration. The investigations revealed that the Lu-doped NiO films consisted of nano-polycrystalline particles with a cubic bunsenite structure and (200) preferential orientation. Optical studies indicated that the optical band gap of pure NiO widened with low levels of Lu incorporation before narrowing with higher concentrations. The Urbach energy value for pure NiO initially decreased with 1 at. % Lu-content, from 224 meV to 190 meV, and then continuously increased to 380 meV with more Lu-level. To investigate the effects of Lu doping on the electronics, magnetic, and optical properties of NiO, first-principle computations were performed. The results showed that bulk magnetization underwent significant modifications due to a high hybridization between the Lu-f/d and Ni-d states. This study suggests that NiO doped with lutetium could be used for spin-polarized transport devices and other spin-dependent applications.
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- 2023
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18. EFFICACY OF COLISTIN AND NON-COLISTIN MONOTHERAPIES IN MULTI-DRUG RESISTANT ACINETOBACTER BAUMANNII BACTEREMIA/SEPSIS
- Author
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OĞUZ KARABAY, Batirel, A., Balkan, I. I., Agalar, C., Akalin, S., Alici, O., Alp, E., Alta, F. A., Altin, N., Arslan, F., Aslan, T., Bekiroglu, N., Cesur, S., Celik, A. D., Dogan, M., Durdu, B., Duygu, F., Engin, A., Engin, D. O., Gonen, I., Guclu, E., Guven, T., Hatipoglu, C. A., Hosoglu, S., Karahocagil, M., Kilic, A. U., Ormen, B., Ozdemir, D., Ozer, S., Oztoprak, N., Sezak, N., Turhan, V., Turker, N., Yilmaz, H., Karabay, O, Batirel, A, Balkan, II, Agalar, C, Akalin, S, Alici, O, Alp, E, Alta, FA, Altin, N, Arslan, F, Aslan, T, Bekiroglu, N, Cesur, S, Celik, AD, Dogan, M, Durdu, B, Duygu, F, Engin, A, Engin, DO, Gonen, I, Guclui, E, Guven, T, Hatipoglu, CA, Hosoglu, S, Karahocagil, M, Kilic, AU, Ormen, B, Ozdemir, D, Ozer, S, Oztoprak, N, Sezak, N, Turhan, V, Turker, N, Yilmaz, H, Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü, Karabay, Oğuz, [Karabay, Oguz] Sakarya Univ, Hlth Sci Inst, Infect Dis & Clin Microbiol, TR-54000 Sakarya, Turkey -- [Batirel, Ayse] Kartal Dr Lutfi Kirdar Educ & Res Hosp, Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Balkan, Ilker Inanc -- Ozer, Serdal] Istanbul Univ, Cerrahpasa Med Fac, Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Agalar, Canan -- Alici, Ozlem] Fatih Sultan Mehmet Educ & Res Hosp, Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Akalin, Serife] Pamukkale Univ, Fac Med, Infect Dis & Clin Microbiol, Denizli, Turkey -- [Alp, Emine -- Kilic, Aysegul Ulu] Erciyes Univ, Fac Med, Infect Dis & Clin Microbiol, Kayseri, Turkey -- [Alta, F. Aybala] Diskapi Educ & Res Hosp, Infect Dis & Clin Microbiol, Ankara, Turkey -- [Altin, N. -- Cesur, Salim] Ankara Etlik Educ & Res Hosp, Infect Dis & Clin Microbiol, Ankara, Turkey -- [Arslan, Ferhat] Istanbul Medipol Univ, Fac Med, Infect Dis, Istanbul, Turkey -- [Aslan, Turan] Bezmi Alem Univ, Fac Med, Infect Dis, Istanbul, Turkey -- [Bekiroglu, Nural] Marmara Univ, Fac Med, Biostat, Istanbul, Turkey -- [Celik, Aygul Dogan] Trakya Univ, Fac Med, Infect Dis, Edirne, Turkey -- [Dogan, Mustafa] Namik Kemal Univ, Fac Med, Infect Dis & Clin Microbiol, Tekirdag, Turkey -- [Durdu, Bulent] Bakirkoy Sadi Konuk Educ & Res Hosp, Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Duygu, Fazilet] Gaziosmanpasa Univ, Fac Med, Infect Dis & Clin Microbiol, Tokat, Turkey -- [Engin, Aynur] Cumhuriyet Univ, Fac Med, Infect Dis & Clin Microbiol, Sivas, Turkey -- [Engin, Derya Ozturk] Haydarpasa Numune Educ & Res Hosp, Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Gonen, Ibak] Suleyman Demirel Univ, Fac Med, Infect Dis & Clin Microbiol, TR-32200 Isparta, Turkey -- [Guven, Tumer] Ankara Ataturk Educ & Res Hosp, Infect Dis & Clin Microbiol, Ankara, Turkey -- [Hatipoglu, Cigdem Ataman] Ankara Educ & Res Hosp, Infect Dis & Clin Microbiol, Ankara, Turkey -- [Hosoglu, Salih] Dicle Univ, Fac Med, Infect Dis & Clin Microbiol, Diyarbakir, Turkey -- [Karahocagil, Mustafa] Yuzuncu Yil Univ, Fac Med, Infect Dis & Clin Microbiol, Van, Turkey -- [Ormen, Bahar] Izmir Ataturk Educ & Res Hosp, Infect Dis & Clin Microbiol, Izmir, Turkey -- [Ozdemir, Davut -- Sezak, Nurbanu -- Turker, N.] Duzce Univ, Educ & Res Hosp, Infect Dis & Clin Microbiol, Duzce, Turkey -- [Oztoprak, Nefise] Antalya Educ & Res Hosp, Infect Dis & Clin Microbiol, Antalya, Turkey -- [Turhan, Vedat] GATA Haydarpasa Educ & Res Hosp, Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Yilmaz, Hava] Ondokuz Mayis Univ, Fac Med, Infect Dis & Clin Microbiol, Samsun, Turkey, Karabay, Oguz -- 0000-0003-0502-432X, and DURDU, BÜLENT
