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4,229 results on '"H. Nakayama"'

2. Revenue augmentation through improved water supply services: a case study of the SMART-WASA team of Faisalabad, Pakistan

Author

R. Ogata, S. Segawa, S. Rashid, and H. Nakayama

Subjects
hydraulic separation, pakistan, revenue augmentation, service improvement, willingness to pay, Environmental technology. Sanitary engineering, TD1-1066
Abstract

The Water and Sanitation Agency of Faisalabad has tried to increase its revenue by increasing both its water demands and total number of customers. To this end, a pilot activity was implemented. Two selected pilot areas were hydraulically separated to increase water pressures within the areas. The results showed that the durations of water supply increased from 3.5 to 12 hours and from 6 to 18 hours per day in the pilot areas. The water pressure in each pilot area increased from 2 to 10 m and from 3 to 18 m, respectively. Wastewater contamination was also eliminated after increasing the water pressure. Customers were informed of these achievements through workshops, flyers, and banners on streets, which encouraged them to shift from a flat rate system to a metering system. Consequently, the total billed amounts for two pilot areas in March 2019 increased by 65.0% and 97.0%, compared with those from November 2016. The bill collection ratios also increased from 48.2% to 56.9% and from 48.1% to 60.6% during pilot activities. Improving services of water supply utilities through the formation of a water distribution area with an increase in water pressure is recommended as an effective method for revenue augmentation. HIGHLIGHTS Water supply services were improved in an attempt to augment revenue.; The pilot areas were hydraulically separated as distribution management areas to increase their water pressures.; Water pressure and duration of water supply both significantly increased following service improvements, and wastewater contamination was eliminated.; The total revenues of the two pilot areas increased by 65.0 and 97.0%.;

Published
2021
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4. Theoretical study on lowering loss of skin effect suppressed multi-layer transmission line with positive/negative (Cu/NiFe) permeability materials for high data-rate and low delay-time I/O interface board

Author

Y. Aizawa, H. Nakayama, K. Kubomura, R. Nakamura, and H. Tanaka

Subjects
Physics, QC1-999
Abstract

This paper proposes a new application of skin effect suppression technology for long wiring on high-speed & low-delay I/O board. This proposal will overcome the difficulty of further reducing the transmission losses on the I/O board with vert >vert 50 Gb/s data rate. In previous research, it was demonstrated that suppression of the skin effect by electroplated conductor/magnetic multi-layer, and estimated that the degree of transmission loss decrease at 16 GHz would be 5 %. A major challenge in this paper is to propose an electromagnetic field calculation theory for rectangular multi-layer transmission line, verify it under the same conditions, clarify a lower loss structure by changing thickness of each layer. Also it is expanded to low loss design technology. Cu and NiFe were selected as metal conductor material and negative permeability magnetic material, respectively. The Cu and NiFe films are alternately stacked to form the multi-layer. The top and bottom surface layers are Cu layers. The loss suppression was compared under the following conditions. 1) Total number of layers was 33 and total thickness was 12.67 μm by a constant ratio, Cu: tN = 0.51μm and NiFe: tF = 0.25μm. 2) Optimal stacking determined by changing the thickness of each layer. Compared to conventional thickness by a constant ratio 1), in our proposal 2), we estimated that the loss would dropped to 92% in optimal thickness. By offsetting the phase change of current density, a lower loss structure could be determined. Compared with Cu conductor, the top and bottom surface current densities become low, and depth center current density becomes slightly high for the multi-layer, showing the skin effect is suppressed.

Published
2020
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5. Improved simulation of beam backgrounds and collimation at SuperKEKB

Author

A. Natochii, S. E. Vahsen, H. Nakayama, T. Ishibashi, and S. Terui

Subjects
Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Mitigation of beam backgrounds via collimators is critical for the success of the Belle II experiment at the SuperKEKB electron-positron collider. We report on an improved simulation methodology, which includes a refined physical description of the collimators and beam pipe, our first implementation of collimator tip scattering, and in which the existing beam particle tracking software has been embedded into a new sequential tracking framework. These improvements resolve longstanding discrepancies between measured and predicted Belle II background levels, and significantly reduce the computing time required to optimize the collimation system in simulation. Finally, we report on collimator aperture scans, which confirm the accuracy of the simulation and suggest a new method for aligning the collimators.

Published
2021
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7. Non-magnetic element substitution effect in Kondo insulator YbB12 and exotic surface effect in this alloy system

Author

F. Iga, K. Yokomichi, W. Matsuhra, H. Nakayama, A. Kondo, K. Kindo, and H. Yoshizawa

Subjects
Physics, QC1-999
Abstract

Kondo temperature TK’s for Kondo insulator alloys Yb1-xRxB12 (R = Y, Lu, Sc and Zr) show drastic variation as every x increase. It is found that YbB12 in a virtual gap-less state would have a peak at about 25 K in magnetic susceptibility χ(T) from analysis of χ(T) of all these alloys. Up-turns shown in χ(T) below 20 K grow as development of an energy gap ΔE. Those behaviors may be related to the second-gap development within the in-gap state showing metallic behaviors.

Published
2018
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8. Divalent ion substitution effect on Yb-site in Kondo insulator YbB12

Author

W. Matsuhra, K. Yokomichi, W. Hirano, S. Kikuchi, N. Uematsu, H. Nakayama, A. Kondo, K. Kindo, and F. Iga

Subjects
Physics, QC1-999
Abstract

YbB12 has been investigated energetically as a typical Kondo insulator. To study detailed formation mechanism of Kondo energy gap, we have investigated transport and magnetic properties of Yb1-xR3+xB12 (R3+ = non-magnetic trivalent ions). Recently, we have recently succeeded in substitution of Ca2+ for Yb site in YbB12 by high-pressure synthesis. In Ca- and Lu-substituted alloys both of magnetic susceptibility and specific heat C/T at low temperatures, remarkably show larger increase than those of powdered YbB12. These increases are due to giant increase of density of state in an in-gap state.

Published
2018
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9. Large-eddy simulation of turbulent winds during the Fukushima Daiichi Nuclear Power Plant accident by coupling with a meso-scale meteorological simulation model

Author

H. Nakayama, T. Takemi, and H. Nagai

Subjects
Science, Physics, QC1-999, Meteorology. Climatology, QC851-999
Abstract

A significant amount of radioactive material was accidentally discharged into the atmosphere from the Fukushima Dai-ichi Nuclear Power Plant from 12 March 2011, which produced high contaminated areas over a wide region in Japan. In conducting regional-scale atmospheric dispersion simulations, the computer-based nuclear emergency response system WSPEEDI-II developed by Japan Atomic Energy Agency was used. Because this system is driven by a meso-scale meteorological (MM) model, it is difficult to reproduce small-scale wind fluctuations due to the effects of local terrain variability and buildings within a nuclear facility that are not explicitly represented in MM models. In this study, we propose a computational approach to couple an LES-based CFD model with a MM model for detailed simulations of turbulent winds with buoyancy effects under real meteorological conditions using turbulent inflow technique. Compared to the simple measurement data, especially, the 10 min averaged wind directions of the LES differ by more than 30 degrees during some period of time. However, distribution patterns of wind speeds, directions, and potential temperature are similar to the MM data. This implies that our coupling technique has potential performance to provide detailed data on contaminated area in the nuclear accidents.

Published
2015
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10. Large-eddy simulation of plume dispersion under various thermally stratified boundary layers

Author

H. Nakayama, T. Takemi, and H. Nagai

Subjects
Science, Physics, QC1-999, Meteorology. Climatology, QC851-999
Abstract

Contaminant gas dispersion in atmospheric boundary layer is of great concern to public health. For the accurate prediction of the dispersion problem, the present study numerically investigates the behavior of plume dispersion by taking into account the atmospheric stability which is classified into three types; neutral, stable, and convective boundary layers. We first proposed an efficient method to generate spatially-developing, thermally-stratified boundary layers and examined the usefulness of our approach by comparing to wind tunnel experimental data for various thermal boundary layers. The spreads of plume in the spanwise direction are quantitatively underestimated especially at large downwind distances from the point source, owing to the underestimation of turbulence intensities for the spanwise component; however, the dependence of the spanwise spreads to atmospheric stability is well represented in a qualitative sense. It was shown that the large-eddy simulation (LES) model provides physically reasonable results.

Published
2014
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11. Large-Eddy Simulation of plume dispersion within various actual urban areas

Author

H. Nakayama, K. Jurcakova, and H. Nagai

Subjects
Science, Physics, QC1-999, Meteorology. Climatology, QC851-999
Abstract

Plume dispersion of hazardous materials within urban area resulting from accidental or intentional releases is of great concern to public health. Many researchers have developed local-scale atmospheric dispersion models using building-resolving computational fluid dynamics. However, an important issue is encountered when determining a reasonable domain size of the computational model in order to capture concentration distribution patterns influenced by urban surface geometries. In this study, we carried out Large-Eddy Simulations (LES) of plume dispersion within various urban areas with a wide range of obstacle density and building height variability. The difference of centerline mean and r.m.s. concentration distributions among various complex urban surface geometries becomes small for downwind distances from the point source greater than 1.0 km. From these results, it can be concluded that a length of a computational model should be at least 1.0 km from a point source.

Published
2013
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12. Large-eddy simulation of plume dispersion within regular arrays of cubic buildings

Author

H. Nakayama, K. Jurcakova, and H. Nagai

Subjects
Science, Physics, QC1-999, Meteorology. Climatology, QC851-999
Abstract

There is a potential problem that hazardous and flammable materials are accidentally or intentionally released within populated urban areas. For the assessment of human health hazard from toxic substances, the existence of high concentration peaks in a plume should be considered. For the safety analysis of flammable gas, certain critical threshold levels should be evaluated. Therefore, in such a situation, not only average levels but also instantaneous magnitudes of concentration should be accurately predicted. In this study, we perform Large-Eddy Simulation (LES) of plume dispersion within regular arrays of cubic buildings with large obstacle densities and investigate the influence of the building arrangement on the characteristics of mean and fluctuating concentrations.

Published
2011
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13. Large-Eddy Simulation on turbulent flow and plume dispersion over a 2-dimensional hill

Author

H. Nakayama and H. Nagai

Subjects
Science, Physics, QC1-999, Meteorology. Climatology, QC851-999
Abstract

The dispersion analysis of airborne contaminants including radioactive substances from industrial or nuclear facilities is an important issue for air quality maintenance and safety assessment. In Japan, many nuclear power plants are located at complex coastal terrains. In these cases, terrain effects on the turbulent flow and plume dispersion should be investigated. In this study, we perform Large-Eddy Simulation (LES) of turbulent flow and plume dispersion over a 2-dimensional hill flow and investigate the characteristics of mean and fluctuating concentrations.

Published
2010
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19. Spontaneous intranasal tumours in degus ( Octodon degus ): 20 cases (2007‐2020)

Author

M, Nakata, Miwa, C C, Wu, J K, Chambers, K, Uchida, Shiga, H, Nakayama, and Sasaki

Subjects
Male, Diagnosis, Differential, Rodent Diseases, Neoplasms, Animals, Female, Nasal Cavity, Small Animals, Octodon, Retrospective Studies
Abstract

The objective of this retrospective study was to describe the clinical and histopathological findings associated with intranasal tumours in degus.Medical records of degus diagnosed with intranasal neoplasms on histopathological examination between the years 2007 and 2020 at one hospital were included in the study.Twenty degus (10 males and 10 females) were eligible for inclusion. Initial clinical signs included sneezing, abnormal nasal sounds, and nasal discharge, followed by anorexia and frequent nose rubbing. On radiography, 15 out of 20 animals showed space-occupying lesions in the nasal cavity. CT was performed in 16 animals and revealed various degrees of changes, including abnormal radiopacity within the nasal cavity and damaged nasal septum. Rhinostomy and excisional biopsy was performed in all 20 animals. Six out of 20 patients died during the perioperative period. Six and seven degus survived for 3 months and 1 year, respectively. One animal was lost to follow-up. In 16 cases the histological diagnosis was consistent with fibromas, while in 4 cases with osteomas.Intranasal neoplasms in degus are mostly benign mesenchymal tumours with various degrees of bone formation, which is unique to this animal species. This occurrence should be considered as an important differential diagnosis for upper respiratory tract disease in degus.

