156 results on '"Hüe S"'
Search Results
2. A study on the psychological functioning of children with specific learning difficulties and typically developing children
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Nurul Shafira Adi, Azizah Othman, Hue San Kuay, and Qarem Mohamed Mustafa
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Children ,Emotional symptoms ,Behavioural ,Dyslexia ,Psychological Functioning ,Psychology ,BF1-990 - Abstract
Abstract Introduction Dyslexia is a widespread Specific Learning Difficulty, and children with dyslexia often face significant psychological difficulties due to their challenges with reading, spelling, and writing. Objective This study examines the psychological functioning of children with dyslexia and compares it with typically developing children. Method This cross-sectional study used the Child Behavior Checklist (CBCL) to evaluate behavioral issues and the State Trait Anxiety Inventory (STAI) to assess anxiety levels. Primary school teachers, who had known the children for at least a year, provided the reports. Data were analyzed using an independent sample t-test. Results Forty children with dyslexia (n = 40) and fifty typically developing children (n = 50) were assessed, in which both groups are predominantly boys (70%, 54%) aged 7–12 years (Mean age:9.3 ± 1.5). The results indicate a significantly greater degree of behavioural problems t(88) = 8.39,p
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- 2024
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3. Electrostatics of salt-dependent reentrant phase behaviors highlights diverse roles of ATP in biomolecular condensates
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Yi-Hsuan Lin, Tae Hun Kim, Suman Das, Tanmoy Pal, Jonas Wessén, Atul Kaushik Rangadurai, Lewis E Kay, Julie D Forman-Kay, and Hue Sun Chan
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liquid-liquid phase separation ,phosphorylation ,intrinsically disordered proteins ,random phase approximation ,field-theoretic simulation ,molecular dynamics ,Medicine ,Science ,Biology (General) ,QH301-705.5 - Abstract
Liquid-liquid phase separation (LLPS) involving intrinsically disordered protein regions (IDRs) is a major physical mechanism for biological membraneless compartmentalization. The multifaceted electrostatic effects in these biomolecular condensates are exemplified here by experimental and theoretical investigations of the different salt- and ATP-dependent LLPSs of an IDR of messenger RNA-regulating protein Caprin1 and its phosphorylated variant pY-Caprin1, exhibiting, for example, reentrant behaviors in some instances but not others. Experimental data are rationalized by physical modeling using analytical theory, molecular dynamics, and polymer field-theoretic simulations, indicating that interchain ion bridges enhance LLPS of polyelectrolytes such as Caprin1 and the high valency of ATP-magnesium is a significant factor for its colocalization with the condensed phases, as similar trends are observed for other IDRs. The electrostatic nature of these features complements ATP’s involvement in π-related interactions and as an amphiphilic hydrotrope, underscoring a general role of biomolecular condensates in modulating ion concentrations and its functional ramifications.
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- 2025
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4. Psychometric properties of the social determinants of health questionnaire (SDH-Q): development and validation
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Abdulwali Sabo, Garry Kuan, Sarimah Abdullah, Hue San Kuay, Mohammed Dauda Goni, and Yee Cheng Kueh
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Social determinants of health ,Questionnaire ,Validity ,Reliability ,Construct ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background The influence of social determinants of health (SDH) on sustainable development goals (SDG) has gained attention in recent years. However, there is a scarcity in the availability of valid and reliable instruments to assess the multiple aspects of SDH. Hence, this study was conducted to develop a brief self-reported measure for assessing SDH. Method A cross-sectional survey was conducted among university undergraduate students in Nigeria. The study consisted of 300 participants in the EFA (males 55.7%, females 44.3%) and 430 participants in the CFA (males 54.0%, females 46.0%). Participants were selected using a convenience sampling approach to assess their perceptions regarding SDH. Content Validity Index (CVI), Face Validity Index (FVI), Exploratory Factor Analysis (EFA), Confirmatory Factor Analysis (CFA), Composite Reliability (CR), Average Variance Extracted (AVE), Cronbach’s alpha, and Intraclass Correlation Coefficient (ICC) were computed to determine the psychometric properties of the newly developed SDH scale. Results In the EFA, two factors were extracted (structural determinants of SDH and intermediary determinants of SDH), with all 20 items retained. The total variance explained by the EFA model was 61.8%, and the factor correlation was 0.178. The Cronbach’s alpha values of the two factors were 0.917 and 0.939. In the CFA, the initial model did not fit the data well based on fit indices. After several re-specification of the model, the final re-specified measurement model demonstrated adequate fit factor structure of the SDH scale with two factors and 20 items (CFI = 0.943, TLI = 0.930, SRMR = 0.056, RMSEA = 0.053, RMSEA p-value = 0.220). The CR was 0.797 for structural determinants of SDH and 0.794 for intermediary determinants of SDH. The ICC was 0.938 for structural determinants of SDH and 0.941 for intermediary determinants of SDH. Conclusion The findings indicate that the SDH scale has adequate psychometric properties and can be used to assess the perceived level of SDH. We recommended that this tool be tested in other populations with diverse age groups and other demographic characteristics.
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- 2024
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5. Psychometric properties of the newly developed self-report environmental determinants of health questionnaire (EDH-Q): development and validation
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Abdulwali Sabo, Garry Kuan, Abdullah Sarimah, Hue San Kuay, and Yee Cheng Kueh
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Environmental determinants of health ,Questionnaire ,Validity ,Reliability ,Construct ,Psychology ,BF1-990 - Abstract
Abstract Background The environmental determinants of health (EDH) have a significant impact on people’s physical, mental, and social wellbeing. Everyone needs access to environmental resources of all types, including food, materials, and energy, to survive. Currently, no valid and reliable instrument exists for evaluating individuals’ perceived levels of EDH. Hence, the purpose of this study was to develop and validate the environmental determinants of health questionnaire (EDH-Q) among undergraduate students in Nigeria. Method We conducted a cross-sectional survey among undergraduate students in Nigeria to assess the psychometric properties of the newly developed Environmental Determinants of Health Questionnaire (EDH-Q). Respondents were selected using a convenience sampling approach to evaluate their perceptions of environmental determinants of health. The Content Validity Index (CVI) and Face Validity Index (FVI) were calculated to ascertain the scale’s content validity and response process validity, respectively. Additionally, exploratory factor analysis (EFA), confirmatory factor analysis (CFA), composite reliability (CR), average variance extracted (AVE), Cronbach’s alpha, and intraclass correlation coefficient (ICC) were computed to assess the scale’s construct validity. Results The study involved 300 respondents in the EFA (males 55.7%, females 44.3%) and 430 respondents in the CFA (males 54.0%, females 46.0%). In the EFA, two constructs were identified (the natural environment and the built environment). The EFA model was able to explain 63.57% of the total cumulative variance, and the factor correlation was 0.671. The whole scale Cronbach’s alpha value was 0.947, while the two constructs’ Cronbach’s alpha values were 0.918 (natural environment) and 0.935 (built environment). In the CFA, six pairs of error covariances were included between items within the same construct to improve the fit indices of the initial proposed measurement model. The final re-specified measurement model showed that the EDH-Q, which has two constructs and 18 items, has adequate construct validity (CFI = 0.948, TLI = 0.938, SRMR = 0.046, RMSEA = 0.052, and RMSEA p-value = 0.344). The CRs were 0.845 (natural environment) and 0.854 (built environment). The ICCs were 0.976 (natural environment) and 0.970 (built environment). Conclusion The results show that the newly created EDH-Q has sufficient construct validity and may be utilized to assess participants’ perceptions of their level of EDH. Researchers should examine this instrument in populations with different age ranges and other demographic characteristics, as the present study only applied it to undergraduate students who may share similar characteristics.
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- 2024
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6. Purpura chez une jeune femme hyperthyroïdienne
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Giraud-Kerleroux, L., Bernigaud, C., Droumaguet, C., Thai, L.H., Marciano-Fellous, L., Thomas, L., Charpentier, C., Helbert-Davidson, S., Fardet, L., Hüe, S., and Ingen-Housz-Oro, S.
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- 2021
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7. Lupus erythematosus and epidermal necrolysis: a case series of 16 patients
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Gaudin, O., primary, Milpied, B., additional, Papouin, B., additional, Hüe, S., additional, Ortonne, N., additional, Régnier, E., additional, Wolkenstein, P., additional, Chosidow, O., additional, de Prost, N., additional, and Ingen‐Housz‐Oro, S., additional
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- 2021
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8. Évolution des caractéristiques cliniques et de la prise en charge des patients atteints de pemphigoïde bulleuse entre 2009 et 2020
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Battesti, G., primary, Le Cleach, L., additional, Hotz, C., additional, Hüe, S., additional, Bonsang, B., additional, Gaudin, O., additional, Belmondo, T., additional, Chosidow, O., additional, Sbidian, E., additional, Wolkenstein, P., additional, and Oro, S., additional
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- 2020
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9. Vascularite cutanée à ANCA : ne pas oublier les antithyroïdiens de synthèse (propylthiouracil, PTU)
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Giraud-Kerleroux, L., primary, Bernigaud, C., additional, Droumaguet, C., additional, Thai, L.-H., additional, Marciano-Fellous, L., additional, Charpentier, C., additional, Bergqvist, C., additional, Helbert-Davidson, S., additional, Hüe, S., additional, Fardet, L., additional, and Oro, S., additional
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- 2020
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10. Nécrolyses épidermiques avec auto-immunité : quelle nosologie ?