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Acinetobacter infection ,Acinetobacter baumannii ,antibiotic resistance ,drug safety ,loading drug dose ,creatinine blood level ,Gram negative sepsis ,retrospective study ,Bacteremia ,blood culture ,intensive care unit ,mental disease ,sepsis ,meropenem ,polycyclic compounds ,cefoperazone plus sulbactam ,colistin ,APACHE ,adult ,nephrotoxicity ,creatinine ,Multi-Drug Resistant ,neurologic disease ,female ,risk factor ,monotherapy ,multicenter study (topic) ,disease severity ,tertiary care center ,lipids (amino acids, peptides, and proteins) ,tigecycline ,pathogen clearance ,Charlson Comorbidity Index ,seizure ,multi-drug resistant ,minimum inhibitory concentration ,piperacillin plus tazobactam ,visual disorder ,Article ,vertigo ,male ,multidrug resistance ,Sepsis ,Karabay O., BATIREL A., Balkan I. I. , AGALAR C., Akalin S., ALICI O., Alp E., ALTA F. A. , ALTIN N., Arslan F., et al., -EFFICACY OF COLISTIN AND NON-COLISTIN MONOTHERAPIES IN MULTI-DRUG RESISTANT ACINETOBACTER BAUMANNII BACTEREMIA/SEPSIS-, ACTA MEDICA MEDITERRANEA, cilt.30, ss.1137-1143, 2014 ,follow up ,controlled study ,human ,bacteremia ,treatment duration ,Colistin ,ataxia ,biochemical phenomena, metabolism, and nutrition ,Monotherapy ,bacterial infections and mycoses ,major clinical study ,multi drug resistant acinetobacter baumannii bacteremia ,drug efficacy ,treatment outcome ,bacteria ,Acinetobacter Baumannii ,imipenem - Abstract
WOS: 000364114800027, Objective: This retrospective study aimed to investigate the efficacies of colistin and non-colistin monotherapies in multi-drug resistant Acinetobacter baumannii bacteremia (MDR-AB). Materials and methods: Cases with MDR-AB from 27 tertiary-referral hospitals between January 2009 and December 2012 were included. Patients' data that were on either colistin monotherapy (CM) or non-colistin monotherapy (NCM) were compared. Mortality on Day 14 was the primary endpoint, whereas microbiological eradication and clinical outcome were the secondary ones. Results: Eighty-four cases were included in the study with 36 being in the CM group and 48 in the NCM group. Thirty-eight (452%) cases were male and the mean age was 602 years. The mean durations of pre-MDR-AB hospital stay and intensive care unit stay were 25.8 days and 20.9 days, respectively. All of the cases had fever (>38 degrees C). The mean Pitt bacteremia score (PBS) of the patients was calculated as 6.8, APACHE 2 score as 18.9 and the Charlson co-morbidity index (CCI) as 3.7 (CM: 3.6 vs. NCM: 3.9). Twenty (55.6%) cases in the CM group and 26 cases in the NCM group (542%) (p=0.81) died; 9 cases in the CM group (25%) and 16 cases in the NCM group (33 3%) had treatment failure (P=0.55). Bacteriological eradication was achieved in 20 (55.6%) cases in the CM group and in 36 cases (75%) in the NCM group (P=0.061). Conclusions: No significant difference could be identified between the colistin monotherapy and non-colistin monotherapy options in MDR-AB cases with respect to the results of efficacy and 14-day mortality.
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- 2014
19. study
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Erdem, H, Senbayrak, S, Meric, K, Batirel, A, Karahocagil, MK, Hasbun, R, Sengoz, G, Karsen, H, Kaya, S, Inal, AS, Pekok, AU, Celen, MK, Deniz, S, Ulug, M, Demirdal, T, Namiduru, M, Tekin, R, Guven, T, Parlak, E, Bolukcu, S, Avci, M, Sipahi, OR, Ozturk-Engin, D, Yasar, K, Pehlivanoglu, F, Yilmaz, E, Ates-Guler, S, Mutlu-Yilmaz, E, Tosun, S, Sirmatel, F, Sahin-Horasan, E, Akbulut, A, Oztoprak, N, Cag, Y, Kadanali, A, Turgut, H, Baran, AI, Gul, HC, Sunnetcioglu, M, Haykir-Solay, A, Denk, A, Inan, A, Ayaz, C, Ulcay, A, Kose, S, Agalar, C, and Elaldi, N
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Diagnosis ,Inflammation ,Neurobrucellosis ,Computerized tomography ,Magnetic resonance imaging - Abstract
Objective Neuroimaging abnormalities in central nervous system (CNS) brucellosis are not well documented. The purpose of this study was to evaluate the prevalence of imaging abnormalities in neurobrucellosis and to identify factors associated with leptomeningeal and basal enhancement, which frequently results in unfavorable outcomes. Methods Istanbul-3 study evaluated 263 adult patients with CNS brucellosis from 26 referral centers and reviewed their 242 magnetic resonance imaging (MRI) and 226 computerized tomography (CT) scans of the brain. Results A normal CT or MRI scan was seen in 143 of 263 patients (54.3 %). Abnormal imaging findings were grouped into the following four categories: (a) inflammatory findings: leptomeningeal involvements (44), basal meningeal enhancements (30), cranial nerve involvements (14), spinal nerve roots enhancement (8), brain abscesses (7), granulomas (6), and arachnoiditis (4). (b) White-matter involvement: white-matter involvement (32) with or without demyelinating lesions (7). (c) Vascular involvement: vascular involvement (42) mostly with chronic cerebral ischemic changes (37). (d) Hydrocephalus/cerebral edema: hydrocephalus (20) and brain edema (40). On multivariate logistic regression analysis duration of symptoms since the onset (OR 1.007; 95 % CI 1-28, p = 0.01), polyneuropathy and radiculopathy (OR 5.4; 95 % CI 1.002-1.013, p = 0.044), cerebrospinal fluid (CSF)/serum glucose rate (OR 0.001; 95 % CI 000-0.067, p = 0.001), and CSF protein (OR 2.5; 95 % CI 2.32.7, p = 0.0001) were associated with diffuse inflammation. Conclusions In this study, 45 % of neurobrucellosis patients had abnormal neuroimaging findings. The duration of symptoms, polyneuropathy and radiculopathy, high CSF protein level, and low CSF/serum glucose rate were associated with inflammatory findings on imaging analyses.
