49 results on '"H Kloosterman"'
Search Results
2. Factual approach for tropical forest parameters measurement and monitoring
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Teshome Soromessa, Yousif A. Hussin, Evert H. Kloosterman, Ismail Mohd Hasmadi, Muluken N. Bazezew, Marian Salim Adan, Department of Natural Resources, UT-I-ITC-FORAGES, and Faculty of Geo-Information Science and Earth Observation
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tropical forest ,010504 meteorology & atmospheric sciences ,0211 other engineering and technologies ,Ecological monitoring ,02 engineering and technology ,Rainforest ,Optical radar ,Above ground biomass ,satellite imagery ,01 natural sciences ,Forest monitoring systems ,Tropical rain forest ,Ecosystem ,Satellite imagery ,monitoring system ,Terrestrial lidars ,lidar ,satellite data ,021101 geological & geomatics engineering ,0105 earth and related environmental sciences ,Biomass (ecology) ,Tree canopy ,Ecology ,Remote sensing data ,business.industry ,airborne sensing ,Environmental resource management ,Tropics ,Forestry ,Remote sensing ,Biophysical properties ,Tropical forest ,forest canopy ,Lidar ,ITC-ISI-JOURNAL-ARTICLE ,General Earth and Planetary Sciences ,Environmental science ,Airborne lidar data ,business ,image resolution - Abstract
Forest biomass and carbon are critical for ecological monitoring, and yet poorly modelled in complex ecosystems such as the tropical rainforests. To overcome this challenge incurred due to the complex biophysical properties of tropical forests, Airborne and Terrestrial LiDAR (Light Detection and Ranging) technologies have been used combinedly. Airborne LiDAR data ‘from above’ are largely restricted to analyses of lower canopy layer trees. Its combination with Terrestrial LiDAR allows the assessment of tree crowns under the upper canopy layer, thus opening up new possibilities for a more complete assessment of all the trees in a multi-layer stand. In this study, Airborne LiDAR was used for upper canopy tree measurements while Terrestrial LiDAR was complimented for lower canopy layer trees. The result showed that LiDAR-based tree measurements of DBH and height were highly accurate. We highly improved the accuracy of estimated above-ground biomass (AGB)/carbon from 87% of Terrestrial and 90% of Airborne LiDAR-based estimates to 97% through combining the use of the two technologies. This approach contributes to the development of efficient techniques for forest monitoring systems and bears the potential to extend the modelling options from remote sensing data to understory layer trees. © 2021 Informa UK Limited, trading as Taylor & Francis Group.
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- 2021
3. Design and Implementation of a User-Oriented Speech Recognition Interface: The Synergy of Technology and Human Factors.
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Sietse H. Kloosterman
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- 1994
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4. Netherlands Journal of Geosciences-Geologie En Mijnbouw
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Pauline P. Kruiver, Ger de Lange, Dirk Doornhof, Fred H. Kloosterman, Russell A. Green, J.L. Gunnink, Jan Stafleu, Freek S. Busschers, Jan van Elk, M. Korff, Ane Wiersma, Ronald Harting, and Civil and Environmental Engineering
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geology ,010506 paleontology ,liquefaction ,site response ,Borehole ,Lithostratigraphy ,Liquefaction ,Geology ,microzonation ,010502 geochemistry & geophysics ,01 natural sciences ,Seismic wave ,Penetration test ,Seismic hazard ,Cone penetration test ,soil properties ,Paleogene ,Geomorphology ,0105 earth and related environmental sciences - Abstract
The shallow subsurface of Groningen, the Netherlands, is heterogeneous due to its formation in a Holocene tidal coastal setting on a periglacially and glacially inherited landscape with strong lateral variation in subsurface architecture. Soft sediments with low, small-strain shear wave velocities (VS30around 200 m s−1) are known to amplify earthquake motions. Knowledge of the architecture and properties of the subsurface and the combined effect on the propagation of earthquake waves is imperative for the prediction of geohazards of ground shaking and liquefaction at the surface. In order to provide information for the seismic hazard and risk analysis, two geological models were constructed. The first is the ‘Geological model for Site response in Groningen’ (GSG model) and is based on the detailed 3D GeoTOP voxel model containing lithostratigraphy and lithoclass attributes. The GeoTOP model was combined with information from boreholes, cone penetration tests, regional digital geological and geohydrological models to cover the full range from the surface down to the base of the North Sea Supergroup (base Paleogene) at ~800 m depth. The GSG model consists of a microzonation based on geology and a stack of soil stratigraphy for each of the 140,000 grid cells (100 m × 100 m) to which properties (VSand parameters relevant for nonlinear soil behaviour) were assigned. The GSG model serves as input to the site response calculations that feed into the Ground Motion Model. The second model is the ‘Geological model for Liquefaction sensitivity in Groningen’ (GLG). Generally, loosely packed sands might be susceptible to liquefaction upon earthquake shaking. In order to delineate zones of loosely packed sand in the first 40 m below the surface, GeoTOP was combined with relative densities inferred from a large cone penetration test database. The marine Naaldwijk and Eem Formations have the highest proportion of loosely packed sand (31% and 38%, respectively) and thus are considered to be the most vulnerable to liquefaction; other units contain 5–17% loosely packed sand. The GLG model serves as one of the inputs for further research on the liquefaction potential in Groningen, such as the development of region-specific magnitude scaling factors (MSF) and depth–stress reduction relationships (rd).
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- 2017
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5. Rigorous test of the performance of shear-wave velocity correlations derived from CPT soundings: A case study for Groningen, the Netherlands
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Pauline P. Kruiver, Dirk Doornhof, Ger de Lange, Fred H. Kloosterman, M. Korff, and Jan van Elk
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Wave velocity ,0211 other engineering and technologies ,Soil Science ,020101 civil engineering ,Soil science ,02 engineering and technology ,Geotechnical Engineering and Engineering Geology ,Standard deviation ,Regression ,0201 civil engineering ,Correlation ,Shear (geology) ,Cone penetration test ,021101 geological & geomatics engineering ,Civil and Structural Engineering ,Mathematics - Abstract
An improved correlation between shear-wave velocity VS and cone penetration test (CPT) parameters was derived for the Groningen region, the Netherlands, using a set of 154 pairs of CPTs and seismic CPTs. An analysis of a high-quality subset showed that the subdivision into Holocene versus Pleistocene intervals or into cohesive versus non-cohesive intervals did not significantly improve correlation, nor did filtering out of the transition intervals between clay and sand in the non-cohesive dataset. In addition, using qt or qc resulted in similar regression results. We therefore propose a single new equation and we applied this to all available CPTs in the region. The analysis of the fitting bias showed that there is a trend relative to the measured VS. We therefore recommend performing SCPT measurements when very soft soils (VS The comparison of the VS30 values from CPTs to the model VS30 of Groningen shows that correlation is excellent: 90% of the calculated VS30 values from the CPTs fall within one standard deviation of the VS30 of the corresponding geological zone of the model. Although the resulting CPT-VS correlation is specific for the Groningen region, the approach can be applied to other regions with a paired SCPT-CPT dataset.
