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1. Real‐world experience with direct brain‐responsive neurostimulation for focal onset seizures

Author

Razavi, Babak, Rao, Vikram R, Lin, Christine, Bujarski, Krzysztof A, Patra, Sanjay E, Burdette, David E, Geller, Eric B, Brown, Mesha‐Gay M, Johnson, Emily A, Drees, Cornelia, Chang, Edward F, Greenwood, Janet E, Heck, Christianne N, Jobst, Barbara C, Gwinn, Ryder P, Warner, Nicole M, and Halpern, Casey H

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Patient Safety, Clinical Research, Neurodegenerative, Brain Disorders, Neurosciences, Epilepsy, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Neurological, Adolescent, Adult, Aged, Drug Resistant Epilepsy, Electric Stimulation Therapy, Electrocorticography, Epilepsies, Partial, Female, Humans, Implantable Neurostimulators, Male, Middle Aged, Retrospective Studies, Treatment Outcome, Young Adult, brain-responsive neurostimulation, drug-resistant, medically intractable epilepsy, RNS System, Neurology & Neurosurgery, Clinical sciences
Abstract

ObjectiveThe RNS System is a direct brain-responsive neurostimulation system that is US Food and Drug Administration-approved for adults with medically intractable focal onset seizures based on safety and effectiveness data from controlled clinical trials. The purpose of this study was to retrospectively evaluate the real-world safety and effectiveness of the RNS System.MethodsEight comprehensive epilepsy centers conducted a chart review of patients treated with the RNS System for at least 1 year, in accordance with the indication for use. Data included device-related serious adverse events and the median percent change in disabling seizure frequency from baseline at years 1, 2, and 3 of treatment and at the most recent follow-up.ResultsOne hundred fifty patients met the criteria for analysis. The median reduction in seizures was 67% (interquartile range [IQR] = 33%-93%, n = 149) at 1 year, 75% (IQR = 50%-94%, n = 93) at 2 years, 82% (IQR = 50%-96%, n = 38) at ≥3 years, and 74% (IQR = 50%-96%, n = 150) at last follow-up (mean = 2.3 years). Thirty-five percent of patients had a ≥90% seizure frequency reduction, and 18% of patients reported being clinically seizure-free at last follow-up. Seizure frequency reductions were similar regardless of patient age, age at epilepsy onset, duration of epilepsy, seizure onset in mesial temporal or neocortical foci, magnetic resonance imaging findings, prior intracranial monitoring, prior epilepsy surgery, or prior vagus nerve stimulation treatment. The infection rate per procedure was 2.9% (6/150 patients); five of the six patients had an implant site infection, and one had osteomyelitis. Lead revisions were required in 2.7% (4/150), and 2.0% (3/150) of patients had a subdural hemorrhage, none of which had long-lasting neurological consequences.SignificanceIn this real-world experience, safety was similar and clinical seizure outcomes exceeded those of the prospective clinical trials, corroborating effectiveness of this therapy and suggesting that clinical experience has informed more effective programming.

Published
2020

2. Mesial temporal resection following long‐term ambulatory intracranial EEG monitoring with a direct brain‐responsive neurostimulation system

Author

Hirsch, Lawrence J, Mirro, Emily A, Salanova, Vicenta, Witt, Thomas C, Drees, Cornelia N, Brown, Mesha‐Gay, Lee, Ricky W, Sadler, Toni L, Felton, Elizabeth A, Rutecki, Paul, Shin, Hae Won, Hadar, Eldad, Hegde, Manu, Rao, Vikram R, Mnatsakanyan, Lilit, Madhavan, Deepak S, Zakaria, Tarek J, Liu, Anli A, Heck, Christianne N, Greenwood, Janet E, Bigelow, Jeffrey K, Nair, Dileep R, Alexopoulos, Andreas V, Mackow, Michael, Edwards, Jonathan C, Sotudeh, Nadia, Kuzniecky, Ruben I, Gwinn, Ryder P, Doherty, Michael J, Geller, Eric B, and Morrell, Martha J

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Epilepsy, Brain Disorders, Neurodegenerative, Neurosciences, Neurological, Adult, Aged, Anterior Temporal Lobectomy, Drug Resistant Epilepsy, Electric Stimulation Therapy, Electrocorticography, Epilepsy, Temporal Lobe, Female, Humans, Implantable Neurostimulators, Male, Middle Aged, Monitoring, Ambulatory, Neurosurgical Procedures, Retrospective Studies, Temporal Lobe, Treatment Outcome, Young Adult, brain-responsive neurostimulation, electrocorticography, epilepsy surgery, intractable temporal lobe epilepsy, mesial temporal lobe resection, temporal lobectomy, Neurology & Neurosurgery, Clinical sciences
Abstract

ObjectiveTo describe seizure outcomes in patients with medically refractory epilepsy who had evidence of bilateral mesial temporal lobe (MTL) seizure onsets and underwent MTL resection based on chronic ambulatory intracranial EEG (ICEEG) data from a direct brain-responsive neurostimulator (RNS) system.MethodsWe retrospectively identified all patients at 17 epilepsy centers with MTL epilepsy who were treated with the RNS System using bilateral MTL leads, and in whom an MTL resection was subsequently performed. Presumed lateralization based on routine presurgical approaches was compared to lateralization determined by RNS System chronic ambulatory ICEEG recordings. The primary outcome was frequency of disabling seizures at last 3-month follow-up after MTL resection compared to seizure frequency 3 months before MTL resection.ResultsWe identified 157 patients treated with the RNS System with bilateral MTL leads due to presumed bitemporal epilepsy. Twenty-five patients (16%) subsequently had an MTL resection informed by chronic ambulatory ICEEG (mean = 42 months ICEEG); follow-up was available for 24 patients. After MTL resection, the median reduction in disabling seizures at last follow-up was 100% (mean: 94%; range: 50%-100%). Nine patients (38%) had exclusively unilateral electrographic seizures recorded by chronic ambulatory ICEEG and all were seizure-free at last follow-up after MTL resection; eight of nine continued RNS System treatment. Fifteen patients (62%) had bilateral MTL electrographic seizures, had an MTL resection on the more active side, continued RNS System treatment, and achieved a median clinical seizure reduction of 100% (mean: 90%; range: 50%-100%) at last follow-up, with eight of fifteen seizure-free. For those with more than 1 year of follow-up (N = 21), 15 patients (71%) were seizure-free during the most recent year, including all eight patients with unilateral onsets and 7 of 13 patients (54%) with bilateral onsets.SignificanceChronic ambulatory ICEEG data provide information about lateralization of MTL seizures and can identify additional patients who may benefit from MTL resection.

Published
2020

4. Conserved cell types with divergent features in human versus mouse cortex.

Author

Hodge, Rebecca D, Bakken, Trygve E, Miller, Jeremy A, Smith, Kimberly A, Barkan, Eliza R, Graybuck, Lucas T, Close, Jennie L, Long, Brian, Johansen, Nelson, Penn, Osnat, Yao, Zizhen, Eggermont, Jeroen, Höllt, Thomas, Levi, Boaz P, Shehata, Soraya I, Aevermann, Brian, Beller, Allison, Bertagnolli, Darren, Brouner, Krissy, Casper, Tamara, Cobbs, Charles, Dalley, Rachel, Dee, Nick, Ding, Song-Lin, Ellenbogen, Richard G, Fong, Olivia, Garren, Emma, Goldy, Jeff, Gwinn, Ryder P, Hirschstein, Daniel, Keene, C Dirk, Keshk, Mohamed, Ko, Andrew L, Lathia, Kanan, Mahfouz, Ahmed, Maltzer, Zoe, McGraw, Medea, Nguyen, Thuc Nghi, Nyhus, Julie, Ojemann, Jeffrey G, Oldre, Aaron, Parry, Sheana, Reynolds, Shannon, Rimorin, Christine, Shapovalova, Nadiya V, Somasundaram, Saroja, Szafer, Aaron, Thomsen, Elliot R, Tieu, Michael, Quon, Gerald, Scheuermann, Richard H, Yuste, Rafael, Sunkin, Susan M, Lelieveldt, Boudewijn, Feng, David, Ng, Lydia, Bernard, Amy, Hawrylycz, Michael, Phillips, John W, Tasic, Bosiljka, Zeng, Hongkui, Jones, Allan R, Koch, Christof, and Lein, Ed S

Subjects
Cerebral Cortex, Astrocytes, Neurons, Animals, Humans, Mice, Species Specificity, Neural Inhibition, Principal Component Analysis, Adolescent, Adult, Aged, Middle Aged, Female, Male, Young Adult, Biological Evolution, Single-Cell Analysis, Transcriptome, RNA-Seq, Genetics, Neurosciences, 1.1 Normal biological development and functioning, 2.1 Biological and endogenous factors, Aetiology, Underpinning research, Neurological, General Science & Technology
Abstract

Elucidating the cellular architecture of the human cerebral cortex is central to understanding our cognitive abilities and susceptibility to disease. Here we used single-nucleus RNA-sequencing analysis to perform a comprehensive study of cell types in the middle temporal gyrus of human cortex. We identified a highly diverse set of excitatory and inhibitory neuron types that are mostly sparse, with excitatory types being less layer-restricted than expected. Comparison to similar mouse cortex single-cell RNA-sequencing datasets revealed a surprisingly well-conserved cellular architecture that enables matching of homologous types and predictions of properties of human cell types. Despite this general conservation, we also found extensive differences between homologous human and mouse cell types, including marked alterations in proportions, laminar distributions, gene expression and morphology. These species-specific features emphasize the importance of directly studying human brain.