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Gaudin, O., primary, Brigitte, M., additional, Papouain, B., additional, Hüe, S., additional, Ortonne, N., additional, Colin, A., additional, Régnier, E., additional, Ben Said, B., additional, Wolkenstein, P., additional, Chosidow, O., additional, De Prost, N., additional, and Oro, S., additional
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- 2020
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11. Impact en vie réelle des tests immunologiques de la pemphigoïde bulleuse dans la décision d’arrêt du traitement et les rechutes
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Battesti, G., primary, Belmondo, T., additional, Le Cleach, L., additional, Hotz, C., additional, Hüe, S., additional, Gaudin, O., additional, Bonsang, B., additional, Chosidow, O., additional, Sbidian, E., additional, Wolkenstein, P., additional, and Oro, S., additional
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- 2020
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12. Extensive cutaneous and muscular mucormycosis complicating insulin pump treatment
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Berot, V., primary, Bernigaud, C., additional, Ferchiou, A., additional, Ingen‐Housz‐Oro, S., additional, Hüe, S., additional, Ajzenberg, C., additional, Thomas, S., additional, Wieliczko‐Duparc, E., additional, Billaud, E., additional, Ait‐Ammar, N., additional, Ortonne, N., additional, Botterel, F., additional, and Chosidow, O., additional
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- 2020
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13. Les auteurs
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Adotévi., O., Amé-Thomas., P., Arnulf., B., Baron., C., Batteux., F., Beauvillain., C., Bérard., F., Blancho., G., Bourdenet., G., Boyer., O., Caillat-Zucman., S., Candon., S., Carapito., R., Carcelain., G., Carnoy., C., Cesbron., J.-Y., Chevailler., A., Chollet-Martin., S., Colombo., B., Contin-Bordes., C., Coutant., F., Dantal., J., de Carvalho Bittencourt., M., de Chaisemartin., L., Delfau-Larue., M.-H., Desplat-Jégo., S., Dragon-Durey., M.-A., Dubucquoi., S., Dumestre-Perard., C., Fischer., A., Fisson., S., Flament., H., Fournel., S., Galaine., J., Garraud., O., Godet., Y., Gorochov., G., Gros., F., Gubler., B., Guffroy., A., Hacein-Bey-Abina., S., Hoarau., C., Hüe., S., Kaplanski., G., Kervella., D., Kolopp Sarda., M.-N., Labalette., M., Lambotte., O., Le Gouvello., S., Le Naour., R., Lelièvre., J.-D., Lemoine., F., Liégeois., S., Martinet., J., Miyara., M., Moins-Teisserenc., H., Molinier-Frenkel., V., Nel., I., Pagès., F., Paul., S., Picard., C., Radosavljevic., M., Renaudineau., Y., Rosain., J., Rosenzwajg., M., Seillès., E., Soulas-Sprauel., P., Sterlin., D., Tartour., É., Taupin., J.-L., Thibault., G., Tiberghien., P., Toubert., A., Visentin., J., Vitte., J., Vivier., É., Watier., H., and Weiss., L.
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- 2023
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14. What causes hidradenitis suppurativa ?—15 years after
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Zouboulis, C.C. Benhadou, F. Byrd, A.S. Chandran, N.S. Giamarellos-Bourboulis, E.J. Fabbrocini, G. Frew, J.W. Fujita, H. González-López, M.A. Guillem, P. Gulliver, W.P.F. Hamzavi, I. Hayran, Y. Hórvath, B. Hüe, S. Hunger, R.E. Ingram, J.R. Jemec, G.B.E. Ju, Q. Kimball, A.B. Kirby, J.S. Konstantinou, M.P. Lowes, M.A. MacLeod, A.S. Martorell, A. Marzano, A.V. Matusiak, Ł. Nassif, A. Nikiphorou, E. Nikolakis, G. Nogueira da Costa, A. Okun, M.M. Orenstein, L.A.V. Pascual, J.C. Paus, R. Perin, B. Prens, E.P. Röhn, T.A. Szegedi, A. Szepietowski, J.C. Tzellos, T. Wang, B. van der Zee, H.H.
- Abstract
The 14 authors of the first review article on hidradenitis suppurativa (HS) pathogenesis published 2008 in EXPERIMENTAL DERMATOLOGY cumulating from the 1st International Hidradenitis Suppurativa Research Symposium held March 30–April 2, 2006 in Dessau, Germany with 33 participants were prophetic when they wrote “Hopefully, this heralds a welcome new tradition: to get to the molecular heart of HS pathogenesis, which can only be achieved by a renaissance of solid basic HS research, as the key to developing more effective HS therapy.” (Kurzen et al. What causes hidradenitis suppurativa? Exp Dermatol 2008;17:455). Fifteen years later, there is no doubt that the desired renaissance of solid basic HS research is progressing with rapid steps and that HS has developed deep roots among inflammatory diseases in Dermatology and beyond, recognized as “the only inflammatory skin disease than can be healed”. This anniversary article of 43 research-performing authors from all around the globe in the official journal of the European Hidradenitis Suppurativa Foundation e.V. (EHSF e.V.) and the Hidradenitis Suppurativa Foundation, Inc (HSF USA) summarizes the evidence of the intense HS clinical and experimental research during the last 15 years in all aspects of the disease and provides information of the developments to come in the near future. © 2020 The Authors. Experimental Dermatology published by John Wiley & Sons Ltd
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- 2020
15. What causes hidradenitis suppurativa ?—15 years after
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Zouboulis, C.C. (Christos), Benhadou, F. (Farida), Byrd, A.S. (Angel S.), Chandran, N.S. (Nisha), Giamarellos-Bourboulis, E.J. (Evangelos J.), Fabbrocini, G. (Gabriella), Frew, J.W. (John), Fujita, H. (Hideki), González-López, M.A. (Marcos A.), Guillem, P. (Philippe), Gulliver, W.P. (Wayne P.), Hamzavi, I., Hayran, Y. (Yildiz), Horvath, B.H. (Barbara), Hüe, S. (Sophie), Hunger, R.E., Ingram, J.R. (John R.), Jemec, G.B.E. (Gregor), Ju, Q. (Qiang), Kimball, A.B. (Alexa), Kirby, J.S. (Joslyn S.), Konstantinou, M.P. (Maria P.), Lowes, M.A. (Michelle A.), MacLeod, A.S. (Amanda S.), Martorell, A. (Antonio), Marzano, A.V. (Angelo V.), Matusiak, L., Nassif, A. (Aude), Nikiphorou, E. (Elena), Nikolakis, G. (Georgios), Nogueira da Costa, A. (André), Okun, M. (Martin), Orenstein, L.A.V. (Lauren A.V.), Pascual, J.C. (José Carlos), Paus, R. (Ralf), Perin, B. (Benjamin), Prens, E.P. (Errol), Röhn, T.A. (Till A.), Szegedi, A. (Andrea), Szepietowski, J.C. (J.), Tzellos, T. (Thrasyvoulos), Wang, B. (Baoxi), Zee, H.H. (Hessel) van der, Zouboulis, C.C. (Christos), Benhadou, F. (Farida), Byrd, A.S. (Angel S.), Chandran, N.S. (Nisha), Giamarellos-Bourboulis, E.J. (Evangelos J.), Fabbrocini, G. (Gabriella), Frew, J.W. (John), Fujita, H. (Hideki), González-López, M.A. (Marcos A.), Guillem, P. (Philippe), Gulliver, W.P. (Wayne P.), Hamzavi, I., Hayran, Y. (Yildiz), Horvath, B.H. (Barbara), Hüe, S. (Sophie), Hunger, R.E., Ingram, J.R. (John R.), Jemec, G.B.E. (Gregor), Ju, Q. (Qiang), Kimball, A.B. (Alexa), Kirby, J.S. (Joslyn S.), Konstantinou, M.P. (Maria P.), Lowes, M.A. (Michelle A.), MacLeod, A.S. (Amanda S.), Martorell, A. (Antonio), Marzano, A.V. (Angelo V.), Matusiak, L., Nassif, A. (Aude), Nikiphorou, E. (Elena), Nikolakis, G. (Georgios), Nogueira da Costa, A. (André), Okun, M. (Martin), Orenstein, L.A.V. (Lauren A.V.), Pascual, J.C. (José Carlos), Paus, R. (Ralf), Perin, B. (Benjamin), Prens, E.P. (Errol), Röhn, T.A. (Till A.), Szegedi, A. (Andrea), Szepietowski, J.C. (J.), Tzellos, T. (Thrasyvoulos), Wang, B. (Baoxi), and Zee, H.H. (Hessel) van der
- Abstract
The 14 authors of the first review article on hidradenitis suppurativa (HS) pathogenesis published 2008 in EXPERIMENTAL DERMATOLOGY cumulating from the 1st International Hidradenitis Suppurativa Research Symposium held March 30–April 2, 2006 in Dessau, Germany with 33 participants were prophetic when they wrote “Hopefully, this heralds a welcome new tradition: to get to the molecular heart of HS pathogenesis, which can only be achieved by a renaissance of solid basic HS research, as the key to developing more effective HS therapy.” (Kurzen et al. What causes hidradenitis suppurativa? Exp Dermatol 2008;17:455). Fifteen years later, the
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- 2020
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16. What causes hidradenitis suppurativa ?—15 years after