Published
2022
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21. {Measurement of the \ensuremath{\Lambda}c+ Lifetime}

Author

F. Abudinén, L. Aggarwal, H. Ahmed, J. K. Ahn, H. Aihara, N. Akopov, A. Aloisio, N. Anh Ky, D. M. Asner, H. Atmacan, T. Aushev, V. Aushev, V. Babu, H. Bae, P. Bambade, Sw. Banerjee, S. Bansal, J. Baudot, M. Bauer, A. Baur, A. Beaubien, J. Becker, J. V. Bennett, E. Bernieri, F. U. Bernlochner, V. Bertacchi, M. Bertemes, E. Bertholet, M. Bessner, S. Bettarini, V. Bhardwaj, F. Bianchi, T. Bilka, D. Biswas, D. Bodrov, A. Bolz, G. Bonvicini, A. Bozek, M. Bračko, P. Branchini, R. A. Briere, T. E. Browder, A. Budano, S. Bussino, M. Campajola, L. Cao, G. Casarosa, C. Cecchi, M. -C. Chang, P. Chang, R. Cheaib, P. Cheema, C. Chen, Y. Q. Chen, Y. -T. Chen, B. G. Cheon, K. Chilikin, K. Chirapatpimol, H. -E. Cho, K. Cho, S. -J. Cho, S. -K. Choi, S. Choudhury, D. Cinabro, L. Corona, L. M. Cremaldi, S. Cunliffe, F. Dattola, E. De La Cruz-Burelo, S. A. De La Motte, G. De Nardo, M. De Nuccio, G. De Pietro, R. de Sangro, M. Destefanis, A. De Yta-Hernandez, R. Dhamija, A. Di Canto, F. Di Capua, J. Dingfelder, Z. Doležal, I. Domínguez Jiménez, T. V. Dong, M. Dorigo, K. Dort, D. Dossett, S. Dreyer, G. Dujany, M. Eliachevitch, D. Epifanov, P. Feichtinger, T. Ferber, D. Ferlewicz, T. Fillinger, G. Finocchiaro, K. Flood, A. Fodor, F. Forti, A. Frey, B. G. Fulsom, A. Gabrielli, E. Ganiev, M. Garcia-Hernandez, A. Gaz, A. Gellrich, G. Ghevondyan, R. Giordano, A. Giri, A. Glazov, B. Gobbo, R. Godang, P. Goldenzweig, W. Gradl, S. Granderath, D. Greenwald, T. Gu, Y. Guan, K. Gudkova, J. Guilliams, S. Halder, K. Hara, O. Hartbrich, K. Hayasaka, H. Hayashii, S. Hazra, C. Hearty, I. Heredia de la Cruz, M. Hernández Villanueva, A. Hershenhorn, T. Higuchi, M. Hohmann, T. Humair, T. Iijima, K. Inami, G. Inguglia, N. Ipsita, A. Ishikawa, S. Ito, R. Itoh, M. Iwasaki, Y. Iwasaki, P. Jackson, W. W. Jacobs, D. E. Jaffe, Q. P. Ji, Y. Jin, H. Junkerkalefeld, M. Kaleta, J. Kandra, K. H. Kang, R. Karl, G. Karyan, C. Kiesling, C. -H. Kim, D. Y. Kim, K. -H. Kim, Y. -K. Kim, H. Kindo, K. Kinoshita, P. Kodyš, T. Koga, S. Kohani, K. Kojima, A. Korobov, S. Korpar, E. Kovalenko, R. Kowalewski, T. M. G. Kraetzschmar, P. Križan, P. Krokovny, T. Kuhr, J. Kumar, R. Kumar, K. Kumara, T. Kunigo, Y. -J. Kwon, S. Lacaprara, T. Lam, L. Lanceri, J. S. Lange, M. Laurenza, R. Leboucher, S. C. Lee, P. Leitl, D. Levit, L. K. Li, S. X. Li, Y. B. Li, J. Libby, Z. Liptak, Q. Y. Liu, D. Liventsev, S. Longo, T. Lueck, C. Lyu, M. Maggiora, R. Maiti, S. Maity, R. Manfredi, E. Manoni, S. Marcello, C. Marinas, L. Martel, A. Martini, L. Massaccesi, M. Masuda, K. Matsuoka, D. Matvienko, J. A. McKenna, F. Meier, M. Merola, M. Milesi, C. Miller, K. Miyabayashi, G. B. Mohanty, N. Molina-Gonzalez, S. Moneta, H. Moon, H. -G. Moser, M. Mrvar, R. Mussa, I. Nakamura, M. Nakao, H. Nakayama, A. Narimani Charan, M. Naruki, Z. Natkaniec, A. Natochii, L. Nayak, M. Nayak, G. Nazaryan, C. Niebuhr, N. K. Nisar, S. Nishida, K. Nishimura, H. Ono, P. Oskin, E. R. Oxford, G. Pakhlova, A. Paladino, A. Panta, E. Paoloni, S. Pardi, K. Parham, H. Park, S. -H. Park, A. Passeri, T. K. Pedlar, I. Peruzzi, R. Peschke, R. Pestotnik, F. Pham, L. E. Piilonen, G. Pinna Angioni, P. L. M. Podesta-Lerma, T. Podobnik, S. Pokharel, L. Polat, C. Praz, S. Prell, E. Prencipe, M. T. Prim, H. Purwar, N. Rad, P. Rados, S. Raiz, M. Reif, S. Reiter, I. Ripp-Baudot, G. Rizzo, S. H. Robertson, J. M. Roney, A. Rostomyan, N. Rout, G. Russo, D. A. Sanders, S. Sandilya, A. Sangal, L. Santelj, Y. Sato, V. Savinov, B. Scavino, C. Schwanda, A. J. Schwartz, Y. Seino, A. Selce, K. Senyo, J. Serrano, C. Sfienti, C. P. Shen, T. Shillington, J. -G. Shiu, A. Sibidanov, F. Simon, R. J. Sobie, A. Soffer, A. Sokolov, E. Solovieva, S. Spataro, B. Spruck, M. Starič, S. Stefkova, R. Stroili, J. Strube, M. Sumihama, K. Sumisawa, W. Sutcliffe, S. Y. Suzuki, H. Svidras, M. Takahashi, M. Takizawa, U. Tamponi, S. Tanaka, K. Tanida, H. Tanigawa, N. Taniguchi, F. Tenchini, R. Tiwary, D. Tonelli, E. Torassa, N. Toutounji, K. Trabelsi, M. Uchida, K. Unger, Y. Unno, K. Uno, S. Uno, P. Urquijo, Y. Ushiroda, S. E. Vahsen, R. van Tonder, G. S. Varner, K. E. Varvell, A. Vinokurova, L. Vitale, V. Vobbilisetti, E. Waheed, H. M. Wakeling, E. Wang, M. -Z. Wang, X. L. Wang, A. Warburton, S. Watanuki, M. Welsch, C. Wessel, J. Wiechczynski, H. Windel, E. Won, X. P. Xu, B. D. Yabsley, S. Yamada, S. B. Yang, H. Ye, J. Yelton, J. H. Yin, K. Yoshihara, Y. Yusa, Y. Zhang, V. Zhilich, Q. D. Zhou, V. I. Zhukova, and R. Žlebčík, Abudinén, F., Aggarwal, L., Ahmed, H., Ahn, J. K., Aihara, H., Akopov, N., Aloisio, A., Anh Ky, N., Asner, D. M., Atmacan, H., Aushev, T., Aushev, V., Babu, V., Bae, H., Bambade, P., Banerjee, Sw., Bansal, S., Baudot, J., Bauer, M., Baur, A., Beaubien, A., Becker, J., Bennett, J. V., Bernieri, E., Bernlochner, F. U., Bertacchi, V., Bertemes, M., Bertholet, E., Bessner, M., Bettarini, S., Bhardwaj, V., Bianchi, F., Bilka, T., Biswas, D., Bodrov, D., Bolz, A., Bonvicini, G., Bozek, A., Bračko, M., Branchini, P., Briere, R. A., Browder, T. E., Budano, A., Bussino, S., Campajola, M., Cao, L., Casarosa, G., Cecchi, C., Chang, M. -C., Chang, P., Cheaib, R., Cheema, P., Chen, C., Chen, Y. Q., Chen, Y. -T., Cheon, B. G., Chilikin, K., Chirapatpimol, K., Cho, H. -E., Cho, K., Cho, S. -J., Choi, S. -K., Choudhury, S., Cinabro, D., Corona, L., Cremaldi, L. M., Cunliffe, S., Dattola, F., De La Cruz-Burelo, E., De La Motte, S. A., De Nardo, G., De Nuccio, M., De Pietro, G., de Sangro, R., Destefanis, M., De Yta-Hernandez, A., Dhamija, R., Di Canto, A., Di Capua, F., Dingfelder, J., Doležal, Z., Domínguez Jiménez, I., Dong, T. V., Dorigo, M., Dort, K., Dossett, D., Dreyer, S., Dujany, G., Eliachevitch, M., Epifanov, D., Feichtinger, P., Ferber, T., Ferlewicz, D., Fillinger, T., Finocchiaro, G., Flood, K., Fodor, A., Forti, F., Frey, A., Fulsom, B. G., Gabrielli, A., Ganiev, E., Garcia-Hernandez, M., Gaz, A., Gellrich, A., Ghevondyan, G., Giordano, R., Giri, A., Glazov, A., Gobbo, B., Godang, R., Goldenzweig, P., Gradl, W., Granderath, S., Greenwald, D., Gu, T., Guan, Y., Gudkova, K., Guilliams, J., Halder, S., Hara, K., Hartbrich, O., Hayasaka, K., Hayashii, H., Hazra, S., Hearty, C., Heredia de la Cruz, I., Hernández Villanueva, M., Hershenhorn, A., Higuchi, T., Hohmann, M., Humair, T., Iijima, T., Inami, K., Inguglia, G., Ipsita, N., Ishikawa, A., Ito, S., Itoh, R., Iwasaki, M., Iwasaki, Y., Jackson, P., Jacobs, W. W., Jaffe, D. E., Ji, Q. P., Jin, Y., Junkerkalefeld, H., Kaleta, M., Kandra, J., Kang, K. H., Karl, R., Karyan, G., Kiesling, C., Kim, C. -H., Kim, D. Y., Kim, K. -H., Kim, Y. -K., Kindo, H., Kinoshita, K., Kodyš, P., Koga, T., Kohani, S., Kojima, K., Korobov, A., Korpar, S., Kovalenko, E., Kowalewski, R., Kraetzschmar, T. M. G., Križan, P., Krokovny, P., Kuhr, T., Kumar, J., Kumar, R., Kumara, K., Kunigo, T., Kwon, Y. -J., Lacaprara, S., Lam, T., Lanceri, L., Lange, J. S., Laurenza, M., Leboucher, R., Lee, S. C., Leitl, P., Levit, D., Li, L. K., Li, S. X., Li, Y. B., Libby, J., Liptak, Z., Liu, Q. Y., Liventsev, D., Longo, S., Lueck, T., Lyu, C., Maggiora, M., Maiti, R., Maity, S., Manfredi, R., Manoni, E., Marcello, S., Marinas, C., Martel, L., Martini, A., Massaccesi, L., Masuda, M., Matsuoka, K., Matvienko, D., Mckenna, J. A., Meier, F., Merola, M., Milesi, M., Miller, C., Miyabayashi, K., Mohanty, G. B., Molina-Gonzalez, N., Moneta, S., Moon, H., Moser, H. -G., Mrvar, M., Mussa, R., Nakamura, I., Nakao, M., Nakayama, H., Narimani Charan, A., Naruki, M., Natkaniec, Z., Natochii, A., Nayak, L., Nayak, M., Nazaryan, G., Niebuhr, C., Nisar, N. K., Nishida, S., Nishimura, K., Ono, H., Oskin, P., Oxford, E. R., Pakhlova, G., Paladino, A., Panta, A., Paoloni, E., Pardi, S., Parham, K., Park, H., Park, S. -H., Passeri, A., Pedlar, T. K., Peruzzi, I., Peschke, R., Pestotnik, R., Pham, F., Piilonen, L. E., Pinna Angioni, G., Podesta-Lerma, P. L. M., Podobnik, T., Pokharel, S., Polat, L., Praz, C., Prell, S., Prencipe, E., Prim, M. T., Purwar, H., Rad, N., Rados, P., Raiz, S., Reif, M., Reiter, S., Ripp-Baudot, I., Rizzo, G., Robertson, S. H., Roney, J. M., Rostomyan, A., Rout, N., Russo, G., Sanders, D. A., Sandilya, S., Sangal, A., Santelj, L., Sato, Y., Savinov, V., Scavino, B., Schwanda, C., Schwartz, A. J., Seino, Y., Selce, A., Senyo, K., Serrano, J., Sfienti, C., Shen, C. P., Shillington, T., Shiu, J. -G., Sibidanov, A., Simon, F., Sobie, R. J., Soffer, A., Sokolov, A., Solovieva, E., Spataro, S., Spruck, B., Starič, M., Stefkova, S., Stroili, R., Strube, J., Sumihama, M., Sumisawa, K., Sutcliffe, W., Suzuki, S. Y., Svidras, H., Takahashi, M., Takizawa, M., Tamponi, U., Tanaka, S., Tanida, K., Tanigawa, H., Taniguchi, N., Tenchini, F., Tiwary, R., Tonelli, D., Torassa, E., Toutounji, N., Trabelsi, K., Uchida, M., Unger, K., Unno, Y., Uno, K., Uno, S., Urquijo, P., Ushiroda, Y., Vahsen, S. E., van Tonder, R., Varner, G. S., Varvell, K. E., Vinokurova, A., Vitale, L., Vobbilisetti, V., Waheed, E., Wakeling, H. M., Wang, E., Wang, M. -Z., Wang, X. L., Warburton, A., Watanuki, S., Welsch, M., Wessel, C., Wiechczynski, J., Windel, H., Won, E., Xu, X. P., Yabsley, B. D., Yamada, S., Yang, S. B., Ye, H., Yelton, J., Yin, J. H., Yoshihara, K., Yusa, Y., Zhang, Y., Zhilich, V., Zhou, Q. D., Zhukova, V. I., and Žlebčík, and R.