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- 2016
20. Mutations in AR or SRD5A2 Genes: Clinical Findings, Endocrine Pitfalls, and Genetic Features of Children with 46,XY DSD
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Neşe Akcan, Oya Uyguner, Firdevs Baş, Umut Altunoğlu, Güven Toksoy, Birsen Karaman, Şahin Avcı, Zehra Yavaş Abalı, Şükran Poyrazoğlu, Agharza Aghayev, Volkan Karaman, Rüveyde Bundak, Seher Başaran, and Feyza Darendeliler
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46 ,xy disorders of sex development ,5α ,-reductase deficiency ,androgen insensitivity syndrome ,androgen receptor gene mutations ,srd5a2 gene mutations ,Pediatrics ,RJ1-570 ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
INTRODUCTION: Objective: Androgen insensivity syndrome (AIS) and 5α-reductase deficiency (5α-RD) present with indistinguishable phenotypes among the 46,XY disorders of sexual development (DSD) that usually necessitate molecular analyses for the definitive diagnosis in the prepubertal period. The aim was to evaluate the clinical, hormonal and genetic findings of 46,XY DSD patients who were diagnosed as AIS or 5α-RD. METHODS: Methods: Patients diagnosed as AIS or 5α-RD according to clinical and hormonal evaluations were investigated. Sequence variants of steroid 5-α-reductase type 2 were analyzed in cases with testosterone/dihydrotestosterone (T/DHT) ratio of ≥20, whereas the androgen receptor (AR) gene was screened when the ratio was T, p.Glu32*, c.330G>C, p.Leu110=; c.2084C>T, p.Pro695Leu, c.2585_2592delAGCTCCTG, p.(Lys862Argfs*16), of these c.330G>C with silent status remained undefined in terms of its causative effects. DISCUSSION AND CONCLUSION: Conclusion: T/DHT ratio is an important hormonal criterion, but in some cases, T/DHT ratio may lead to diagnostic confusion. Molecular diagnosis is important for the robust diagnosis of 46,XY DSD patients. Four novel AR variants were identified in our study.
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- 2022
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21. The course of spinal tuberculosis (Pott disease): results of the multinational, multicentre Backbone-2 study
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Batirel, A. Erdem, H. Sengoz, G. Pehlivanoglu, F. and Ramosaco, E. Gulsun, S. Tekin, R. Mete, B. Balkan, I. I. and Sevgi, D. Y. Giannitsioti, E. Fragou, A. Kaya, S. and Cetin, B. Oktenoglu, T. Celik, A. D. Karaca, B. Horasan, E. S. Ulug, M. Senbayrak, S. Kaya, S. Arslanalp, E. and Hasbun, R. Ates-Guler, S. Willke, A. Senol, S. Inan, D. and Guclu, E. Ertem, G. T. Koc, M. M. Tasbakan, M. Ocal, G. Kocagoz, S. Kusoglu, H. Guven, T. Baran, A. I. and Dede, B. Karadag, F. Y. Yilmaz, H. Aslan, G. Al-Gallad, D. A. Cesur, S. El-Sokkary, R. Sirmatel, F. Savasci, U. and Karaahmetoglu, G. Vahaboglu, H.
- Abstract
We aimed to describe clinical, laboratory, diagnostic and therapeutic features of spinal tuberculosis (ST), also known as Pott disease. A total of 314 patients with ST from 35 centres in Turkey, Egypt, Albania and Greece were included. Median duration from initial symptoms to the time of diagnosis was 78 days. The most common complications presented before diagnosis were abscesses (69%), neurologic deficits (40%), spinal instability (21%) and spinal deformity (16%). Lumbar (56%), thoracic (49%) and thoracolumbar (13%) vertebrae were the most commonly involved sites of infection. Although 51% of the patients had multiple levels of vertebral involvement, 8% had noncontiguous involvement of multiple vertebral bodies. The causative agent was identified in 41% of cases. Histopathologic examination was performed in 200 patients (64%), and 74% were consistent with tuberculosis. Medical treatment alone was implemented in 103 patients (33%), while 211 patients (67%) underwent diagnostic and/or therapeutic surgical intervention. Ten percent of the patients required more than one surgical intervention. Mortality occurred in 7 patients (2%), and 77 (25%) developed sequelae. The distribution of the posttreatment sequelae were as follows: 11% kyphosis, 6% Gibbus deformity, 5% scoliosis, 5% paraparesis, 5% paraplegia and 4% loss of sensation. Older age, presence of neurologic deficit and spinal deformity were predictors of unfavourable outcome. ST results in significant morbidity as a result of its insidious course and delayed diagnosis because of diagnostic and therapeutic challenges. ST should be considered in the differential diagnosis of patients with vertebral osteomyelitis, especially in tuberculosis-endemic regions. Early establishment of definitive aetiologic diagnosis and appropriate treatment are of paramount importance to prevent development of sequelae. Clinical Microbiology and Infection (C) 2015 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
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- 2015
22. Tuberculous and brucellosis meningitis differential diagnosis
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Erdem H, Senbayrak S, Gencer S, Hasbun R, Karahocagil MK, Sengoz G, Karsen H, Kaya S, Civljak R, Inal AS, Pekok AU, Celen MK, Deniz S, Ulug M, Demirdal T, Namiduru M, Tekin R, Guven T, Parlak E, Bolukcu S, Avci M, Sipahi OR, Nayman-Alpat S, Yaşar K, Pehlivanoğlu F, Yilmaz E, Ates-Guler S, Mutlu-Yilmaz E, Tosun S, Sirmatel F, Şahin-Horasan E, Akbulut A, Johansen IS, Simeon S, Batirel A, Öztoprak N, Cag Y, Catroux M, Hansmann Y, Kadanali A, Turgut H, Baran AI, Gul HC, Karaahmetoglu G, and Sunnetcioglu
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Adult ,Brucellosis/*diagnosis/epidemiology ,Diagnosis, Differential ,Female ,Humans ,Male ,Meningitis, Bacterial/diagnosis/epidemiology ,Middle Aged ,Retrospective Studies ,Tuberculosis, Meningeal/*diagnosis/epidemiology ,Turkey ,Young Adult ,urologic and male genital diseases - Abstract
BACKGROUND: The Thwaites and Lancet scoring systems have been used in the rapid diagnosis of tuberculous meningitis (TBM). However, brucellar meningoencephalitis (BME) has similar characteristics with TBM. The ultimate aim of this study is to infer data to see if BME should be included in the differential diagnosis of TBM when these two systems suggest the presence of TBM. METHOD: BME and TBM patients from 35 tertiary hospitals were included in this study. Overall 294 adult patients with BME and 190 patients with TBM were enrolled. All patients involved in the study had microbiological confirmation for either TBM or BME. Finally, the Thwaites and Lancet scoring systems were assessed in both groups. RESULTS: The Thwaites scoring system more frequently predicted BME cases (n = 292, 99.3%) compared to the TBM group (n = 182, 95.8%) (P = 0.017). According to the Lancet scoring system, the mean scores for BME and TBM were 9.43 ± 1.71 and 11.45 ± 3.01, respectively (P < 0.001). In addition, TBM cases were classified into "probable" category more significantly compared to BME cases, and BME cases were categorized into the "possible" category more frequently. CONCLUSIONS: When the Thwaites or Lancet scoring systems indicate TBM, brucellar etiology should also be taken into consideration particularly in endemic countries.