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Zouboulis, CC, Benhadou, F, Byrd, AS, Chandran, NS, Giamarellos-Bourboulis, E J, Fabbrocini, G, Frew, JW, Fujita, H, González-López, MA, Guillem, P, Gulliver, WPF, Hamzavi, I, Hayran, Y, Hórvath, B, Hüe, S, Hunger, RE, Ingram, J R, Jemec, G B, Ju, Q, Kimball, AB, Kirby, JS, Konstantinou, MP, Lowes, MA, MacLeod, AS, Martorell, A, Marzano, AV, Matusiak, ?, Nassif, A, Nikiphorou, E, Nikolakis, G, Costa, A, Okun, M M, Orenstein, LAV, Pascual, JC, Paus, R, Perin, B, Prens, Errol, Röhn, TA, Szegedi, A, Szepietowski, JC, Tzellos, T, Wang, B, van der Zee, Hessel, Zouboulis, CC, Benhadou, F, Byrd, AS, Chandran, NS, Giamarellos-Bourboulis, E J, Fabbrocini, G, Frew, JW, Fujita, H, González-López, MA, Guillem, P, Gulliver, WPF, Hamzavi, I, Hayran, Y, Hórvath, B, Hüe, S, Hunger, RE, Ingram, J R, Jemec, G B, Ju, Q, Kimball, AB, Kirby, JS, Konstantinou, MP, Lowes, MA, MacLeod, AS, Martorell, A, Marzano, AV, Matusiak, ?, Nassif, A, Nikiphorou, E, Nikolakis, G, Costa, A, Okun, M M, Orenstein, LAV, Pascual, JC, Paus, R, Perin, B, Prens, Errol, Röhn, TA, Szegedi, A, Szepietowski, JC, Tzellos, T, Wang, B, and van der Zee, Hessel
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- 2020
17. Place des laboratoires de génétique, d’anatomie pathologique et d’immunologie dans la prise en charge des maladies rares dermatologiques
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Vidaud, D., Silve, C., Leclerc-Mercier, S., Hüe, S., Ingen-Housz-Oro, S., and Bodemer, C.
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- 2018
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18. A study looking at different types of severe rashes called acute exanthemas
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Deschamps, O., primary, Ortonne, N., additional, Hüe, S., additional, Rodriguez, C., additional, Deschodt, C., additional, Hirsch, G., additional, Colin, A., additional, Grégoire, L., additional, Delfau‐Larue, M.‐H., additional, Chosidow, O., additional, Wolkenstein, P., additional, and Ingen‐Housz‐Oro, S., additional
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- 2020
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19. 一项探讨称不同类型重度皮疹(急性皮疹)的研究
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Deschamps, O., primary, Ortonne, N., additional, Hüe, S., additional, Rodriguez, C., additional, Deschodt, C., additional, Hirsch, G., additional, Colin, A., additional, Grégoire, L., additional, Delfau‐Larue, M.‐H., additional, Chosidow, O., additional, Wolkenstein, P., additional, and Ingen‐Housz‐Oro, S., additional
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- 2020
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20. Un stress réplicatif spontané des cellules souches du follicule pileux serait à l’origine de l’inflammation dans l’hidradénite suppurée
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Orvain, C., primary, Lin, Y.-L., additional, Jean-Louis, F., additional, Hocini, H., additional, Hersant, B., additional, Bennasser, Y., additional, Ortonne, N., additional, Hotz, C., additional, Wolkenstein, P., additional, Boniotto, M., additional, Tisserand, P., additional, Lefebvre, C., additional, Lelièvre, J.-D., additional, Benkirane, M., additional, Pasero, P., additional, Levy, Y., additional, and Hüe, S., additional
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- 2019
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21. Acute exanthemas: a prospective study of 98 adult patients with an emphasis on cytokinic and metagenomic investigation
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Deschamps, O., primary, Ortonne, N., additional, Hüe, S., additional, Rodriguez, C., additional, Deschodt, C., additional, Hirsch, G., additional, Colin, A., additional, Grégoire, L., additional, Delfau‐Larue, M.‐H., additional, Chosidow, O., additional, Wolkenstein, P., additional, and Ingen‐Housz‐Oro, S., additional
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- 2019
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22. Lupus erythematosus and epidermal necrolysis: a case series of 16 patients.
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Gaudin, O., Milpied, B., Papouin, B., Hüe, S., Ortonne, N., Régnier, E., Wolkenstein, P., Chosidow, O., de Prost, N., and Ingen‐Housz‐Oro, S.
- Subjects
STEVENS-Johnson Syndrome ,LUPUS erythematosus ,TOXIC epidermal necrolysis ,DRUG side effects - Abstract
In our series, histology revealed mucin in seven patients, five with previous LE or clinical signs of LE, and only one with a positive lupus band test. During follow-up, one patient with LE antibodies showed recurrent cutaneous LE lesions, and the case was retrospectively concluded as TEN-like LE. In patients without previous LE/SS and no clinical sign of LE, especially those with a trigger drug, the pathophysiology of the LE autoantibodies remains unknown (possibly epitope spreading). [Extracted from the article]
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- 2022
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23. Anticorps de la dermatomyosite et autres myopathies inflammatoires : ce que le dermatologue doit savoir
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Hüe, S., Ingen-Housz-Oro, S., and Fardet, L.
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- 2015
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24. Epidermal necrolysis and autoimmune diseases: two more observations supporting the concept that ‘toxic’ epidermal necrolysis can be ‘non-toxic’
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Dumas, M., primary, Hua, C., additional, Hotz, C., additional, Velter, C., additional, Duong, T.A., additional, Maraffi, T., additional, Ortonne, N., additional, Hüe, S., additional, Fardet, L., additional, de Prost, N., additional, Wolkenstein, P., additional, Ingen-Housz-Oro, S., additional, and Chosidow, O., additional
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- 2018
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25. Exanthèmes aigus : analyse histologique et cytokinique d’une cohorte prospective de 98 patients
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Deschamps, O., primary, Ortonne, N., additional, Hüe, S., additional, Rodriguez, C., additional, Deschodt, C., additional, Hirsh, G., additional, Colin, A., additional, Delfau-Larue, M.-H., additional, Chosidow, O., additional, Wolkenstein, P., additional, and Oro, S., additional
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- 2017
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26. Hidradénite suppurée : infiltration de cellules dendritiques plasmacytoïdes dans les lésions
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Fertitta, L., primary, Orvain, C., additional, Kervevan, J., additional, Hotz, C., additional, Jean-Louis, F., additional, Aguilar, P., additional, Hersant, B., additional, Bosc, R., additional, Wolkenstein, P., additional, Lelievre, J.-D., additional, Boniotto, M., additional, and Hüe, S., additional
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- 2017
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27. Idiopathic linear IgA bullous dermatosis: prognostic factors based on a case series of 72 adults
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Gottlieb, J., primary, Ingen-Housz-Oro, S., additional, Alexandre, M., additional, Grootenboer-Mignot, S., additional, Aucouturier, F., additional, Sbidian, E., additional, Tancrede, E., additional, Schneider, P., additional, Regnier, E., additional, Picard-Dahan, C., additional, Begon, E., additional, Pauwels, C., additional, Cury, K., additional, Hüe, S., additional, Bernardeschi, C., additional, Ortonne, N., additional, Caux, F., additional, Wolkenstein, P., additional, Chosidow, O., additional, and Prost-Squarcioni, C., additional
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- 2017
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28. Acute exanthemas: a prospective study of 98 adult patients with an emphasis on cytokinic and metagenomic investigation.
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Deschamps, O., Ortonne, N., Hüe, S., Rodriguez, C., Deschodt, C., Hirsch, G., Colin, A., Grégoire, L., Delfau‐Larue, M.‐H., Chosidow, O., Wolkenstein, P., and Ingen‐Housz‐Oro, S.