Abstract

An absolute measurement of the Λ_{c}^{+} lifetime is reported using Λ_{c}^{+}→pK^{-}π^{+} decays in events reconstructed from data collected by the Belle II experiment at the SuperKEKB asymmetric-energy electron-positron collider. The total integrated luminosity of the data sample, which was collected at center-of-mass energies at or near the ϒ(4S) resonance, is 207.2 fb^{-1}. The result, τ(Λ_{c}^{+})=203.20±0.89±0.77 fs, where the first uncertainty is statistical and the second systematic, is the most precise measurement to date and is consistent with previous determinations.

Published
2023

22. {Measurement of the \ensuremath{\Omega}c0 lifetime at Belle II}

Author

F. Abudinén, I. Adachi, L. Aggarwal, H. Ahmed, H. Aihara, N. Akopov, A. Aloisio, N. Anh Ky, D. M. Asner, T. Aushev, V. Aushev, H. Bae, P. Bambade, Sw. Banerjee, J. Baudot, M. Bauer, A. Beaubien, J. Becker, P. K. Behera, J. V. Bennett, E. Bernieri, F. U. Bernlochner, V. Bertacchi, M. Bertemes, E. Bertholet, M. Bessner, S. Bettarini, B. Bhuyan, F. Bianchi, T. Bilka, D. Biswas, D. Bodrov, A. Bolz, J. Borah, A. Bozek, M. Bračko, P. Branchini, R. A. Briere, T. E. Browder, A. Budano, S. Bussino, M. Campajola, L. Cao, G. Casarosa, C. Cecchi, M. -C. Chang, P. Cheema, V. Chekelian, Y. Q. Chen, K. Chilikin, K. Chirapatpimol, H. -E. Cho, K. Cho, S. -J. Cho, S. -K. Choi, S. Choudhury, D. Cinabro, L. Corona, S. Cunliffe, S. Das, F. Dattola, E. De La Cruz-Burelo, S. A. De La Motte, G. de Marino, G. De Nardo, M. De Nuccio, G. De Pietro, R. de Sangro, M. Destefanis, S. Dey, A. De Yta-Hernandez, R. Dhamija, A. Di Canto, F. Di Capua, J. Dingfelder, Z. Doležal, I. Domínguez Jiménez, T. V. Dong, M. Dorigo, K. Dort, S. Dreyer, S. Dubey, G. Dujany, P. Ecker, M. Eliachevitch, D. Epifanov, P. Feichtinger, T. Ferber, D. Ferlewicz, T. Fillinger, G. Finocchiaro, A. Fodor, F. Forti, B. G. Fulsom, E. Ganiev, V. Gaur, A. Gaz, A. Gellrich, G. Ghevondyan, R. Giordano, A. Giri, A. Glazov, B. Gobbo, R. Godang, P. Goldenzweig, W. Gradl, S. Granderath, E. Graziani, D. Greenwald, T. Gu, Y. Guan, K. Gudkova, J. Guilliams, K. Hayasaka, H. Hayashii, S. Hazra, C. Hearty, I. Heredia de la Cruz, M. Hernández Villanueva, A. Hershenhorn, T. Higuchi, E. C. Hill, H. Hirata, M. Hohmann, C. -L. Hsu, T. Iijima, K. Inami, G. Inguglia, N. Ipsita, A. Ishikawa, S. Ito, R. Itoh, M. Iwasaki, P. Jackson, W. W. Jacobs, D. E. Jaffe, E. -J. Jang, S. Jia, Y. Jin, K. K. Joo, H. Junkerkalefeld, A. B. Kaliyar, K. H. Kang, R. Karl, G. Karyan, C. Kiesling, C. -H. Kim, D. Y. Kim, K. -H. Kim, Y. -K. Kim, H. Kindo, K. Kinoshita, P. Kodyš, T. Koga, S. Kohani, K. Kojima, T. Konno, A. Korobov, S. Korpar, E. Kovalenko, R. Kowalewski, T. M. G. Kraetzschmar, P. Križan, P. Krokovny, J. Kumar, K. Kumara, T. Kunigo, A. Kuzmin, Y. -J. Kwon, S. Lacaprara, T. Lam, L. Lanceri, J. S. Lange, M. Laurenza, K. Lautenbach, R. Leboucher, C. Li, L. K. Li, J. Libby, K. Lieret, Z. Liptak, Q. Y. Liu, D. Liventsev, S. Longo, A. Lozar, T. Lueck, C. Lyu, M. Maggiora, R. Maiti, R. Manfredi, E. Manoni, S. Marcello, C. Marinas, A. Martini, T. Martinov, L. Massaccesi, M. Masuda, S. K. Maurya, J. A. McKenna, F. Meier, M. Merola, F. Metzner, M. Milesi, C. Miller, K. Miyabayashi, R. Mizuk, G. B. Mohanty, N. Molina-Gonzalez, S. Moneta, H. -G. Moser, M. Mrvar, R. Mussa, I. Nakamura, M. Nakao, H. Nakayama, Y. Nakazawa, A. Narimani Charan, M. Naruki, Z. Natkaniec, A. Natochii, L. Nayak, M. Nayak, G. Nazaryan, N. K. Nisar, S. Ogawa, H. Ono, Y. Onuki, E. R. Oxford, A. Paladino, A. Panta, E. Paoloni, S. Pardi, H. Park, S. -H. Park, A. Passeri, S. Paul, T. K. Pedlar, I. Peruzzi, R. Peschke, R. Pestotnik, M. Piccolo, L. E. Piilonen, P. L. M. Podesta-Lerma, T. Podobnik, S. Pokharel, L. Polat, C. Praz, S. Prell, E. Prencipe, M. T. Prim, H. Purwar, N. Rad, P. Rados, S. Raiz, A. Ramirez Morales, M. Reif, S. Reiter, M. Remnev, I. Ripp-Baudot, G. Rizzo, S. H. Robertson, J. M. Roney, A. Rostomyan, N. Rout, G. Russo, D. A. Sanders, S. Sandilya, A. Sangal, Y. Sato, V. Savinov, B. Scavino, J. Schueler, C. Schwanda, A. J. Schwartz, B. Schwenker, Y. Seino, A. Selce, K. Senyo, J. Serrano, M. E. Sevior, C. Sfienti, C. P. Shen, X. D. Shi, T. Shillington, A. Sibidanov, J. B. Singh, J. Skorupa, R. J. Sobie, A. Soffer, E. Solovieva, S. Spataro, B. Spruck, M. Starič, S. Stefkova, Z. S. Stottler, R. Stroili, J. Strube, M. Sumihama, K. Sumisawa, W. Sutcliffe, S. Y. Suzuki, H. Svidras, M. Takizawa, U. Tamponi, K. Tanida, H. Tanigawa, F. Tenchini, A. Thaller, R. Tiwary, D. Tonelli, E. Torassa, N. Toutounji, K. Trabelsi, M. Uchida, I. Ueda, Y. Uematsu, T. Uglov, K. Unger, Y. Unno, K. Uno, S. Uno, Y. Ushiroda, S. E. Vahsen, R. van Tonder, G. S. Varner, K. E. Varvell, A. Vinokurova, L. Vitale, V. Vobbilisetti, H. M. Wakeling, E. Wang, M. -Z. Wang, X. L. Wang, A. Warburton, M. Watanabe, S. Watanuki, M. Welsch, C. Wessel, E. Won, B. D. Yabsley, S. Yamada, W. Yan, S. B. Yang, H. Ye, J. Yelton, J. H. Yin, Y. M. Yook, K. Yoshihara, C. Z. Yuan, L. Zani, Y. Zhang, V. Zhilich, Q. D. Zhou, X. Y. Zhou, V. I. Zhukova, and R. Žlebčík, Abudinén, F., Adachi, I., Aggarwal, L., Ahmed, H., Aihara, H., Akopov, N., Aloisio, A., Anh Ky, N., Asner, D. M., Aushev, T., Aushev, V., Bae, H., Bambade, P., Banerjee, Sw., Baudot, J., Bauer, M., Beaubien, A., Becker, J., Behera, P. K., Bennett, J. V., Bernieri, E., Bernlochner, F. U., Bertacchi, V., Bertemes, M., Bertholet, E., Bessner, M., Bettarini, S., Bhuyan, B., Bianchi, F., Bilka, T., Biswas, D., Bodrov, D., Bolz, A., Borah, J., Bozek, A., Bračko, M., Branchini, P., Briere, R. A., Browder, T. E., Budano, A., Bussino, S., Campajola, M., Cao, L., Casarosa, G., Cecchi, C., Chang, M. -C., Cheema, P., Chekelian, V., Chen, Y. Q., Chilikin, K., Chirapatpimol, K., Cho, H. -E., Cho, K., Cho, S. -J., Choi, S. -K., Choudhury, S., Cinabro, D., Corona, L., Cunliffe, S., Das, S., Dattola, F., De La Cruz-Burelo, E., De La Motte, S. A., de Marino, G., De Nardo, G., De Nuccio, M., De Pietro, G., de Sangro, R., Destefanis, M., Dey, S., De Yta-Hernandez, A., Dhamija, R., Di Canto, A., Di Capua, F., Dingfelder, J., Doležal, Z., Domínguez Jiménez, I., Dong, T. V., Dorigo, M., Dort, K., Dreyer, S., Dubey, S., Dujany, G., Ecker, P., Eliachevitch, M., Epifanov, D., Feichtinger, P., Ferber, T., Ferlewicz, D., Fillinger, T., Finocchiaro, G., Fodor, A., Forti, F., Fulsom, B. G., Ganiev, E., Gaur, V., Gaz, A., Gellrich, A., Ghevondyan, G., Giordano, R., Giri, A., Glazov, A., Gobbo, B., Godang, R., Goldenzweig, P., Gradl, W., Granderath, S., Graziani, E., Greenwald, D., Gu, T., Guan, Y., Gudkova, K., Guilliams, J., Hayasaka, K., Hayashii, H., Hazra, S., Hearty, C., Heredia de la Cruz, I., Hernández Villanueva, M., Hershenhorn, A., Higuchi, T., Hill, E. C., Hirata, H., Hohmann, M., Hsu, C. -L., Iijima, T., Inami, K., Inguglia, G., Ipsita, N., Ishikawa, A., Ito, S., Itoh, R., Iwasaki, M., Jackson, P., Jacobs, W. W., Jaffe, D. E., Jang, E. -J., Jia, S., Jin, Y., Joo, K. K., Junkerkalefeld, H., Kaliyar, A. B., Kang, K. H., Karl, R., Karyan, G., Kiesling, C., Kim, C. -H., Kim, D. Y., Kim, K. -H., Kim, Y. -K., Kindo, H., Kinoshita, K., Kodyš, P., Koga, T., Kohani, S., Kojima, K., Konno, T., Korobov, A., Korpar, S., Kovalenko, E., Kowalewski, R., Kraetzschmar, T. M. G., Križan, P., Krokovny, P., Kumar, J., Kumara, K., Kunigo, T., Kuzmin, A., Kwon, Y. -J., Lacaprara, S., Lam, T., Lanceri, L., Lange, J. S., Laurenza, M., Lautenbach, K., Leboucher, R., Li, C., Li, L. K., Libby, J., Lieret, K., Liptak, Z., Liu, Q. Y., Liventsev, D., Longo, S., Lozar, A., Lueck, T., Lyu, C., Maggiora, M., Maiti, R., Manfredi, R., Manoni, E., Marcello, S., Marinas, C., Martini, A., Martinov, T., Massaccesi, L., Masuda, M., Maurya, S. K., Mckenna, J. A., Meier, F., Merola, M., Metzner, F., Milesi, M., Miller, C., Miyabayashi, K., Mizuk, R., Mohanty, G. B., Molina-Gonzalez, N., Moneta, S., Moser, H. -G., Mrvar, M., Mussa, R., Nakamura, I., Nakao, M., Nakayama, H., Nakazawa, Y., Narimani Charan, A., Naruki, M., Natkaniec, Z., Natochii, A., Nayak, L., Nayak, M., Nazaryan, G., Nisar, N. K., Ogawa, S., Ono, H., Onuki, Y., Oxford, E. R., Paladino, A., Panta, A., Paoloni, E., Pardi, S., Park, H., Park, S. -H., Passeri, A., Paul, S., Pedlar, T. K., Peruzzi, I., Peschke, R., Pestotnik, R., Piccolo, M., Piilonen, L. E., Podesta-Lerma, P. L. M., Podobnik, T., Pokharel, S., Polat, L., Praz, C., Prell, S., Prencipe, E., Prim, M. T., Purwar, H., Rad, N., Rados, P., Raiz, S., Ramirez Morales, A., Reif, M., Reiter, S., Remnev, M., Ripp-Baudot, I., Rizzo, G., Robertson, S. H., Roney, J. M., Rostomyan, A., Rout, N., Russo, G., Sanders, D. A., Sandilya, S., Sangal, A., Sato, Y., Savinov, V., Scavino, B., Schueler, J., Schwanda, C., Schwartz, A. J., Schwenker, B., Seino, Y., Selce, A., Senyo, K., Serrano, J., Sevior, M. E., Sfienti, C., Shen, C. P., Shi, X. D., Shillington, T., Sibidanov, A., Singh, J. B., Skorupa, J., Sobie, R. J., Soffer, A., Solovieva, E., Spataro, S., Spruck, B., Starič, M., Stefkova, S., Stottler, Z. S., Stroili, R., Strube, J., Sumihama, M., Sumisawa, K., Sutcliffe, W., Suzuki, S. Y., Svidras, H., Takizawa, M., Tamponi, U., Tanida, K., Tanigawa, H., Tenchini, F., Thaller, A., Tiwary, R., Tonelli, D., Torassa, E., Toutounji, N., Trabelsi, K., Uchida, M., Ueda, I., Uematsu, Y., Uglov, T., Unger, K., Unno, Y., Uno, K., Uno, S., Ushiroda, Y., Vahsen, S. E., van Tonder, R., Varner, G. S., Varvell, K. E., Vinokurova, A., Vitale, L., Vobbilisetti, V., Wakeling, H. M., Wang, E., Wang, M. -Z., Wang, X. L., Warburton, A., Watanabe, M., Watanuki, S., Welsch, M., Wessel, C., Won, E., Yabsley, B. D., Yamada, S., Yan, W., Yang, S. B., Ye, H., Yelton, J., Yin, J. H., Yook, Y. M., Yoshihara, K., Yuan, C. Z., Zani, L., Zhang, Y., Zhilich, V., Zhou, Q. D., Zhou, X. Y., Zhukova, V. I., and Žlebčík, and R.