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- 2015
23. Comparison of brucellar and tuberculous spondylodiscitis patients: Results of the multicenter 'backbone-1 Study'
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Erdem, H. Elaldi, N. Batirel, A. Aliyu, S. Sengoz, G. Pehlivanoglu, F. Ramosaco, E. Gulsun, S. Tekin, R. Mete, B. Balkan, I.I. Sevgi, D.Y. Giannitsioti, E. Fragou, A. Kaya, S. Cetin, B. Oktenoglu, T. Dogancelik, A. Karaca, B. Horasan, E.S. Ulug, M. Inan, A. Kaya, S. Arslanalp, E. Ates-Guler, S. Willke, A. Senol, S. Inan, D. Guclu, E. Tuncer-Ertem, G. Meric-Koc, M. Tasbakan, M. Senbayrak, S. Cicek-Senturk, G. Sirmatel, F. Ocal, G. Kocagoz, S. Kusoglu, H. Guven, T. Baran, A.I. Dede, B. Yilmaz-Karadag, F. Kose, S. Yilmaz, H. Aslan, G. Algallad, D.A. Cesur, S. El-Sokkary, R. Bekiroǧlu, N. Vahaboglu, H.
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endocrine system - Abstract
Background Context No direct comparison between brucellar spondylodiscitis (BSD) and tuberculous spondylodiscitis (TSD) exists in the literature. Purpose This study aimed to compare directly the clinical features, laboratory and radiological aspects, treatment, and outcome data of patients diagnosed as BSD and TSD. Study Design A retrospective, multinational, and multicenter study was used. Patient Sample A total of 641 (TSD, 314 and BSD, 327) spondylodiscitis patients from 35 different centers in four countries (Turkey, Egypt, Albania, and Greece) were included. Outcome Measures The pre- and peri- or post-treatment spinal deformity and neurologic deficit parameters, and mortality were carried out. Methods Brucellar spondylodiscitis and TSD groups were compared for demographics, clinical, laboratory, radiological, surgical interventions, treatment, and outcome data. The Student t test and Mann-Whitney U test were used for group comparisons. Significance was analyzed as two sided and inferred at 0.05 levels. Results The median baseline laboratory parameters including white blood cell count, C-reactive protein, and erythrocyte sedimentation rate were higher in TSD than BSD (p
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- 2015
24. Comparison of colistin monotherapy and non-colistin combinations in the
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Balkan, II, Batirel, A, Karabay, O, Agalar, C, Akalin, S, Alici, O, Alp, E, Altay, FA, Altin, N, Arslan, F, Aslan, T, Bekiroglu, N, Cesur, S, Celik, AD, Dogan, M, Durdu, B, Duygu, F, Engin, A, Engin, DO, Gonen, I, Guciu, E, Guven, T, Hatipogiu, CA, Hosoglu, S, Karahocagil, MK, Kilic, AU, Ormen, B, Ozdemir, D, Ozer, S, Oztoprak, N, Sezak, N, Turhan, V, Turker, N, and Yilmaz, H
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Acinetobacter spp ,Blood stream infection ,colistin ,monotherapy ,multi drug resistant - Abstract
Objectives: To compare the efficacy of colistin (COL) monotherapy versus non-COL based combinations in the treatment of bloodstream infections (BSIs) due to multidrug resistant Acinetobacter spp.(MDR-A) . Materials and Methods: Retrospective data of 107 MDR-A BSI cases from 27 tertiary centers in Turkey were included. Primary End-Point: 14-day mortality. Secondary End-Points: Microbial eradication and clinical improvement. Results: Thirty-six patients in the COL monotherapy (CM) group and 71 in the non-COL based combinations (NCC) group were included in the study. Mean age was 59.98 20 years (range: 18-89) and 50.5% were male. Median duration of follow-up was 40 days (range: 9-297). The 14-day survival rates were 52.8% in CM and 47.23% in NCC group (P = 0.36). Microbiological eradication was achieved in 69% of CM and 83% of NCC group (P = 0.13). Treatment failure was detected in 22.9% of cases in both CM and NCC groups. Univariate analysis revealed that mean age (P = 0.001), Charlson comorbidity index (P = 0.03), duration of hospital stay before MDR-A BSI (P = 0.04), Pitt bacteremia score (P = 0.043) and Acute Physiology and Chronic Health Evaluation II score (P = 0.05) were significant in terms of 14-day mortality. Advanced age (P = 0.01) and duration of hospital stay before MDR-A BSI (P = 0.04) were independently associated with 14-day mortality in multivariate analysis. Conclusion: No significant difference was detected between CM and non-COL based combinations in the treatment of MDR-A BSIs in terms of efficacy and 14-day mortality.