- Subjects
MACROPHAGE inflammatory proteins ,LONGITUDINAL method ,INVESTIGATIONS ,POLYMERASE chain reaction ,PITYRIASIS rosea - Abstract
Summary: Background: Acute exanthemas (AEs) are frequently seen; they can be caused by drugs or viruses but often the cause is unknown. Objectives: To describe the clinical, virological and histological aspects of AEs and explore their cytokinic and metagenomic profiles. Methods: This prospective study examined 98 patients with AE, from February to July 2014. Clinical data were recorded in a standardized chart. Virological investigation and skin biopsies were performed. In addition, blood and skin samples were analysed for cytokines and then by a shotgun metagenomic approach. We identified five groups of patients: those with maculopapular exanthemas (MPEs) that were virally induced (group 1); those with drug‐induced MPEs (group 2), those with MPEs that were both viral and drug induced (group 3), those with idiopathic MPEs (group 4) and those with pityriasis rosea (group 5). Results: A virus was identified in 29 cases (human herpesvirus 6, 72%). Cytokinic analysis of the skin (n = 23 MPEs) showed higher levels of interferon‐γ and interleukin‐1 receptor‐α in viral MPEs, higher interleukin‐33 levels in idiopathic MPEs, and higher macrophage inflammatory protein 1α levels in drug‐induced MPEs. By metagenomics analysis (n = 10 MPEs), viruses identified with routine practice methods were not found in group 1 (n = 4 MPEs). However, Enterovirus A was detected in two cases, especially in a group 1 patient for whom metagenomic analysis rectified the diagnosis of the culprit agent. Conclusions: Human herpesvirus 6 was the virus most frequently identified, and histology did not discriminate MPEs. In addition, the level of interleukin‐33 seen in idiopathic MPEs suggests that an environmental factor may be the trigger for these. The results bring into question the utility of routine polymerase chain reaction analysis and viral serology for determining cause in AE. What's already known about this topic? Acute exanthemas, especially maculopapular exanthemas, are a frequent reason for patients consulting emergency and dermatology departments.It is difficult to evaluate the aetiology of acute exanthema based on the clinical aspects.Few data are available on the investigations needed in routine practice, and no prospective series have been published. What does this study add? Our study provides a global and prospective description of acute exanthemas.Cytokine analysis could help to investigate the pathophysiology of idiopathic eruptions.Metagenomic analysis provides new insights about the value of routine practice virological investigations.We show for the first time the feasibility of metagenomics analysis in the skin, which results question the interest of routine PCR and viral sérologies for the exploration of such acute exanthemas. Linked Comment: Shearer et al. Br J Dermatol 2020; 182:268–269. Plain language summary available online [ABSTRACT FROM AUTHOR]
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- 2020
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29. Anticorps de la dermatite herpétiforme : ce que le dermatologue doit savoir
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Ingen-Housz-Oro, S., Amiot, A., Ortonne, N., and Hüe, S.
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- 2014
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30. Biological condensates form percolated networks with molecular motion properties distinctly different from dilute solutions
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Zeyu Shen, Bowen Jia, Yang Xu, Jonas Wessén, Tanmoy Pal, Hue Sun Chan, Shengwang Du, and Mingjie Zhang
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phase separation ,multivalent interaction ,molecular network formation ,percolation ,biological condensate ,Medicine ,Science ,Biology (General) ,QH301-705.5 - Abstract
Formation of membraneless organelles or biological condensates via phase separation and related processes hugely expands the cellular organelle repertoire. Biological condensates are dense and viscoelastic soft matters instead of canonical dilute solutions. To date, numerous different biological condensates have been discovered, but mechanistic understanding of biological condensates remains scarce. In this study, we developed an adaptive single-molecule imaging method that allows simultaneous tracking of individual molecules and their motion trajectories in both condensed and dilute phases of various biological condensates. The method enables quantitative measurements of concentrations, phase boundary, motion behavior, and speed of molecules in both condensed and dilute phases, as well as the scale and speed of molecular exchanges between the two phases. Notably, molecules in the condensed phase do not undergo uniform Brownian motion, but instead constantly switch between a (class of) confined state(s) and a random diffusion-like motion state. Transient confinement is consistent with strong interactions associated with large molecular networks (i.e., percolation) in the condensed phase. In this way, molecules in biological condensates behave distinctly different from those in dilute solutions. The methods and findings described herein should be generally applicable for deciphering the molecular mechanisms underlying the assembly, dynamics, and consequently functional implications of biological condensates.
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- 2023
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31. Anticorps antinucléaires : ce que le dermatologue doit savoir
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Guillaud, C., Hüe, S., and Ingen-Housz-Oro, S.
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- 2013
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32. Auto-anticorps des dermatoses bulleuses auto-immunes (pemphigus, pemphigoïde bulleuse) : ce que le dermatologue doit savoir
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Ingen-Housz-Oro, S., Hüe, S., Grootenboer-Mignot, S., and André, C.
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- 2013
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33. French Intensive Care Society, International congress - Réanimation 2016
