1. Long-term effect of vaccination against gonadotropin-releasing hormone, using Improvac™, on hormonal profile and behaviour of male pigs
- Author
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Galia Zamaratskaia, G. Chen, Séverine Lowagie, Lotta Rydhmer, Kjell Andersson, H. Kristina Andersson, and Kerstin Lundström
- Subjects
Male ,medicine.medical_specialty ,Indoles ,Boar taint ,Estrone ,Swine ,Gonadotropin-releasing hormone ,Biology ,Androsterone ,Antibodies ,Gonadotropin-Releasing Hormone ,Sexual Behavior, Animal ,chemistry.chemical_compound ,Bulbourethral gland ,Endocrinology ,Food Animals ,Internal medicine ,Testis ,medicine ,Animals ,Testosterone ,Vaccines ,Androstenone ,Organ Size ,General Medicine ,Skatole ,Vaccination ,medicine.anatomical_structure ,Adipose Tissue ,chemistry ,Bulbourethral Glands ,Animal Science and Zoology ,Orchiectomy ,Hormone - Abstract
The objective of this study was to evaluate the long-term effect of a gonadotropin-releasing hormone (GnRH) vaccine, Improvac (Pfizer Ltd.), on the levels of GnRH antibodies, testosterone, estrone sulphate (E1S) and androstenone, as well as skatole and indole in male pigs. Additionally, the long-term effect of immunocastration on social and sexual behaviour was studied. Male pigs were assigned to two treatment groups: a treatment group given two doses of Improvac (n=12) and a control group of entire male pigs (n=12). The pigs were kept either 16 or 22 weeks after vaccination. Blood samples were collected five or six times; prior to both first and second vaccination, then three or four times during the 16 or 22 week period after second vaccination. Immunocastration significantly reduced levels of testosterone and E1S in plasma, and levels of androstenone in fat (P
- Published
- 2008
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