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20. Association of lower serum irisin levels with diabetes mellitus: Irrespective of coronary collateral circulation, and syntax score.

Author

Akyuz, Aydin, Mert, Beysim, Gur, Demet Ozkaramanli, Efe, Muhammet Mucip, Aykac, Huseyin, Alpsoy, Seref, and Guzel, Savas

Subjects
IRISIN, BLOOD serum analysis, DIABETES, PATHOLOGICAL physiology, ATHEROSCLEROSIS
Abstract

OBJECTIVE: Irisin is a myokine thought to be involved in the pathophysiological process of atherosclerosis with its' cardiovascular protective effects. Patients with diabetes mellitus (DM) have lower levels of irisin. Therefore, we investigated whether there is a connection between irisin, DM, coronary collateral circulation (CCC), and SYNTAX scores representing coronary artery disease (CAD) severity. METHODS: This study evaluated 86 patients who have at least one epicardial coronary artery with chronic total occlusion. We included Rentrop 0-1 into the poor CCC group (n=45) and Rentrop 2-3 into the good CCC group (n=41) and measured serum irisin levels. RESULTS: Irisin levels did not differ (17585 [882-37741] pg/ml and (17504 [813-47683] pg/ml, p=0.772) between the two groups. Irisin levels were lower in patients with diabetes (n=41; 14485 [813-29398] pg/ml) than those without diabetes (n=45; 19724 [865-47683] pg/ml (p=0.002). Irisin was not correlated with SYNTAX scores. In multivariate analysis, DM (OR=0.463; CI: 0.184-0.783; p=0.012) was a negative predictor of good CCC development CONCLUSION: Although its level is decreased in patients with diabetes, serum irisin levels have no role in the pathophysiology of collateral development and CAD severity. [ABSTRACT FROM AUTHOR]

Published
2021
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23. Assessment of salusin alpha and salusin beta levels in patients with newly diagnosed dipper and non-dipper hypertension.

Author

Alpsoy, Seref, Dogan, Burcin, Ozkaramanli Gur, Demet, Akyüz, Aydin, Fidan, Çiğdem, Guzel, Savas, and Ozkoyuncu, Berna

Subjects
HYPERTENSION, AMBULATORY blood pressure monitoring, BLOOD pressure, LOGISTIC regression analysis
Abstract

The pathophysiology of non-dipper hypertension has not been clarified. The relationship between salusins with atherosclerosis and hypertension has gained attention in recent years. The aim of this paper is to investigate whether salusins are associated with circadian blood pressure, left ventricular mass index, and diastolic functions in newly diagnosed hypertensives. The study included 88 newly diagnosed hypertensive individuals. Twenty-four-hour ambulatory blood pressure monitoring and echocardiographic examinations were performed. The patients were assigned to dipper hypertension (n = 41) and non-dipper hypertension (n = 47) groups based on the ambulatory blood pressure monitoring results according to the presence of ≥ a 10% decrease in nighttime blood pressure values or not. Serum salusin α and β levels were determined by electrochemiluminescence immunological test method. Compared to dipper hypertension, non-dipper hypertension group demonstrated lower salusin α levels (1818.71 ± 221.67 vs 1963 ± 200.75 pg/mL, p =.002), mitral E/A, septal E'/A' and higher salusin β levels (576.24 ± 68.15 vs 516.13 ± 90.7 pg/ml, p =.001) and left ventricular mass index. Multivariate logistic regression analysis revealed salusin-α (OR 0.474, 95% CI 0.262 to 0.986, p =.001), salusin-β (OR 2.550, 95% CI 2.123 to 2.991, p =.018), and left ventricular mass index (OR 2.620, 95% CI 2.124 to 2.860, p =.011) as independent predictors of non-dipper hypertension. As candidate markers to predict non-dipper hypertension, decreased salusin α, and increased salusin β levels may mediate crosstalk between sympathetic and parasympathetic systems and indicate poor cardiovascular prognosis in hypertension. [ABSTRACT FROM AUTHOR]

Published
2021
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24. Hipertansif Hastalarda Kognitif Fonksiyonların Değerlendirilmesi ve Serum Midkine Düzeyleriyle İlişkisi