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- 2015
25. A Large-scale Pilot Breast Cancer Screening Program: Findings and Recommendations for National Screening Programs
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Abdullah Emre Guner, Aral Surmeli, Guven Turan, Kemal Kural, Engin Ersin Simsek, and Isil Maral
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breast cancer screening ,imaging ,mammography ,screening ,Medicine ,Medicine (General) ,R5-920 - Abstract
Aim:Breast cancer is the most prevalent cancer diagnosed in women. Screening programs to diagnose breast anomalies increase the likelihood of early diagnosis and survival. This study describes the most extensive breast cancer screening program in Istanbul/Turkey between 2018 and 2019 and offers recommendations for nationwide programs.Methods:We collected data from the Istanbul Health Directorate’s cancer surveillance database from May 2018 to December 2019. We analyzed data on patients referred for further investigation due to suspicion of possible tumors in their screening radiography. The database included socio-demographic information and further examination details (tests, outcomes, and planned treatment).Results:The mean age of the 3,577 women who were invited for further examination was 52.3 [standard deviation (SD): 7.5]. The age group with the highest percentage of further investigation invitations was between 50 and 54. The mean time between the results of screening mammography was 16.2 days (SD: 15.3). 5.1% of the women referred were diagnosed with some sort of cancer. Women who went to the place of scheduled appointments, instead of getting an appointment in another place of their choosing, were diagnosed and treated earlier.Conclusion:For a breast screening program to reach the entirety of the target population, a comprehensive approach to every step of the process (screening, diagnosis, treatment) needs to be considered together.
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- 2022
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26. Turkey
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Kutlu, M, Ergonul, O, Sayin-Kutlu, S, Guven, T, Ustun, C, Alp-Cavus, S, Ozturk, SB, Acicbe, O, Akalin, S, Tekin, R, Tekin-Koruk, S, Demiroglu, YZ, Keskiner, R, Gonen, I, Sapmaz-Karabag, S, Bosnak, V, and Kazak, E
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analysis ,Vaccine related brucellosis ,Veterinarians ,Zoonotic ,Brucella ,Occupational health ,Retrospective cohort study ,Risk ,infections - Abstract
Veterinarians and veterinary technicians are at risk for occupational brucellosis. We described the risk factors of occupational brucellosis among veterinary personnel in Turkey. A multicenter retrospective survey was performed among veterinary personnel who were actively working in the field. Of 712 veterinary personnel, 84(11.8%) had occupational brucellosis. The median number of years since graduation was 7 (interquartile ranges [IQR], 4-11) years in the occupational brucellosis group, whereas this number was 9 (IQR, 4-16) years in the non-brucellosis group (p < 0.001). In multivariable analysis, working in the private sector (odds ratio [OR], 2.8; 95% confidence interval [95% CI], 1.55-5.28, p = 0.001), being male (OR, 4.5; 95% CI, 1.05-18.84, p = 0.041), number of performed deliveries (OR, 1.01; 95% CI, 1.002-1.02, p = 0.014), and injury during Brucella vaccine administration (OR, 5.4; 95% CI, 3.16-9.3, p < 0.001) were found to be risk factors for occupational brucellosis. We suggest that all veterinary personnel should be trained on brucellosis and the importance of using personal protective equipment in order to avoid this infection. (C) 2014 Elsevier B.V. All rights reserved.
- Published
- 2014
27. EFFICACY OF COLISTIN AND NON-COLISTIN MONOTHERAPIES IN MULTI-DRUG
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Karabay, O, Batirel, A, Balkan, II, Agalar, C, Akalin, S, Alici, O, Alp, E, Alta, FA, Altin, N, Arslan, F, Aslan, T, Bekiroglu, N, Cesur, S, Celik, AD, Dogan, M, Durdu, B, Duygu, F, Engin, A, Engin, DO, Gonen, I, Guclui, E, Guven, T, Hatipoglu, CA, Hosoglu, S, Karahocagil, M, Kilic, AU, Ormen, B, Ozdemir, D, Ozer, S, Oztoprak, N, Sezak, N, Turhan, V, Turker, N, and Yilmaz, H
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resistant ,sepsis ,Acinetobacter baumannii ,bacteremia ,colistin ,monotherapy ,multi-drug - Abstract
Objective: This retrospective study aimed to investigate the efficacies of colistin and non-colistin monotherapies in multi-drug resistant Acinetobacter baumannii bacteremia (MDR-AB). Materials and methods: Cases with MDR-AB from 27 tertiary-referral hospitals between January 2009 and December 2012 were included. Patients' data that were on either colistin monotherapy (CM) or non-colistin monotherapy (NCM) were compared. Mortality on Day 14 was the primary endpoint, whereas microbiological eradication and clinical outcome were the secondary ones. Results: Eighty-four cases were included in the study with 36 being in the CM group and 48 in the NCM group. Thirty-eight (452%) cases were male and the mean age was 602 years. The mean durations of pre-MDR-AB hospital stay and intensive care unit stay were 25.8 days and 20.9 days, respectively. All of the cases had fever (>38 degrees C). The mean Pitt bacteremia score (PBS) of the patients was calculated as 6.8, APACHE 2 score as 18.9 and the Charlson co-morbidity index (CCI) as 3.7 (CM: 3.6 vs. NCM: 3.9). Twenty (55.6%) cases in the CM group and 26 cases in the NCM group (542%) (p=0.81) died; 9 cases in the CM group (25%) and 16 cases in the NCM group (33 3%) had treatment failure (P=0.55). Bacteriological eradication was achieved in 20 (55.6%) cases in the CM group and in 36 cases (75%) in the NCM group (P=0.061). Conclusions: No significant difference could be identified between the colistin monotherapy and non-colistin monotherapy options in MDR-AB cases with respect to the results of efficacy and 14-day mortality.