Published
2019

5. An Acute Randomized Controlled Trial of Noninvasive Peripheral Nerve Stimulation in Essential Tremor

Author

Pahwa, Rajesh, Dhall, Rohit, Ostrem, Jill, Gwinn, Ryder, Lyons, Kelly, Ro, Susie, Dietiker, Cameron, Luthra, Nijee, Chidester, Paula, Hamner, Samuel, Ross, Erika, and Delp, Scott

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Neurosciences, Rehabilitation, Clinical Trials and Supportive Activities, Clinical Research, Patient Safety, Evaluation of treatments and therapeutic interventions, 6.3 Medical devices, Activities of Daily Living, Aged, Aged, 80 and over, Essential Tremor, Female, Humans, Male, Middle Aged, Peripheral Nerves, Transcutaneous Electric Nerve Stimulation, Wrist, Essential tremor, movement disorders, neurostimulation, noninvasive stimulation, peripheral nerve stimulation, tremor, Cognitive Sciences, Neurology & Neurosurgery, Clinical sciences
Abstract

ObjectiveTo evaluate the safety and effectiveness of a wrist-worn peripheral nerve stimulation device in patients with essential tremor (ET) in a single in-office session.MethodsThis was a randomized controlled study of 77 ET patients who received either treatment stimulation (N = 40) or sham stimulation (N = 37) on the wrist of the hand with more severe tremor. Tremor was evaluated before and immediately after the end of a single 40-minute stimulation session. The primary endpoint compared spiral drawing in the stimulated hand using the Tremor Research Group Essential Tremor Rating Assessment Scale (TETRAS) Archimedes spiral scores in treatment and sham groups. Additional endpoints included TETRAS upper limb tremor scores, subject-rated tasks from the Bain and Findley activities of daily living (ADL) scale before and after stimulation as well as clinical global impression-improvement (CGI-I) rating after stimulation.ResultsSubjects who received peripheral nerve stimulation did not show significantly larger improvement in the Archimedes spiral task compared to sham but did show significantly greater improvement in upper limb TETRAS tremor scores (p = 0.017) compared to sham. Subject-rated improvements in ADLs were significantly greater with treatment (49% reduction) than with sham (27% reduction; p = 0.001). A greater percentage of ET patients (88%) reported improvement in the stimulation group as compared to the sham group (62%) according to CGI-I ratings (p = 0.019). No significant adverse events were reported; 3% of subjects experienced mild adverse events.ConclusionsPeripheral nerve stimulation in ET may provide a safe, well-tolerated, and effective treatment for transient relief of hand tremor symptoms.

Published
2019

6. Morpho-electric diversity of human hippocampal CA1 pyramidal neurons

Author

Mertens, Eline J., primary, Leibner, Yoni, additional, Pie, Jean, additional, Galakhova, Anna A., additional, Waleboer, Femke, additional, Meijer, Julia, additional, Heistek, Tim S., additional, Wilbers, René, additional, Heyer, Djai, additional, Goriounova, Natalia A., additional, Idema, Sander, additional, Verhoog, Matthijs B., additional, Kalmbach, Brian E., additional, Lee, Brian R., additional, Gwinn, Ryder P., additional, Lein, Ed S., additional, Aronica, Eleonora, additional, Ting, Jonathan, additional, Mansvelder, Huibert D., additional, Segev, Idan, additional, and de Kock, Christiaan P.J., additional

Published
2024
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8. Human neocortical expansion involves glutamatergic neuron diversification

Author

Berg, Jim, Sorensen, Staci A., Ting, Jonathan T., Miller, Jeremy A., Chartrand, Thomas, Buchin, Anatoly, Bakken, Trygve E., Budzillo, Agata, Dee, Nick, Ding, Song-Lin, Gouwens, Nathan W., Hodge, Rebecca D., Kalmbach, Brian, Lee, Changkyu, Lee, Brian R., Alfiler, Lauren, Baker, Katherine, Barkan, Eliza, Beller, Allison, Berry, Kyla, Bertagnolli, Darren, Bickley, Kris, Bomben, Jasmine, Braun, Thomas, Brouner, Krissy, Casper, Tamara, Chong, Peter, Crichton, Kirsten, Dalley, Rachel, de Frates, Rebecca, Desta, Tsega, Lee, Samuel Dingman, D’Orazi, Florence, Dotson, Nadezhda, Egdorf, Tom, Enstrom, Rachel, Farrell, Colin, Feng, David, Fong, Olivia, Furdan, Szabina, Galakhova, Anna A., Gamlin, Clare, Gary, Amanda, Glandon, Alexandra, Goldy, Jeff, Gorham, Melissa, Goriounova, Natalia A., Gratiy, Sergey, Graybuck, Lucas, Gu, Hong, Hadley, Kristen, Hansen, Nathan, Heistek, Tim S., Henry, Alex M., Heyer, Djai B., Hill, DiJon, Hill, Chris, Hupp, Madie, Jarsky, Tim, Kebede, Sara, Keene, Lisa, Kim, Lisa, Kim, Mean-Hwan, Kroll, Matthew, Latimer, Caitlin, Levi, Boaz P., Link, Katherine E., Mallory, Matthew, Mann, Rusty, Marshall, Desiree, Maxwell, Michelle, McGraw, Medea, McMillen, Delissa, Melief, Erica, Mertens, Eline J., Mezei, Leona, Mihut, Norbert, Mok, Stephanie, Molnar, Gabor, Mukora, Alice, Ng, Lindsay, Ngo, Kiet, Nicovich, Philip R., Nyhus, Julie, Olah, Gaspar, Oldre, Aaron, Omstead, Victoria, Ozsvar, Attila, Park, Daniel, Peng, Hanchuan, Pham, Trangthanh, Pom, Christina A., Potekhina, Lydia, Rajanbabu, Ramkumar, Ransford, Shea, Reid, David, Rimorin, Christine, Ruiz, Augustin, Sandman, David, Sulc, Josef, Sunkin, Susan M., Szafer, Aaron, Szemenyei, Viktor, Thomsen, Elliot R., Tieu, Michael, Torkelson, Amy, Trinh, Jessica, Tung, Herman, Wakeman, Wayne, Waleboer, Femke, Ward, Katelyn, Wilbers, René, Williams, Grace, Yao, Zizhen, Yoon, Jae-Geun, Anastassiou, Costas, Arkhipov, Anton, Barzo, Pal, Bernard, Amy, Cobbs, Charles, de Witt Hamer, Philip C., Ellenbogen, Richard G., Esposito, Luke, Ferreira, Manuel, Gwinn, Ryder P., Hawrylycz, Michael J., Hof, Patrick R., Idema, Sander, Jones, Allan R., Keene, C. Dirk, Ko, Andrew L., Murphy, Gabe J., Ng, Lydia, Ojemann, Jeffrey G., Patel, Anoop P., Phillips, John W., Silbergeld, Daniel L., Smith, Kimberly, Tasic, Bosiljka, Yuste, Rafael, Segev, Idan, de Kock, Christiaan P. J., Mansvelder, Huibert D., Tamas, Gabor, Zeng, Hongkui, Koch, Christof, and Lein, Ed S.

Published
2021
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11. Lateralization of mesial temporal lobe epilepsy with chronic ambulatory electrocorticography.

Author

King-Stephens, David, Mirro, Emily, Weber, Peter, Laxer, Kenneth, Van Ness, Paul, Salanova, Vicenta, Spencer, David, Heck, Christianne, Goldman, Alica, Jobst, Barbara, Shields, Donald, Bergey, Gregory, Eisenschenk, Stephan, Worrell, Gregory, Rossi, Marvin, Gross, Robert, Cole, Andrew, Sperling, Michael, Nair, Dileep, Gwinn, Ryder, Park, Yong, Rutecki, Paul, Fountain, Nathan, Wharen, Robert, Hirsch, Lawrence, Miller, Ian, Barkley, Gregory, Edwards, Jonathan, Geller, Eric, Berg, Michel, Sadler, Toni, Sun, Felice, and Morrell, Martha

Subjects
Ambulatory EEG, EEG monitoring, Electrocorticography, Intracranial EEG, Localization, Responsive stimulation, Adolescent, Adult, Brain Waves, Electrocardiography, Ambulatory, Electrodes, Implanted, Epilepsy, Temporal Lobe, Female, Functional Laterality, Hippocampus, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Middle Aged, Retrospective Studies, Young Adult
Abstract

OBJECTIVE: Patients with suspected mesial temporal lobe (MTL) epilepsy typically undergo inpatient video-electroencephalography (EEG) monitoring with scalp and/or intracranial electrodes for 1 to 2 weeks to localize and lateralize the seizure focus or foci. Chronic ambulatory electrocorticography (ECoG) in patients with MTL epilepsy may provide additional information about seizure lateralization. This analysis describes data obtained from chronic ambulatory ECoG in patients with suspected bilateral MTL epilepsy in order to assess the time required to determine the seizure lateralization and whether this information could influence treatment decisions. METHODS: Ambulatory ECoG was reviewed in patients with suspected bilateral MTL epilepsy who were among a larger cohort with intractable epilepsy participating in a randomized controlled trial of responsive neurostimulation. Subjects were implanted with bilateral MTL leads and a cranially implanted neurostimulator programmed to detect abnormal interictal and ictal ECoG activity. ECoG data stored by the neurostimulator were reviewed to determine the lateralization of electrographic seizures and the interval of time until independent bilateral MTL electrographic seizures were recorded. RESULTS: Eighty-two subjects were implanted with bilateral MTL leads and followed for 4.7 years on average (median 4.9 years). Independent bilateral MTL electrographic seizures were recorded in 84%. The average time to record bilateral electrographic seizures in the ambulatory setting was 41.6 days (median 13 days, range 0-376 days). Sixteen percent had only unilateral electrographic seizures after an average of 4.6 years of recording. SIGNIFICANCE: About one third of the subjects implanted with bilateral MTL electrodes required >1 month of chronic ambulatory ECoG before the first contralateral MTL electrographic seizure was recorded. Some patients with suspected bilateral MTL seizures had only unilateral electrographic seizures. Chronic ambulatory ECoG in patients with suspected bilateral MTL seizures provides data in a naturalistic setting, may complement data from inpatient video-EEG monitoring, and can contribute to treatment decisions.