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Jaillette, E, Girault, C, Brunin, G, Zerimech, F, Chiche, A, Broucqsault Dedrie, C, Fayolle, C, Minacori, F, Alves, I, Barrailler, S, Robriquet, L, Delaporte, E, Thellier, D, Delcourte, C, Duhamel, A, Nseir, S, Valette, X, Desmeulles, I, Savary, B, Masson, R, Seguin, A, Daubin, C, Sauneuf, B, Verrier, P, Pottier, V, Orabona, M, Samba, D, Viquesnel, G, Lermuzeaux, M, Hazera, P, Hanouz, J, Parienti, J, Du Cheyron, D, Demoule, A, Clavel, M, Rolland Debord, C, Perbet, S, Terzi, N, Kouatchet, A, Wallet, F, Roze, H, Vargas, F, Guérin, C, Dellamonica, J, Jaber, S, Similowski, T, Quenot, J, Binquet, C, Vinsonneau, C, Barbar, S, Vinault, S, Deckert, V, Lemaire, S, Hssain, A, Bruyère, R, Souweine, B, Lagrost, L, Adrie, C, Jung, B, Daurat, A, De Jong, A, Chanques, G, Mahul, M, Monnin, M, Molinari, N, Lheureux, O, Trepo, E, Hites, M, Cotton, F, Wolff, F, Surin, R, Créteur, J, Vincent, J, Gustot, T, Jacobs, F, Taccone, F, Neuville, M, Timsit, J, El Helali, N, Le Monnier, A, Magalhaes, E, Radjou, A, Smonig, R, Soubirou, J, Voiriot, G, Sonneville, R, Bouadma, L, Mourvillier, B, Gélisse, E, Brasseur, A, Roisin, S, De Backer, D, Van Ruychevelt, V, Carlier, E, Piagnerelli, M, Vanhaeverbeek, M, Danguy, C, Biston, P, Au, S, Begot, E, Dalmay, F, Repessé, X, Prat, G, Bouferrache, K, Slama, M, Vieillard Baron, A, Monnet, X, Marik, P, Teboul, J, Jozwiak, M, Richard, C, Chauvet, J, El Dash, S, Delastre, O, Bouffandeau, B, Jusserand, D, Michot, J, Bauer, F, Brazier, F, Mercado, P, Kontar, L, Titeca, D, De Cagny, B, Bacari Risal, G, Riviere, A, Maizel, J, Guillot, C, Le Reun, C, Lampin, M, Sadik, A, Botte, A, Leteurtre, S, Collins, A, Kempeneers, C, Cajgfinger, N, Ohlmann, C, Pouyau, R, Subtil, F, Baudin, F, Massenavette, B, Javouhey, E, Milesi, C, Essouri, S, Liet, J, Afanetti, M, Durand, S, Durand, P, Roze, J, Dupont, D, Cambonie, G, Soyer, B, Rusca, M, Lukaszewicz, A, Crassard, I, Guichard, J, Bresson, D, de la Garanderie, D, Cantier, M, Sabben, C, Louedec, L, Delbosc, S, Journé, C, Ou, P, Klein, I, Chau, F, Lefort, A, Desilles, J, Michel, J, Mazighi, M, Salem, O, Demeret, S, Bolgert, F, Sharshar, T, Grabli, D, Arib, S, Crippa, I, Soummer, A, Engrand, N, Guedin, P, Aldea, S, Cerf, C, Desailly, V, Pasquier, P, Brun, P, Roux, D, Latournerie, G, Kasprzyk, L, Grosjean, V, Latreche, A, Habert, P, Huot, S, Jobin, T, Tesnière, A, Dreyfuss, D, Ricard, J, Mignon, A, Gaudry, S, Laithier, F, Kimmoun, A, Chouihed, T, Albizzati, S, Camenzind, E, Vanhuyse, F, Levy, B, Cour, M, Venet, F, Hernu, R, Demaret, J, Monneret, G, Argaud, L, Dumas, F, Lamhaut, L, Rosencher, J, Pène, F, Varenne, O, Carli, P, Jouven, X, Spaulding, C, Cariou, A, Geri, G, Bonnetain, F, Marijon, E, Empana, J, Mirouse, A, Resche Rigon, M, Mayaux, J, Rabbat, A, Meert, A, Benoit, D, Bruneel, F, Azoulay, E, Dupuis, C, Schwebel, C, Ruckly, S, Goldgran Toledano, D, Marcotte, G, Lafarge, A, Pichereau, C, Theodose, I, Scotto, M, Kemlin, D, Ghrenassia, E, Schlemmer, B, Vimpere, D, Galicier, L, Contou, D, Guérot, E, Grimaldi, D, Ricome, S, Maury, E, Plantefève, G, Dessap, A, Brun Buisson, C, de Prost, N, Dubé, B, Delemazure, J, Dres, M, Rousseau, L, Drouot, X, Diaz, V, Rebollar, Y, Frat, J, Thille, A, Aissa, D, Coquet, P, Ruiz, J, Ferre, F, Hoarau, L, Riu Poulenc, B, Bataille, B, Silva, S, Baudel, J, Bigé, N, Tahiri, J, Dubée, V, Guidet, B, Ait Oufella, H, Jinglun, L, Shen, F, Bailly, S, Leroy, O, Montravers, P, Constantin, J, Dupont, H, Guillemot, D, Lortholary, O, Perrigault, P, Gangneux, J, Razazi, K, Mekontso Dessap, A, Jansen, C, Lecronier, M, Sandrine, V, Mira, J, Blein, S, Marin, N, Rousseau, C, Charpentier, J, Pachot, A, Hraiech, S, Bordes, J, De, L, Mège, J, Forel, J, Guervilly, C, Adda, M, Raoult, D, Papazian, L, Kentish Barnes, N, Cohen Solal, Z, Souppart, V, Kerhuel, L, Haubertin, C, Exbrayat, I, Rozières, E, Argain, A, Suc, A, Vignes, M, Cougot, P, Fourcade, O, Brunel, E, Messika, J, Tubach, F, Dubief, E, Pasquet, B, Guillo, S, Pierron, C, Grimaud, M, Farnoux, C, Maillard, A, Decavèle, M, Prodanovic, H, Idbaih, A, Alentorn, A, Delattre, J, De Montmollin, E, Brule, N, Conrad, M, Dailler, F, Navellou, J, Alves, M, Tonnelier, J, Picard, G, Rogemond, V, Honnorat, J, Marzorati, C, Lebert, C, Perez, P, Citerio, G, Legriel, S, Tripon, S, Mallet, M, Rudler, M, Imbert Bismut, F, Thabut, D, Canet, E, Faguer, S, Moreau, A, Barbier, F, Merceron, S, Guitton, C, Labadie, F, Lemiale, V, Faucher, E, Klouche, K, Chevret, S, Ragot, S, Coudroy, R, Boulain, T, Jamet, A, Mercat, A, Brochard, L, Roux, A, Franchineau, G, Brechot, N, Lebreton, G, Hekimian, G, Nieszkowska, A, Leprince, P, Trouillet, J, Combes, A, Schmidt, M, Barrot, L, Piton, G, Bailey, M, Panwar, R, Belin, N, Belon, F, Patry, C, Grandperrin, M, Chaignat, C, Labro, G, Vivet, B, Capellier, G, Daix, T, Guérin, E, Tavernier, E, Mercier, E, Gissot, V, Vallejo, C, François, B, Ravry, C, Pichon, N, Chapellas, C, Fedou, A, Galy, A, Ploy, M, Barraud, O, Vignon, P, Thooft, A, Conotte, R, Colet, J, Le Dorze, M, Tarazona, V, Brumpt, C, Moins Teisserenc, H, Uhel, F, Azzaoui, I, Gregoire, M, Pangault, C, Dulong, J, Cynober, L, Roussel, M, Le Tulzo, Y, Tarte, K, Demiselle, J, Auchabie, J, Dequin, P, Chudeau, N, Fourrier, F, Grange, S, Piquilloud, L, Lautrette, A, Boyer, S, Letheulle, J, Lerolle, N, Truche, A, Clec'H, C, Zaoui, P, Laurent, V, Toledano, D, Ragey, S, Gros, A, Dumenil, A, Jamali, S, Darmon, M, Chouraqui, M, Dewitte, A, Chastel, B, Carles, P, Fleureau, C, Joannes Boyau, O, Ouattara, A, Joseph, A, Garrouste Orgeas, M, Max, A, Lerin, T, Grégoire, C, Kloeckner, M, Bruel, C, Brochon, S, Philippart, F, Pichot, E, Simons, C, Flint, A, Aubron, C, Bellomo, R, Pilcher, D, Cheng, A, Hegarty, C, Martinelli, A, Howden, B, Reade, M, Mcquilten, Z, Bretonnière, C, Villers, D, Soares, M, Gonzalez, F, Vincent, F, Fauché, C, Gay, S, Skowron, O, Levrat, A, Dorez, D, Foucrier, A, Pease, S, Gauss, T, Paugam, C, Gorham, J, Ameye, L, Paesmans, M, Berghmans, T, Sculier, J, Deras, P, Martinez, O, Latry, P, Capdevila, X, Charbit, J, Jaubert, J, Etiennar, C, Ginoux, L, Sebbah, J, Haouache, H, Dhonneur, G, Cheikh, C, Moussaid, I, Ghazaoui, O, Belkadi, K, El Youssoufi, S, Salmi, S, Pajot, L, Zuber, B, Bedos, J, Dupont, B, Eugène, A, Galateau Sallé, F, Michard, B, Lebas, B, Boivin, A, Guillot, M, Harlay, M, Janssen Langenstein, R, Schenck, M, Ellero, B, Woehl Jaegle, M, Besch, C, Castelain, V, Bachellier, P, Schneider, F, Camus, C, Saliba, F, Goubaux, B, Bonadona, A, Lavayssiere, L, Quinart, A, Barbot, O, Dharancy, S, Delafosse, B, Barraud, H, Galbois, A, Veber, B, Cayot, S, Souche, B, Locher, C, Roux, O, Figorilli, F, Putignano, A, Houssel, P, Francoz, C, Weiss, E, Agarwal, B, Jalan, R, Durand, F, Ghezala, H, Daoudi, R, Kaddour, M, Ghadhoune, H, Rachedi, E, Guissouma, J, Ben Slimene, A, Azzeza, W, Brahmi, H, Elghord, H, Kada, A, Chikh, R, Slimani, R, A. Bouyoucef, K, Regaieg, K, Kamilia, C, Baccouche, N, Turki, O, Chaari, A, Ben, H, Bouaziz, M, Medhioub, F, Zekri, M, Rgieg, K, Bhimada, C, Mounir, B, Lang, E, Welschbillig, S, Perrin, M, Devys, J, Benbernou, S, Mokhtari Djebli, H, Ilies, S, Bouyacoub, K, Azza, A, Zogheib, E, Nader, J, Villeret, L, Guilbart, M, Besserve, P, Caus, T, Mastroianni, C, Santi, F, Hékimian, G, Pascal, L, Chastre, J, Perrier, V, Deniau, B, Klasen, F, Ponthus, J, Ngasseu, P, Amilien, V, Barsam, E, Lehericey, P, Tchir, M, Georger, J, Puech, B, Vandroux, D, Roussiaux, A, Belcour, D, Ferdynus, C, Martinet, O, Jabot, J, Fresco, M, Demeilliers Pfister, G, Merle, V, Brunel, V, Dureuil, B, Leydier, S, Clerc Urmes, I, Lemarie, J, Maigrat, C, Cravoisy Popovic, A, Barraud, D, Nace, L, Gibot, S, Agrinier, N, Bollaert, P, Daban, J, Boutonnet, M, Dumas, G, Falzone, E, Jault, P, Lenoir, B, Makunza, J, Mejeni, N, Mazaud, A, Béague, S, Rousselle, A, Durocher, A, Grinea, A, Bedoui, N, Stoian, A, Baboi, L, Gobert, F, Yonis, H, Tapponier, R, Bruyneel, A, Bonus, T, Cuvelier, G, Machayeckhi, S, Olieuz, S, Legrand, A, Feki, F, Jamoussi, A, Merhebene, T, Braham, E, Ghariani, A, Mezni, F, Slim, L, Khelil, J, Besbes, M, Marchalot, A, Beduneau, G, Carpentier, D, Besnier, E, Gastaldi, G, Abily, J, Beuzelin, M, Nay, M, Mankikian, J, Hervé, V, Soulie, M, Cronier, P, Kantor, E, Federici, L, Gilbert, M, Mezhari, I, Choukroun, G, Marque, S, Coppere, Z, Fulgencio, J, Blayau, C, Pham, T, Djibre, M, Reffienna, M, Lefort, S, Debue, A, Daviaud, F, Cabon, S, Addou, Z, Douah, A, Moussati, M, Belhabiche, K, Aouffen, N, Soulier, S, Mauriat, P, Tafer, N, Mortamet, G, Amaddeo, A, Khirani, S, Fauroux, B, Khanes, G, Liutko, O, Bidnenko, S, Doye, E, Voirin, N, Maucort