Published
2023

23. Revenue augmentation through improved water supply services: a case study of the SMART-WASA team of Faisalabad, Pakistan

Author

H. Nakayama, S. Rashid, R. Ogata, and S. Segawa

Subjects
hydraulic separation, pakistan, business.industry, Public Health, Environmental and Occupational Health, Water supply, Development, Environmental technology. Sanitary engineering, Pollution, Agricultural economics, revenue augmentation, Revenue, Business, willingness to pay, Waste Management and Disposal, TD1-1066, service improvement, Water Science and Technology
Abstract

The Water and Sanitation Agency of Faisalabad has tried to increase its revenue by increasing both its water demands and total number of customers. To this end, a pilot activity was implemented. Two selected pilot areas were hydraulically separated to increase water pressures within the areas. The results showed that the durations of water supply increased from 3.5 to 12 hours and from 6 to 18 hours per day in the pilot areas. The water pressure in each pilot area increased from 2 to 10 m and from 3 to 18 m, respectively. Wastewater contamination was also eliminated after increasing the water pressure. Customers were informed of these achievements through workshops, flyers, and banners on streets, which encouraged them to shift from a flat rate system to a metering system. Consequently, the total billed amounts for two pilot areas in March 2019 increased by 65.0% and 97.0%, compared with those from November 2016. The bill collection ratios also increased from 48.2% to 56.9% and from 48.1% to 60.6% during pilot activities. Improving services of water supply utilities through the formation of a water distribution area with an increase in water pressure is recommended as an effective method for revenue augmentation. HIGHLIGHTS Water supply services were improved in an attempt to augment revenue.; The pilot areas were hydraulically separated as distribution management areas to increase their water pressures.; Water pressure and duration of water supply both significantly increased following service improvements, and wastewater contamination was eliminated.; The total revenues of the two pilot areas increased by 65.0 and 97.0%.

Published
2021
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24. A neural network for beam background decomposition in Belle II at SuperKEKB

Author

B. Schwenker, L. Herzberg, Y. Buch, A. Frey, A. Natochii, S. Vahsen, and H. Nakayama

Subjects
High Energy Physics - Experiment (hep-ex), Nuclear and High Energy Physics, FOS: Physical sciences, Instrumentation, High Energy Physics - Experiment
Abstract

We describe a neural network for predicting the background hit rate in the Belle II detector produced by the SuperKEKB electron-positron collider. The neural network, BGNet, learns to predict the individual contributions of different physical background sources, such as beam-gas scattering or continuous top-up injections into the collider, to Belle II sub-detector rates. The samples for learning are archived 1 Hz time series of diagnostic variables from the SuperKEKB collider subsystems and measured hit rates of Belle II used as regression targets. We test the learned model by predicting detector hit rates on archived data from different run periods not used during training. We show that a feature attribution method can help interpret the source of changes in the background level over time., Submitted to NIM-A

Published
2023
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25. Transplantation of insulin-like growth factor-1 laden scaffolds combined with exercise promotes neuroregeneration and angiogenesis in a preclinical muscle injury model

Author

Caroline K. Hu, Ngan F. Huang, Thomas A. Rando, Cynthia Alcazar, and Karina H. Nakayama

Subjects
Angiogenesis, Muscle Fibers, Skeletal, Biomedical Engineering, 02 engineering and technology, Motor Activity, Article, Mice, 03 medical and health sciences, Tibialis anterior muscle, medicine, Animals, Regeneration, Myocyte, General Materials Science, Insulin-Like Growth Factor I, Muscle, Skeletal, 030304 developmental biology, 0303 health sciences, Tissue Scaffolds, Chemistry, Myogenesis, Regeneration (biology), Skeletal muscle, 021001 nanoscience & nanotechnology, Neuroregeneration, Nerve Regeneration, Cell biology, Transplantation, medicine.anatomical_structure, 0210 nano-technology
Abstract

The regeneration of skeletal muscle can be permanently impaired by traumatic injuries, despite the high regenerative capacity of native muscle. An attractive therapeutic approach for treating severe muscle inuries is the implantation of off-the-shelf engineered biomimetic scaffolds into the site of tissue damage to enhance muscle regeneration. Anisotropic nanofibrillar scaffolds provide spatial patterning cues to create organized myofibers, and growth factors such as insulin-like growth factor-1 (IGF-1) are potent inducers of both muscle regeneration as well as angiogenesis. The aim of this study was to test the therapeutic efficacy of anisotropic IGF-1-releasing collagen scaffolds combined with voluntary exercise for the treatment of acute volumetric muscle loss, with a focus on histomorphological effects. To enhance the angiogenic and regenerative potential of injured murine skeletal muscle, IGF-1-laden nanofibrillar scaffolds with aligned topography were fabricated using a shear-mediated extrusion approach, followed by growth factor adsorption. Individual scaffolds released a cumulative total of 1244 ng ± 153 ng of IGF-1 over the course of 21 days in vitro. To test the bioactivity of IGF-1-releasing scaffolds, the myotube formation capacity of murine myoblasts was quantified. On IGF-1-releasing scaffolds seeded with myoblasts, the resulting myotubes formed were 1.5-fold longer in length and contained 2-fold greater nuclei per myotube, when compared to scaffolds without IGF-1. When implanted into the ablated murine tibialis anterior muscle, the IGF-1-laden scaffolds, in conjunction with voluntary wheel running, significantly increased the density of perfused microvessels by greater than 3-fold, in comparison to treatment with scaffolds without IGF-1. Enhanced myogenesis was also observed in animals treated with the IGF-1-laden scaffolds combined with exercise, compared to control scaffolds transplanted into mice that did not receive exercise. Furthermore, the abundance of mature neuromuscular junctions was greater by approximately 2-fold in muscles treated with IGF-1-laden scaffolds, when paired with exercise, in comparison to the same treatment without exercise. These findings demonstrate that voluntary exercise improves the regenerative effect of growth factor-laden scaffolds by augmenting neurovascular regeneration, and have important translational implications in the design of off-the-shelf therapeutics for the treatment of traumatic muscle injury.