Published
2015

12. Long-term treatment with responsive brain stimulation in adults with refractory partial seizures.

Author

Bergey, Gregory, Morrell, Martha, Mizrahi, Eli, Goldman, Alica, King-Stephens, David, Nair, Dileep, Srinivasan, Shraddha, Jobst, Barbara, Gross, Robert, Shields, Donald, Barkley, Gregory, Salanova, Vicenta, Olejniczak, Piotr, Cole, Andrew, Cash, Sydney, Noe, Katherine, Wharen, Robert, Worrell, Gregory, Murro, Anthony, Edwards, Jonathan, Duchowny, Michael, Spencer, David, Smith, Michael, Geller, Eric, Gwinn, Ryder, Skidmore, Christopher, Eisenschenk, Stephan, Berg, Michel, Heck, Christianne, Van Ness, Paul, Fountain, Nathan, Rutecki, Paul, Massey, Andrew, ODonovan, Cormac, Labar, Douglas, Duckrow, Robert, Hirsch, Lawrence, Courtney, Tracy, Sun, Felice, and Seale, Cairn

Subjects
Adolescent, Adult, Aged, Deep Brain Stimulation, Double-Blind Method, Epilepsies, Partial, Female, Follow-Up Studies, Humans, Male, Middle Aged, Prospective Studies, Time Factors, Treatment Outcome, Young Adult
Abstract

OBJECTIVE: The long-term efficacy and safety of responsive direct neurostimulation was assessed in adults with medically refractory partial onset seizures. METHODS: All participants were treated with a cranially implanted responsive neurostimulator that delivers stimulation to 1 or 2 seizure foci via chronically implanted electrodes when specific electrocorticographic patterns are detected (RNS System). Participants had completed a 2-year primarily open-label safety study (n = 65) or a 2-year randomized blinded controlled safety and efficacy study (n = 191); 230 participants transitioned into an ongoing 7-year study to assess safety and efficacy. RESULTS: The average participant was 34 (±11.4) years old with epilepsy for 19.6 (±11.4) years. The median preimplant frequency of disabling partial or generalized tonic-clonic seizures was 10.2 seizures a month. The median percent seizure reduction in the randomized blinded controlled trial was 44% at 1 year and 53% at 2 years (p < 0.0001, generalized estimating equation) and ranged from 48% to 66% over postimplant years 3 through 6 in the long-term study. Improvements in quality of life were maintained (p < 0.05). The most common serious device-related adverse events over the mean 5.4 years of follow-up were implant site infection (9.0%) involving soft tissue and neurostimulator explantation (4.7%). CONCLUSIONS: The RNS System is the first direct brain responsive neurostimulator. Acute and sustained efficacy and safety were demonstrated in adults with medically refractory partial onset seizures arising from 1 or 2 foci over a mean follow-up of 5.4 years. This experience supports the RNS System as a treatment option for refractory partial seizures. CLASSIFICATION OF EVIDENCE: This study provides Class IV evidence that for adults with medically refractory partial onset seizures, responsive direct cortical stimulation reduces seizures and improves quality of life over a mean follow-up of 5.4 years.

Published
2015

13. Two‐year seizure reduction in adults with medically intractable partial onset epilepsy treated with responsive neurostimulation: Final results of the RNS System Pivotal trial

Author

Heck, Christianne N, King‐Stephens, David, Massey, Andrew D, Nair, Dileep R, Jobst, Barbara C, Barkley, Gregory L, Salanova, Vicenta, Cole, Andrew J, Smith, Michael C, Gwinn, Ryder P, Skidmore, Christopher, Van Ness, Paul C, Bergey, Gregory K, Park, Yong D, Miller, Ian, Geller, Eric, Rutecki, Paul A, Zimmerman, Richard, Spencer, David C, Goldman, Alica, Edwards, Jonathan C, Leiphart, James W, Wharen, Robert E, Fessler, James, Fountain, Nathan B, Worrell, Gregory A, Gross, Robert E, Eisenschenk, Stephan, Duckrow, Robert B, Hirsch, Lawrence J, Bazil, Carl, O'Donovan, Cormac A, Sun, Felice T, Courtney, Tracy A, Seale, Cairn G, and Morrell, Martha J

Subjects
Biomedical and Clinical Sciences, Neurosciences, Clinical Sciences, Clinical Research, Brain Disorders, Patient Safety, Epilepsy, Clinical Trials and Supportive Activities, Health Services, Neurodegenerative, Neurological, Adolescent, Adult, Aged, Double-Blind Method, Electric Stimulation Therapy, Epilepsies, Partial, Female, Follow-Up Studies, Humans, Implantable Neurostimulators, Male, Middle Aged, Quality of Life, Time Factors, Treatment Outcome, Young Adult, Cortical stimulation, Focal seizures, Neurostimulator, Partial seizures, Responsive stimulation, Neurology & Neurosurgery, Clinical sciences
Abstract

ObjectiveTo demonstrate the safety and effectiveness of responsive stimulation at the seizure focus as an adjunctive therapy to reduce the frequency of seizures in adults with medically intractable partial onset seizures arising from one or two seizure foci.MethodsRandomized multicenter double-blinded controlled trial of responsive focal cortical stimulation (RNS System). Subjects with medically intractable partial onset seizures from one or two foci were implanted, and 1 month postimplant were randomized 1:1 to active or sham stimulation. After the fifth postimplant month, all subjects received responsive stimulation in an open label period (OLP) to complete 2 years of postimplant follow-up.ResultsAll 191 subjects were randomized. The percent change in seizures at the end of the blinded period was -37.9% in the active and -17.3% in the sham stimulation group (p = 0.012, Generalized Estimating Equations). The median percent reduction in seizures in the OLP was 44% at 1 year and 53% at 2 years, which represents a progressive and significant improvement with time (p

Published
2014

14. Signature morphoelectric properties of diverse GABAergic interneurons in the human neocortex

Author

Lee, Brian R., primary, Dalley, Rachel, additional, Miller, Jeremy A., additional, Chartrand, Thomas, additional, Close, Jennie, additional, Mann, Rusty, additional, Mukora, Alice, additional, Ng, Lindsay, additional, Alfiler, Lauren, additional, Baker, Katherine, additional, Bertagnolli, Darren, additional, Brouner, Krissy, additional, Casper, Tamara, additional, Csajbok, Eva, additional, Donadio, Nicholas, additional, Driessens, Stan L.W., additional, Egdorf, Tom, additional, Enstrom, Rachel, additional, Galakhova, Anna A., additional, Gary, Amanda, additional, Gelfand, Emily, additional, Goldy, Jeff, additional, Hadley, Kristen, additional, Heistek, Tim S., additional, Hill, Dijon, additional, Hou, Wen-Hsien, additional, Johansen, Nelson, additional, Jorstad, Nik, additional, Kim, Lisa, additional, Kocsis, Agnes Katalin, additional, Kruse, Lauren, additional, Kunst, Michael, additional, León, Gabriela, additional, Long, Brian, additional, Mallory, Matthew, additional, Maxwell, Michelle, additional, McGraw, Medea, additional, McMillen, Delissa, additional, Melief, Erica J., additional, Molnar, Gabor, additional, Mortrud, Marty T., additional, Newman, Dakota, additional, Nyhus, Julie, additional, Opitz-Araya, Ximena, additional, Ozsvár, Attila, additional, Pham, Trangthanh, additional, Pom, Alice, additional, Potekhina, Lydia, additional, Rajanbabu, Ram, additional, Ruiz, Augustin, additional, Sunkin, Susan M., additional, Szöts, Ildikó, additional, Taskin, Naz, additional, Thyagarajan, Bargavi, additional, Tieu, Michael, additional, Trinh, Jessica, additional, Vargas, Sara, additional, Vumbaco, David, additional, Waleboer, Femke, additional, Walling-Bell, Sarah, additional, Weed, Natalie, additional, Williams, Grace, additional, Wilson, Julia, additional, Yao, Shenqin, additional, Zhou, Thomas, additional, Barzó, Pál, additional, Bakken, Trygve, additional, Cobbs, Charles, additional, Dee, Nick, additional, Ellenbogen, Richard G., additional, Esposito, Luke, additional, Ferreira, Manuel, additional, Gouwens, Nathan W., additional, Grannan, Benjamin, additional, Gwinn, Ryder P., additional, Hauptman, Jason S., additional, Hodge, Rebecca, additional, Jarsky, Tim, additional, Keene, C. Dirk, additional, Ko, Andrew L., additional, Korshoej, Anders Rosendal, additional, Levi, Boaz P., additional, Meier, Kaare, additional, Ojemann, Jeffrey G., additional, Patel, Anoop, additional, Ruzevick, Jacob, additional, Silbergeld, Daniel L., additional, Smith, Kimberly, additional, Sørensen, Jens Christian, additional, Waters, Jack, additional, Zeng, Hongkui, additional, Berg, Jim, additional, Capogna, Marco, additional, Goriounova, Natalia A., additional, Kalmbach, Brian, additional, de Kock, Christiaan P.J., additional, Mansvelder, Huib D., additional, Sorensen, Staci A., additional, Tamas, Gabor, additional, Lein, Ed S., additional, and Ting, Jonathan T., additional