Author

CELİK GUZEL, Eda, SERİNKAN CİNEMRE, Fatma Behice, GUZEL, Savas, KUÇUKYALCİN, Volkan, KİZİLER, Ali Riza, CAVUSOGLU, Coskun, GULYASAR, Tevfik, CİNEMRE, Hakan, and AYDEMİR, Birsen

Subjects
Health Care Sciences and Services, Hipertansiyon,Kognitif Bozulma,Midkine,Mini Mental Durum Değerlendirme, Sağlık Bilimleri ve Hizmetleri, Hypertension,Cognitive decline,Midkine,Mini Mental State Examination
Abstract

Objective: Hypertension (HT) is one of the risk factors associated with dementia. Our aim was to research cognitive functions in patients with HT and its relationship to midkine levels in serum. Material and Methods: This study examined 45 patients who were over 60 years of age, had at least five years of education, and had an essential HT diagnosis. We also had 30 healthy control subjects. The Mini Mental State Examination (MMSE) was applied to the patients. Scores of 24 and lower from the MMSE indicated a cognitive disorder. In relation serum levels of midkine were also evaluated. Results: The MMSE scores of the HT patients were compared to the control group and were significantly lower (p, Amaç:Hipertansiyon (HT) demans ile ilişkili risk faktörlerinden biridir. Çalışmanın amacı, HT’lu hastalarda kognitif fonksiyonlar ve serum midkine düzeyleri ile ilişkisini araştırmaktır. Gereç ve Yöntem: Bu çalışmada, 60 yaşın üstünde, en az beş yıllık eğitim alan ve HT tanısı almış 45 hasta ve 30 sağlıklı kontrol incelendi. Hastalara Mini Mental Durum Değerlendirme (MMDD) testi uygulanmıştır. MMDD skoru 24 ve daha düşük olanlar kognitif bozukluk olarak tanımlandı. Bu gruplarda serum midkine seviyeleri değerlendirildi. Bulgular: HT’lu hastalarının MMDD skorları kontrol grubuyla karşılaştırıldı ve anlamlı olarak düşük bulundu (p

Published
2017

25. C-reactive protein (CRP)/mean platelet volume (MPV) ratio as a new biomarker for community-acquired pneumonia in children

Author

GÜZEL, EDA ÇELİK, Fidan, Cigdem, Guzel, Savas, and Paketci, Cem

Subjects
Blood-Cell Count, mean platelet volume, Bacterial, Neutrophil/Lymphocyte, Indexes, Pneumonia, Pneumonia,C-reactive protein,white blood cell,mean platelet volume,disease severity, Marker, C-reactive protein, Health Care Sciences and Services, hemic and lymphatic diseases, Pnömoni,C-reaktif protein,beyaz küre sayısı,ortalama trombosit hacmi,hastalık şiddeti, disease severity, Sağlık Bilimleri ve Hizmetleri, white blood cell, Mortality, Clinical Characteristics, circulatory and respiratory physiology
Abstract