- Published
- 2014
28. Clinical and Molecular Genetic Findings of Cerebral Arteriopathy with Subcortical Infarcts and Leukoencephalopathy
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Burcu Sevinç Rüstemoğlu, Bedia Samanci, Fatih Tepgeç, Murat Kürtüncü, Umut Altunoglu, Tuncay Gündüz, Gözde Yeşil, Şahin Avcı, Hakan Gürvit, Başar Bilgiç, Güven Toksoy, Mefkure Eraksoy, Haşmet Hanağası, and Zehra Oya Uyguner
- Subjects
carasil ,cadasil ,autosomal dominant ,recessive ,notch3 ,htra1 ,Medicine ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Objective: Most lacunar strokes are sporadic, and hypertension, diabetes, smoking, and cardiovascular diseases are among its main risk factors. Strokes caused by small vessel diseases are generally associated with single-gene disorders with familial dominant and recessive inheritance. The most common condition is cerebral autosomal dominant arteriopathy, with subcortical infarcts and leukoencephalopathy (CADASIL), associated with the NOTCH3 gene. An infrequent form of this disease is the cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL), revealed with pathogenic HTRA1 gene variants related to distinct molecular pathways. The neurological and cranial magnetic resonance imaging (MRI) findings are very similar to CADASIL; however, earlier than expected onset of common alopecia in man, low back pain, and more severe memory impairment are the differences in terms of clinical presentations. Clinical findings of 22 patients from 16 families with widespread white matter lesions in the periventricular field in the brain were investigated with molecular genetic findings. Materials and Methods: Clinical examination results and cranial MRI findings are reported, and NOTCH3 and HTRA1 genes are sequenced stepwise by Sanger and next-generation sequencing techniques. Results: Missense changes in epidermal growth factor (EGF)-like domain in the NOTCH3 are found in 18 cases from 14 families. Two different homozygous pathogenic missense and non-sense variants, in the HTRA1 gene, were detected in four patients from two families. The disease onset age was approximately 16 years earlier in cases carrying pathogenic variants located in the encoding region of EGF-like domains 1-6 of NOTCH3. Conclusion: In the NOTCH3 gene with c.382T>C (p.C128R), c.555T>G (p.C185W), and c.1903C>T (p.R635C) and in the HTRA1 gene c.235C>T (p.Q79*) are presented for the first time in this study. Molecular genetic investigation of CADASIL and CARASIL is important to support the clinical diagnosis, determine the inheritance model, provide patient and family counseling, manage disease process, and evaluate possible treatment strategies.
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- 2021
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29. Effect of Screw Speed, Drawing Ratio and PET Concentration on the Properties of PET/PP Blends.
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ERKOC, I. GOKGOZ, GUVEN, T., YILDIRIM, F., SÖZER, M., and GÜNER, F.
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POLYETHYLENE terephthalate , *POLYMER blends , *MECHANICAL properties of polymers , *EXTRUSION process , *SCANNING electron microscopy - Abstract
The objective of this study is to investigate the influence of screw speed, drawing ratio and composition of blend on the morphology and the mechanical properties of extruded and drawn PET/PP blends. Samples were generated by a two-step process. Firstly, PET was dispersed in PP matrix at different extrusion screw speeds in order to determine optimum mixing condition, and then extrudates were stretched by a take up device. Final morphology and mechanical properties of the samples were examined using scanning electron microscopy, dynamic mechanical analysis, and a universal testing machine. The results showed that low screw speeds were not enough to distribute PET droplets homogeneously inside the matrix. With increasing of the screw speed more homogeneous phase morphology was obtained but further increase caused to agglomeration of PET droplets. Scanning electron microscopy images also showed that with increasing of draw ratio PET droplets changed from spherical to rod-like shape, and finally to microfibrils in matrix. It was also found that with increasing of concentration of PET and draw ratio, mechanical properties increased up to 6-7 times compared to non-oriented samples. [ABSTRACT FROM AUTHOR]
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- 2018
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30. Varicella zoster virus encephalitis in an immunocompetent woman
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Yilmaz, G.R., primary, Guven, T., additional, Demirturk, A., additional, Korukluoğlu, G., additional, Tufan, Z. Kocak, additional, Guner, R., additional, and Tasyaran, M., additional
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- 2014
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31. How fast we are? Consultation of and from infectious diseases department, a retrospective observational study
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Bekgoz, G., primary, Tufan, Z. Kocak, additional, Guven, T., additional, Guner, R., additional, Yilmaz, G.R., additional, and Tasyaran, M., additional
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- 2014
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32. Growing fungal etiology in catheter-associated urinary tract infection: 2008-2013
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Yilmaz, G.R., primary, Guven, T., additional, Guner, R., additional, Tufan, Z. Kocak, additional, Acikgoz, Z., additional, and Tasyaran, M., additional
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- 2014
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33. Evaluation of surgical prophylaxis in a tertiary care hospital in Turkey: Point prevalence results
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Guven, T., primary, Yilmaz, G.R., additional, Guner, R., additional, Keske, S., additional, Yapar, D., additional, Gulen, T. Arslan, additional, and Tasyaran, M., additional
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- 2014
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34. An investigation of the effects of photothrombosis and photocoagulation on corneal neovascularization
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Yel, M, Guven, T, Sobaci, G, and Ilker, SS
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genetic structures ,sense organs ,eye diseases - Abstract
This study reports on the intracellular effects of photocoagulation and photothrombosis applications on experimental corneal neovascularization created in rabbit eyes. Some vessels were left untreated as controls while others were subjected to argon laser photocoagulation and photothrombosis. The resulting ultrastructural changes, which take place relatively moderately in photocoagulation compared with those in photothrombosis, were responsible for the vessel blockage occurring at low energy levels in photothrombosis.
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- 1998
35. Protective role of antioxidant vitamins on adriamycin-induced free radical production and cardiotoxicity in guinea pigs
- Author
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Durak, I., HASAN SERDAR OZTURK, Kavutcu, M., Birey, M., Yel, M., Guven, T., Olcay, E., Kacmaz, M., and Canbolat, O.
- Subjects
carbohydrates (lipids) ,polycyclic compounds - Abstract
Guinea pigs were divided into three groups: control, adriamycin and adriamycin plus vitamin groups, and treated with physiological saline solution (control group), adriamycin (adriamycin group) and adriamycin plus vitamins E and C (adriamycin plus vitamin group). Activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) and concentrations of malondialdehyde (MDA), conjugated dienes (CD), hydroxyl radical (OH.) and iron were measured in heart and liver tissues of all animals. Electron microscopic analysis and free radical concentrations of all tissues were also carried out.