Published
2023
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15. Morpho-electric and computational properties of three types of human hippocampal CA1 pyramidal neurons

Author

Mertens, Eline, primary, Leibner, Yoni, additional, Pie, Jean, additional, Galakhova, Anna, additional, Waleboer, Femke, additional, Meijer, Julia, additional, Heistek, Tim, additional, Wilbers, Rene, additional, Heyer, Djai, additional, Goriounova, Natalia, additional, Idema, Sander, additional, Verhoog, Matthijs, additional, Kalmbach, Brian, additional, Lee, Brian, additional, Gwinn, Ryder, additional, Lein, Ed, additional, Aronica, Eleonora, additional, Ting, Jonathan, additional, Mansvelder, Huib, additional, Segev, Idan, additional, and de Kock, Christiaan, additional

Published
2023
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16. Nine-year prospective efficacy and safety of brain-responsive neurostimulation for focal epilepsy

Author

Nair, Dileep R, Laxer, Kenneth D, Weber, Peter B, Murro, Anthony M, Park, Yong D, Barkley, Gregory L, Smith, Brien J, Gwinn, Ryder P, Doherty, Michael J, Noe, Katherine H, Zimmerman, Richard S, Bergey, Gregory K, Anderson, William S, Heck, Christianne, Liu, Charles Y, Lee, Ricky W, Sadler, Toni, Duckrow, Robert B, Hirsch, Lawrence J, Wharen, Robert E, Jr, Tatum, William, Srinivasan, Shraddha, McKhann, Guy M, Agostini, Mark A, Alexopoulos, Andreas V, Jobst, Barbara C, Roberts, David W, Salanova, Vicenta, Witt, Thomas C, Cash, Sydney S, Cole, Andrew J, Worrell, Gregory A, Lundstrom, Brian N, Edwards, Jonathan C, Halford, Jonathan J, Spencer, David C, Ernst, Lia, Skidmore, Christopher T, Sperling, Michael R, Miller, Ian, Geller, Eric B, Berg, Michel J, Fessler, A James, Rutecki, Paul, Goldman, Alica M, Mizrahi, Eli M, Gross, Robert E, Shields, Donald C, Schwartz, Theodore H, Labar, Douglas R, Fountain, Nathan B, Elias, W Jeff, Olejniczak, Piotr W, Villemarette-Pittman, Nicole R, Eisenschenk, Stephan, Roper, Steven N, Boggs, Jane G, Courtney, Tracy A, Sun, Felice T, Seale, Cairn G, Miller, Kathy L, Skarpaas, Tara L, and Morrell, Martha J

Published
2020
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17. Author Correction: Human neocortical expansion involves glutamatergic neuron diversification

Author

Berg, Jim, Sorensen, Staci A., Ting, Jonathan T., Miller, Jeremy A., Chartrand, Thomas, Buchin, Anatoly, Bakken, Trygve E., Budzillo, Agata, Dee, Nick, Ding, Song-Lin, Gouwens, Nathan W., Hodge, Rebecca D., Kalmbach, Brian, Lee, Changkyu, Lee, Brian R., Alfiler, Lauren, Baker, Katherine, Barkan, Eliza, Beller, Allison, Berry, Kyla, Bertagnolli, Darren, Bickley, Kris, Bomben, Jasmine, Braun, Thomas, Brouner, Krissy, Casper, Tamara, Chong, Peter, Crichton, Kirsten, Dalley, Rachel, de Frates, Rebecca, Desta, Tsega, Lee, Samuel Dingman, D’Orazi, Florence, Dotson, Nadezhda, Egdorf, Tom, Enstrom, Rachel, Farrell, Colin, Feng, David, Fong, Olivia, Furdan, Szabina, Galakhova, Anna A., Gamlin, Clare, Gary, Amanda, Glandon, Alexandra, Goldy, Jeff, Gorham, Melissa, Goriounova, Natalia A., Gratiy, Sergey, Graybuck, Lucas, Gu, Hong, Hadley, Kristen, Hansen, Nathan, Heistek, Tim S., Henry, Alex M., Heyer, Djai B., Hill, DiJon, Hill, Chris, Hupp, Madie, Jarsky, Tim, Kebede, Sara, Keene, Lisa, Kim, Lisa, Kim, Mean-Hwan, Kroll, Matthew, Latimer, Caitlin, Levi, Boaz P., Link, Katherine E., Mallory, Matthew, Mann, Rusty, Marshall, Desiree, Maxwell, Michelle, McGraw, Medea, McMillen, Delissa, Melief, Erica, Mertens, Eline J., Mezei, Leona, Mihut, Norbert, Mok, Stephanie, Molnar, Gabor, Mukora, Alice, Ng, Lindsay, Ngo, Kiet, Nicovich, Philip R., Nyhus, Julie, Olah, Gaspar, Oldre, Aaron, Omstead, Victoria, Ozsvar, Attila, Park, Daniel, Peng, Hanchuan, Pham, Trangthanh, Pom, Christina A., Potekhina, Lydia, Rajanbabu, Ramkumar, Ransford, Shea, Reid, David, Rimorin, Christine, Ruiz, Augustin, Sandman, David, Sulc, Josef, Sunkin, Susan M., Szafer, Aaron, Szemenyei, Viktor, Thomsen, Elliot R., Tieu, Michael, Torkelson, Amy, Trinh, Jessica, Tung, Herman, Wakeman, Wayne, Waleboer, Femke, Ward, Katelyn, Wilbers, René, Williams, Grace, Yao, Zizhen, Yoon, Jae-Geun, Anastassiou, Costas, Arkhipov, Anton, Barzo, Pal, Bernard, Amy, Cobbs, Charles, de Witt Hamer, Philip C., Ellenbogen, Richard G., Esposito, Luke, Ferreira, Manuel, Gwinn, Ryder P., Hawrylycz, Michael J., Hof, Patrick R., Idema, Sander, Jones, Allan R., Keene, C. Dirk, Ko, Andrew L., Murphy, Gabe J., Ng, Lydia, Ojemann, Jeffrey G., Patel, Anoop P., Phillips, John W., Silbergeld, Daniel L., Smith, Kimberly, Tasic, Bosiljka, Yuste, Rafael, Segev, Idan, de Kock, Christiaan P. J., Mansvelder, Huibert D., Tamas, Gabor, Zeng, Hongkui, Koch, Christof, and Lein, Ed S.

Published
2022
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19. Three-year follow-up of prospective trial of focused ultrasound thalamotomy for essential tremor

Author

Halpern, Casey H., Santini, Veronica, Lipsman, Nir, Lozano, Andres M., Schwartz, Michael L., Shah, Binit B., Elias, W. Jeff, Cosgrove, Garth R., Hayes, Michael T., McDannold, Nathan, Aldrich, Christina, Eisenberg, Howard M., Gandhi, Dheeraj, Taira, Takaomi, Gwinn, Ryder, Ro, Susie, Witt, Jennifer, Jung, Na Young, Chang, Jin Woo, Rosenberg, Jarrett, and Ghanouni, Pejman

Published
2019
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20. Target cell-specific synaptic dynamics of excitatory to inhibitory neuron connections in supragranular layers of human neocortex

Author

Kim, Mean-Hwan, primary, Radaelli, Cristina, additional, Thomsen, Elliot R, additional, Monet, Deja, additional, Chartrand, Thomas, additional, Jorstad, Nikolas L, additional, Mahoney, Joseph T, additional, Taormina, Michael J, additional, Long, Brian, additional, Baker, Katherine, additional, Bakken, Trygve E, additional, Campagnola, Luke, additional, Casper, Tamara, additional, Clark, Michael, additional, Dee, Nick, additional, D'Orazi, Florence, additional, Gamlin, Clare, additional, Kalmbach, Brian E, additional, Kebede, Sara, additional, Lee, Brian R, additional, Ng, Lindsay, additional, Trinh, Jessica, additional, Cobbs, Charles, additional, Gwinn, Ryder P, additional, Keene, C Dirk, additional, Ko, Andrew L, additional, Ojemann, Jeffrey G, additional, Silbergeld, Daniel L, additional, Sorensen, Staci A, additional, Berg, Jim, additional, Smith, Kimberly A, additional, Nicovich, Philip R, additional, Jarsky, Tim, additional, Zeng, Hongkui, additional, Ting, Jonathan T, additional, Levi, Boaz P, additional, and Lein, Ed, additional

Published
2023
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21. Morphoelectric and transcriptomic divergence of the layer 1 interneuron repertoire in human versus mouse neocortex