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- 2021
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6. Brief Report: Do You See What I See? The Perception of Bullying in Male Adolescents with Autism Spectrum Disorder
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Patricia H. Kloosterman, Zoe Hodgins, Layla Hall, Elizabeth Kelley, Rosaria Furlano, Chloe C. Hudson, and Wendy M. Craig
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Male ,medicine.medical_specialty ,Adolescent ,Autism Spectrum Disorder ,media_common.quotation_subject ,education ,Population ,behavioral disciplines and activities ,Developmental psychology ,03 medical and health sciences ,0302 clinical medicine ,Social cognition ,Perception ,mental disorders ,Developmental and Educational Psychology ,medicine ,Humans ,0501 psychology and cognitive sciences ,Crime Victims ,media_common ,education.field_of_study ,Public health ,Knowledge level ,05 social sciences ,Bullying ,medicine.disease ,Comprehension ,Autism spectrum disorder ,Case-Control Studies ,Autism ,Psychology ,030217 neurology & neurosurgery ,050104 developmental & child psychology - Abstract
Although there is evidence to suggest that adolescents with autism spectrum disorder (ASD) have difficulty interpreting complex social situations, little is known about their understanding of bullying. Given the high rates of victimization in this population, it is important to investigate how adolescents with ASD comprehend bullying. Male adolescents with ASD and IQ-matched typically-developing (TD) controls (Mage = 14.62, SD = 1.91) watched six videos portraying bullying scenarios and were interviewed after each video. The interviews were coded for the participants’ understanding of the bullying scenarios. Results indicated that adolescents with ASD had significantly lower bullying understanding scores than TD adolescents. These novel findings suggest that male adolescents with ASD understand bullying differently than their TD peers. Implications for experiences with victimization are discussed.
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- 2018
7. The relationship between trait emotional intelligence and ADHD symptoms in adolescents and young adults
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Kateryna V. Keefer, Laura J. Summerfeldt, James D. A. Parker, Robyn N. Taylor, Patricia H. Kloosterman, and Holly A. Kristensen
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Stress management ,Emotional intelligence ,Psychological intervention ,Trait ,Adhd symptoms ,Young adult ,Emotional processing ,Psychology ,Association (psychology) ,General Psychology ,Developmental psychology - Abstract
The present study examined the association between trait emotional intelligence (TEI) and ADHD symptomatology in samples of 1388 adolescents (ages 14–17 years) and 3313 young adults (ages 18–24 years). Consistent with the notion that difficulties in emotion processing and affect regulation are important features of ADHD, TEI was found to be a moderate to strong predictor in both samples. The TEI dimensions of stress management and adaptability uniquely predicted both hyperactivity–impulsive and inattentive symptomatology for both samples. Implications are discussed in terms of the usefulness of the TEI framework for enhancing understanding of the socio-emotional difficulties associated with ADHD symptoms and for informing interventions and coping strategies.
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- 2014
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8. Examining an obsessive-compulsive core dimensions model: Structural validity of harm avoidance and incompleteness
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Laura J. Summerfeldt, Martin M. Antony, Richard P. Swinson, and Patricia H. Kloosterman
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Soundness ,Generality ,education.field_of_study ,Population ,Structural validity ,Dimensional modeling ,medicine.disease ,Developmental psychology ,Psychiatry and Mental health ,Clinical Psychology ,Core (game theory) ,medicine ,Trait ,Harm avoidance ,education ,Psychology ,Clinical psychology - Abstract
Building upon work by Rasmussen and Eisen, our group has proposed a model comprising two core motivational dimensions underlying obsessive-compulsive symptoms: harm avoidance and incompleteness. The model has received increasing attention; however the structural soundness and divergence of its factors are yet to be investigated fully, either as symptom-specific motivations for clinical OCD symptoms or as stylistic traits in the nonclinical population. This paper presents four studies designed to investigate the structural validity of harm avoidance and incompleteness in clinical and nonclinical samples. Results yielded support across the method of assessment (interview, questionnaire), level of generality (symptom-specific state, trait), and population (clinical, nonclinical). Evidence was also found of the model׳s method invariance, with both factors strongly self-associated across method forms when ascertained as symptom-specific motivations. The results provide support for key assertions of the core dimensions model and also point to the utility of the interviewer-rated and questionnaire measures developed during this work: the Obsessive-Compulsive Core Dimensions Interview (OC-CDI) and Core Dimensions Questionnaire (OC-CDQ). Clinical and theoretical implications and challenges for future research are discussed.
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- 2014
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9. Executive functioning as a predictor of peer victimization in adolescents with and without an Autism Spectrum Disorder
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James D. A. Parker, Elizabeth Kelley, Patricia H. Kloosterman, and Wendy M. Craig
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Group membership ,education ,Executive functions ,medicine.disease ,Special education ,Developmental psychology ,Psychiatry and Mental health ,Clinical Psychology ,Typically developing ,Autism spectrum disorder ,Peer victimization ,Developmental and Educational Psychology ,medicine ,Autism ,Psychology ,Clinical psychology - Abstract
The present study examined pragmatic language and executive functions (EF) as predictors of peer victimization in three groups: high-functioning adolescent boys with an Autism Spectrum Disorder (ASD) (n = 30); typically developing adolescent boys (n = 40); and adolescent boys (n = 22) without ASD with special education needs (SN). Controlling for age and bullying others, regression analyses revealed EF as measured by the Behavior Rating Inventory of Executive Functioning (Gioia et al., 2000) to be a significant predictor across all types of peer victimization (physical, social, and verbal) regardless of group membership. It is concluded that EF may play a pivotal role in explaining why some SN adolescents with and without ASD are at-risk for peer victimization.
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- 2014
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10. Automated scoring of the Rey-Osterrieth Complex Figure Test using a deep-learning algorithm
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G Van Elswijk, Stefan Vermeent, B Schmand, Juergen Vogt, Ron Dotsch, and H Kloosterman
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Psychiatry and Mental health ,Clinical Psychology ,Neuropsychology and Physiological Psychology ,Computer science ,business.industry ,Deep learning ,Ceiling effect ,General Medicine ,Artificial intelligence ,Arithmetic ,business ,Rey–Osterrieth complex figure ,Test (assessment) - Abstract
Objective To validate a fully automated scoring algorithm for the Rey-Osterrieth Complex Figure Test (ROCFT) by comparing the scoring results of the algorithm to the results of human raters. Method The algorithm consisted of a cascade of deep neural networks which were trained on human rater scores to extract the 18 segments of the figure, and to quantify the patient’s performance. Algorithm results were compared to six expert raters for 303 drawings. We tested whether the average correlation between algorithm scores and scores by all human raters was equivalent to the average inter-rater correlation (with equality bound Δr < .05). The immediate and delayed recall trial were used; the copy trial showed a strong ceiling effect. Results The mean Pearson correlation between raters was .94 (SD = 0.01). The correlation between to algorithm and the raters was .88 (SD = 0.02). A two-one-sided t-tests (TOST) equivalence test showed that these correlations were not strictly equivalent, t(5) = 4.02, p = .995, 95% CI [0.35, 0.52]. Conclusions Although not strictly equivalent to human ratings, the algorithm’s performance is high, approaching a level of reliability found among human raters. We expect that improved individual segment detection will bring the algorithm scoring accuracy on par with that of human raters. Algorithmic scoring of the ROCFT will likely save valuable time and lead to higher levels of standardization in clinical practice.
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- 2019
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11. Problem gambling, gaming and Internet use in adolescents: Relationships with emotional intelligence in clinical and special needs samples
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James D. A. Parker, Laura J. Summerfeldt, Patricia H. Kloosterman, Kateryna V. Keefer, and Robyn N. Taylor
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Internet use ,Emotional intelligence ,Addiction ,media_common.quotation_subject ,Special needs ,Dysfunctional family ,Latent variable ,Psychology ,Path analysis (statistics) ,General Psychology ,Clinical psychology ,media_common ,Adolescent health - Abstract
The study examined the relationship between emotional intelligence (EI) and several addiction-related behaviours (gambling problems, Internet abuse, and computer gaming misuse) in two adolescent samples: 270 clinical outpatients (180 males and 90 females) and 256 special needs students (160 males and 96 females). Gambling problems, Internet abuse, and computer gaming misuse were positively inter-correlated in both samples; approximately half of the variability in these addiction-related behaviours could be accounted for by a common dysfunctional preoccupation latent variable. Latent variable path analysis found emotional intelligence to be a moderate predictor of dysfunctional preoccupation in both adolescent samples.