Boulch, D, Kolev Descamp, K, Aouane, I, Essid, A, Hammami, W, Haegy, I, Bataille, J, Bergounioux, J, Morin, L, Ray, S, Maclaren, G, Nadel, S, Kneyber, M, Peters, M, Jansen, K, De Luca, D, Wilson, C, Schlapbach, L, Tissières, P, Girard, A, Savajols, E, Burguet, A, Semama, D, Litzler Renault, S, Fredj, H, Hassouna, M, Hechmi, Y, Cherif, M, Zouheir, J, Dernane, A, Bouakkaz, F, Taleb, L, Zeddine Mouhsen, A, Lyazidi, A, Richard, J, Mouhsen, A, Harmouchi, M, Rattal, M, Huck, M, Leclerc, T, Donat, N, Cirodde, A, Schaal, J, Masson, Y, Hoffmann, C, Cerland, L, Valentino, R, Chabartier, C, Villain Coquet, L, Ferge, J, Brouste, Y, Mehdaoui, H, Louriz, M, Madani, N, Amlaiky, F, Dendane, T, Abidi, K, Zekraoui, A, Zeggwagh, A, Abouqal, R, Brahim, A, Ferhi, F, Bouslama, M, Benjazia, K, Zeineb, A, Mahassen, D, Cadiet, J, Ferron, M, Prat, V, Erraud, A, Aillerie, V, Mevel, M, Grabherr, A, Chatham, J, Gauthier, C, Lauzier, B, Rozec, B, Joffre, J, Loyer, X, Lavillegrand, J, Zeboudj, L, Laurans, L, Esposito, B, Tedgui, A, Mallat, Z, Wei, C, Kattani, N, Louis, H, Orlowski, S, Tharaux, P, Burban, M, Meyer, G, Olland, A, Yver, B, Toti, F, Schini Kerth, V, Monnier, A, Leborgne, P, Meziani, F, Clavier, T, Paulus, M, Castel, H, Richard, V, Pons, S, Skurnik, D, Six, S, Jaffal, K, 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Gisbert Mora, C, Bonnardel, E, Biais, M, Hilbert, G, Joannon, T, Marincamp, A, Chiche, J, Ferre, A, Lichtenstein, D, Meziere, G, Gonzalez, C, Hamzaoui, O, Geffriaud, T, Leleu, F, Boissier, F, Cuquemelle, E, Lim, P, Amara, R, Léger, J, Jacob, C, Bouferache, K, Ragot, C, Corradi, L, Maurice, L, Julliand, S, Deho, A, Le Bourgeois, F, Jacquot, A, Valla, F, Letois, F, Salvadori, A, Ottonello, G, Blanot, S, Montmayeur, J, Orliaguet, G, Tarmiz, K, Habas, F, Baleine, J, Lebouhellec, J, Combes, C, Chomton, M, Jouvet, P, Ranchin, B, Macher, M, Gaillot, T, Moine, M, Ageron, F, Jannel, C, Debillon, T, Wroblewski, I, Duprey, M, Jarlier, V, Luyt, C, Longval, T, Schnell, D, Padoin, C, Cohen, Y, Gaies, E, Triki, S, Klouz, A, Moussa, M, Desrumaux, F, May, F, Nguyen, J, Tiercelet, K, Fournier, J, Cherin, M, Kitzis, M, Misset, B, Mathien, C, Poidevin, A, Donatti, L, Mootien, J, Pinto, L, Egard, M, Bodur, G, Barberet, G, Ionescu, C, Ganster, F, Guiot, P, Kuteifan, K, Mpela, A, Chelly, J, Guérin, L, Persichini, R, Hullin, T, Deye, N, Aubertein, P, Paul, M, Bougouin, W, Sandroni, C, Passouant, O, Llitjos, J, Chenevier Gobeaux, C, Batteux, F, Drouet, L, Voicu, S, Henry, P, Dillinger, J, Resiere, D, Dessoy, A, Faivre, V, Damoisel, C, Stiel, L, Galoisy, A, Mauvieux, L, Zobairi, F, Angles Cano, E, Piau, C, Jeannet, R, Feuillard, J, Jolly, L, Boufenzer, A, Carrasco, K, Derive, M, Merdji, H, Belaidouni, N, Toubiana, J, L'Hermitte, Y, Woimant, F, Oppenheim, C, Couvreur, C, Dolveck, F, Devriese, M, Dupeyrat, S, Ray, P, Lefevre, G, Fartoukh, M, Roothaer, N, Carpentier, A, Vaniet, F, Maisonneuve, A, Wiel, E, Canu, S, Hammad, E, Antonini, F, Poirier, M, Vigne, C, Haddam, M, Alingrin, J, Dangers, L, Mangiapan, G, Huet, I, Dhalluin, X, Bautin, N, Quiot, J, De Vecchi, C, Chenivesse, C, Smaoui, M, El Alami, E, Weiss, N, Mochel, F, Galanaud, D, Puybasset, L, Lodey, M, Guiller, E, Vuillaume, C, De Pasquale, F, Demonet, J, Sinnah, F, Dalloz, M, D'Ortho, M, Rouvel Tallec, A, Couret, D, Catan, A, Nativel, B, Planesse, C, Diotel, N, Meilhac, O, Roy Gash, F, Lebard, C, Larbi, A, Gaudin, V, Bonnin, F, Sultan, O, Hoc, C, Mathieu, E, Lapergue, B, Bourdain, F, Caron, M, Parrot, A, Labbe, V, Hafiani, E, Quesnel, C, Genay, S, Décaudin, B, Ethgen, S, Odou, P, Lebuffe, G, Mcquilte, Z, Allaouchiche, B, Verdière, B, Nyunga, M, Banaias, N, Colling, D, Kauv, M, Blondeau, E, Auclin, E, Haw Berlemont, C, Taieb, J, Oudard, S, Morissette, G, Kechaou, W, Litalien, C, Merouani, A, Phan, V, Bouchard, J, Starck, J, Briand, N, Sachs, P, Angoulvant, F, Sommet, J, Holvoet, L, Benkerrou, M, Dreyfus, L, Bordet, F, Touzet, S, Denis, A, Le Coz, J, Chéron, G, Nabbout, R, Patteau, G, Heilbronner, C, Hubert, P, Oualha, M, Crulli, B, Toledano, B, Poirier, N, Vobecky, S, Khouadja, H, Vinet, M, Vinclair, C, Beloncle, F, Radermacher, P, Asfar, P, Coupez, E, Bohé, J, Shinotsuka, C, Caironi, P, Villois, P, Fontana, V, Creteur, J, Pourcine, F, Vong, L, Weyer, C, Akando, B, Abdallah, R, Wetzstein, M, Antier, N, Serroukh, Y, Boudjeltia, K, Joosten, A, Rousseau, A, Delabranche, X, Grunebaum, L, Mootien, Y, Gaci, R, Garric, J, Delbove, A, Darreau, C, Dargent, A, Soudry Faure, A, De Chambrun, M, Demondion, P, Blanchard, J, Chocron, S, Meneveau, N, Corsi, F, Meynieu, P, Repusseau, B, Germain, A, Baudry, G, Hierle, L, Besch, G, Thomas, G, Cassir, N, Dizier, S, Roch, A, Trebbia, G, Govindaradjou, K, Devaquet, J, Picard, C, Parquin, F, Leguen, M, Felten, M, Sage, E, Chapelier, A, Duruisseaux, M, Fleury, J, Antoine, M, Carette, M, Wislez, M, Givel, C, De Margerie Mellon, C, De Kerviler, E, Tandjaoui Lambiotte, Y, Freynet, O, Baux, E, Das, V, Talec, P, Anguel, N, Louis, G, Girerd, N, Tallon, P, Hadchouel Duvergé, A, Salvi, N, Cairet, P, Delacourt, C, Blandine, B, Beraud, L, Lamaziere, A, Lionnet, F, Lehingue, S, D'Journo, X, Jean Marie, F, Thibault, R, Makhlouf, A, Mulliez, A, Dadet, S, Kekstas, G, Preiser, J, Rotovnik, K, Rozalen, I, Kupczyk, K, Krznaric, Z, Cano, N, Pichard, C, Le Roux, B, Jotterand, C, Rooze, S, Moullet, C, Henin, A, Ettori, F, Zemmour, C, Boher, J, Feltry, A, Ben, S, Audibert, J, Conia, A, Gontier, O, Hamrouni, M, Lherm, T, Ouchenir, A, Rétif, J, Proudhom, A, Lagardere, C, Tissot, S, Kalfon, P, Sacre, L, Villa, A, Khadija, A, Garnier, R, Vasset, B, Heinzelman, A, Jouffroy, R, Durand, E, Compagnon, P, Jebri, A, Legout, C, Castot Villepelet, A, Valade, S, Lesieur, O, Delmas, B, Visseaux, B, Cohen, J, Nguyen, L, Morbieu, C, Burdet, C, Lescure, F, Armand Lefevre, L, Yazdanpanah, Y, Houhou Fidouh, N, Cazaux, M, Goff Jérôme, L, Meignin, V, Boutboul, D, Rispail, P, Besnard, N, Ceballos, P, Stoclin, A, Rotolo, F, Wartelle, M, Hicheri, Y, Maillet, S, Chachaty, E, Pignon, J, Bialais, E, Julie, D, Paoloni, L, Wittebolle, X, Hickmann, C, Castanares Zapatero, D, Tordeur, A, Colmant, L, Wittebole, X, Tirone, G, Laterre, P, Ducroux, L, Kemlin, C, Moulton, E, Rosso, C, Le Neindre, A, Mongodi, S, Bouhemad, B, Rodrigues, J, Botteau, C, Waroquier, F, Christiaens, K, Vantrimpont, F, Elkhawand, C, Vermeesh, F, Vermeesh, F., and CITERIO, GIUSEPPE
- Abstract
Determinants of outcome in critically ill patients with hematological malignancy and central neurological failure: data from the TRIAL OH study
- Published
- 2016
34. Anticorps de la sclérodermie systémique : ce que le dermatologue doit savoir
- Author
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Hüe, S., Ingen-Housz-Oro, S., and Cosnes, A.