Author

Chartrand, Thomas, Dalley, Rachel, Close, Jennie, Goriounova, Natalia A., Lee, Brian R., Mann, Rusty, Miller, Jeremy A., Molnar, Gabor, Mukora, Alice, Alfiler, Lauren, Baker, Katherine, Bakken, Trygve E., Berg, Jim, Bertagnolli, Darren, Braun, Thomas, Brouner, Krissy, Casper, Tamara, Csajbok, Eva Adrienn, Dee, Nick, Egdorf, Tom, Enstrom, Rachel, Galakhova, Anna A., Gary, Amanda, Gelfand, Emily, Goldy, Jeff, Hadley, Kristen, Heistek, Tim S., Hill, Di Jon, Jorstad, Nik, Kim, Lisa, Kocsis, Agnes Katalin, Kruse, Lauren, Kunst, Michael, Leon, Gabriela, Long, Brian, Mallory, Matthew, McGraw, Medea, McMillen, Delissa, Melief, Erica J., Mihut, Norbert, Ng, Lindsay, Nyhus, Julie, Oláh, Gáspár, Ozsvár, Attila, Omstead, Victoria, Peterfi, Zoltan, Pom, Alice, Potekhina, Lydia, Rajanbabu, Ramkumar, Rozsa, Marton, Ruiz, Augustin, Sandle, Joanna, Sunkin, Susan M., Szots, Ildiko, Tieu, Michael, Toth, Martin, Trinh, Jessica, Vargas, Sara, Vumbaco, David, Williams, Grace, Wilson, Julia, Yao, Zizhen, Barzo, Pal, Cobbs, Charles, Ellenbogen, Richard G., Esposito, Luke, Ferreira, Manuel, Gouwens, Nathan W., Grannan, Benjamin, Gwinn, Ryder P., Hauptman, Jason S., Jarsky, Tim, Keene, C. Dirk, Ko, Andrew L., Koch, Christof, Ojemann, Jeffrey G., Patel, Anoop, Ruzevick, Jacob, Silbergeld, Daniel L., Smith, Kimberly, Sorensen, Staci A., Tasic, Bosiljka, Ting, Jonathan T., Waters, Jack, de Kock, Christiaan P.J., Mansvelder, Huib D., Tamas, Gabor, Zeng, Hongkui, Kalmbach, Brian, Lein, Ed S., Chartrand, Thomas, Dalley, Rachel, Close, Jennie, Goriounova, Natalia A., Lee, Brian R., Mann, Rusty, Miller, Jeremy A., Molnar, Gabor, Mukora, Alice, Alfiler, Lauren, Baker, Katherine, Bakken, Trygve E., Berg, Jim, Bertagnolli, Darren, Braun, Thomas, Brouner, Krissy, Casper, Tamara, Csajbok, Eva Adrienn, Dee, Nick, Egdorf, Tom, Enstrom, Rachel, Galakhova, Anna A., Gary, Amanda, Gelfand, Emily, Goldy, Jeff, Hadley, Kristen, Heistek, Tim S., Hill, Di Jon, Jorstad, Nik, Kim, Lisa, Kocsis, Agnes Katalin, Kruse, Lauren, Kunst, Michael, Leon, Gabriela, Long, Brian, Mallory, Matthew, McGraw, Medea, McMillen, Delissa, Melief, Erica J., Mihut, Norbert, Ng, Lindsay, Nyhus, Julie, Oláh, Gáspár, Ozsvár, Attila, Omstead, Victoria, Peterfi, Zoltan, Pom, Alice, Potekhina, Lydia, Rajanbabu, Ramkumar, Rozsa, Marton, Ruiz, Augustin, Sandle, Joanna, Sunkin, Susan M., Szots, Ildiko, Tieu, Michael, Toth, Martin, Trinh, Jessica, Vargas, Sara, Vumbaco, David, Williams, Grace, Wilson, Julia, Yao, Zizhen, Barzo, Pal, Cobbs, Charles, Ellenbogen, Richard G., Esposito, Luke, Ferreira, Manuel, Gouwens, Nathan W., Grannan, Benjamin, Gwinn, Ryder P., Hauptman, Jason S., Jarsky, Tim, Keene, C. Dirk, Ko, Andrew L., Koch, Christof, Ojemann, Jeffrey G., Patel, Anoop, Ruzevick, Jacob, Silbergeld, Daniel L., Smith, Kimberly, Sorensen, Staci A., Tasic, Bosiljka, Ting, Jonathan T., Waters, Jack, de Kock, Christiaan P.J., Mansvelder, Huib D., Tamas, Gabor, Zeng, Hongkui, Kalmbach, Brian, and Lein, Ed S.

Abstract

Neocortical layer 1 (L1) is a site of convergence between pyramidal-neuron dendrites and feedback axons where local inhibitory signaling can profoundly shape cortical processing. Evolutionary expansion of human neocortex is marked by distinctive pyramidal neurons with extensive L1 branching, but whether L1 interneurons are similarly diverse is underexplored. Using Patch-seq recordings from human neurosurgical tissue, we identified four transcriptomic subclasses with mouse L1 homologs, along with distinct subtypes and types unmatched in mouse L1. Subclass and subtype comparisons showed stronger transcriptomic differences in human L1 and were correlated with strong morphoelectric variability along dimensions distinct from mouse L1 variability. Accompanied by greater layer thickness and other cytoarchitecture changes, these findings suggest that L1 has diverged in evolution, reflecting the demands of regulating the expanded human neocortical circuit.

Published
2023
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22. Trial of Globus Pallidus Focused Ultrasound Ablation in Parkinson’s Disease

Author

Krishna, Vibhor, primary, Fishman, Paul S., additional, Eisenberg, Howard M., additional, Kaplitt, Michael, additional, Baltuch, Gordon, additional, Chang, Jin Woo, additional, Chang, Wei-Chieh, additional, Martinez Fernandez, Raul, additional, del Alamo, Marta, additional, Halpern, Casey H., additional, Ghanouni, Pejman, additional, Eleopra, Roberto, additional, Cosgrove, Rees, additional, Guridi, Jorge, additional, Gwinn, Ryder, additional, Khemani, Pravin, additional, Lozano, Andres M., additional, McDannold, Nathan, additional, Fasano, Alfonso, additional, Constantinescu, Marius, additional, Schlesinger, Ilana, additional, Dalvi, Arif, additional, and Elias, W. Jeff, additional

Published
2023
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23. Long-term safety of spinal cord stimulation systems in a prospective, global registry of patients with chronic pain

Author

Rauck, Richard L, primary, Loudermilk, Eric, additional, Thomson, Simon J, additional, Paz-Solis, Jose Francisco, additional, Bojrab, Louis, additional, Noles, John, additional, Vesper, Jan, additional, Atallah, Joseph, additional, Roth, Daniel, additional, Hegarty, Joseph, additional, Prud'Homme, Michel, additional, Phillips, Gregory M, additional, Smith, Stephen G, additional, Ibrahim, Mohab, additional, Willoughby, Channing D, additional, Obray, Jon B, additional, Gupta, Mayank, additional, Paez, Julio, additional, Berg, Anthony P, additional, Harrison, Nathan J, additional, Maino, Paolo, additional, Mambalam, Praveen, additional, McCarty, Matthew, additional, Towlerton, Glyn, additional, Love-Jones, Sarah, additional, Ahmed, Shakil, additional, Lee, Albert, additional, Shah, Binit, additional, Goor-Aryeh, Itay, additional, Russo, Marc A, additional, Varela, Nicolas, additional, Phelps, Jeffrey B, additional, Cid, José, additional, Fernandez, Tacson, additional, Pérez-Hernández, Concepción, additional, Keehn, Douglas, additional, Rosenow, Joshua M, additional, Haider, Nameer, additional, Parrent, Andrew G, additional, Lawrence, Melinda M, additional, Georgius, Peter, additional, Demartini, Laura, additional, Mendiola, Agustin, additional, Mehta, Vivek, additional, Thoma, Reinhard, additional, Israel, Atef F, additional, Carolis, Giuliano De, additional, Bhatia, Sanjay, additional, Green, Matthew, additional, Villarreal, Armando, additional, Crooks, Matthew T, additional, Gwinn, Ryder P, additional, Pilitsis, Julie G, additional, Sato, Hitoaki, additional, Vega, Sergio Maldonado, additional, Hillegass, M. Gabriel, additional, Carnes, Paul, additional, Scherer, Christian, additional, Brill, Silviu, additional, Yu, James, additional, Brennan, James J, additional, Gatzinsky, Kliment, additional, Navani, Annu, additional, Snook Jr, Lee T, additional, Bujedo, Borja Mugabure, additional, Andrés Ares, Javier De, additional, Murillo, Abel, additional, Trobridge, Andrew T, additional, Assil, Kamyar, additional, Shah, Jawad, additional, McLeod, Carroll, additional, Buwembo, Joseph, additional, Coster, Olivier De, additional, Miller, Nathan, additional, Sanapati, Mehendra, additional, Mikhael, Medhat, additional, Przkora, Rene, additional, Sukenaga, Norihiko, additional, Raso, Louis J, additional, Calodney, Aaron K, additional, Cáceres Jerez, Luz Elena, additional, Uchiyama, Takuya, additional, Kallewaard, Jan-Willem, additional, Chandler, Brett, additional, Piedimonte, Fabián, additional, Candido, Kenneth D, additional, Weaver, Tristan E, additional, Agari, Takashi, additional, Holthouse, David, additional, Woon, Rex, additional, Patel, Nileshkumar, additional, Lechleiter, Kristen, additional, and Jain, Roshini, additional

Published
2023
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25. SOUND SURGERY

Author

Monteith, Stephen J., Gwinn, Ryder, and Newell, David W.