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- 2013
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12. Types and experiences of bullying in adolescents with an autism spectrum disorder
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Christine Javier, James D. A. Parker, Elizabeth Kelley, Wendy M. Craig, and Patricia H. Kloosterman
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education ,Special needs ,Physical bullying ,medicine.disease ,behavioral disciplines and activities ,Developmental psychology ,Psychiatry and Mental health ,Clinical Psychology ,Typically developing ,Autism spectrum disorder ,mental disorders ,Developmental and Educational Psychology ,medicine ,Autism ,Psychology ,Self report ,Clinical psychology - Abstract
Being victimized by one's peers is a major problem in adolescence, and research has suggested that individuals with autism spectrum disorders (ASD) may experience higher rates of bullying than their typically-developing (TD) peers. However, it is currently unclear whether adolescents with ASD are victimized more by their peers simply because they are ‘different’. This study was designed to examine percentage rates across different types of bullying behaviour in adolescents with an ASD (n = 24), in comparison to a group of special-needs adolescents without an ASD (n = 22), and a group of typically developing peers (n = 24), to determine whether simply being ‘different’ leads to higher rates of victimization. We also examined the agreement between parental and self-reports of bullying behaviour experienced by these groups. Overall, more adolescents with ASD reported victimization than adolescents in the other two groups. In addition, those with ASD reported more social bullying in comparison to the other two groups and more physical bullying than the TD group. No difference was found between parental and self-reports for the bullying experienced by the adolescents with ASD or special needs; however, TD adolescents reported higher levels of victimization than their parents reported for them. Contributing factors for the victimization experienced by adolescents with an ASD are discussed.
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- 2013
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13. The obsessive-compulsive trait of Incompleteness in parents of children with autism spectrum disorders
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Jeanette J. A. Holden, James D. A. Parker, Patricia H. Kloosterman, and Laura J. Summerfeldt
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Sensory motor ,Obsessive-compulsive trait ,media_common.quotation_subject ,medicine.disease ,behavioral disciplines and activities ,Developmental psychology ,Age and gender ,Psychiatry and Mental health ,Clinical Psychology ,Feeling ,Endophenotype ,mental disorders ,medicine ,Autism ,Association (psychology) ,Construct (philosophy) ,Psychology ,media_common - Abstract
The obsessive-compulsive behaviors central to Obsessive-Compulsive Disorder (OCD) are not uncommon in Autism Spectrum Disorders (ASD), however the association between these disorders is not yet clear. One construct which may be useful in delineating their overlapping characteristics is “Incompleteness” or a sense of things feeling “not just right”. Incompleteness has been related to a constellation of symptoms in OCD, but its association with ASD has not yet been examined. In this study parents with two or more children with ASD (P-MC) ( n =115) were compared to an independent sample of parents having a single child with an ASD (P-SC), matched by age and gender, on level of Incompleteness. Results indicate that P-MC parents scored significantly higher in Incompleteness than P-SC parents. Incompleteness scores were also associated with a profile of behaviors in their children with ASD ( n =357) characterized by high scores on the empirically derived repetitive sensory motor actions and resistance to change domains of the Autism Diagnostic Interview-Revised ( Cuccaro et al., 2003 ). We discuss the implications of Incompleteness found in parents of children with an ASD, as well as its utility as a possible endophenotype for both ASD and OCD.
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- 2013
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14. Emotional Intelligence in Social Phobia and Other Anxiety Disorders
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Randi E. McCabe, Martin M. Antony, Laura J. Summerfeldt, James D. A. Parker, and Patricia H. Kloosterman
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Clinical Psychology ,Panic disorder ,Emotional intelligence ,medicine ,Anxiety ,Interpersonal communication ,medicine.symptom ,medicine.disease ,Psychology ,Comorbidity ,Anxiety disorder ,Intrapersonal communication ,Clinical psychology - Abstract
This study examined the associations between clinical anxiety, domains of emotional intelligence (EI), and three clinician-rated indices of maladjustment. Of key interest was whether social phobia (SP) is unique among anxiety disorders in being characterized by lower levels of Interpersonal and, particularly, Intrapersonal EI, and whether these differentially predict maladjustment. Individuals with SP (n = 169) obsessive-compulsive disorder (n = 65) and panic disorder (n = 64), and nonclinical controls (n = 169) completed the short form self-report Emotional Quotient Inventory (EQ-i: S). All anxiety disorder groups showed lower total EI than controls, and differed among themselves with the SP group displaying the lowest levels of total EI and lower scores on two EQ-i:S subscales (Interpersonal and, more robustly, Intrapersonal). The Intrapersonal dimension alone predicted all indices of greater maladjustment in the SP group. These findings indicate a negative relationship between anxiety disorders and EI, and reaffirm the foremost link between Intrapersonal EI and SP and its functional outcomes.
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- 2010
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15. Social Anxiety, Emotional Intelligence, and Interpersonal Adjustment
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Martin M. Antony, Laura J. Summerfeldt, James D. A. Parker, and Patricia H. Kloosterman
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Clinical Psychology ,Emotional intelligence ,Social anxiety ,medicine ,Anxiety ,Interpersonal communication ,medicine.symptom ,Psychology ,Structural equation modeling ,Social relation ,Intrapersonal communication ,Developmental psychology - Abstract
There has been no published investigation made of the relationship between social anxiety and emotional intelligence (EI), or of their shared impact upon interpersonal adjustment. This study examined these questions using structural equation modeling with self-report data from a large nonclinical sample (N = 2629). EI was found to be highly related to social interaction anxiety, but not performance anxiety. A model permitting these three predictors to inter-correlate indicated that the EI factor was the dominant predictor of interpersonal adjustment, substantially reducing the unique contribution made by interaction anxiety. This pattern reflected the principal contributions made to interaction anxiety by the interpersonal and, particularly, intrapersonal domains of EI.
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- 2006
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16. Gambling Related Cognitive Distortions in Adolescence: Relationships with Gambling Problems in Typically Developing and Special Needs Students
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Robyn N. Taylor, James D. A. Parker, Kateryna V. Keefer, Patricia H. Kloosterman, and Laura J. Summerfeldt
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Male ,Sociology and Political Science ,Adolescent ,media_common.quotation_subject ,Special needs ,Special education ,Developmental psychology ,Intervention (counseling) ,Surveys and Questionnaires ,medicine ,Attention deficit hyperactivity disorder ,Humans ,Students ,General Psychology ,media_common ,Ontario ,Learning Disabilities ,Addiction ,Cognition ,medicine.disease ,Disabled Children ,Behavior, Addictive ,Adolescent Behavior ,Attention Deficit Disorder with Hyperactivity ,Scale (social sciences) ,Education, Special ,Gambling ,Female ,Psychology ,Adolescent health - Abstract
The present study examined the link between problematic gambling and gambling related cognitions (GRCs) in a large sample of adolescents with (N = 266) and without (N = 1,738) special education needs (SEN) between the ages of 14 and 18 years attending several high schools in eastern central Ontario. The adolescents with SENs were identified as having various learning disorders and/or internalizing and externalizing problems [e.g., attention deficit hyperactivity disorder (ADHD)]. All adolescents completed a self-report questionnaire package that included the GRC Scale (GRCS; Raylu and Oei in Addiction 99:757-769, 2004), as well as measures of problem gambling, negative affect, and ADHD symptomatology. Results showed that adolescents with SEN hold more erroneous beliefs about gambling and had a higher risk of developing problematic patterns of gambling behaviour than their typically developing peers. Moreover, the GRCS subscales were found to be strong predictors of problem gambling among adolescents both with and without SEN, accounting for a substantial amount of the variance even when controlling for the effects of age, gender, ADHD, and negative affect. It is suggested that intervention and prevention programs aimed at adolescent gambling need to give particular attention to those with SEN.