- Published
- 1998
36. When Organ Donation from Living Donors Serves as the Main Source of Organ Procurement: A Critical Examination of the Ethical and Legal Challenges to Turkey's Recent Efforts to Overcome Organ Shortage
- Author
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Sert, G., primary, Guven, T., additional, and Gorkey, S., additional
- Published
- 2013
- Full Text
- View/download PDF
37. Reply to Kesav et al
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Ergonul, O., primary, Guven, T., additional, Ugurlu, K., additional, Celikbas, A. K., additional, Gok, s. E., additional, Comoglu, S., additional, Baykam, N., additional, and Dokuzoguz, B., additional
- Published
- 2013
- Full Text
- View/download PDF
38. Laboratory-acquired brucellosis in Turkey
- Author
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Sayin-Kutlu, S., primary, Kutlu, M., additional, Ergonul, O., additional, Akalin, S., additional, Guven, T., additional, Demiroglu, Y.Z., additional, Acicbe, O., additional, and Akova, M., additional
- Published
- 2012
- Full Text
- View/download PDF
39. A Unified Framework for Multipath Routing for Unicast and Multicast Traffic
- Author
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Guven, T., primary, La, R.J., additional, Shayman, M.A., additional, and Bhattacharjee, B., additional
- Published
- 2008
- Full Text
- View/download PDF
40. Monte Carlo analysis of LWR spent fuel transmutation in a fusion-fission hybrid reactor system
- Author
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Sümer Şahi̇n, Hacı Mehmet Şahin, and Güven Tunç
- Subjects
Nuclear engineering. Atomic power ,TK9001-9401 - Abstract
The aim of this paper is to determine neutronic performances of the light water reactor (LWR) spent fuel mixed with fertile thorium fuel in a FFHR. Time dependent three dimensional calculations for major technical data, such as blanket energy multiplication, tritium breeding ratio, cumulative fissile fuel enrichment and burnup have been performed by using Monte Carlo Neutron-Particle Transport code MCNP5 1.4, coupled with a novel interface code MCNPAS, which is developed by our research group. A self-sustaining tritium breeding ratio (TBR>1.05) has been kept throughout the calculations. The study has shown that the fissile fuel quality will be improved in the course of the transmutation of the LWR spent in the FFHR. The latter has gained the reusable fuel enrichment level conventional LWRs between one and two years. Furthermore, LWR spent fuel - thorium mixture provides higher burn-up values than in light water reactors. Keywords: LWR spent fuel, Thorium, Time dependent neutronic analysis, Fusion-fission hybrid reactor
- Published
- 2018
- Full Text
- View/download PDF
41. Measurement-Based Multipath Multicast
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Guven, T., primary, La, R. J., additional, Shayman, M. A., additional, and Bhattacharjee, B., additional
- Published
- 2006
- Full Text
- View/download PDF
42. The Resazurin Microplate Method for Rapid Detection of Vancomycin Resistance in Enterococci
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Coban, A.Y., primary, Darka, O., additional, Fisgin, N.T., additional, Cihan, C.C., additional, Bilgin, K., additional, Akgunes, A., additional, Guven, T., additional, Dokuzoguz, B., additional, Birinci, A., additional, and Durupinar, B., additional
- Published
- 2005
- Full Text
- View/download PDF
43. A multi-layer approach for seamless handoff in ad hoc networks with wireless heterogenity.
- Author
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Guven, T., Hui Zeng, Li, J.H., Luo, S., Das, S., McAuley, T., Stuhrmann, T., Sherrick, J., Adelfio, C., Spoenlein, S., Staikos, A., and Gerla, M.
- Published
- 2009
- Full Text
- View/download PDF
44. On providing seamless handoff in ad hoc networks with wireless heterogeneity.
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Li, J.H., Luo, S., Guven, T., Yi Cheng, Das, S., McAuley, T., Sherrick, J., Adelfio, C., Spoenlein, S., Staikos, A., and Gerla, M.
- Published
- 2008
- Full Text
- View/download PDF
45. Relay Deployment and Power Control for Lifetime Elongation in Sensor Networks.
- Author
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Yufeng Xin, Guven, T., and Shayman, M.
- Published
- 2006
- Full Text
- View/download PDF
46. Measurement based optimal multi-path routing.
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Guven, T., Kommareddy, C., La, R.J., Shayman, M.A., and Bhattacharjee, B.
- Published
- 2004
- Full Text
- View/download PDF
47. Pallister-Killian syndrome: clinical, cytogenetic and molecular findings in 15 cases
- Author
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Birsen Karaman, Hülya Kayserili, Asadollah Ghanbari, Zehra Oya Uyguner, Güven Toksoy, Umut Altunoglu, and Seher Basaran
- Subjects
OMIM 601803 ,Pallister-Killian syndrome ,Somatic mosaicism ,Mosaic tetrasomy 12p ,Isochromosome 12p ,Parental origin ,Genetics ,QH426-470 - Abstract
Abstract Background Pallister Killian syndrome (PKS, OMIM 601803) is a rare genetic disorder with a distinct phenotype caused by tissue- limited mosaicism tetrasomy of the short arm of chromosome 12, which usually cytogenetically presents as an extra isochromosome 12p. Wide phenotypic variability in PKS has been reported, ranging from pre-to perinatal death due to multiple congenital anomalies, especially diaphragmatic hernia, and classic phenotypes including seizures, severe developmental delay, macrosomia at birth, deafness, and distinct dysmorphic features, such as coarse face, temporal alopecia, a small nose with anteverted nostrils, long philtrum, and hypo−/hyper- pigmented streaks on the skin. Results Karyotypes obtained from cultured peripheral lymphocytes of 13 cases, who were diagnosed as PKS, were normal, while karyotypes obtained from cultured skin samples and buccal mucosa revealed the supernumerary mosaic i(12p). Mosaic karyotype was found in both fibroblast and buccal mucosa in 14 of 15 patients in our series, whereas in one stillbirth, following the clinical diagnosis of PKS, skin and buccal smear samples were taken, and all karyotypes from cultured fibroblasts revealed a supernumerary i(12p), while I-FISH study showed 60% mosaicism in mucosal cells. Conclusions We here share the clinical, cytogenetic and molecular cytogenetic findings of 15 cases with PKS phenotype and the parental origin of seven i(12p) identified by molecular analyses. To our knowledge, this is the largest series of PKS patients with parental origin study from a single center. We believe that our study makes a significant contribution to the literature because we specifically found no differences in the phenotypes of cases with either a maternal or paternal origin of the extra element and differential imprinting appeared not to be a factor.