Published
2015

26. Signature morpho-electric properties of diverse GABAergic interneurons in the human neocortex

Author

Lee, Brian, primary, Dalley, Rachel, additional, Miller, Jeremy A, additional, Chartrand, Thomas, additional, Close, Jennie, additional, Mann, Rusty, additional, Mukora, Alice, additional, Ng, Lindsay, additional, Alfiler, Lauren, additional, Baker, Katherine, additional, Bertagnolli, Darren, additional, Brouner, Krissy, additional, Casper, Tamara, additional, Csajbok, Eva, additional, Dee, Nick, additional, Donadio, Nicholas, additional, Driessens, Stan L.W., additional, Egdorf, Tom, additional, Enstrom, Rachel, additional, Galakhova, Anna A, additional, Gary, Amanda, additional, Gelfand, Emily, additional, Goldy, Jeff, additional, Hadley, Kristen, additional, Heistek, Tim S., additional, Hill, Dijon, additional, Johansen, Nelson, additional, Jorstad, Nik, additional, Kim, Lisa, additional, Kocsis, Agnes Katalin, additional, Kruse, Lauren, additional, Kunst, Michael, additional, Leon, Gabriela, additional, Long, Brian, additional, Mallory, Matthew, additional, Maxwell, Michelle, additional, McGraw, Medea, additional, McMillen, Delissa, additional, Melief, Erica J, additional, Molnar, Gabor, additional, Mortrud, Marty T, additional, Newman, Dakota, additional, Nyhus, Julie, additional, Opitz-Araya, Ximena, additional, Pham, Trangthanh, additional, Pom, Alice, additional, Potekhina, Lydia, additional, Rajanbabu, Ram, additional, Ruiz, Augustin, additional, Sunkin, Susan M, additional, Szots, Ildiko, additional, Taskin, Naz, additional, Thyagarajan, Bargavi, additional, Tieu, Michael, additional, Trinh, Jessica, additional, Vargas, Sara, additional, Vumbaco, David, additional, Waleboer, Femke, additional, Weed, Natalie, additional, Williams, Grace, additional, Wilson, Julia, additional, Yao, Shenqin, additional, Zhou, Thomas, additional, Barzo, Pal, additional, Bakken, Trygve, additional, Cobbs, Charles, additional, Ellenbogen, Richard G., additional, Esposito, Luke, additional, Ferreira, Manuel, additional, Gouwens, Nathan W, additional, Grannan, Benjamin, additional, Gwinn, Ryder P., additional, Hauptman, Jason S., additional, Hodge, Rebecca, additional, Jarsky, Tim, additional, Keene, C.Dirk, additional, Ko, Andrew L., additional, Levi, Boaz, additional, Ojemann, Jeffrey G., additional, Patel, Anoop, additional, Ruzevick, Jacob, additional, Silbergeld, Daniel L., additional, Smith, Kim, additional, Waters, Jack, additional, Zeng, Hongkui, additional, Berg, Jim, additional, Goriounova, Natalia A., additional, Kalmbach, Brian, additional, de Kock, Christiaan P.J., additional, Mansvelder, Huib D, additional, Sorensen, Staci A, additional, Tamas, Gabor, additional, Lein, Ed S., additional, and Ting, Jonathan T, additional

Published
2022
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27. Morpho-electric and transcriptomic divergence of the layer 1 interneuron repertoire in human versus mouse neocortex

Author

Chartrand, Thomas, primary, Dalley, Rachel, additional, Close, Jennie, additional, Goriounova, Natalia A., additional, Lee, Brian R., additional, Mann, Rusty, additional, Miller, Jeremy A., additional, Molnar, Gabor, additional, Mukora, Alice, additional, Alfiler, Lauren, additional, Baker, Katherine, additional, Bakken, Trygve E., additional, Berg, Jim, additional, Bertagnolli, Darren, additional, Braun, Thomas, additional, Brouner, Krissy, additional, Casper, Tamara, additional, Csajbok, Eva Adrienn, additional, Dee, Nick, additional, Egdorf, Tom, additional, Enstrom, Rachel, additional, Galakhova, Anna A., additional, Gary, Amanda, additional, Gelfand, Emily, additional, Goldy, Jeff, additional, Hadley, Kristen, additional, Heistek, Tim S., additional, Hill, DiJon, additional, Jorstad, Nik, additional, Kim, Lisa, additional, Kocsis, Agnes Katalin, additional, Kruse, Lauren, additional, Kunst, Michael, additional, Leon, Gabriela, additional, Long, Brian, additional, Mallory, Matthew, additional, McGraw, Medea, additional, McMillen, Delissa, additional, Melief, Erica J., additional, Mihut, Norbert, additional, Ng, Lindsay, additional, Nyhus, Julie, additional, Omstead, Victoria, additional, Peterfi, Zoltan, additional, Pom, Alice, additional, Potekhina, Lydia, additional, Rajanbabu, Ramkumar, additional, Rozsa, Marton, additional, Ruiz, Augustin, additional, Sandle, Joanna, additional, Sunkin, Susan M., additional, Szots, Ildiko, additional, Tieu, Michael, additional, Toth, Martin, additional, Trinh, Jessica, additional, Vargas, Sara, additional, Vumbaco, David, additional, Williams, Grace, additional, Wilson, Julia, additional, Yao, Zizhen, additional, Barzo, Pal, additional, Cobbs, Charles, additional, Ellenbogen, Richard G., additional, Esposito, Luke, additional, Ferreira, Manuel, additional, Gouwens, Nathan W., additional, Grannan, Benjamin, additional, Gwinn, Ryder P., additional, Hauptman, Jason S., additional, Jarsky, Tim, additional, Keene, C.Dirk, additional, Ko, Andrew L., additional, Koch, Christof, additional, Ojemann, Jeffrey G., additional, Patel, Anoop, additional, Ruzevick, Jacob, additional, Silberberg, Daniel L., additional, Smith, Kimberly, additional, Sorensen, Staci A., additional, Tasic, Bosiljka, additional, Ting, Jonathan T., additional, Waters, Jack, additional, de Kock, Christiaan P.J., additional, Mansvelder, Huib D., additional, Tamas, Gabor, additional, Zeng, Hongkui, additional, Kalmbach, Brian, additional, and Lein, Ed S., additional

Published
2022
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28. Inter-individual variation in human cortical cell type abundance and expression

Author

Johansen, Nelson, primary, Somasundaram, Saroja, additional, Travaglini, Kyle J., additional, Yanny, Anna Marie, additional, Shumyatcher, Maya, additional, Casper, Tamara, additional, Cobbs, Charles, additional, Dee, Nick, additional, Ellenbogen, Richard, additional, Ferreira, Manuel, additional, Goldy, Jeff, additional, Guzman, Junitta, additional, Gwinn, Ryder, additional, Hirschstein, Daniel, additional, Jorstad, Nikolas L., additional, Keene, C. Dirk, additional, Ko, Andrew, additional, Levi, Boaz P., additional, Ojemann, Jeffrey G., additional, Pham, Thanh, additional, Shapovalova, Nadiya, additional, Silbergeld, Daniel, additional, Sulc, Josef, additional, Torkelson, Amy, additional, Tung, Herman, additional, Smith, Kimberly, additional, Lein, Ed S., additional, Bakken, Trygve E., additional, Hodge, Rebecca D., additional, and Miller, Jeremy A., additional

Published
2022
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34. Magnetic resonance imaging–guided focused ultrasound thalamotomy for essential tremor: 5-year follow-up results

Author

Cosgrove, G. Rees, primary, Lipsman, Nir, additional, Lozano, Andres M., additional, Chang, Jin Woo, additional, Halpern, Casey, additional, Ghanouni, Pejman, additional, Eisenberg, Howard, additional, Fishman, Paul, additional, Taira, Takaomi, additional, Schwartz, Michael L., additional, McDannold, Nathan, additional, Hayes, Michael, additional, Ro, Susie, additional, Shah, Binit, additional, Gwinn, Ryder, additional, Santini, Veronica E., additional, Hynynen, Kullervo, additional, and Elias, W. Jeff, additional

Published
2022
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35. A scalable and modular automated pipeline for stitching of large electron microscopy datasets

Author

Mahalingam, Gayathri, primary, Torres, Russel, primary, Kapner, Daniel, additional, Trautman, Eric T, additional, Fliss, Tim, additional, Seshamani, Shamishtaa, additional, Perlman, Eric, additional, Young, Rob, additional, Kinn, Samuel, additional, Buchanan, JoAnn, additional, Takeno, Marc M, additional, Yin, Wenjing, additional, Bumbarger, Daniel J, additional, Gwinn, Ryder P, additional, Nyhus, Julie, additional, Lein, Ed, additional, Smith, Steven J, additional, Reid, R Clay, additional, Khairy, Khaled A, additional, Saalfeld, Stephan, additional, Collman, Forrest, additional, and Macarico da Costa, Nuno, additional

Published
2022
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36. Author response: A scalable and modular automated pipeline for stitching of large electron microscopy datasets

Author

Mahalingam, Gayathri, primary, Torres, Russel, primary, Kapner, Daniel, additional, Trautman, Eric T, additional, Fliss, Tim, additional, Seshamani, Shamishtaa, additional, Perlman, Eric, additional, Young, Rob, additional, Kinn, Samuel, additional, Buchanan, JoAnn, additional, Takeno, Marc M, additional, Yin, Wenjing, additional, Bumbarger, Daniel J, additional, Gwinn, Ryder P, additional, Nyhus, Julie, additional, Lein, Ed, additional, Smith, Steven J, additional, Reid, R Clay, additional, Khairy, Khaled A, additional, Saalfeld, Stephan, additional, Collman, Forrest, additional, and Macarico da Costa, Nuno, additional

Published
2022
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38. Local connectivity and synaptic dynamics in mouse and human neocortex