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- 2014
17. ISDN2014_0203: Inhibition as a mediator of the relation between autism spectrum disorder and victimization
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Patricia H. Kloosterman, Elizabeth Kelley, and Chloe C. Hudson
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Mediator ,Developmental Neuroscience ,Autism spectrum disorder ,medicine ,Psychology ,medicine.disease ,Relation (history of concept) ,Developmental Biology ,Clinical psychology - Published
- 2015
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18. Are gambling related cognitions in adolescence multidimensional?: Factor structure of the Gambling Related Cognitions Scale
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Kateryna V. Keefer, Laura J. Summerfeldt, James D. A. Parker, Robyn N. Taylor, and Patricia H. Kloosterman
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Male ,Ontario ,Sociology and Political Science ,Adolescent ,Addiction ,media_common.quotation_subject ,Cognition ,Factor structure ,Developmental psychology ,Large sample ,Behavior, Addictive ,Diagnostic and Statistical Manual of Mental Disorders ,Scale (social sciences) ,Gambling ,Humans ,Female ,Psychology ,Factor Analysis, Statistical ,General Psychology ,Clinical psychology ,Adolescent health ,media_common - Abstract
The present study examined the factor structure of the Gambling Related Cognitions Scale (GRCS); (Raylu and Oei in Addiction 99:757–769, 2004) in a large sample of adolescents (N = 1,490) between the ages of 16 and 18 years (630 males, 860 females) attending several high schools in central Ontario. Problem gambling was measured using the DSM-IV-J (Fisher in J Gambl Stud 8:263–285, 1992). A 5-factor GRCS model was found to have the best fit to the data, and gambling-related cognitions were found to be powerful predictors of disordered gambling among adolescents. However, strong associations among GRCS subscales, as well as the small amount of variance in problem gambling accounted for by specific GRCS subscales, call into question the multidimensionality of the GRCS when used with adolescents.
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- 2013
19. Gambling behaviour in adolescents with learning disorders
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Kateryna V. Keefer, Robyn N. Taylor, Patricia H. Kloosterman, James D. A. Parker, and Laura J. Summerfeldt
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Male ,medicine.medical_specialty ,Sociology and Political Science ,Adolescent ,MEDLINE ,Risk Assessment ,Negative affectivity ,Intervention (counseling) ,medicine ,Prevalence ,Learning disorders ,Humans ,Affective Symptoms ,Psychiatry ,General Psychology ,Ontario ,Learning Disabilities ,Case-control study ,Attention Deficit Disorder with Hyperactivity ,Case-Control Studies ,Gambling ,Female ,Psychology ,Risk assessment ,Clinical psychology ,Adolescent health - Abstract
The present study examined the prevalence of disordered gambling behaviours in a community-based sample of adolescents (N = 532) living in eastern central Ontario. Of particular interest was examining the hypothesis that adolescents with learning disorders are at elevated risk for disordered gambling. Rates of disordered gambling in male adolescents with learning disorders were found to be significantly higher than adolescents without learning problems, even after controlling for negative affectivity and ADHD symptomatology. The implications for treatment and intervention of gambling problems in adolescence are discussed.
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- 2012
20. Emotional Intelligence and Gifted Children
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James D. A. Parker, Leslie Widdifield-Konkin, Vicki L. Schwean, Patricia H. Kloosterman, and Donald H. Saklofske
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business.industry ,Emotional intelligence ,education ,Intellectual giftedness ,business ,Psychology ,humanities ,Parent ratings ,Developmental psychology ,Personal development ,Emotional competence - Abstract
Two issues regarding academic and intellectually gifted children are debated to this day. The first concerns the social-emotional competency of gifted children and the second focuses on the question of what is the most appropriate educational setting to support the academic and personal development of these children. Self, teacher and parent ratings of emotional intelligence (EI) were obtained from samples of gifted children in both special and regular class programs and a group of matched average ability and average achieving students in grades 4-8. While a number of small but statistically significant differences were obtained between the groups on the various EI subscales, gifted children tended to show well developed EI competencies, whether in regular or segregated classes, and compared with average ability students.
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- 2006
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21. Oxybutynin: dry days for patients with hyperhidrosis
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G S, Mijnhout, H, Kloosterman, S, Simsek, R J M, Strack van Schijndel, and J C, Netelenbos
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Humans ,Hyperhidrosis ,Mandelic Acids ,Female ,Muscarinic Antagonists ,Middle Aged ,Sweat Glands - Abstract
We report the case of a 56-year-old postmenopausal woman who was referred to our Endocrinology Outpatient Clinic because of severe hyperhidrosis. She had a four-year history of excessive sweating of her face and upper body. On presentation no sweating could be documented. Physical examination was also unremarkable. It appeared that five days earlier her general practitioner had prescribed oxybutynin for urge incontinence and this accidentally cured her hyperhidrosis. She was diagnosed with idiopathic hyperhidrosis. We advised her to continue the oxybutynin and six months later, she was still symptom-free. Oral anticholinergic drugs are known to be effective for hyperhidrosis, but only anecdotal reports on oxybutynin can be found in the literature. Oxybutynin is not approved for hyperhidrosis, explaining the unfamiliarity with this medicine. This case shows that oxybutynin can be a very effective and simple treatment with only mild side effects. Therefore, oxybutynin merits consideration in patients with idiopathic hyperhidrosis. This report includes a concise review of the causes and treatment options of hyperhidrosis.
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- 2006
22. Introduction to Flow Systems
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G. B. Engelen and F. H. Kloosterman
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Hydrology ,Flow system ,Groundwater flow ,Volume (thermodynamics) ,Nesting (computing) ,Geology - Abstract
In 1986 the International Association of Hydrological Sciences published a volume on “Developments in the analysis of groundwater flow systems” (Engelen & Jones eds., 1986). That volume presented an overview of concepts and case studies evolving from the fundamental ideas of Toth on the hierarchical nesting of gravity-driven groundwater flow systems.
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- 1996
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23. Regional Hydrological Systems Analysis in the northern coastal plain of Java, Indonesia
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G. B. Engelen and F. H. Kloosterman
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Deltaic plain ,Hydrology ,geography.geographical_feature_category ,Groundwater flow ,Java ,Coastal plain ,Humid subtropical climate ,Monsoon ,Geography ,medicine ,Flushing ,medicine.symptom ,computer ,Geomorphology ,Groundwater ,computer.programming_language - Abstract
Groundwater conditions in extensive humid tropical coastal lowlands such as found along the northern side of the island of Java, are closely related to the overall clayey and silty character of the sediments. The ample supply of suspended sediments in the present-day tropical humid and monsoonal setting is sufficient to result in a net outbuilding of coastal lowlands in a shallow marine and deltaic environment. Hydraulic gradients are far too small and permeabilities are usually too low, to ensure adequate flushing by groundwater flows of the recently deposited marine and deltaic sediments. In general, when marine and deltaic sediments predominate, fairly unfavourable groundwater conditions are met. Shallow and deep groundwaters may be highly mineralised (TDS up to several grams per litre) and mostly unfit for human or livestock consumption, even at great distances from a present-day coastline.