Published
2020
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26. Decellularization Strategies for Regenerating Cardiac and Skeletal Muscle Tissues

Author

Yong How, Tan, Haylie R, Helms, and Karina H, Nakayama

Subjects
Histology, Biomedical Engineering, Bioengineering, Biotechnology
Abstract

Cardiovascular disease is the leading cause of death worldwide and is associated with approximately 17.9 million deaths each year. Musculoskeletal conditions affect more than 1.71 billion people globally and are the leading cause of disability. These two areas represent a massive global health burden that is perpetuated by a lack of functionally restorative treatment options. The fields of regenerative medicine and tissue engineering offer great promise for the development of therapies to repair damaged or diseased tissues. Decellularized tissues and extracellular matrices are cornerstones of regenerative biomaterials and have been used clinically for decades and many have received FDA approval. In this review, we first discuss and compare methods used to produce decellularized tissues and ECMs from cardiac and skeletal muscle. We take a focused look at how different biophysical properties such as spatial topography, extracellular matrix composition, and mechanical characteristics influence cell behavior and function in the context of regenerative medicine. Lastly, we describe emerging research and forecast the future high impact applications of decellularized cardiac and skeletal muscle that will drive novel and effective regenerative therapies.

Published
2022
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27. Low-Z collimator for SuperKEKB

Author

S. Terui, T. Ishibashi, T. Abe, Y. Funakoshi, H. Nakayama, K. Ohmi, D. Zhou, A. Natochii, and N. Yoshifuji

Subjects
Nuclear and High Energy Physics, Instrumentation
Published
2023
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31. Application of recoil-imaging time projection chambers to directional neutron background measurements in the SuperKEKB accelerator tunnel

Author

J. Schueler, S.E. Vahsen, P.M. Lewis, M.T. Hedges, D. Liventsev, F. Meier, H. Nakayama, A. Natochii, and T.N. Thorpe

Subjects
High Energy Physics - Experiment (hep-ex), Nuclear and High Energy Physics, Physics - Instrumentation and Detectors, Physics::Instrumentation and Detectors, FOS: Physical sciences, Instrumentation and Detectors (physics.ins-det), Nuclear Experiment, Instrumentation, High Energy Physics - Experiment
Abstract

Gaseous time projection chambers (TPCs) with high readout segmentation are capable of reconstructing detailed 3D ionization distributions of nuclear recoils resulting from elastic neutron scattering. Using a system of six compact TPCs with pixel ASIC readout, filled with a 70:30 mixture of He:CO$_2$ gas, we analyze the first directional measurements of beam-induced neutron backgrounds in the tunnel regions surrounding the Belle II detector at the SuperKEKB $e^+e^-$ collider. With the use of 3D recoil tracking, we show that these TPCs are capable of maintaining nearly $100\%$ nuclear recoil purity to reconstructed ionization energies ($E_\text{reco}$) as low as 5 $\mathrm{keV_\text{ee}}$. Using a large sample of simulated $^4$He, $^{12}$C, and $^{16}$O recoil tracks, we find consistency between predicted and measured recoil energy spectra in five of the six TPCs, providing useful validation of the neutron production mechanisms modeled in simulation. Restricting this sample to $^4$He recoil tracks with $E_\text{reco}>40$ $\mathrm{keV_\text{ee}}$, we demonstrate axial angular resolutions within $8^{\circ}$ and we introduce a procedure that under suitable conditions, correctly assigns the vector direction to $91\%$ of simulated $^4$He recoils. Applying this procedure to assign vector directions to measured $^4$He recoil tracks, we observe consistency between the angular distributions of observed and simulated recoils, providing first experimental evidence of localized neutron "hotspots" in the accelerator tunnel. Observed rates of nuclear recoils in these TPCs suggest that simulation overestimates the neutron flux from these hotspots., 21 pages, 19 figures. Accepted by Nuclear Instruments & Methods In Physics Research, A

Published
2021

32. Improved simulation of beam backgrounds and collimation at SuperKEKB

Author

S. E. Vahsen, Takuya Ishibashi, Shinji Terui, A. Natochii, and H. Nakayama

Subjects
Accelerator Physics (physics.acc-ph), Nuclear and High Energy Physics, Physics and Astronomy (miscellaneous), Aperture, Computer science, Astrophysics::High Energy Astrophysical Phenomena, Physics::Medical Physics, FOS: Physical sciences, QC770-798, Tracking (particle physics), Collimated light, High Energy Physics - Experiment, law.invention, High Energy Physics - Experiment (hep-ex), Software, Optics, law, Nuclear and particle physics. Atomic energy. Radioactivity, Collider, Scattering, business.industry, Collimator, Surfaces and Interfaces, Physics::Accelerator Physics, Physics - Accelerator Physics, business, Beam (structure)
Abstract

Mitigation of beam backgrounds via collimators is critical for the success of the Belle~II experiment at the SuperKEKB electron-positron collider. We report on an improved simulation methodology, which includes a refined physical description of the collimators and beam pipe, our first implementation of collimator tip scattering, and in which the existing beam particle tracking software has been embedded into a new sequential tracking framework. These improvements resolve longstanding discrepancies between measured and predicted Belle~II background levels, and significantly reduce the computing time required to optimize the collimation system in simulation. Finally, we report on collimator aperture scans, which confirm the accuracy of the simulation and suggest a new method for aligning the collimators., 18 pages, 30 figures (including subfigures), 5 tables, to be submitted to PRAB

Published
2021
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33. Comprehensive genetic analyses using targeted next-generation sequencing and genotype-phenotype correlations in 53 Japanese patients with osteogenesis imperfecta

Author

Y. Ohata, S. Takeyari, Y. Nakano, T. Kitaoka, H. Nakayama, V. Bizaoui, K. Yamamoto, K. Miyata, M. Fujiwara, T. Kubota, T. Michigami, T. Yamamoto, N. Namba, K. Ebina, H. Yoshikawa, and K. Ozono

Subjects
musculoskeletal diseases, 0301 basic medicine, Genotype-phenotype correlation, congenital, hereditary, and neonatal diseases and abnormalities, Candidate gene, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, macromolecular substances, medicine.disease_cause, DNA sequencing, 03 medical and health sciences, symbols.namesake, 0302 clinical medicine, Trabecular bone score, medicine, Type I collagen, skin and connective tissue diseases, Gene, Sanger sequencing, Genetics, Mutation, business.industry, medicine.disease, Short stature, Fracture, Osteogenesis imperfecta, Next-generation sequencing, symbols, Original Article, 030101 anatomy & morphology, business
Abstract

Summary To elucidate mutation spectrum and genotype-phenotype correlations in Japanese patients with OI, we conducted comprehensive genetic analyses using NGS, as this had not been analyzed comprehensively in this patient population. Most mutations were located on COL1A1 and COL1A2. Glycine substitutions in COL1A1 resulted in the severe phenotype. Introduction Most cases of osteogenesis imperfecta (OI) are caused by mutations in COL1A1 or COL1A2, which encode α chains of type I collagen. However, mutations in at least 16 other genes also cause OI. The mutation spectrum in Japanese patients with OI has not been comprehensively analyzed, as it is difficult to identify using classical Sanger sequencing. In this study, we aimed to reveal the mutation spectrum and genotype-phenotype correlations in Japanese patients with OI using next-generation sequencing (NGS). Methods We designed a capture panel for sequencing 15 candidate OI genes and 19 candidate genes that are associated with bone fragility or Wnt signaling. Using NGS, we examined 53 Japanese patients with OI from unrelated families. Results Pathogenic mutations were detected in 43 out of 53 individuals. All mutations were heterozygous. Among the 43 individuals, 40 variants were identified including 15 novel mutations. We found these mutations in COL1A1 (n = 30, 69.8%), COL1A2 (n = 12, 27.9%), and IFITM5 (n = 1, 2.3%). Patients with glycine substitution on COL1A1 had a higher frequency of fractures and were more severely short-statured. Although no significant genotype-phenotype correlation was observed for bone mineral density, the trabecular bone score was significantly lower in patients with glycine substitutions. Conclusion We identified pathogenic mutations in 81% of our Japanese patients with OI. Most mutations were located on COL1A1 and COL1A2. This study revealed that glycine substitutions on COL1A1 resulted in the severe phenotype among Japanese patients with OI. Electronic supplementary material The online version of this article (10.1007/s00198-019-05076-6) contains supplementary material, which is available to authorized users.

Published
2019
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35. Performance of the diamond-based beam-loss monitor system of Belle II

Author

C. La Licata, Keigo Hara, A. Paladino, Y. Jin, Dario Giuressi, Andrea Gabrielli, S. Bacher, Giuseppe Cautero, M. Dorigo, G. Bassi, K. Nakamura, H. Nakayama, L. Bosisio, A. Natochii, L. Lanceri, P. Cristaudo, L. Vitale, R. Manfredi, G. Rizzo, H. Yin, Bacher, S., Bassi, G., Bosisio, L., Cautero, G., Cristaudo, P., Dorigo, M., Gabrielli, A., Giuressi, D., Hara, K., Jin, Y., La Licata, C., Lanceri, L., Manfredi, R., Nakayama, H., Nakamura, K. R., Natochii, A., Paladino, A., Rizzo, G., Vitale, L., and Yin, H.

Subjects
Nuclear and High Energy Physics, Physics - Instrumentation and Detectors, Radiation monitoring, Synthetic diamond, FOS: Physical sciences, Diamond sensor, Radiation, engineering.material, 01 natural sciences, law.invention, Optics, law, Accelerator interlock, 0103 physical sciences, Beam-loss monitoring, 010306 general physics, Collider, Instrumentation, Physics, 010308 nuclear & particles physics, business.industry, Detector, Diamond, Instrumentation and Detectors (physics.ins-det), Accelerator interlocks, sCVD diamond sensor, engineering, Physics::Accelerator Physics, High Energy Physics::Experiment, business, Beam (structure)
Abstract

We designed, constructed and have been operating a system based on single-crystal synthetic diamond sensors, to monitor the beam losses at the interaction region of the SuperKEKB asymmetric-energy electron–positron collider. The system records the radiation dose-rates in positions close to the inner detectors of the Belle II experiment, and protects both the detector and accelerator components against destructive beam losses, by participating in the beam-abort system. It also provides complementary information for the dedicated studies of beam-related backgrounds. We describe the performance of the system during the commissioning of the accelerator and during the first physics data taking.