Amaç: Son yıllarda inflamasyon göstergesi olarak değerlendirilen C-reaktif proteinin (CRP)/ortalama trombosit hacmi (OTH) oranı ve beyaz küre sayısı (BKS)/ortalama trombosit hacmi (OTH) oranının toplum kökenli pnömonili (TKP) çocuklarda tanı ve hastalık şiddeti ile ilişkisini araştırmaktır.Gereç ve Yöntem: Çalışma TKP tanısı alan 3 ay ile 18 yaş arasında 60 hasta ve 30 sağlıklı çocuktan oluşturuldu. Hasta ve kontrol grubunda CRP, BKS, OTH, nötrofil/lenfosit oranı (NLO) değerleri ile birlikte CRP/OTH ve BKS/OTH değerleri incelendi. Bulgular: Hasta ve kontrol grubu arasında OTH düzeyleri açısından anlamlı fark saptanmazken, CRP/OTH, BKS/OTH, NLO ve plateletkrit düzeyleri hasta grubunda anlamlı olarak yüksek bulundu. Ciddi pnömonili hasta grubunda (n=27) BKS, NLO, BKS/OTH, CRP/OTH ve CRP düzeyleri hafif-ılımlı pnömonili gruba (n=33) göre anlamlı olarak yüksek saptandı. CRP/OTH ve BKS/OTH oranlarının hastalık belirtilerinin süresiyle arasında pozitif korelasyon gösterildi. Receiver Operating Characteric (ROC) analizinde CRP (Eğri altındaki alan (EAA)=0.801), BKS (EAA=0.761) ve BKS/OTH (EAA=0.731) düzeylerinin TKP’nin tanısında yeterliliği anlamlı bulundu. Ciddi TKP’li hastaların ayrımında ise CRP/OTH (EAA=0.733) ve CRP (EAA=0.708) düzeyleri anlamlı bulundu.Sonuç: CRP/OTH ve BKS/OTH oranları TKP tanısının değerlendirilmesinde ve CRP/OTH oranı hastalık aktivitesinin belirlenmesinde iyi bir belirteç olabileceğini göstermektedir., Purpose: Our aim is to evaluate the relationship between C-reactive protein (CRP)/mean platelet volume (MPV) ratio and white blood cell (WBC)/mean platelet volume (MPV) ratio and diagnosis and disease severity in children with community-acquired pneumonia (CAP).Material and Methods: 60 patients with CAP including 33 mild-moderate (Group 1) and 27 severe pneumonia (Group 2) and 30 healthy children were examined for routine blood test. WBC, MPV, neuotrophile/lymhocyte ratio (NLR), CRP, WBC/MPV, CRP/MPV values were recorded on each patient and healthy groups.Result: CRP/MPV, WBC/MPV, NLR and plateletcrit values were significantly higher in patients group than controls, while MPV value is not correlated between patient and control groups. WBC, NLR, WBC/MPV, CRP/MPV and CRP values were higher in the Group 2 compared to Group 1. CRP/MPV and WBC/MPV were positively correlated with duration of symptoms in the CAP. The area under ROC curve of CRP, WBC and WBC/MPV in diagnosing CAP was significant (0.801, 0.761 and 0.731). Also the area under ROC curve of Group 2 in CRP/MPV and CRP in diagnosing CAP was significant (0.733, 0.708).Conclusion: CRP/MPV and WBC/MPV ratio may be used a marker in the evaluation of CAP diagnosis and CRP/MPV ratio can be good marker prediction of disease activity.

Published
2017

31. Can low brain-derived neurotrophic factor levels be a marker of the presence of depression in obese women?

Author

Celik Guzel,Eda, Bakkal,Esra, Guzel,Savas, Eroglu,Hasan Emre, Acar,Ayse, Kuçukyalcin,Volkan, Topcu,Birol, Celik Guzel,Eda, Bakkal,Esra, Guzel,Savas, Eroglu,Hasan Emre, Acar,Ayse, Kuçukyalcin,Volkan, and Topcu,Birol

Abstract

Eda Celik Guzel,1 Esra Bakkal,1 Savas Guzel,2 Hasan Emre Eroglu,3 Ayse Acar,2 Volkan Kuçukyalcin,2 Birol Topcu4 1Department of Family Physician, Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey; 2Department of Biochemistry, Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey; 3Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey; 4Department of Biostatistics, Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey Objective: Depression is a common condition in obese women that can result in severe impairment of their physical and social functioning. A deficiency of brain-derived neurotrophic factor (BDNF) is involved in the mechanism of depression. The aim of this study is to investigate whether BDNF levels differ between obese female patients and healthy controls and whether BDNF levels alter with affective states in depressive obese women.Methods: The study group included 40 obese, 40 preobese, and 40 normal weight women. BDNF levels were measured with an enzyme-linked immunosorbent assay in patient and control groups. For identifying the depression and anxiety status, Beck Depression/Anxiety Inventories were used; and for the evaluation of cognitive functions, the mini-mental state examination was used.Results: BDNF levels were significantly lower in obese patients compared to the control group (P<0.01). BDNF levels were significantly lower in obese patients with depression compared to the obese patients without depression (P<0.05). The Beck Depression Inventory showed a negative correlation with BDNF (r=−0.044; P<0.01) and a positive correlation with the Beck Anxiety Inventory (r=0.643; P<0.001), vitamin B12 levels (r=0.023; P<0.001), and insulin levels (r=0.257; P<0.05) in obese patients. When receiver operating characteristic curve analysis was used to analyze the suitability of BDNF to identify depression in obese women, the area under the curve for BDNF, 0.75

Published
2014

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