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- 1996
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24. Optimisation of Water Management in the Wierden Area
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G. B. Engelen and F. H. Kloosterman
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Hydrology ,Groundwater abstraction ,Groundwater depth ,Geology - Abstract
The study “Optimisation of water management in the Wierden area” by Hoogendoorn & Te Stroet (1993) represents the most detailed and applied step in the (eco-)hydrological systems analysis of the region Twente. The area of 20 × 20 = 400 km2 is located in the Regge valley, east of the city of Almelo, between the eastern and western complexes of ice-pushed ridges of the province Overijssel (see figure 14.1).
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- 1996
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25. Groundwater Flow Systems and Hydrocarbon Migration
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F. H. Kloosterman and G. B. Engelen
- Subjects
chemistry.chemical_classification ,geography ,geography.geographical_feature_category ,Groundwater flow ,Sedimentary basin ,Graben ,Flow system ,Hydrocarbon ,chemistry ,Flow (mathematics) ,Groundwater discharge ,Petrology ,Foreland basin ,Geology - Abstract
Toth has gradually extended his concept of a hierarchy of flow systems, originally developed for small drainaige basins, to large sedimentary basins with large width-, depth- and time scales, for instance the study of gravity-induced cross-formational flow of formation fluids in the Red Earth Region of Alberta, Canada (Toth, 1978) and the study of oil deposits in the Upper Rhine Graben (Toth and Otto, 1989)
- Published
- 1996
- Full Text
- View/download PDF
26. Major Types of Hydrological Systems in the Netherlands
- Author
-
F. H. Kloosterman and G. B. Engelen
- Subjects
Graben ,geography ,Paleontology ,geography.geographical_feature_category ,Environmental protection ,Massif ,Structural basin ,Fault (geology) ,Horst ,Quaternary ,Cenozoic ,Subsoil - Abstract
The Netherlands are tectonically positioned at the southern end of the North Sea Basin (see figure 7.1). This Basin dates from Cenozoic times. Near the area of the Netherlands it becomes narrow and grades into the NW-SE trending Ruhr Graben structures which in turn are connected to the Rhine Graben. South of the Netherlands the stable Brabant Massif forms a border of the North Sea Basin. Graben and horst structures, some of which are still tectonically active, are frequently found in the subsoil. During the Quaternary the fault systems have been very active. Thicknesses of the Quaternary series are therefore characterised by strong differences especially in the southern parts.
- Published
- 1996
- Full Text
- View/download PDF
27. Hydrological Systems Analysis of the Lake IJssel Area
- Author
-
F. H. Kloosterman and G. B. Engelen
- Subjects
Hydrology ,Flow system ,Structural basin ,North sea ,Geomorphology ,Geology - Abstract
The man-made fresh Lake IJssel resulted in 1932 from barring the inland branch Zuyder Sea from the North Sea basin by a barrier dam. It covers a large part of the central area of the Netherlands (see figure 10.1).
- Published
- 1996
- Full Text
- View/download PDF
28. REGISPRO, a Geohydrological Information System
- Author
-
G. B. Engelen and F. H. Kloosterman
- Subjects
Water resources ,Agriculture ,business.industry ,media_common.quotation_subject ,Control (management) ,Information system ,Legislation ,business ,Publicity ,Environmental planning ,Recreation ,media_common ,Task (project management) - Abstract
Water resources management, nature conservation and environmental legislation in general have become very complex in recent years, in particular in industrialised countries. Environmental legislation has developed into a difficult and unpleasant task to many planners at national, regional and local governmental levels, because of the need to reconcile the interests of different users with the functions of certain elements of the hydrological cycle. Groundwater supply for industries and drinking water, nature conservation, recreation, agriculture, pollution control, etc. are examples of such rivalling users with often strongly conflicting interests. Planners, managers and legislators are faced with the difficult task of finding both realistic and economically feasible solutions which hopefully satisfy the needs and demands of all involved parties. Furthermore, thanks to the publicity on ecology and environment, the general public has become aware of the ongoing deterioration of ecosystems and of groundwater quality and is urging policy makers to take firm action.
- Published
- 1996
- Full Text
- View/download PDF
29. Types of Hydrological Systems in the Major Geological/Physiographic Terranes in Poland
- Author
-
F. H. Kloosterman and G. B. Engelen
- Subjects
Craton ,geography ,Precambrian ,Paleontology ,geography.geographical_feature_category ,Rift ,Mining engineering ,Permian ,Trough (geology) ,Alpine orogeny ,Cretaceous ,Terrane - Abstract
In Poland a fairly complete sequence of Late Precambrian to Cenozoic sediments has been deposited on two fringing cratons. In the Northeast the sediments are underlain by the ancient stable East European Platform and in the Southwest by the Variscan Central European Platform. In the south, bordering the Czech republic, the Carpathian Mountain range is found forming the frontier of the Alpine Orogeny in this region. Post-Cambrian tectonic movements in Poland were largely confined to a narrow rifting zone along the bordering margins of the East and Central European crustal Platforms which gave rise to the long NE-SW trending Mid-Polish Trough. From Permian until Late Cretaceous times the trough became filled with a thick pile of sediments. Afterwards in early Tertiary times inversion took place and folding of the 10 km thick sedimentary fill occurred forming the Mid-Polish Anticlinorium.
- Published
- 1996
- Full Text
- View/download PDF
30. Ecotope Typologies, Ecotope Groups of Plant Species and Ecotope Protection and -Restoration in Hydrological Systems Analysis
- Author
-
F. H. Kloosterman and G. B. Engelen
- Subjects
Flora ,Herbarium ,Ecological amplitude ,business.industry ,Ecology ,Ecotope ,Plant species ,Environmental science ,Forestry ,Ecosystem ,business ,Landscape planning ,Indigenous - Abstract
In descriptions of indigenous flora of the Netherlands special codes have been attributed to all plant species. These codes refer to the preference of species for specific ecosystems. Initially (Van der Maarel, 1971), the coding system was strongly related to the position of the plant species in the plant-sociological classification system (Westhoff & Den Held, 1969). In the 1970’s the coding system was revised and more ecologically oriented (Arnolds & Van der Meijden, 1976). Still objections to this system were voiced concerning the ecological amplitude and the poor relation with abiotic factors. In 1982 the Centre for Environmental Studies (CML) of the State University of Leiden designed a preliminary structure for a national ecotope system (Everts et al., 1982). In 1987 the new ecotope typology was extended (Stevers et al., 1987). CML and the National Herbarium of the State University of Leiden used this new system to generate new codes for wild plant species in the Netherlands (Runhaar et al., 1987).
- Published
- 1996
- Full Text
- View/download PDF
31. Stages in the Development of Water Resources Management
- Author
-
F. H. Kloosterman and G. B. Engelen
- Subjects
Water resources ,media_common.quotation_subject ,Economic shortage ,Quality (business) ,Socioeconomic development ,Business ,Sophistication ,Environmental planning ,Natural (archaeology) ,media_common - Abstract
The ever increasing use of water by competing users leads more and more to shortages of water. Insufficient water at the right time in the right place and with the right quality necessitates increasing sophistication in water resources management world-wide. Depending upon the natural availability of water and the socioeconomic development of a region or country different stages in analysis, planning, use and management can be discerned.
- Published
- 1996
- Full Text
- View/download PDF
32. Regional Hydrological Systems Analysis Twente
- Author
-
G. B. Engelen and F. H. Kloosterman
- Subjects
Background information ,Nature reserve ,Flow system ,Geography ,Systems analysis ,business.industry ,Scale (social sciences) ,Environmental resource management ,Fluvial ,Glacial period ,Integrated approach ,business - Abstract
The report deals with reconnaissance survey of the hydrological systems at the scale 1:100,000 in the region Twente in the province of Overijssel in the eastern part of the Netherlands (see figure 11.1). The region of approximately 50 × 25 km has a diversified topography of glacial, eolian and fluvial origin with a number of existing and potential nature reserves. National, provincial and local authorities, public companies and private organisations and landowners have an interest in an integrated approach to water management from regional, down to local scales. The main focus of the report is on background information for policy formulation and management of existing and designated or potential nature reserves.