- Published
- 2013
- Full Text
- View/download PDF
35. Validation of the inventory of Callous-Unemotional Traits among school-going adolescents in Malaysia
- Author
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Aref Ezrin Mohamad Khalil, Hue San Kuay, Maruzairi Husain, and Yee Cheng Kueh
- Subjects
Medicine ,Science - Abstract
A key component in the study of antisocial behaviour among adolescents is the presence of callous-unemotional (CU) traits. Among the established tools available to measure CU traits is the Inventory of Callous-Unemotional traits (ICU). To date, there is no validated questionnaire to assess CU traits for the local population. Therefore, there is a need to validate the Malay version of the ICU (M-ICU) so that research can be conducted to explore CU traits among adolescents in Malaysia. The aim of the study is to validate the M-ICU. Two phases of cross-sectional study involving 409 (phase 1 –exploratory factor analysis (EFA), n = 180; phase 2—confirmatory factor analysis (CFA), n = 229) adolescents aged between 13 to 18 years old were conducted from July until October 2020 at six secondary schools in Kuantan district. Participants were selected via multistage random sampling. The ICU was initially translated into Malay language using forward-backward translation procedure by a group of bilingual researchers. Study participants completed the final version of the M-ICU questionnaire and socio-demographic questionnaire. Data was analysed using SPSS version 26 and MPlus software for factor structure validity by performing EFA and CFA. Initial EFA revealed three factors with two items deleted. A further EFA with two factors resulted in the deletion of unemotional factor items. Cronbach’s alpha for overall scale improved from 0.70 to 0.74. CFA supported a two-factor solution with 17 items compared to the original English version that has three factors with 24 items. The findings revealed acceptable fit indices (RMSEA = 0.057, CFI = 0.941, TLI = 0.932, WRMR = 0.968). The study revealed that a two-factor model with 17 items of the M-ICU has good psychometric properties. The scale is valid and reliable to measure CU traits among adolescents in Malaysia.
- Published
- 2023
36. Anticorps anticytoplasme des polynucléaires neutrophiles (ANCA) : ce que le dermatologue doit savoir
- Author
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Ingen-Housz-Oro, S. and Hüe, S.
- Published
- 2012
- Full Text
- View/download PDF
37. Anticorps antiphospholipides : ce que le dermatologue doit savoir
- Author
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Ingen-Housz-Oro, S., Leroy-Matheron, C., and Hüe, S.
- Published
- 2012
- Full Text
- View/download PDF
38. Exanthèmes aigus : analyse d’une cohorte de 100 patients
- Author
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Hirsch, G., primary, Oro, S., additional, Ortonne, N., additional, Rodriguez, C., additional, Colin, A., additional, Fardet, L., additional, Challine, D., additional, Hüe, S., additional, Chosidow, O., additional, and Wolkenstein, P., additional
- Published
- 2015
- Full Text
- View/download PDF
39. L’hypertension artérielle pulmonaire au cours de l’infection par le VIH est associée à une inflammation systémique nourrie par une translocation bactérienne digestive
- Author
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Issoufaly, T., primary, Zucman, D., additional, Ellouze, M., additional, Hüe, S., additional, Lelièvre, J.D., additional, Couderc, L.J., additional, Devillier, P., additional, Godot, V., additional, and Tcherakian, C., additional
- Published
- 2015
- Full Text
- View/download PDF
40. Association rituximab-dermocorticoïdes en traitement d’attaque du pemphigus profond : 5 cas
- Author
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Oro, S., primary, Valeyrie-Allanore, L., additional, Cosnes, A., additional, Ortonne, N., additional, Hüe, S., additional, Wolkenstein, P., additional, and Chosidow, O., additional
- Published
- 2014
- Full Text
- View/download PDF
41. Un défaut de peptides anti-microbiens à l’origine d’un cercle vicieux inflammatoire dans l’hidradénite suppurée
- Author
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Hotz, C., primary, Boniotto, M., additional, Guguin, A., additional, Surenaud, M., additional, Ortonne, N., additional, Bosc, R., additional, Chosidow, O., additional, Wolkenstein, P., additional, Lévy, Y., additional, and Hüe, S., additional
- Published
- 2014
- Full Text
- View/download PDF
42. MALAY TRADITIONAL GAMES ARE NEVER A LOSS: AN EMOTIONAL REFLECTION OF MALAYSIANS AND IMMIGRANTS IN MALAYSIA
- Author
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Nasir YUSOFF, Hue San KUAY, Rabeta MOHD SALLEH, Rohani ISMAIL, Roslee AHMAD, and Audrey ANTOINE
- Subjects
cultural heritage ,emotion ,valence ,immigrant ,ethnic minority ,Geography. Anthropology. Recreation ,Geography (General) ,G1-922 - Abstract
Introduction-Aims: In the modern days, traditional games have been perceived less preferred than universal games. This study examines the emotional reflection of Malaysians and Immigrants in Malaysia towards Malay traditional games and universal games. Malays (ethnic majority), Malaysian minorities (Chinese and Indian) and immigrants responded to the displayed images of Malay traditional games and universal games using a 9-point rating scale for valence domain of Self-Assessment Manikin. The emotional pleasantness towards Malay traditional games are higher in immigrants than Malaysians. There are emotional similarities between Malays and Malaysian minorities. Socio-cultural factors should be examined in future research to further understand this cultural situation.
- Published
- 2020
- Full Text
- View/download PDF
43. An allosteric conduit facilitates dynamic multisite substrate recognition by the SCFCdc4 ubiquitin ligase
- Author
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Veronika Csizmok, Stephen Orlicky, Jing Cheng, Jianhui Song, Alaji Bah, Neda Delgoshaie, Hong Lin, Tanja Mittag, Frank Sicheri, Hue Sun Chan, Mike Tyers, and Julie D. Forman-Kay
- Subjects
Science - Abstract
The WD40 domain of the SCFCdc4ubiquitin ligase targets substrates via multiple phosphorylated degron motifs. The authors define a second degron-binding WD40 pocket that imparts a negative allosteric effect on binding to the primary pocket, and thereby enables the dynamic exchange of bound degrons.
