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1. RandomiSed clinical trial assessing Use of an anti-inflammatoRy aGent in attenUating peri-operatiVe inflAmmatioN in non-meTastatic colon cancer – the S.U.R.G.U.V.A.N.T. trial

2. Activation of Both TLR and NOD Signaling Confers Host Innate Immunity-Mediated Protection Against Microbial Infection

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3. Induction of Trained Immunity Protects Neonatal Mice Against Microbial Sepsis by Boosting Both the Inflammatory Response and Antimicrobial Activity

4. Impact of the COVID-19 pandemic on cancer care in Ireland – Perspectives from a COVID-19 and Cancer Working Group

5. Evaluation of the Cytotoxic Effects of the Novel Antineoplastic Agent 1,4,5-Oxathiazinane-4,4-dioxide on Triple Negative Breast Cancer Cells

6. Autophagy induced by taurolidine protects against polymicrobial sepsis by promoting both host resistance and disease tolerance

7. Metabolomic pathway activity with genomic single-nucleotide polymorphisms associated with colorectal cancer recurrence and 5-year overall survival

8. Metabolomic Pathway Activity with Genomic Single-Nucleotide Polymorphisms Associated with Colorectal Cancer Recurrence and 5-Year Overall Survival

9. Antagonism of Integrin CD11b Affords Protection against Endotoxin Shock and Polymicrobial Sepsis via Attenuation of HMGB1 Nucleocytoplasmic Translocation and Extracellular Release

10. Activation of the TLR2-mediated downstream signaling pathways NF-κB and MAPK is responsible for B7-H3-augmented inflammatory response during S. pneumoniae infection

11. Surviving Sepsis: Tolerance Towards Bacteria and Their Cell Wall Components

12. An Early Neutrophil Recruitment into the Infectious Site Is Critical for Bacterial Lipoprotein Tolerance-Afforded Protection against Microbial Sepsis

13. Siliconosis and the long‐term implications of silent breast implant rupture

14. Surgical management of metastatic melanoma in the era of targeted systemic therapies

15. Inefficient antimicrobial functions of innate phagocytes render infant mice more susceptible to bacterial infection

16. B7-H3 Augments Inflammatory Responses and Exacerbates Brain Damage via Amplifying NF-κB p65 and MAPK p38 Activation during Experimental Pneumococcal Meningitis

17. NF-κB activation is critical for bacterial lipoprotein tolerance-enhanced bactericidal activity in macrophages during microbial infection

18. Inflammatory regulation of stem-like cells in melanoma

19. B7H3 ameliorates LPS-induced acute lung injury via attenuation of neutrophil migration and infiltration

20. B7-H3 Participates in the Development of Experimental Pneumococcal Meningitis by Augmentation of the Inflammatory Response via a TLR2-Dependent Mechanism

21. From Theater to the World Wide Web—a New Online Era for Surgical Education

22. Increased Susceptibility of ST2-Deficient Mice to Polymicrobial Sepsis Is Associated with an Impaired Bactericidal Function

23. B7-H3 Augments the Inflammatory Response and Is Associated with Human Sepsis

24. ST2 Negatively Regulates TLR2 Signaling, but Is Not Required for Bacterial Lipoprotein-Induced Tolerance

25. Combined IFN-γ–Endostatin Gene Therapy and Radiotherapy Attenuates Primary Breast Tumor Growth and Lung Metastases via Enhanced CTL and NK Cell Activation and Attenuated Tumor Angiogenesis in a Murine Model

26. Enteric bacteria and their antigens may stimulate postoperative peritoneal adhesion formation

27. Taurolidine induces apoptosis of murine melanoma cells in vitro and in vivo by modulation of the Bcl-2 family proteins

28. Myeloid-related protein 8 induces self-tolerance and cross-tolerance to bacterial infection via TLR4- and TLR2-mediated signal pathways

29. Cellular reprogramming by gram-positive bacterial components: a review

30. Bacterial lipoprotein-induced self-tolerance and cross-tolerance to LPS are associated with reduced IRAK-1 expression and MyD88-IRAK complex formation

31. Phosphoinositide 3-Kinase Accelerates Postoperative Tumor Growth by Inhibiting Apoptosis and Enhancing Resistance to Chemotherapy-induced Apoptosis

32. Sentinel Nodes Are Identifiable in Formalin-Fixed Specimens After Surgeon-Performed Ex Vivo Sentinel Lymph Node Mapping in Colorectal Cancer

33. Duration of increased bleeding tendency after cessation of aspirin therapy

34. Hypertonic saline impedes tumor cell–endothelial cell interaction by reducing adhesion molecule and laminin expression

35. The effect of aspirin on blood loss and transfusion requirements in patients with femoral neck fractures

36. Hypertonic Saline Enhances Host Response to Bacterial Challenge by Augmenting Receptor-Independent Neutrophil Intracellular Superoxide Formation

37. Cutting Edge: Bacterial Lipoprotein Induces Endotoxin-Independent Tolerance to Septic Shock

39. Current knowledge and future directions of TLR and NOD signaling in sepsis

40. Induction of Bacterial Lipoprotein Tolerance Is Associated with Suppression of Toll-like Receptor 2 Expression

41. Cellular Apoptosis and Organ Injury in Sepsis: A Review

42. Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover

43. Antiseptic wick: Does it reduce the incidence of wound infection following appendectomy?

44. Lung injury in acute pancreatitis: mechanisms, prevention, and therapy

45. Nasogastric intubation causes gastroesophageal reflux in patients undergoing elective laparotomy

46. Book reviews

47. Nitric oxide mediates hepatocyte injury

48. Taurine attenuates recombinant interleukin-2-activated, lymphocyte-mediated endothelial cell injury

49. [Untitled]

50. Review: Host Defense-A Role for the Amino Acid Taurine?