- Published
- 2018
- Full Text
- View/download PDF
48. 'Homozygous, and compound heterozygous mutation in 3 Turkish family with Jervell and Lange-Nielsen syndrome: case reports'
- Author
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Fahrettin Uysal, Burcu Turkgenc, Guven Toksoy, Ozlem M. Bostan, Elif Evke, Oya Uyguner, Cengiz Yakicier, Hulya Kayserili, Ergun Cil, and Sehime G. Temel
- Subjects
Jervell-Lange-Nielsen syndrome ,Deafness ,Homozygous or compound heterozygous mutations ,Case report ,Internal medicine ,RC31-1245 ,Genetics ,QH426-470 - Abstract
Abstract Background Jervell and Lange-Nielsen syndrome (JLNS) isa recessive model of long QT syndrome which might also be related to possible hearing loss. Although the syndrome has been demonstrated to be originated from homozygous or compound heterozygous mutations in either the KCNQ1 or KCNE1 genes, additional mutations in other genetic loci should be considered, particularly in malignant course patients. Case presentations Three patients were admitted into hospital due to recurrent seizures/syncope, intrauterine and postnatal bradycardia respectively; moreover all three patients had congenital sensorineural hearing-loss. Their electrocardiograms showed markedly prolonged QT interval. Implantable defibrillator was implanted and left cardiac sympathetic denervation was performed due to the progressive disease in case 1. She had countless ventricular fibrillation and appropriate shock while using an implantable defibrillator. The DNA sequencing analysis of the KCNQ1 gene disclosed a homozygous c.728G > A (p.Arg243His) missense mutation in case1. Further targeted next generation sequencing of cardiac panel comprising 68 gene revealed a heterozygous c.1346 T > G (p.Ile449Arg) variant in RYR2 gene and a heterozygous c.809G > A (p.Cys270Tyr) variant in NKX2–5 gene in the same patient. Additional gene alterations in RYR2 and NKX2–5 genes were thought to be responsible for progressive and malignant course of the disease. As a result of DNA sequencing analysis of KCNQ1 and KCNE1 genes, a compound heterozygosity for two mutations had been detected in KCNQ1 gene in case 2: a maternally derived c.477 + 1G > A splice site mutation and a paternally derived c.520C > T (p.Arg174Cys) missense mutation. Sanger sequencing of KCNQ1 and KCNE1 genes displayed a homozygous c.1097G > A (p.Arg366Gln) mutation in KCNQ1 gene in case 3. β-blocker therapy was initiated to all the index subjects. Conclusions Three families of JLNS who presented with long QT and deafness and who carry homozygous, or compound heterozygous mutation in KCNQ1 gene were presented in this report. It was emphasized that broad targeted cardiac panels may be useful to predict the outcome especially in patients with unexplained phenotype-genotype correlation. Clinical presentations and molecular findings will be discussed further to clarify the phenotype genotype associations.
- Published
- 2017
- Full Text
- View/download PDF
49. A study of the opinions and behaviors of physicians with regard to informed consent and refusing treatment.
- Author
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Ataç A, Guven T, Uçar M, Kir T, Ataç, Adnan, Guven, Tolga, Uçar, Muharrem, and Kir, Tayfun
- Abstract
Objective: To examine the opinions and the self-reported behaviors of physicians regarding the issues of informed consent and refusing treatment.Design: This study was performed between July and September 2003, with 51 physicians selected by simple random sampling. The data were collected by using a questionnaire.Setting: A training hospital of medicine faculty.Participants: Fifty-one clinicians working in the branches of internal medicine and surgery.Results: Although the majority (80.4%) of the participants think that information about diagnosis and treatment should always be disclosed to patients, 60.8% reported that they always disclose information about the diagnosis and 49% did the same for information about treatment. A total of 84.3% think that patients' consent should always be obtained before diagnostic and therapeutic procedures, whereas 47% reported that they always obtain consent in their clinical practice. It was also seen that physicians have doubts concerning the comprehension of the information they disclose to their patients. In addition, most (86.3%) of the participants think that a competent patient always has the right to refuse treatment, regardless of the disease and the outcomes.Conclusions: Although opinions favoring the duties implied by informed consent are in the majority, these do not always reflect the behaviors in daily clinical practice, and there may be problems in carrying out the duties implied by the elements of informed consent. Some recommendations that could be beneficial in addressing these problems are presented at the end of the study. [ABSTRACT FROM AUTHOR]- Published
- 2005
50. Electrical investigation of Al/PEDOT/C/p-Si structure
- Author
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Fikriye Seyma Kaya, Tuba Oznuluer Ozer, Guven Turgut, Ayse Bayrakceken Yurtcan, and Songul Duman
- Subjects
Physics ,QC1-999 - Abstract
In this investigation, Al/PEDOT/C/p-Si structure has been fabricated by synthesizing PEDOT/C composites on the p-Si substrate. The thickness and surface morphology of PEDOT/C on p-Si have been investigated by using the scanning electron microscope. The optical characterization of PEDOT/C solution indicated a strong optical absorbance peak located at 267 nm. The electrical characterization of Al/PEDOT/C/p-Si structure was made under dark and illumination conditions at the room temperature. The ideality factor, and barrier height were identified to be 1.28, 1.12 and 0.80 eV, 0.83 eV from current–voltage (I–V) measurements for dark and illuminated conditions, respectively. The results show that the Al/PEDOT/C/p-Si structure may be utilized to be a photodiode in optoelectronic implementations. Keywords: Polymeric composites, Electrical properties, Contacts
- Published
- 2019
- Full Text
- View/download PDF
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