Published
2021

36. First 3D vector tracking of helium recoils for fast neutron measurements at SuperKEKB

Author

M.T. Hedges, S.E. Vahsen, I. Jaegle, P.M. Lewis, H. Nakayama, J. Schueler, and T.N. Thorpe

Subjects
Nuclear and High Energy Physics, High Energy Physics - Experiment (hep-ex), Physics - Instrumentation and Detectors, Physics::Instrumentation and Detectors, FOS: Physical sciences, Instrumentation and Detectors (physics.ins-det), Instrumentation, High Energy Physics - Experiment
Abstract

We present results from the first deployment of novel, high definition, compact gas Time Projection Chambers (TPCs) with pixel chip readout as part of the BEAST II beam background measurement project at SuperKEKB. The TPCs provide detailed 3D imaging of ionization from neutron-induced nuclear recoils in a helium and carbon dioxide target gas mixture at standard temperature and pressure. We find excellent electron background rejection, leading to background-free nuclear recoil measurements above 50 keVee, despite the extreme high-background environment. We measure an angular resolution better than 20{\deg} for recoil tracks longer than 1.7 mm, corresponding to an average ionization energy of ~100 keVee. We also obtain the 3D vector direction of helium recoils by utilizing charge profile measurements along the recoil axis, with a correct head/tail assignment efficiency of approximately 80%. With this performance, we present comparisons between measured and simulated event rates, recoil energy spectra, and directional distributions originating from beam-gas and Touschek beam losses at SuperKEKB. We utilize head/tail recognition to distinguish neutron components travelling with positive radial velocity in the Belle II coordinate system from those with opposite directionality. Finally, we present a novel method of discriminating beam-gas interactions from Touschek beam losses that can eliminate the need for dedicated accelerator runs for background measurements. This method is still statistics-limited. However, future studies should be able to verify this method, which in turn could lead to neutron background analysis runs symbiotic with normal Belle II operation. The capabilities demonstrated here also suggest that high definition recoil imaging in gas TPCs is applicable to low energy, low-background experiments, such as directional dark matter searches.

Published
2021
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37. Measurements of Beam Backgrounds in SuperKEKB Phase 2

Author

Z. Liptak, A. Paladino, L. Santelj, J. Schueler, S. Stefkova, H. Tanigawa, N. Tsuzuki, A. Aloisio, P. Ahlburg, P. Bambade, G. Bassi, M. Barrett, J. Baudot, T.E. Browder, G. Casarosa, G. Cautero, D. Cinabro, G. Claus, D. Cuesta, F. Di Capua, S. Di Carlo, J. Flanagan, A. Frey, B.G. Fulsom, Y. Funakoshi, M. Gabriel, R. Giordano, D. Giuressi, M. Goffe, K. Hara, O. Hartbrich, M.T. Hedges, D. Heuchel, N. Iida, T. Ishibashi, K. Jaaskelainen, D. Jehanno, S. de Jong, T. Kraetzschmar, C. La Licata, L. Lanceri, P. Leitl, P.M. Lewis, C. Marinas, C. Miller, H. Moser, K.R. Nakamura, H. Nakayama, C. Niebuhr, Y. Onuki, C. Pang, B. Paschen, I. Ripp-Baudot, G. Rizzo, J.M. Roney, H. Schreeck, B. Schwenker, F. Simon, M. Specht, B. Spruck, Y. Soloviev, M. Szelezniak, S. Tanaka, S. Terui, G. Tortone, T. Tsuboyama, Y. Uematsu, S.E. Vahsen, L. Vitale, H. Windel, Liptak, Z., Paladino, A., Santelj, L., Schueler, J., Stefkova, S., Tanigawa, H., Tsuzuki, N., Aloisio, A., Ahlburg, P., Bambade, P., Bassi, G., Barrett, M., Baudot, J., Browder, T. E., Casarosa, G., Cautero, G., Cinabro, D., Claus, G., Cuesta, D., Di Capua, F., Di Carlo, S., Flanagan, J., Frey, A., Fulsom, B. G., Funakoshi, Y., Gabriel, M., Giordano, R., Giuressi, D., Goffe, M., Hara, K., Hartbrich, O., Hedges, M. T., Heuchel, D., Iida, N., Ishibashi, T., Jaaskelainen, K., Jehanno, D., de Jong, S., Kraetzschmar, T., La Licata, C., Lanceri, L., Leitl, P., Lewis, P. M., Marinas, C., Miller, C., Moser, H., Nakamura, K. R., Nakayama, H., Niebuhr, C., Onuki, Y., Pang, C., Paschen, B., Ripp-Baudot, I., Rizzo, G., Roney, J. M., Schreeck, H., Schwenker, B., Simon, F., Specht, M., Spruck, B., Soloviev, Y., Szelezniak, M., Tanaka, S., Terui, S., Tortone, G., Tsuboyama, T., Uematsu, Y., Vahsen, S. E., Vitale, L., and Windel, H.

Subjects
Nuclear and High Energy Physics, Physics - Instrumentation and Detectors, FOS: Physical sciences, SuperKEKB, Instrumentation and Detectors (physics.ins-det), Accelerator background, High Energy Physics - Experiment, Beam background, High Energy Physics - Experiment (hep-ex), Belle II, Physics::Accelerator Physics, High Energy Physics::Experiment, Instrumentation
Abstract

The high design luminosity of the SuperKEKB electron-positron collider will result in challenging levels of beam-induced backgro\ unds in the interaction region. Understanding and mitigating these backgrounds is critical to the success of the Belle~II experi\ ment. We report on the first background measurements performed after roll-in of the Belle II detector, a period known as SuperKE\ KB Phase 2, utilizing both the BEAST II system of dedicated background detectors and the Belle II detector itself. We also repor\ t on first revisions to the background simulation made in response to our findings. Backgrounds measured include contributions f\ rom synchrotron radiation, beam-gas, Touschek, and injection backgrounds. At the end of Phase 2, single-beam backgrounds origina\ ting from the 4 GeV positron Low Energy Ring (LER) agree reasonably well with simulation, while backgrounds from the 7 GeV elect\ ron High Energy Ring (HER) are approximately one order of magnitude higher than simulation. We extrapolate these backgrounds for\ ward and conclude it is safe to install the Belle II vertex detector., Comment: 22 Pages, 33 figures

Published
2021
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39. Novel Guest–Host Type Polymer Films for Stable and Large Second-Order Nonlinearity and Waveguide Property

Author

Makoto Nakanishi, N. Okamoto, H. Nakayama, Okihiro Sugihara, K. Hirota, and M. Ozawa

Subjects
chemistry.chemical_classification, High concentration, Materials science, Guest host, business.industry, Doping, Physics::Optics, macromolecular substances, Polymer, Waveguide (optics), Nonlinear system, chemistry, Optoelectronics, Glass transition, business
Abstract

New host polymers with high glass transition temperature doped with guest several dye in high concentration are prepared. Large and temporally stable second-harmonic generation (SHG) is observed, and optical waveguide properties are investigated.

Published
2020
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40. The risk of interstitial lung disease during biological treatment in Japanese patients with psoriasis

Author

H. Nakayama, Yuka Matsumoto, Namiko Abe, Rie Tobita, Ryoji Tsuboi, Yukari Okubo, Y. Setoguchi, and Hiroshi Kawakami

Subjects
Adult, Male, medicine.medical_specialty, Dermatology, Antibodies, Monoclonal, Humanized, 030207 dermatology & venereal diseases, 03 medical and health sciences, Biological Factors, 0302 clinical medicine, Japan, Risk Factors, Psoriasis, Internal medicine, Ustekinumab, medicine, Adalimumab, Humans, Adverse effect, Aged, business.industry, Mucin-1, Interstitial lung disease, respiratory system, Middle Aged, medicine.disease, Infliximab, respiratory tract diseases, Ixekizumab, Early Diagnosis, 030220 oncology & carcinogenesis, Antirheumatic Agents, Secukinumab, Female, Tumor Necrosis Factor Inhibitors, business, Lung Diseases, Interstitial, medicine.drug
Abstract

Background With the increasing use of biological agents for the treatment of psoriasis, the numbers of patients with interstitial lung disease (ILD) associated with biologics have also increased. Many of these cases were associated with tumour necrosis factor (TNF)-α inhibitors, but cases associated with other families of biologics have also been reported in Japan. Aim To analyse the background factors of patients who developed ILD, and to discuss better management of biological treatment. Method We reviewed 246 patients with psoriasis who were treated with biological agents in our department to identify any pulmonary adverse events (AEs). Data on patients who developed ILD were extracted to analyse background factors, clinical type of psoriasis, time to onset of ILD, pre-existing ILD, smoking habit and prescribed drugs. Results Pulmonary AEs were seen in 22 cases, of which 11 were diagnosed as drug-induced ILD. The causative drugs were mainly TNF-α inhibitors, accounting for eight cases (six treated with infliximab, two with adalimumab). The remaining three cases were associated with secukinumab, ustekinumab and ixekizumab (n = 1 each). Notably, these three cases also had a history of drug-induced ILD. Conclusion Patients with a history of drug-induced ILD seem to be more susceptible to developing another ILD induced by biologics, even if treated with interleukin-17 inhibitors. Thorough screening of risk factors and evaluation for eligibility, and careful monitoring during treatment are the best solutions to avoid serious pulmonary AE. Early detection and precise diagnosis of pulmonary AEs, especially differentiation from infectious diseases, is essential for managing biological treatment.

Published
2020

41. Beam background study for the Belle II Silicon Vertex Detector

Author

H. Aihara, S. Watanuki, T. Aziz, W. Ostrowicz, B. Gobbo, K. Lalwani, T. Lueck, G. Casarosa, T. Czank, Surajit Maity, H. B. Jeon, H. Park, L. Lanceri, H. Nakayama, F. Buchsteiner, T. Zhang, Takeo Higuchi, G. Dujany, Rajeev Kumar, L. Corona, Yonghu Chen, Markus Friedl, T. Tsuboyama, S. Hazra, S. E. Vahsen, Prafulla Kumar Behera, H. Tanigawa, J. Wiechczynski, A. B. Kaliyar, Y. Onuki, A. Bozek, Keigo Hara, L. Santelj, P. Kodyš, K. Nakamura, Z. Natkaniec, Y. Uematsu, J. Suzuki, N. Dash, Jakub Kandra, G. Batignani, N. Rout, J. A. Mora Grimaldo, Christoph Schwanda, Satoshi Tanaka, John Webb, Z. Doležal, L. Vitale, K. Wan, P. Kapusta, I. Ripp-Baudot, M. Kumar, F. Forti, K. K. Rao, O. Verbycka, C. La Licata, Shih-Chang Lee, J. Libby, S. Halder, T. Morii, T. Bilka, D. Červenkov, S. Bettarini, Christian Irmler, E. Ganiev, A. Ishikawa, A. Paladino, Peter Kvasnicka, M. Kaleta, R. Thalmeier, K. Adamczyk, H. Yin, E. Paoloni, N. Sato, G. B. Mohanty, S. N. Mayekar, K. H. Kang, G. de Marino, G. Rizzo, S. Das, J. Baudot, S. Bacher, T. Kohriki, C. W. Joo, Dipak Kumar Sahoo, L. Zani, Y. B. Li, S. Bahinipati, Tanigawa, H., Adamczyk, K., Aihara, H., Aziz, T., Bacher, S., Bahinipati, S., Batignani, G., Baudot, J., Behera, P. K., Bettarini, S., Bilka, T., Bozek, A., Buchsteiner, F., Casarosa, G., Cervenkov, D., Chen, Y. Q., Corona, L., Czank, T., Das, S. B., Dash, N., de Marino, G., Dolezal, Z., Dujany, G., Forti, F., Friedl, M., Ganiev, E., Gobbo, B., Halder, S., Hara, K., Hazra, S., Higuchi, T., Irmler, C., Ishikawa, A., Jeon, H. B., Joo, C., Kaleta, M., Kaliyar, A. B., Kandra, J., Kang, K. H., Kapusta, P., Kodys, P., Kohriki, T., Kumar, M., Kumar, R., Kvasnicka, P., Licata, C. L., Lalwani, K., Lanceri, L., Lee, S. C., Li, Y. B., Libby, J., Lueck, T., Maity, S., Mayekar, S. N., Mohanty, G. B., Grimaldo, J. A. M., Morii, T., Nakamura, K. R., Nakayama, H., Natkaniec, Z., Onuki, Y., Ostrowicz, W., Paladino, A., Paoloni, E., Park, H., Rao, K. K., Ripp-Baudot, I., Rizzo, G., Rout, N., Sahoo, D., Santelj, L., Sato, N., Schwanda, C., Suzuki, J., Tanaka, S., Thalmeier, R., Tsuboyama, T., Uematsu, Y., Vahsen, S. E., Verbycka, O., Vitale, L., Wan, K., Watanuki, S., Webb, J., Wiechczynski, J., Yin, H., Zani, L., Zhang, T., Institut Pluridisciplinaire Hubert Curien (IPHC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), and Belle-II SVD