- Published
- 1996
- Full Text
- View/download PDF
33. Eco-Hydrological Systems Analysis and the Protection and Restoration of Wetland Ecosystems in the Twente/Regge Catchment
- Author
-
G. B. Engelen and F. H. Kloosterman
- Subjects
Hydrology ,geography ,Flow system ,geography.geographical_feature_category ,Systems analysis ,Groundwater flow ,Drainage basin ,Environmental science ,Ecosystem ,Wetland ,Scale (map) ,Groundwater - Abstract
In “Effects of interventions in the groundwater systems in the Regge valley” by Gieske (1990) the first part of the second phase in the eco-hydrological systems analysis of the region Twente is presented. After the regional reconnaissance of the hydrological systems of the region Twente at the scale 1:100,000 in the first phase, in the second phase the Regge valley was studied more in detail by flow systems modelling at the scale 1:50,000. The Regge valley is located in the western part of the region Twente within the province of Overijssel. The modelled area has a size of 16,5 × 24 km.
- Published
- 1996
- Full Text
- View/download PDF
34. Hydrological Systems Analysis
- Author
-
G. B. Engelen and F. H. Kloosterman
- Published
- 1996
- Full Text
- View/download PDF
35. Hydrological Systems Analysis Dinkel valley/Borne creek
- Author
-
F. H. Kloosterman and G. B. Engelen
- Subjects
Hydrology ,Flow system ,Groundwater abstraction ,Systems analysis ,Environmental science ,Groundwater recharge - Abstract
In “Hydrological systems analysis of the Dinkel valley/Borne creek area” by Hoogendoorn (1992) the second part of the second phase in the eco-hydrological systems analysis of the region Twente is presented. The area was studied, as a follow up to the reconnaissance study of the first phase, by flow systems modelling at the scale 1:50,000.
- Published
- 1996
- Full Text
- View/download PDF
36. Regional Hydrological Systems Analysis and Water Systems Management at European Scale
- Author
-
F. H. Kloosterman and G. B. Engelen
- Subjects
Sustainable development ,business.industry ,Environmental resource management ,Water supply ,computer.software_genre ,Systems analysis ,Agriculture ,Systems management ,Scale (social sciences) ,Nature Conservation ,Environmental science ,business ,Quality characteristics ,Environmental planning ,computer - Abstract
Water is one of the key factors for a sustainable development in Europe (OECD, 1989; Van der Ven and Kohsiek, 1991; United Nations, 1991; Fried 1992; Engelen, 1992). The complex of relations requires an integrated, holistic approach (IIASA, 1991). There are many different sources of supply with time-dependent quantity- and quality characteristics on the one hand and many demand and use sectors, nature conservation, agriculture, industry, public water supply and navigation, on the other hand.
- Published
- 1996
- Full Text
- View/download PDF
37. Groundwater Situation Drenthe
- Author
-
G. B. Engelen and F. H. Kloosterman
- Subjects
Government ,Environmental science ,Groundwater recharge ,Water resource management ,Groundwater - Abstract
The provincial government of Drenthe needed a clarification on the desired (“optimal”) groundwater levels in the province for its provincial water management plan, given the national and provincial policy to combat damage to nature from decreasing groundwater levels. The purpose of the study was: 1. to establish the present groundwater situation; 2. to search for trends in the groundwater situation; 3. to substantiate which human factors cause the groundwater situation and how those factors could be modified to improve the situation.
- Published
- 1996
- Full Text
- View/download PDF
38. National Hydrological Systems Analysis in the Netherlands
- Author
-
F. H. Kloosterman and G. B. Engelen
- Subjects
Physical planning ,Systems analysis ,Public work ,Agriculture ,business.industry ,Scale (social sciences) ,Nature management ,Environmental science ,Christian ministry ,business ,Environmental planning ,Ministry of Transport - Abstract
In 1989 TNO-IAG published the last sheet of the “National Groundwater Map of the Netherlands” at a scale 1:50,000. This large project was initiated by the institute in the 1960’s and financed by: Ministry of Transport, Public Works and Water Management; Ministry of Housing, Physical Planning and Environment; Ministry of Agriculture, Nature Management and Fisheries.
- Published
- 1996
- Full Text
- View/download PDF
39. Numerical Modelling of Groundwater Flow Systems; a Case Study in the SE part of the Netherlands
- Author
-
G. B. Engelen and F. H. Kloosterman
- Subjects
Graben ,Ground level ,Hydrology ,Tectonics ,Tectonic subsidence ,Groundwater flow ,Pleistocene ,Annual production ,Geochemistry ,Geology ,Groundwater - Abstract
In the south and south-eastern parts of the Netherlands, situated on the Pleistocene coversands much groundwater is abstracted for drinking water and industrial purposes. Just across the border in neighbouring Germany lignite is being mined in huge open pits, measuring depths up to 400 m below ground level. The amount of groundwater which has to be pumped to allow mining of the Miocene lignite layers at the bottom of the pits equals about 1000 million m3 per year. This huge amount of pumped groundwater matches the total annual production of drinking water in the Netherlands. It is not surprising that the influences of the strongly depressed piezometric heads around the open lignite mines are also noticeable in the southern part of the Netherlands, in particular in the Central Graben. The Central Graben forms the tectonic continuation of the Ruhr Graben in Germany, developed from Miocene times onwards, in which the lignites were deposited in thick layers following the tectonic subsidence (see figure 7.1 in chapter 7).
- Published
- 1996
- Full Text
- View/download PDF
40. [Relationship between the use of postgraduate educational material on human immunodeficiency virus and the number of HIV consultations in family practice]
- Author
-
L, Wigersma, A M, Heijnen, E H, Hochheimer, and H, Kloosterman
- Subjects
Acquired Immunodeficiency Syndrome ,Audiovisual Aids ,Surveys and Questionnaires ,Humans ,Education, Medical, Continuing ,HIV Infections ,Family Practice ,Netherlands - Abstract
An enquiry using a structured questionnaire was conducted among all 6300 GPs in the Netherlands in order to assess the distribution of HIV-related problems over general practices in the Netherlands and the influence on it of the use of the 'HIV-wijzer voor de huisarts', a loose-leaf handbook on HIV, distributed since 1988 among all Dutch general practitioners. The enquiry was conducted one year after its publication. The 2156 respondents (34%) appeared to be reasonably representative of all GPs. The results show minor imperfections because a small proportion of the questionnaires was filled out incompletely. Almost 90% of respondents mentioned HIV-related consultations, 24% had HIV-seropositive patients and 18% had AIDS patients. These numbers were correlated mainly with municipality size, less with region. The use of the 'HIV-wijzer' was related to occurrence of HIV-related consultations and AIDS patients in a practice. GPs who do not encounter these problems are little motivated to read the 'HIV-wijzer'. For them, other means of education have to be developed or HIV has to be included in existing education programmes on other subjects.
- Published
- 1991
41. Application of beam forming techniques to measurements of acoustic scattering from the ocean bottom
- Author
-
J. Berrou, T. Akal, J. M. Berkson, and H. Kloosterman
- Subjects
Hydrophone ,Scattering ,Mechanical Engineering ,Acoustics ,Array processing ,Ocean Engineering ,Sonar signal processing ,Sensor array ,Electrical and Electronic Engineering ,Underwater acoustics ,Seabed ,Geology ,Seismology ,Beam (structure) - Abstract
Signals from an explosive source backscattered from the seafloor and received at long range by hydrophones of a towed array are processed to estimate the directional distribution of energy for a given time increment. As assembly of these data shows the time and amplitude of scattering features, and after conversion to distance, the geographic location of the return. A frequency-domain beam-forming procedure is used in which beam levels are averaged over a given band of a broad-band source. The processing is applied to experimental data obtained in the southern Tyrrhenian Sea. The major backscattering occurred at the Baconi Seamounts and the coastal margin of Sardinia.