Author

Campagnola, Luke, primary, Seeman, Stephanie C., additional, Chartrand, Thomas, additional, Kim, Lisa, additional, Hoggarth, Alex, additional, Gamlin, Clare, additional, Ito, Shinya, additional, Trinh, Jessica, additional, Davoudian, Pasha, additional, Radaelli, Cristina, additional, Kim, Mean-Hwan, additional, Hage, Travis, additional, Braun, Thomas, additional, Alfiler, Lauren, additional, Andrade, Julia, additional, Bohn, Phillip, additional, Dalley, Rachel, additional, Henry, Alex, additional, Kebede, Sara, additional, Alice, Mukora, additional, Sandman, David, additional, Williams, Grace, additional, Larsen, Rachael, additional, Teeter, Corinne, additional, Daigle, Tanya L., additional, Berry, Kyla, additional, Dotson, Nadia, additional, Enstrom, Rachel, additional, Gorham, Melissa, additional, Hupp, Madie, additional, Dingman Lee, Samuel, additional, Ngo, Kiet, additional, Nicovich, Philip R., additional, Potekhina, Lydia, additional, Ransford, Shea, additional, Gary, Amanda, additional, Goldy, Jeff, additional, McMillen, Delissa, additional, Pham, Trangthanh, additional, Tieu, Michael, additional, Siverts, La’Akea, additional, Walker, Miranda, additional, Farrell, Colin, additional, Schroedter, Martin, additional, Slaughterbeck, Cliff, additional, Cobb, Charles, additional, Ellenbogen, Richard, additional, Gwinn, Ryder P., additional, Keene, C. Dirk, additional, Ko, Andrew L., additional, Ojemann, Jeffrey G., additional, Silbergeld, Daniel L., additional, Carey, Daniel, additional, Casper, Tamara, additional, Crichton, Kirsten, additional, Clark, Michael, additional, Dee, Nick, additional, Ellingwood, Lauren, additional, Gloe, Jessica, additional, Kroll, Matthew, additional, Sulc, Josef, additional, Tung, Herman, additional, Wadhwani, Katherine, additional, Brouner, Krissy, additional, Egdorf, Tom, additional, Maxwell, Michelle, additional, McGraw, Medea, additional, Pom, Christina Alice, additional, Ruiz, Augustin, additional, Bomben, Jasmine, additional, Feng, David, additional, Hejazinia, Nika, additional, Shi, Shu, additional, Szafer, Aaron, additional, Wakeman, Wayne, additional, Phillips, John, additional, Bernard, Amy, additional, Esposito, Luke, additional, D’Orazi, Florence D., additional, Sunkin, Susan, additional, Smith, Kimberly, additional, Tasic, Bosiljka, additional, Arkhipov, Anton, additional, Sorensen, Staci, additional, Lein, Ed, additional, Koch, Christof, additional, Murphy, Gabe, additional, Zeng, Hongkui, additional, and Jarsky, Tim, additional

Published
2022
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39. Author Correction:Human neocortical expansion involves glutamatergic neuron diversification (Nature, (2021), 598, 7879, (151-158), 10.1038/s41586-021-03813-8)

Author

Berg, Jim, Sorensen, Staci A., Ting, Jonathan T., Miller, Jeremy A., Chartrand, Thomas, Buchin, Anatoly, Bakken, Trygve E., Budzillo, Agata, Dee, Nick, Ding, Song-Lin, Gouwens, Nathan W., Hodge, Rebecca D., Kalmbach, Brian, Lee, Changkyu, Lee, Brian R., Alfiler, Lauren, Baker, Katherine, Barkan, Eliza, Beller, Allison, Berry, Kyla, Bertagnolli, Darren, Bickley, Kris, Bomben, Jasmine, Braun, Thomas, Brouner, Krissy, Casper, Tamara, Chong, Peter, Crichton, Kirsten, Dalley, Rachel, de Frates, Rebecca, Desta, Tsega, Lee, Samuel Dingman, D’Orazi, Florence, Dotson, Nadezhda, Egdorf, Tom, Enstrom, Rachel, Farrell, Colin, Feng, David, Fong, Olivia, Furdan, Szabina, Galakhova, Anna A., Gamlin, Clare, Gary, Amanda, Glandon, Alexandra, Goldy, Jeff, Gorham, Melissa, Goriounova, Natalia A., Gratiy, Sergey, Graybuck, Lucas, Gu, Hong, Hadley, Kristen, Hansen, Nathan, Heistek, Tim S., Henry, Alex M., Heyer, Djai B., Hill, DiJon, Hill, Chris, Hupp, Madie, Jarsky, Tim, Kebede, Sara, Keene, Lisa, Kim, Lisa, Kim, Mean-Hwan, Kroll, Matthew, Latimer, Caitlin, Levi, Boaz P., Link, Katherine E., Mallory, Matthew, Mann, Rusty, Marshall, Desiree, Maxwell, Michelle, McGraw, Medea, McMillen, Delissa, Melief, Erica, Mertens, Eline J., Mezei, Leona, Mihut, Norbert, Mok, Stephanie, Molnar, Gabor, Mukora, Alice, Ng, Lindsay, Ngo, Kiet, Nicovich, Philip R., Nyhus, Julie, Olah, Gaspar, Oldre, Aaron, Omstead, Victoria, Ozsvar, Attila, Park, Daniel, Peng, Hanchuan, Pham, Trangthanh, Pom, Christina A., Potekhina, Lydia, Rajanbabu, Ramkumar, Ransford, Shea, Reid, David, Rimorin, Christine, Ruiz, Augustin, Sandman, David, Sulc, Josef, Sunkin, Susan M., Szafer, Aaron, Szemenyei, Viktor, Thomsen, Elliot R., Tieu, Michael, Torkelson, Amy, Trinh, Jessica, Tung, Herman, Wakeman, Wayne, Waleboer, Femke, Ward, Katelyn, Wilbers, René, Williams, Grace, Yao, Zizhen, Yoon, Jae-Geun, Anastassiou, Costas, Arkhipov, Anton, Barzo, Pal, Bernard, Amy, Cobbs, Charles, de Witt Hamer, Philip C., Ellenbogen, Richard G., Esposito, Luke, Ferreira, Manuel, Gwinn, Ryder P., Hawrylycz, Michael J., Hof, Patrick R., Idema, Sander, Jones, Allan R., Keene, C. Dirk, Ko, Andrew L., Murphy, Gabe J., Ng, Lydia, Ojemann, Jeffrey G., Patel, Anoop P., Phillips, John W., Silbergeld, Daniel L., Smith, Kimberly, Tasic, Bosiljka, Yuste, Rafael, Segev, Idan, de Kock, Christiaan P. J., Mansvelder, Huibert D., Tamas, Gabor, Zeng, Hongkui, Koch, Christof, and Lein, Ed S.

Abstract

In the version of this Article initially published, the Acknowledgements statement contained an error. Originally appearing with thanks for support given in part as follows, “R01EY023173 from The National Eye Institute, U01MH105982 from the National Institute of Mental Health and Eunice Kennedy Shriver National Institute of Child Health and Human Development, and R011EY023173 from The National Institute of Allergy and Infectious Disease,” the last number (R011EY023173) was mistakenly added and is not in fact a grant or one provided by the NIAID. The mention has been removed. The changes have been made to the online version of the Article.

Published
2022

40. A Scalable and Modular Automated Pipeline for Stitching of Large Electron Microscopy Datasets

Author

Mahalingam, Gayathri, primary, Torres, Russel, additional, Kapner, Daniel, additional, Trautman, Eric T., additional, Fliss, Tim, additional, Seshamani, Sharmishtaa, additional, Perlman, Eric, additional, Young, Rob, additional, Kinn, Samuel, additional, Buchanan, JoAnn, additional, Takeno, Marc, additional, Yin, Wenjing, additional, Bumbarger, Daniel, additional, Gwinn, Ryder P., additional, Nyhus, Julie, additional, Lein, Ed, additional, Smith, Stephen, additional, Reid, Clay, additional, Khairy, Khaled, additional, Saalfeld, Stephan, additional, Collman, Forrest, additional, and Macarico da Costa, Nuno, additional

Published
2021
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41. Signature morpho-electric, transcriptomic, and dendritic properties of human layer 5 neocortical pyramidal neurons

Author

Kalmbach, Brian E., primary, Hodge, Rebecca D., additional, Jorstad, Nikolas L., additional, Owen, Scott, additional, de Frates, Rebecca, additional, Yanny, Anna Marie, additional, Dalley, Rachel, additional, Mallory, Matt, additional, Graybuck, Lucas T., additional, Radaelli, Cristina, additional, Keene, C. Dirk, additional, Gwinn, Ryder P., additional, Silbergeld, Daniel L., additional, Cobbs, Charles, additional, Ojemann, Jeffrey G., additional, Ko, Andrew L., additional, Patel, Anoop P., additional, Ellenbogen, Richard G., additional, Bakken, Trygve E., additional, Daigle, Tanya L., additional, Dee, Nick, additional, Lee, Brian R., additional, McGraw, Medea, additional, Nicovich, Philip R., additional, Smith, Kimberly, additional, Sorensen, Staci A., additional, Tasic, Bosiljka, additional, Zeng, Hongkui, additional, Koch, Christof, additional, Lein, Ed S., additional, and Ting, Jonathan T., additional

Published
2021
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42. Advanced SCS with anatomically-guided neural targeting: a view from the prospective 4800 patient global registry: 08 June – 088.