Subjects
Nuclear and High Energy Physics, Meson, Silicon, vertex detector, chemistry.chemical_element, BELLE, 7. Clean energy, 01 natural sciences, law.invention, Beam background, Nuclear physics, Belle II, Silicon vertex detector, law, 0103 physical sciences, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 010306 general physics, Collider, Instrumentation, Physics, Luminosity (scattering theory), 010308 nuclear & particles physics, Scattering, Detector, beam: background, chemistry, semiconductor detector, Physics::Accelerator Physics, High Energy Physics::Experiment, performance, Energy (signal processing), Beam (structure)
Abstract

The Belle II experiment aims to accumulate 50 ab−1 of e + e − collision data at the SuperKEKB asymmetric energy collider (Tsukuba, Japan). The first physics data using all Belle II detectors were taken in spring 2019. In the vast physics program of the Belle II experiment, the vertex detector plays a crucial role for the determination of the B -meson decay vertices. It consists of two inner layers of pixelated silicon detectors and four outer layers of double-sided silicon strip detectors (SVD). To achieve a design luminosity of 8 × 1 0 35 cm − 2 s − 1 , 40 times higher than the recorded luminosity of its predecessor, the SuperKEKB collider squeezes the beams to a vertical size of 50 nm (“nano-beam scheme”) and doubles the beam currents. Therefore, the detectors are required to tolerate intense beam induced background due to the very high luminosity. During the 2019 spring run we measured the occupancy rate in the SVD to estimate the level of the beam induced background. With the low initial luminosity, the observed beam induced background mostly originated from Touschek processes and beam-gas scattering within individual beams. Since these different background contributions depend differently on accelerator conditions, such as the beam current, beam size and pressure, they can be disentangled. We estimate the background rate of each contribution and compare them with simulated ones. The results enable us to predict the background levels at increased beam currents and luminosity in the coming years. They also hint at background mitigation measures for running at higher luminosity. In this proceeding we present the results of our study of the beam induced background in the SVD and the prospects for future operation.

Published
2020
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43. Magnetic design and method of a superconducting magnet for muon g−2/EDM precise measurements in a cylindrical volume with homogeneous magnetic field

Author

Norihito Saito, Tsutomu Mibe, Hiromi Iinuma, Ken-ichi Sasaki, M. Abe, H. Nakayama, Toru Ogitsu, and Y. Murata

Subjects
010302 applied physics, Superconductivity, Physics, Nuclear and High Energy Physics, Muon, Superconducting magnet, 01 natural sciences, Computational physics, Magnetic field, Electromagnetic coil, Magnet, 0103 physical sciences, Cylindrical coordinate system, 010306 general physics, Instrumentation, Current density
Abstract

A magnetic field design method of magneto-motive force (coil block (CB) and iron yoke) placements for g − 2 /EDM measurements has been developed and a candidate placements were designed under superconducting limitations of current density 125 A/mm2 and maximum magnetic field on CBs less than 5.5 T. Placements of CBs and an iron yoke with poles were determined by tuning SVD (singular value decomposition) eigenmode strengths. The SVD was applied on a response matrix from magneto-motive forces to the magnetic fields in the muon storage region and two-dimensional (2D) placements of magneto-motive forces were designed by tuning the magnetic field eigenmode strengths obtained by the magnetic field. The tuning was performed iteratively. Magnetic field ripples in the azimuthal direction were minimized for the design. The candidate magnetic design had five CBs and an iron yoke with center iron poles. The magnet satisfied specifications of homogeneity (0.2 ppm peak-to-peak in 2D placements (the cylindrical coordinate of the radial position R and axial position Z ) and less than 1.0 ppm ripples in the ring muon storage volume (0.318 m R 0 . 348 m and -0.05 Z 0.05 m) with 3.0 T strength and a slightly negative B R (magnetic field radial component) at Z > 0.0 m) for the spiral muon injection from the iron yoke at top.

Published
2018
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45. Measurement of the Michel parameters (η‾, ξκ ) in the radiative leptonic decay of τ

Author

J. E. Fast, D. Dossett, M. Niiyama, L. Pesántez, V. Trusov, Andrey Sokolov, S. Shinomiya, Byeong Rok Ko, M. Feindt, I. Nakamura, V. Babu, Hui Li, Jingxu Wang, T. Aushev, O. Frost, Z. Suzuki, J. Grygier, J. H. Kang, Y. Miyachi, Hikaru Kawai, M. Belhorn, Benjamin Schwenker, T. Zivko, Y. B. Hsiung, K. Neichi, A. Zupanc, C. C. Zhang, E. Nakano, Antonio Limosani, T. Ferber, D. H. Lee, H. Kakuno, H. Shibuya, M. Watanabe, L. S. Peak, C. Niebuhr, O. Nitoh, K. Nishimura, Chawon Park, A. Loos, J. C. Dingfelder, M. V. Purohit, P. Goldenzweig, Rupert Leitner, V. V. Zhulanov, J. Yamaoka, Xiuwan Li, K. Senyo, S. Eidelman, L. Shang, Ihn Sik Seong, S. Sandilya, K. Ueno, M. Heck, M. J. Kim, T. Kawasaki, P. Pakhlov, W. Ostrowicz, U. Tamponi, Anton Poluektov, T. Schlüter, S. Sugihara, M. Starič, Y. Igarashi, M. Masuda, Dipanwita Dutta, A. Sugiyama, T. Kumita, M. Uchida, X. H. He, D. Cinabro, Philip Lewis, G. B. Mohanty, C. H. Li, Massimo Berger, B. H. Kim, Y. Yook, H. Yamamoto, L. K. Li, V.N. Zhilich, Y. Kato, V. Chobanova, Y. Kuroki, Satoshi Tanaka, D. Liventsev, Y. Arita, I. Jaegle, K. Miyabayashi, M. Lubej, G. Inguglia, I. Badhrees, Y. Koga, E. Nedelkovska, F. Breibeck, H. Park, J. Stypula, C. Kiesling, E. J. White, A. Bozek, P. Chang, G. S. Varner, Y.-T. Lai, K. Suzuki, P. Schonmeier, M. Iwabuchi, R. Mussa, H. B. Jeon, O. Grzymkowska, C. H. Wang, M. Grosse Perdekamp, R. Itoh, Jung-Hyun Kim, S. Wehle, T. Keck, S. Paul, L. Li Gioi, Y. Yamashita, C. Z. Yuan, Yukinori Sato, J. G. Shiu, M. Nayak, T. Bloomfield, A. Ishikawa, A. Drutskoy, S. E. Vahsen, A. Bay, C.-L. Hsu, T. Saito, S. Rummel, T. Matsuda, Yu Nakahama, M. Tanaka, T. Peng, G. Schnell, A. Rostomyan, Tsukasa Aso, P. Wang, H. Miyata, Y. Hoshi, M. Barrett, B. Bhuyan, Y.L. Han, A. Frey, H. Ye, P. Križan, T. Iijima, Jun Sasaki, H. G. Moser, M. Bračko, Y. Iwasaki, B. G. Fulsom, Peter Kodys, W. W. Jacobs, T. E. Browder, Y. J. Kwon, K. Nakamura, Ya-Qiu Jin, P. Hamer, K. Hayasaka, A. Bobrov, H. Hayashii, Hyunyong Kim, O. Schneider, K. Prasanth, M. Imamura, T. Nagamine, K. Trabelsi, P. Katrenko, T. Müller, J. Klucar, K. T. Kim, C. P. Shen, S. Di Carlo, Seok Kim, S. Okuno, B. Shwartz, Jamal Rorie, D. Getzkow, C. B. Van Hulse, I. Adachi, A. Ogawa, K. Negishi, T. Kuhr, D. Z. Besson, E. Ribežl, D. Santel, Phillip Urquijo, N. Sasao, Victoria Zhukova, V. Savinov, M. Danilov, H. Nakayama, D. Y. Kim, R. Gillard, R. Mizuk, Eberhard Widmann, J. F. Strube, Matthew Jones, M. Z. Wang, K. Kinoshita, M. Yamauchi, G. Bonvicini, Y. B. Li, Y. Teramoto, I. Tikhomirov, D. Mohapatra, J. B. Singh, A. Chen, K. Hara, S. K. Choi, Sanmay Ganguly, T. Uchida, Y. Ban, N. Zwahlen, Bruce Yabsley, L. Zhao, M. Heider, M. Rozanska, D. Kotchetkov, Y. Yusa, A. Vinokurova, S. Dubey, Rahul Kumar, J. Libby, R. Louvot, Y. Chao, G. N. Taylor, R. Glattauer, V.E. Shebalin, J. Haba, W. Bartel, S. Nishida, S. Al Said, K. Hoshina, Y. Seino, Y. Onuki, K. Vervink, Z. Drásal, Marko Petrič, M. T. Prim, K. Itagaki, Z. Q. Liu, C. Bookwalter, B. G. Cheon, H. J. Hyun, S. Uozumi, P. Smerkol, Tariq Aziz, X. L. Wang, D. Heffernan, T. Morii, C. Boulahouache, J. Hasenbusch, V. Chekelian, J. Li, V. M. Aulchenko, H. Guo, T.-A. Shibata, T. Horiguchi, Y. Ono, S. Koblitz, Seema Bahinipati, Y. Choi, H. Takeichi, K. J. Nath, S. Uno, C. Schwanda, P. Krokovny, M. T. Hedges, Samo Stanič, L.M. Zhang, E. Kurihara, A.E. Bondar, P.A. Lukin, T. Nakano, K. Dutta, A. Garmash, Daniel Greenwald, M. Takizawa, B. Reisert, Y. Sakai, J. Rauch, B. K. Pal, E. L. Barberio, M. Shapkin, Noritaka Shimizu, T. Hara, L. Santelj, J. Dalseno, Robin Wedd, K. M. Williams, V. Bansal, K. Belous, A. M. Bakich, S. Korpar, Jolanta Brodzicka, John Yelton, T. Ohshima, Z. Doležal, K. Chilikin, Y. J. Kim, N. Dash, S. Iwata, H. Ozaki, H. Nakano, C. Ng, K. H. Kang, K. Cho, K. Inami, M. Sumihama, A. Heller, M. D. Peters, Motoki Iwasaki, Y. Ushiroda, N. Taniguchi, Y. M. Goh, S. H. Lee, K. Prothmann, R. Pestotnik, N. Gabyshev, D. Červenkov, A. Abdesselam, M. Steder, M. E. Sevior, I. S. Lee, D. Matvienko, Y. Miyazaki, R. Sinha, P. K. Behera, Yasushi Nagasaka, B. Kronenbitter, Sumio Yamada, E. Kato, M. Leitgab, Tao Luo, K. Tanida, F. Tenchini, T. Sumiyoshi, A. Bala, D. Epifanov, Soumya D. Mohanty, C. Pulvermacher, Martin Ritter, Dmytro Levit, Z. Natkaniec, S. L. Blyth, T. Sanuki, Shigeki Hirose, K. K. Joo, Hirokazu Miyake, R. Seidl, Y. Guan, E. Solovieva, Norihito Muramatsu, M. Huschle, K. Sakai, Y. Watanabe, S. K. Kim, A.L. Sibidanov, H. Kichimi, M. C. Chang, K. S. Park, V. Bhardwaj, T. K. Pedlar, T. Tsuboyama, H. Palka, L. E. Piilonen, G. Pakhlova, J. Wiechczynski, R. Kulasiri, S. U. Kataoka, S. Yashchenko, A. Moll, S. L. Olsen, D. Joffe, T. Julius, Po-Hsun Chen, R. Chistov, A. Vossen, O. Seon, Frank Simon, D. Semmler, Y. Unno, K. F. Chen, R. Ayad, T. Nozaki, S. Uehara, M. N. Wagner, Peter Kvasnicka, A. B. Kaliyar, Sunmin Ryu, C. W. Park, E. Won, C. Oswald, H. Atmacan, P. Vanhoefer, E. Panzenböck, B. Golob, M. Schram, N. K. Nisar, H. K. Moon, J. S. Lange, M. Ziegler, K. Adamczyk, Y. Soloviev, W. S. Hou, K. Arinstein, Y. Mikami, Alexei Kuzmin, V. Vorobyev, Nagao Kobayashi, Y. F. Liu, C. Kleinwort, Z. P. Zhang, H. Sahoo, Tara Nanut, T. Uglov, Yoji Hasegawa, S. Y. Suzuki, Richard T. Kouzes, K. Sumisawa, D. M. Asner, S. Himori, Kevin Varvell, A. Matyja, Jason Crnkovic, T. Mori, H. Aihara, Y. Usov, Jyoti Prakash Biswal, C. Liu, H. Nakazawa, A. J. Schwartz, H. Farhat, J. B. Kim, T. Higuchi, S. Ogawa, V. Gaur, Y. S. Sohn, Ferdinando Giordano, M. Nakao, E. Waheed, S. McOnie, J. MacNaughton, and P. Kapusta