- Published
- 1985
- Full Text
- View/download PDF
42. RepAM of the Amycolatopsis methanolica integrative element pMEA300 belongs to a novel class of replication initiator proteins.
- Author
-
Te Poele EM, Kloosterman H, Hessels GI, Bolhuis H, and Dijkhuizen L
- Subjects
- Actinomycetales genetics, DNA Helicases genetics, DNA, Bacterial chemistry, DNA, Bacterial metabolism, DNA-Binding Proteins genetics, Nucleic Acid Conformation, Open Reading Frames, Protein Binding, Repetitive Sequences, Nucleic Acid, Trans-Activators genetics, Actinomycetales enzymology, DNA Helicases isolation & purification, DNA Helicases metabolism, DNA-Binding Proteins isolation & purification, DNA-Binding Proteins metabolism, Trans-Activators isolation & purification, Trans-Activators metabolism
- Abstract
Accessory genetic elements, such as plasmids and integrative elements, are widespread amongst actinomycetes, but little is known about their functions and mode of replication. The conjugative element pMEA300 from Amycolatopsis methanolica is present mostly in an integrated state at a single specific site in the chromosome, but it can also replicate autonomously. Complete nucleotide sequencing, in combination with deletion studies, has revealed that orfB of pMEA300 is essential for autonomous replication in its host. In this study, it was shown that purified OrfB protein binds specifically to the 3' end of its own coding sequence. Within this short sequence, a putative hairpin structure is located, which contains several direct and inverted repeats, and a nucleotide stretch that resembles the nicking site of the pC194 family of rolling circle replicating plasmids. Additional binding studies revealed that OrfB binds to an 8 bp inverted repeat that occurs three times within the hairpin structure. The data presented show that OrfB is the replication initiator (Rep) protein of pMEA300, and is therefore termed RepAM. Surprisingly, RepAM lacks significant sequence similarity with known prokaryotic Rep proteins, but it is highly similar to a number of yet uncharacterized ORFs that are located on integrative and conjugative elements of other actinomycetes. It is concluded that RepAM and its homologues are members of a novel class of Rep proteins.
- Published
- 2006
- Full Text
- View/download PDF
43. Oxybutynin: dry days for patients with hyperhidrosis.
- Author
-
Mijnhout GS, Kloosterman H, Simsek S, Strack van Schijndel RJ, and Netelenbos JC
- Subjects
- Female, Humans, Middle Aged, Sweat Glands drug effects, Hyperhidrosis drug therapy, Mandelic Acids therapeutic use, Muscarinic Antagonists therapeutic use
- Abstract
We report the case of a 56-year-old postmenopausal woman who was referred to our Endocrinology Outpatient Clinic because of severe hyperhidrosis. She had a four-year history of excessive sweating of her face and upper body. On presentation no sweating could be documented. Physical examination was also unremarkable. It appeared that five days earlier her general practitioner had prescribed oxybutynin for urge incontinence and this accidentally cured her hyperhidrosis. She was diagnosed with idiopathic hyperhidrosis. We advised her to continue the oxybutynin and six months later, she was still symptom-free. Oral anticholinergic drugs are known to be effective for hyperhidrosis, but only anecdotal reports on oxybutynin can be found in the literature. Oxybutynin is not approved for hyperhidrosis, explaining the unfamiliarity with this medicine. This case shows that oxybutynin can be a very effective and simple treatment with only mild side effects. Therefore, oxybutynin merits consideration in patients with idiopathic hyperhidrosis. This report includes a concise review of the causes and treatment options of hyperhidrosis.
- Published
- 2006
44. Organization of the teicoplanin gene cluster in Actinoplanes teichomyceticus.
- Author
-
Sosio M, Kloosterman H, Bianchi A, de Vreugd P, Dijkhuizen L, and Donadio S
- Subjects
- Base Sequence, DNA, Bacterial genetics, Gene Expression, Glycosyltransferases genetics, Glycosyltransferases metabolism, Molecular Sequence Data, Open Reading Frames, Teicoplanin chemistry, Anti-Bacterial Agents biosynthesis, Genes, Bacterial, Micromonosporaceae genetics, Micromonosporaceae metabolism, Multigene Family, Teicoplanin biosynthesis
- Abstract
The glycopeptide teicoplanin is used for the treatment of serious infections caused by Gram-positive pathogens. The tcp gene cluster, devoted to teicoplanin biosynthesis in the actinomycete Actinoplanes teichomyceticus, was isolated and characterized. From sequence analysis, the tcp cluster spans approximately 73 kb and includes 39 ORFs participating in teicoplanin biosynthesis, regulation, resistance and export. Of these, 34 ORFs find a match in at least one of the five glycopeptide gene clusters previously characterized. Putative roles could be assigned for most of the tcp genes. The two glycosyltransferases responsible for attaching amino sugars to amino acids 4 and 6 of the teicoplanin aglycon were overexpressed in Escherichia coli and characterized. They both recognize N-acetylglucosamine as the substrate. tGtfA can add a sugar residue in the presence or absence of N-acetylglucosamine at amino acid 4, while tGtfB can only glycosylate the teicoplanin aglycon.
- Published
- 2004
- Full Text
- View/download PDF
45. (De)regulation of key enzyme steps in the shikimate pathway and phenylalanine-specific pathway of the actinomycete Amycolatopsis methanolica.
- Author
-
Kloosterman H, Hessels GI, Vrijbloed JW, Euverink GJ, and Dijkhuizen L
- Subjects
- 3-Deoxy-7-Phosphoheptulonate Synthase drug effects, 3-Deoxy-7-Phosphoheptulonate Synthase genetics, 3-Deoxy-7-Phosphoheptulonate Synthase metabolism, Amino Acid Sequence, Aminoacylation, Chorismate Mutase drug effects, Chorismate Mutase genetics, Chorismate Mutase metabolism, Enzyme Inhibitors pharmacology, Gene Expression Regulation, Enzymologic genetics, Molecular Sequence Data, Mutagenesis, Site-Directed, Phenylalanine metabolism, Phenylalanine pharmacology, Prephenate Dehydratase drug effects, Prephenate Dehydratase genetics, Prephenate Dehydratase metabolism, Recombinant Proteins drug effects, Recombinant Proteins metabolism, Sequence Alignment, Sequence Homology, Amino Acid, Shikimic Acid metabolism, Tyrosine pharmacology, Actinomyces enzymology, Gene Expression Regulation, Bacterial genetics
- Abstract
Prephenate dehydratase (PDT), chorismate mutase (CM) and 3-deoxy-D-arabino-7-heptulosonate 7-phosphate (DAHP) synthase are key regulatory enzymes in aromatic amino acid biosynthesis in the actinomycete Amycolatopsis methanolica. Deregulated, feedback-control-resistant mutants were isolated by incubation of A. methanolica on glucose mineral agar containing the toxic analogue p-fluoro-DL-phenylalanine (pFPhe). Several of these mutants had completely lost PDT sensitivity to Phe inhibition and Tyr activation. Mutant characterization yielded new information about PDT amino acid residues involved in Phe and Tyr effector binding sites. A. methanolica wild-type cells grown on glucose mineral medium normally possess a bifunctional CM/DAHP synthase protein complex (with DS1, a plant-type DAHP synthase). The CM activity of this protein complex is feedback-inhibited by Tyr and Phe, while DS1 activity is mainly inhibited by Trp. Isolation of pFPhe-resistant mutants yielded two feedback-inhibition-resistant CM mutants. These were characterized as regulatory mutants, derepressed in (a) synthesis of CM, now occurring as an abundant, feedback-inhibition-resistant, separate protein, and (b) synthesis of an alternative DAHP synthase (DS2, an E. coli-type DAHP synthase), only inhibited by Tyr and Trp. DS1 and DS2 thus are well integrated in A. methanolica primary metabolism: DS1 and CM form a protein complex, which stimulates CM activity and renders it sensitive to feedback inhibition by Phe and Tyr. Synthesis of CM and DS2 proteins appears to be controlled co-ordinately, sensitive to Phe-mediated feedback repression.