Author

Loudermilk, Eric, Roth, Daniel, Willoughby, Channing, Brewer, Randall, Berg, Anthony, McCarty, Matthew, Atallah, Joseph, Smith, Stephen, Rauck, Richard, Hegarty, Joseph, Phillips, Gregory, Haider, Nameer, Phelps, Jeff, Crooks, Matthew T., Lawrence, Melinda, Bojrab, Louis, Kim, Chong, Ahmed, Shakil, Lee, Albert, Brennan, James, Snook, Lee, Assil, Kamyar, Gwinn, Ryder, Navani, Annu, Gupta, Mayank, Mambalam, Praveen, Murillo, Abel, Raso, Louis, McLeod, Carroll, Trobridge, Andrew, Rosenow, Joshua, Mikhael, Medhat, Sanapati, Mahendra, Candido, Kenneth, Deogaonkar, Milind, North, James, Lechleiter, Kristen, Huynh, Dat, Jain, Roshini, and Mekel-Bobrov, Nitzan

Published
2015

45. INTER-INDIVIDUAL VARIATION IN HUMAN CORTICAL CELL TYPE ABUNDANCE AND EXPRESSION

Author

Johansen, Nelson, Somasundaram, Saroja, Travaglini, Kyle, Yanny, Anna Marie, Shumyatcher, Maya, Casper, Tamara, Cobbs, Charles, Dee, Nick, Ellenbogen, Richard, Ferreira, Manuel, Goldy, Jeff, Guzman, Junitta, Gwinn, Ryder, Hirschstein, Daniel, Jorstad, Nikolas, Keene, C. Dirk, Ko, Andrew, Levi, Boaz, Ojemann, Jeffrey, Pham, Thanh, Shapovalova, Nadiya, Silbergeld, Daniel, Sulc, Josef, Torkelson, Amy, Tung, Herman, Smith, Kimberly, Lein, Ed, Bakken, Trygve, Hodge, Rebecca, and Miller, Jeremy

Published
2023
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46. Local Connectivity and Synaptic Dynamics in Mouse and Human Neocortex

Author

Campagnola, Luke, primary, Seeman, Stephanie C, additional, Chartrand, Thomas, additional, Kim, Lisa, additional, Hoggarth, Alex, additional, Gamlin, Clare, additional, Ito, Shinya, additional, Trinh, Jessica, additional, Davoudian, Pasha, additional, Radaelli, Cristina, additional, Kim, Mean-Hwan, additional, Hage, Travis, additional, Braun, Thomas, additional, Alfiler, Lauren, additional, Andrade, Juia, additional, Bohn, Phillip, additional, Dalley, Rachel, additional, Henry, Alex, additional, Kebede, Sara, additional, Mukora, Alice, additional, Sandman, David, additional, Williams, Grace, additional, Larsen, Rachael, additional, Teeter, Corinne, additional, Daigle, Tanya L., additional, Berry, Kyla, additional, Dotson, Nadia, additional, Enstrom, Rachel, additional, Gorham, Melissa, additional, Hupp, Madie, additional, Lee, Samuel Dingman, additional, Ngo, Kiet, additional, Nicovich, Rusty, additional, Potekhina, Lydia, additional, Ransford, Shea, additional, Gary, Amanda, additional, Goldy, Jeff, additional, McMillen, Delissa, additional, Pham, Trangthanh, additional, Tieu, Michael, additional, Siverts, La’Akea, additional, Walker, Miranda, additional, Farrell, Colin, additional, Schroedter, Martin, additional, Slaughterbeck, Cliff, additional, Cobb, Charles, additional, Ellenbogen, Richard, additional, Gwinn, Ryder P, additional, Keene, C. Dirk, additional, Ko, Andrew L, additional, Ojemann, Jeffrey G, additional, Silbergeld, Daniel L, additional, Carey, Daniel, additional, Casper, Tamara, additional, Crichton, Kirsten, additional, Clark, Michael, additional, Dee, Nick, additional, Ellingwood, Lauren, additional, Gloe, Jessica, additional, Kroll, Matthew, additional, Sulc, Josef, additional, Tung, Herman, additional, Wadhwani, Katherine, additional, Brouner, Krissy, additional, Egdorf, Tom, additional, Maxwell, Michelle, additional, McGraw, Medea, additional, Pom, Christina Alice, additional, Ruiz, Augustin, additional, Bomben, Jasmine, additional, Feng, David, additional, Hejazinia, Nika, additional, Shi, Shu, additional, Szafer, Aaron, additional, Wakeman, Wayne, additional, Phillips, John, additional, Bernard, Amy, additional, Esposito, Luke, additional, D’Orazi, Florence D, additional, Sunkin, Susan, additional, Smith, Kimberly, additional, Tasic, Bosiljka, additional, Arkhipov, Anton, additional, Sorensen, Staci, additional, Lein, Ed, additional, Koch, Christof, additional, Murphy, Gabe, additional, Zeng, Hongkui, additional, and Jarsky, Tim, additional

Published
2021
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47. Functional enhancer elements drive subclass-selective expression from mouse to primate neocortex

Author

Mich, John K., primary, Graybuck, Lucas T., additional, Hess, Erik E., additional, Mahoney, Joseph T., additional, Kojima, Yoshiko, additional, Ding, Yi, additional, Somasundaram, Saroja, additional, Miller, Jeremy A., additional, Kalmbach, Brian E., additional, Radaelli, Cristina, additional, Gore, Bryan B., additional, Weed, Natalie, additional, Omstead, Victoria, additional, Bishaw, Yemeserach, additional, Shapovalova, Nadiya V., additional, Martinez, Refugio A., additional, Fong, Olivia, additional, Yao, Shenqin, additional, Mortrud, Marty, additional, Chong, Peter, additional, Loftus, Luke, additional, Bertagnolli, Darren, additional, Goldy, Jeff, additional, Casper, Tamara, additional, Dee, Nick, additional, Opitz-Araya, Ximena, additional, Cetin, Ali, additional, Smith, Kimberly A., additional, Gwinn, Ryder P., additional, Cobbs, Charles, additional, Ko, Andrew L., additional, Ojemann, Jeffrey G., additional, Keene, C. Dirk, additional, Silbergeld, Daniel L., additional, Sunkin, Susan M., additional, Gradinaru, Viviana, additional, Horwitz, Gregory D., additional, Zeng, Hongkui, additional, Tasic, Bosiljka, additional, Lein, Ed S., additional, Ting, Jonathan T., additional, and Levi, Boaz P., additional

Published
2021
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48. Multi-modal characterization and simulation of human epileptic circuitry

Author

Buchin, Anatoly, de Frates, Rebecca, Nandi, Anirban, Mann, Rusty, Chong, Peter, Ng, Lindsay, Miller, Jeremy, Hodge, Rebecca, Kalmbach, Brian, Bose, Soumita, Rutishauser, Ueli, McConoughey, Stephen, Lein, Ed, Berg, Jim, Sorensen, Staci, Gwinn, Ryder, Koch, Christof, Ting, Jonathan, Anastassiou, Costas A., Buchin, Anatoly, de Frates, Rebecca, Nandi, Anirban, Mann, Rusty, Chong, Peter, Ng, Lindsay, Miller, Jeremy, Hodge, Rebecca, Kalmbach, Brian, Bose, Soumita, Rutishauser, Ueli, McConoughey, Stephen, Lein, Ed, Berg, Jim, Sorensen, Staci, Gwinn, Ryder, Koch, Christof, Ting, Jonathan, and Anastassiou, Costas A.

Abstract

Temporal lobe epilepsy is the fourth most common neurological disorder with about 40% of patients not responding to pharmacological treatment. Increased cellular loss in the hippocampus is linked to disease severity and pathological phenotypes such as heightened seizure propensity. While the hippocampus is the target of therapeutic interventions such as temporal lobe resection, the impact of the disease at the cellular level remains unclear in humans. Here we show that properties of hippocampal granule cells change with disease progression as measured in living, resected hippocampal tissue excised from epilepsy patients. We show that granule cells increase excitability and shorten response latency while also enlarging in cellular volume, surface area and spine density. Single-cell RNA sequencing combined with simulations ascribe the observed electrophysiological changes to gradual modification in three key ion channel conductances: BK, Cav2.2 and Kir2.1. In a bio-realistic computational network model, we show that the changes related to disease progression bring the circuit into a more excitable state. In turn, we observe that by reversing these changes in the three key conductances produces a less excitable, early disease-like state. These results provide mechanistic understanding of epilepsy in humans and will inform future therapies such as viral gene delivery to reverse the course of the disorder.

Published
2020

50. Target cell-specific synaptic dynamics of excitatory to inhibitory neuron connections in supragranular layers of human neocortex

Author

Kim, Mean-Hwan, primary, Radaelli, Cristina, additional, Thomsen, Elliot R., additional, Machen, Deja, additional, Chartrand, Tom, additional, Jorstad, Nikolas L., additional, Mahoney, Joseph T., additional, Taormina, Michael J., additional, Long, Brian, additional, Baker, Katherine, additional, Campagnola, Luke, additional, Casper, Tamara, additional, Clark, Michael, additional, Dee, Nick, additional, D’Orazi, Florence, additional, Gamlin, Clare, additional, Kalmbach, Brian, additional, Kebede, Sara, additional, Lee, Brian R., additional, Ng, Lindsay, additional, Trinh, Jessica, additional, Cobbs, Charles, additional, Gwinn, Ryder P., additional, Keene, C. Dirk, additional, Ko, Andrew L., additional, Ojemann, Jeffrey G., additional, Silbergeld, Daniel L., additional, Sorensen, Staci A., additional, Berg, Jim, additional, Smith, Kimberly, additional, Nicovich, Philip R., additional, Jarsky, Tim, additional, Murphy, Gabe, additional, Zeng, Hongkui, additional, Ting, Jonathan T., additional, Levi, Boaz P., additional, and Lein, Ed S., additional

Published
2020
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