Subjects
Physics, Nuclear and High Energy Physics, Particle physics, 010308 nuclear & particles physics, Maximum likelihood, Electron–positron annihilation, 01 natural sciences, law.invention, Nuclear physics, KEKB, law, 0103 physical sciences, Radiative transfer, Michel parameters, Statistical analysis, 010306 general physics, Collider, Lepton
Abstract

We present the first measurement of the Michel parameters η ‾ and ξκ in the radiative leptonic decay of the τ lepton using 703 fb-1 of data collected with the Belle detector at the KEKB e + e − collider. The Michel parameters are measured by an unbinned maximum likelihood fit to the kinematic information of e + e − → τ + τ − → ( π + π 0 ν ‾ ) ( l − ν ν ‾ γ ) ( l = e or μ ) . The preliminary values of the measured Michel parameters are η ‾ = − 2.0 ± 1.5 ± 0.8 and ξ κ = 0.6 ± 0.4 ± 0.2 , where the first error is statistical and the second is systematic.

Published
2017
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46. Anisotropic microfibrous scaffolds enhance the organization and function of cardiomyocytes derived from induced pluripotent stem cells

Author

Joseph J. Kim, Joseph C. Wu, Ngan F. Huang, Nicholas P. Mezak, Karina H. Nakayama, Evangeline Tzatzalos, Maureen Wanjare, Oscar J. Abilez, and Luqia Hou

Subjects
0301 basic medicine, Scaffold, business.product_category, Induced Pluripotent Stem Cells, Biomedical Engineering, Biocompatible Materials, Nanotechnology, 02 engineering and technology, Article, Contractility, 03 medical and health sciences, chemistry.chemical_compound, Tissue engineering, Myosin, Microfiber, Humans, Myocyte, Myocytes, Cardiac, General Materials Science, Induced pluripotent stem cell, reproductive and urinary physiology, Tissue Engineering, Tissue Scaffolds, Chemistry, 021001 nanoscience & nanotechnology, Cell biology, 030104 developmental biology, embryonic structures, Polycaprolactone, Anisotropy, 0210 nano-technology, business, Porosity
Abstract

Engineering of myocardial tissue constructs is a promising approach for treatment of coronary heart disease. To engineer myocardial tissues that better mimic the highly ordered physiological arrangement and function of native cardiomyocytes, we generated electrospun microfibrous polycaprolactone scaffolds with either randomly oriented (14-µm fiber diameter) or parallel-aligned (7-µm fiber diameter) microfiber arrangement and co-seeded the scaffolds with human induced pluripotent stem cell-derived cardiomyocytes (iCMs) and endothelial cells (iECs) for up to 12 days after iCM seeding. Here we demonstrated that aligned microfibrous scaffolds induced iCM alignment along the direction of the aligned microfibers after 2 days of iCM seeding, as well as promoted greater iCM maturation by increasing the sarcomeric length and gene expression of myosin heavy chain adult isoform (MYH7), in comparison to randomly oriented scaffolds. Furthermore, the benefit of scaffold anisotropy was evident in the significantly higher maximum contraction velocity of iCMs on the aligned scaffolds, compared to randomly oriented scaffolds, at 12 days of culture. Co-seeding of iCMs with iECs led to reduced contractility, compared to when iCMs were seeded alone. These findings demonstrate an dominant role of scaffold anisotropy in engineering cardiovascular tissues that maintain iCM organization and contractile function.

Published
2017
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48. P1650Clinical significance of uNGAL, uKIM-1, and uL-FABP in patients with acute pulmonary edema

Author

T Kobayashi, K Yoshitani, T Kuragaichi, Y Nishimoto, A Miyata, R Taniguchi, R Fukuhara, H Nakayama, K Hotta, T Miyamoto, M Toma, Syunsuke Saga, and Y Sato

Subjects
medicine.medical_specialty, business.industry, Internal medicine, Acute pulmonary edema, Medicine, In patient, Cardiology and Cardiovascular Medicine, business, Gastroenterology
Abstract

Introduction Novel urinary biomarkers such as urinary neutrophil gelatinase-associated lipocalin (u-NGAL),urinary kidney injury molecule-1 (u-KIM-1), and urinary liver-type fatty acid-binding protein (uL-FABP) are proposed to be reliable markers for acute heart failure (AHF). Acute pulmonary edema (APE) is one of the vascular phenotypes of AHF, such as `vascular failure”, often with high blood pressure at admission. We aimed to investigate the differences in the clinical impact and prognostic utility of urinary biomarkers in AHF patients with and without APE. Methods and results This prospective observational study included 203 AHF patients (mean age: 77 years, 52% male). uL-FABP, u-NGAL, and u-KIM-1 were measured at admission and before discharge, with correction for urinary creatinine. APE was defined as acute-onset dyspnea and radiographic alveolar edema requiring non-invasive positive pressure ventilation. The primary outcome was a composite of all-cause death and AHF rehospitalization for 1 year. The median uL-FABP levels at admission were higher in APE (n=42) than in non-APE patients (n=161; 10.8 [4.5–23.7] vs. 20.7 [5.9–63.5] μg/gCr, p=0.017), whereas u-KIM-1, u-NGAL, and serum creatinine did not significantly differ between AHF patients with and without APE. The primary outcome did not differ between patients with and without APE. However, among patients with APE, Kaplan–Meier analysis showed that higher uL-FABP (≥median: 20.7 μg/gCr) was associated with adverse events (log-rank: p=0.019). After adjusting for age, sex, serum creatinine, and brain natriuretic peptide, multivariable Cox hazard analysis showed that higher uL-FABP is an independent predictor of adverse events (HR: 4.0 [1.2–18.2], p=0.023). Conclusion Unlike u-NGAL and u-KIM-1, uL-FABP was higher in APE patients than in non-APE patients. Further, among patients with APE, higher uL-FABP was predictive for poor prognosis. Acknowledgement/Funding None

Published
2019
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50. Ral GTPase Activation by Downregulation of RalGAP Enhances Oral Squamous Cell Carcinoma Progression

Author

S. Liu, K. Kato, Ryutaro Shirakawa, Kota Goto, H. Nakayama, Shuichi Kawashiri, P. Gao, Hisanori Horiuchi, C.Y. Shi, X.Y. Wang, J. Sakata, R. Yoshida, Shingo Yoshimachi, Natsumi Sakata, and Tomohiro Kimura

Subjects
0301 basic medicine, animal structures, GTPase-activating protein, Down-Regulation, Epigenesis, Genetic, Histones, 03 medical and health sciences, 0302 clinical medicine, Downregulation and upregulation, Cell Line, Tumor, Humans, General Dentistry, RALB, biology, Chemistry, GTPase-Activating Proteins, Cell migration, DNA Methylation, RALA, stomatognathic diseases, 030104 developmental biology, Histone, 030220 oncology & carcinogenesis, Gene Knockdown Techniques, DNA methylation, Cancer research, biology.protein, Carcinoma, Squamous Cell, Disease Progression, Mouth Neoplasms, ral GTP-Binding Proteins, Guanine nucleotide exchange factor
Abstract

Ral small GTPases, consisting of RalA and RalB, are members of the Ras family. Their activity is upregulated by RalGEFs. Since several RalGEFs are downstream effectors of Ras, Ral is activated by the oncogenic mutant Ras. Ral is negatively regulated by RalGAP complexes that consist of a catalytic α1 or α2 subunit and its common partner β subunit and similarly regulate the activity of RalA as well as RalB in vitro. Ral plays an important role in the formation and progression of pancreatic and lung cancers. However, the involvement of Ral in oral squamous cell carcinoma (OSCC) is unclear. In this study, we investigated OSCC by focusing on Ral. OSCC cell lines with high Ral activation exhibited higher motility. We showed that knockdown of RalGAPβ increased the activation level of RalA and promoted the migration and invasion of HSC-2 OSCC cells in vitro. In contrast, overexpression of wild-type RalGAPα2 in TSU OSCC cells attenuated the activation level of RalA and inhibited cell migration and invasion. Real-time quantitative polymerase chain reaction analysis of samples from patients with OSCC showed that RalGAPα2 was downregulated in oral cancer tissues as compared with normal epithelia. Among patients with OSCC, those with a lower expression of RalGAPα2 showed a worse overall survival rate. A comparison of DNA methylation and histone modifications of the RalGAPα2 gene in OSCC cell lines suggested that crosstalk among DNA methylation, histone H4Ac, and H3K27me2 was involved in the downregulation of RalGAPα2. Thus, activation of Ral GTPase by downregulation of RalGAP expression via a potential epigenetic mechanism may enhance OSCC progression.

Published
2019

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