- Published
- 2003
- Full Text
- View/download PDF
46. Identification of a magnesium-dependent NAD(P)(H)-binding domain in the nicotinoprotein methanol dehydrogenase from Bacillus methanolicus.
- Author
-
Hektor HJ, Kloosterman H, and Dijkhuizen L
- Subjects
- Alcohol Oxidoreductases metabolism, Amino Acid Sequence, Base Sequence, Binding Sites, Chromatography, Ion Exchange, Escherichia coli metabolism, Kinetics, Models, Chemical, Molecular Sequence Data, Mutagenesis, Site-Directed, Mutation, NADP metabolism, Protein Binding, Protein Structure, Secondary, Protein Structure, Tertiary, Sequence Homology, Amino Acid, Time Factors, Zinc metabolism, Alcohol Oxidoreductases chemistry, Bacillus enzymology, NADP chemistry
- Abstract
The Bacillus methanolicus methanol dehydrogenase (MDH) is a decameric nicotinoprotein alcohol dehydrogenase (family III) with one Zn(2+) ion, one or two Mg(2+) ions, and a tightly bound cofactor NAD(H) per subunit. The Mg(2+) ions are essential for binding of cofactor NAD(H) in MDH. A B. methanolicus activator protein strongly stimulates the relatively low coenzyme NAD(+)-dependent MDH activity, involving hydrolytic removal of the NMN(H) moiety of cofactor NAD(H) (Kloosterman, H., Vrijbloed, J. W., and Dijkhuizen, L. (2002) J. Biol. Chem. 277, 34785-34792). Members of family III of NAD(P)-dependent alcohol dehydrogenases contain three unique, conserved sequence motifs (domains A, B, and C). Domain C is thought to be involved in metal binding, whereas the functions of domains A and B are still unknown. This paper provides evidence that domain A constitutes (part of) a new magnesium-dependent NAD(P)(H)-binding domain. Site-directed mutants D100N and K103R lacked (most of the) bound cofactor NAD(H) and had lost all coenzyme NAD(+)-dependent MDH activity. Also mutants G95A and S97G were both impaired in cofactor NAD(H) binding but retained coenzyme NAD(+)-dependent MDH activity. Mutant G95A displayed a rather low MDH activity, whereas mutant S97G was insensitive to activator protein but displayed "fully activated" MDH reaction rates. The various roles of these amino acid residues in coenzyme and/or cofactor NAD(H) binding in MDH are discussed.
- Published
- 2002
- Full Text
- View/download PDF
47. Molecular, biochemical, and functional characterization of a Nudix hydrolase protein that stimulates the activity of a nicotinoprotein alcohol dehydrogenase.
- Author
-
Kloosterman H, Vrijbloed JW, and Dijkhuizen L
- Subjects
- Alcohol Oxidoreductases metabolism, Amino Acid Sequence, Bacillus enzymology, Base Sequence, Cloning, Molecular, DNA Primers, Enzyme Activation, Humans, Hydrolysis, Molecular Sequence Data, NAD metabolism, Pyrophosphatases chemistry, Pyrophosphatases genetics, Sequence Homology, Amino Acid, Alcohol Dehydrogenase metabolism, Pyrophosphatases metabolism
- Abstract
The cytoplasmic coenzyme NAD(+)-dependent alcohol (methanol) dehydrogenase (MDH) employed by Bacillus methanolicus during growth on C(1)-C(4) primary alcohols is a decameric protein with 1 Zn(2+)-ion and 1-2 Mg(2+)-ions plus a tightly bound NAD(H) cofactor per subunit (a nicotinoprotein). Mg(2+)-ions are essential for binding of NAD(H) cofactor in MDH protein expressed in Escherichia coli. The low coenzyme NAD(+)-dependent activity of MDH with C(1)-C(4) primary alcohols is strongly stimulated by a second B. methanolicus protein (ACT), provided that MDH contains NAD(H) cofactor and Mg(2+)-ions are present in the assay mixture. Characterization of the act gene revealed the presence of the highly conserved amino acid sequence motif typical of Nudix hydrolase proteins in the deduced ACT amino acid sequence. The act gene was successfully expressed in E. coli allowing purification and characterization of active ACT protein. MDH activation by ACT involved hydrolytic removal of the nicotinamide mononucleotide NMN(H) moiety of the NAD(H) cofactor of MDH, changing its Ping-Pong type of reaction mechanism into a ternary complex reaction mechanism. Increased cellular NADH/NAD(+) ratios may reduce the ACT-mediated activation of MDH, thus preventing accumulation of toxic aldehydes. This represents a novel mechanism for alcohol dehydrogenase activity regulation.
- Published
- 2002
- Full Text
- View/download PDF
48. [Reliability of assessment of audible stuttering behavior].
- Author
-
Althaus M, Goohuis-Brouwer SM, Kloosterman H, Vink H, and Minderaa RB
- Subjects
- Child, Female, Humans, Male, Reproducibility of Results, Stuttering classification, Stuttering etiology, Speech Intelligibility, Speech Production Measurement, Stuttering diagnosis
- Abstract
The authors examine the essential aspects of the behaviour of the stutterer as perceived by the ear and discuss the reliability of the appreciation. The method of molecular analysis of speech samples of children aged from 7 to 12 years is described. The conclusion is that using this method, four out of the six categories of children examined show complete concordance and can be repeated as required; this is particularly true insofar as elongations, blockages, repetitions and interjections are concerned. However, one cannot consider as valid criteria the length of the pauses and the quality of breathing during phonation.
- Published
- 1993
49. [Relationship between the use of postgraduate educational material on human immunodeficiency virus and the number of HIV consultations in family practice].
- Author
-
Wigersma L, Heijnen AM, Hochheimer EH, and Kloosterman H
- Subjects
- Education, Medical, Continuing, Humans, Netherlands, Surveys and Questionnaires, Acquired Immunodeficiency Syndrome therapy, Audiovisual Aids, Family Practice education, HIV Infections therapy
- Abstract
An enquiry using a structured questionnaire was conducted among all 6300 GPs in the Netherlands in order to assess the distribution of HIV-related problems over general practices in the Netherlands and the influence on it of the use of the 'HIV-wijzer voor de huisarts', a loose-leaf handbook on HIV, distributed since 1988 among all Dutch general practitioners. The enquiry was conducted one year after its publication. The 2156 respondents (34%) appeared to be reasonably representative of all GPs. The results show minor imperfections because a small proportion of the questionnaires was filled out incompletely. Almost 90% of respondents mentioned HIV-related consultations, 24% had HIV-seropositive patients and 18% had AIDS patients. These numbers were correlated mainly with municipality size, less with region. The use of the 'HIV-wijzer' was related to occurrence of HIV-related consultations and AIDS patients in a practice. GPs who do not encounter these problems are little motivated to read the 'HIV-wijzer'. For them, other means of education have to be developed or HIV has to be included in existing education programmes on other subjects.
- Published
- 1991
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