- Published
- 2017
- Full Text
- View/download PDF
44. Molecular recognition and packing frustration in a helical protein.
- Author
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Loan Huynh, Chris Neale, Régis Pomès, and Hue Sun Chan
- Subjects
Biology (General) ,QH301-705.5 - Abstract
Biomolecular recognition entails attractive forces for the functional native states and discrimination against potential nonnative interactions that favor alternate stable configurations. The challenge posed by the competition of nonnative stabilization against native-centric forces is conceptualized as frustration. Experiment indicates that frustration is often minimal in evolved biological systems although nonnative possibilities are intuitively abundant. Much of the physical basis of minimal frustration in protein folding thus remains to be elucidated. Here we make progress by studying the colicin immunity protein Im9. To assess the energetic favorability of nonnative versus native interactions, we compute free energies of association of various combinations of the four helices in Im9 (referred to as H1, H2, H3, and H4) by extensive explicit-water molecular dynamics simulations (total simulated time > 300 μs), focusing primarily on the pairs with the largest native contact surfaces, H1-H2 and H1-H4. Frustration is detected in H1-H2 packing in that a nonnative packing orientation is significantly stabilized relative to native, whereas such a prominent nonnative effect is not observed for H1-H4 packing. However, in contrast to the favored nonnative H1-H2 packing in isolation, the native H1-H2 packing orientation is stabilized by H3 and loop residues surrounding H4. Taken together, these results showcase the contextual nature of molecular recognition, and suggest further that nonnative effects in H1-H2 packing may be largely avoided by the experimentally inferred Im9 folding transition state with native packing most developed at the H1-H4 rather than the H1-H2 interface.
- Published
- 2017
- Full Text
- View/download PDF
45. Theoretical Insights into the Biophysics of Protein Bi-stability and Evolutionary Switches.
- Author
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Tobias Sikosek, Heinrich Krobath, and Hue Sun Chan
- Subjects
Biology (General) ,QH301-705.5 - Abstract
Deciphering the effects of nonsynonymous mutations on protein structure is central to many areas of biomedical research and is of fundamental importance to the study of molecular evolution. Much of the investigation of protein evolution has focused on mutations that leave a protein's folded structure essentially unchanged. However, to evolve novel folds of proteins, mutations that lead to large conformational modifications have to be involved. Unraveling the basic biophysics of such mutations is a challenge to theory, especially when only one or two amino acid substitutions cause a large-scale conformational switch. Among the few such mutational switches identified experimentally, the one between the GA all-α and GB α+β folds is extensively characterized; but all-atom simulations using fully transferrable potentials have not been able to account for this striking switching behavior. Here we introduce an explicit-chain model that combines structure-based native biases for multiple alternative structures with a general physical atomic force field, and apply this construct to twelve mutants spanning the sequence variation between GA and GB. In agreement with experiment, we observe conformational switching from GA to GB upon a single L45Y substitution in the GA98 mutant. In line with the latent evolutionary potential concept, our model shows a gradual sequence-dependent change in fold preference in the mutants before this switch. Our analysis also indicates that a sharp GA/GB switch may arise from the orientation dependence of aromatic π-interactions. These findings provide physical insights toward rationalizing, predicting and designing evolutionary conformational switches.
- Published
- 2016
- Full Text
- View/download PDF
46. Native contact density and nonnative hydrophobic effects in the folding of bacterial immunity proteins.
- Author
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Tao Chen and Hue Sun Chan
- Subjects
Biology (General) ,QH301-705.5 - Abstract
The bacterial colicin-immunity proteins Im7 and Im9 fold by different mechanisms. Experimentally, at pH 7.0 and 10°C, Im7 folds in a three-state manner via an intermediate but Im9 folding is two-state-like. Accordingly, Im7 exhibits a chevron rollover, whereas the chevron arm for Im9 folding is linear. Here we address the biophysical basis of their different behaviors by using native-centric models with and without additional transferrable, sequence-dependent energies. The Im7 chevron rollover is not captured by either a pure native-centric model or a model augmented by nonnative hydrophobic interactions with a uniform strength irrespective of residue type. By contrast, a more realistic nonnative interaction scheme that accounts for the difference in hydrophobicity among residues leads simultaneously to a chevron rollover for Im7 and an essentially linear folding chevron arm for Im9. Hydrophobic residues identified by published experiments to be involved in nonnative interactions during Im7 folding are found to participate in the strongest nonnative contacts in this model. Thus our observations support the experimental perspective that the Im7 folding intermediate is largely underpinned by nonnative interactions involving large hydrophobics. Our simulation suggests further that nonnative effects in Im7 are facilitated by a lower local native contact density relative to that of Im9. In a one-dimensional diffusion picture of Im7 folding with a coordinate- and stability-dependent diffusion coefficient, a significant chevron rollover is consistent with a diffusion coefficient that depends strongly on native stability at the conformational position of the folding intermediate.
- Published
- 2015
- Full Text
- View/download PDF
47. New tools to study MICA-NKG2D interactions
- Author
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Hüe, S., Monteiro, R., and Sophie Caillat-Zucman
48. Charge pattern matching as a ‘fuzzy’ mode of molecular recognition for the functional phase separations of intrinsically disordered proteins
- Author
-
Yi-Hsuan Lin, Jacob P Brady, Julie D Forman-Kay, and Hue Sun Chan
- Subjects
random phase approximation polymer theory ,liquid–liquid phase separation ,membraneless organelles ,effective medium approximations ,Science ,Physics ,QC1-999 - Abstract
Biologically functional liquid–liquid phase separation of intrinsically disordered proteins (IDPs) is driven by interactions encoded by their amino acid sequences. Little is currently known about the molecular recognition mechanisms for distributing different IDP sequences into various cellular membraneless compartments. Pertinent physics was addressed recently by applying random-phase-approximation (RPA) polymer theory to electrostatics, which is a major energetic component governing IDP phase properties. RPA accounts for charge patterns and thus has advantages over Flory–Huggins (FH) and Overbeek–Voorn mean-field theories. To make progress toward deciphering the phase behaviors of multiple IDP sequences, the RPA formulation for one IDP species plus solvent is hereby extended to treat polyampholyte solutions containing two IDP species plus solvent. The new formulation generally allows for binary coexistence of two phases, each containing a different set of volume fractions $({\phi }_{1},{\phi }_{2})$ for the two different IDP sequences. The asymmetry between the two predicted coexisting phases with regard to their ${\phi }_{1}/{\phi }_{2}$ ratios for the two sequences increases with increasing mismatch between their charge patterns. This finding points to a multivalent, stochastic, ‘fuzzy’ mode of molecular recognition that helps populate various IDP sequences differentially into separate phase compartments. An intuitive illustration of this trend is provided by FH models, whereby a hypothetical case of ternary coexistence is also explored. Augmentations of the present RPA theory with a relative permittivity ${\epsilon }_{{\rm{r}}}(\phi )$ that depends on IDP volume fraction $\phi ={\phi }_{1}+{\phi }_{2}$ lead to higher propensities to phase separate, in line with the case with one IDP species we studied previously. Notably, the cooperative, phase-separation-enhancing effects predicted by the prescriptions for ${\epsilon }_{{\rm{r}}}(\phi )$ we deem physically plausible are much more prominent than that entailed by common effective medium approximations based on Maxwell Garnett and Bruggeman mixing formulas. Ramifications of our findings on further theoretical development for IDP phase separation are discussed.
- Published
- 2017
- Full Text
- View/download PDF
49. Polycation-π interactions are a driving force for molecular recognition by an intrinsically disordered oncoprotein family.
- Author
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Jianhui Song, Sheung Chun Ng, Peter Tompa, Kevin A W Lee, and Hue Sun Chan
- Subjects
Biology (General) ,QH301-705.5 - Abstract
Molecular recognition by intrinsically disordered proteins (IDPs) commonly involves specific localized contacts and target-induced disorder to order transitions. However, some IDPs remain disordered in the bound state, a phenomenon coined "fuzziness", often characterized by IDP polyvalency, sequence-insensitivity and a dynamic ensemble of disordered bound-state conformations. Besides the above general features, specific biophysical models for fuzzy interactions are mostly lacking. The transcriptional activation domain of the Ewing's Sarcoma oncoprotein family (EAD) is an IDP that exhibits many features of fuzziness, with multiple EAD aromatic side chains driving molecular recognition. Considering the prevalent role of cation-π interactions at various protein-protein interfaces, we hypothesized that EAD-target binding involves polycation- π contacts between a disordered EAD and basic residues on the target. Herein we evaluated the polycation-π hypothesis via functional and theoretical interrogation of EAD variants. The experimental effects of a range of EAD sequence variations, including aromatic number, aromatic density and charge perturbations, all support the cation-π model. Moreover, the activity trends observed are well captured by a coarse-grained EAD chain model and a corresponding analytical model based on interaction between EAD aromatics and surface cations of a generic globular target. EAD-target binding, in the context of pathological Ewing's Sarcoma oncoproteins, is thus seen to be driven by a balance between EAD conformational entropy and favorable EAD-target cation-π contacts. Such a highly versatile mode of molecular recognition offers a general conceptual framework for promiscuous target recognition by polyvalent IDPs.
- Published
- 2013
- Full Text
- View/download PDF
50. Continuous evolution of HIV-1 more than ten years after infection in an elite neutralizer
- Author
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Chaillon A, Braibant M, Hué S, Bencharif S, Moreau A, Enard D, Samri A, Agut H, and Barin F
- Subjects
Immunologic diseases. Allergy ,RC581-607 - Published
- 2012
- Full Text
- View/download PDF
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