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This paper analyzes the root causes of attitude-orbit coupling effects of spacecraft proximity relative motion in space precision collaborative tasks from three aspects: mathematical representation, physical definition, and engineering applications. At first, taking mathematical representation as the context, spacecraft proximity relative motion representations such as particle relative dynamic model, extended particle relative dynamic model, and dual-spiral-based relative dynamic model are investigated in detail. On this basis, the mechanism of attitude-orbit coupling effects originating from different mathematical representations is further investigated. Second, spiral theory–based attitude-orbit coupling relative dynamics is developed. The innovation of this work is extending the dual number representation from rigid body to flexible body, which makes it possible to describe the proximity relative motion between two rigid-flexible coupling spacecraft. Third, the application value of attitude-orbit coupling relative dynamic model in precision collaborative mission such as precision formation, rendezvous and docking, space manipulation, and on-orbit assembly is provided. Finally, simulation results verify the engineering significance of the attitude-orbit coupling relative dynamic model.

C23H25BrO6, triclinic, P1‾$\overline{1}$ (no. 2), a = 7.8451(3) Å, b = 7.9428(2) Å, c = 17.6360(6) Å, α = 90.146(3), β = 90.433(3)∘, γ = 99.307(3)∘, V = 1084.44(7) Å3, Z = 2, Rgt(F) = 0.0464, wRref(F2) = 0.1402, T = 297.37(10) K.

Objective To investigate relationship between vitamin D level and season, sleep quality and anxiety and depression in patients with chronic insomnia. Methods Total 246 patients with chronic insomnia and treated in The First Hospital of Hebei Medical University from August 2020 to August 2022 were included. Serum 25⁃hydroxy vitamin D [25 (OH) D] levels were determined. Pittsburgh Sleep Quality Index (PSQI) was used to evaluate sleep quality, Hamilton Anxiety Rating Scale⁃14 (HAMA⁃14) to evaluate anxiety, and Hamilton Depression Rating Scale⁃24 (HAMD⁃24) to evaluate depression. Results The incidence of serum 25 (OH) D deficiency ( < 20 ng/ml) in chronic insomnia patients was higher than that in control group (χ2 = 78.202, P = 0.000), and serum 25 (OH) D level was lower than that in control group (Z = ⁃ 6.677, P = 0.000). According to the onset season, 246 chronic insomnia patients were divided into winter and spring group (n = 156) and summer and autumn group (n = 90). PSQI score (Z = ⁃ 2.694, P = 0.007), HAMA⁃14 total score (Z = ⁃ 2.166, P = 0.030), somatic anxiety score (Z = ⁃ 2.545, P = 0.011) and HAMD⁃24 score (Z = ⁃ 2.065, P = 0.039) in winter and spring group were higher than those in summer and autumn group. Serum 25 (OH) D level in winter and spring group was lower than that in summer and autumn group (Z = ⁃ 2.681, P = 0.007). According to PSQI score, 246 patients with chronic insomnia were divided into mild ⁃ moderate insomnia group (n = 114) and severe insomnia group (n = 132). In severe insomnia group, the proportion of female (χ2 = 10.733, P = 0.001), HAMA⁃14 total score (Z = ⁃ 4.633, P = 0.000), mental anxiety score (Z = ⁃ 5.273, P = 0.000) and physical anxiety score (Z = ⁃ 2.859, P = 0.004), and HAMD⁃24 score (Z = ⁃ 5.430, P = 0.000) were higher than those in the mild⁃moderate insomnia group, and serum 25 (OH) D level was lower than those in the mild⁃moderate insomnia group (Z = ⁃1.986, P = 0.047). Correlation analysis showed that serum 25 (OH) D was negatively correlated with PSQI score (r = ⁃ 0.331, P = 0.000), HAMA ⁃ 14 total score (r = ⁃ 0.178, P = 0.005) and HAMD ⁃ 24 score (r = ⁃ 0.142, P = 0.027). Conclusions Patients with chronic insomnia have lower vitamin D level, and patients with winter and spring onset have lower vitamin D level, worse sleep quality, and more severe anxiety, depression and somatization symptoms. Patients with worse sleep quality had lower vitamin D level, and more anxiety and depression. Vitamin D deficiency is associated with sleep quality and risk of anxiety and depression in patients with chronic insomnia.

C17H13NO3, monoclinic, P21/c (no. 14), a = 9.5306(2) Å, b = 6.1971(2) Å, c = 23.3849(7) Å, β = 101.445(3)°, V = 1353.70(7) Å3, Z = 4, Rgt(F) = 0.0644, wRref(F2) = 0.1909, T = 120 K.

Objective To investigate the incidence and risk factors of orthostatic hypotension (OH) in Parkinson's disease (PD) by Active Standing Test (AST) and Head⁃Up Tilt Test (HUTT). Methods A total of 54 patients with PD were admitted to The First Hospital of Hebei Medical University from February to September 2020. Blood pressure was measured by AST and HUTT, the incidence of OH detected by the two methods was compared. Montreal Cognitive Assessment (MoCA) and Mini⁃Mental State Examination (MMSE) were used to assess the cognitive function. Hamilton Depression Rating Scale⁃24 (HAMD⁃24) was used to evaluate depressive symptoms. Hamilton Anxiety Rating Scale⁃14 (HAMA⁃14) was used to evaluate anxiety symptoms. Pittsburgh Sleep Quality Index (PSQI) was used to evaluate the sleep quality. Unified Parkinson's Disease Rating Scale (UPDRS) and its third part were used to assess motor and non⁃motor symptoms of PD. Modified Hoehn⁃Yahr staging was assessed for disease severity. Functional gastroenteropathy Rome Ⅲ diagnostic criteria to assess constipation. KINPAMOR was used to assess olfactory function. Univariate and multivariate forward Logistic regression analyses were used to analyze the risk factors for OH in PD. Results The incidence of OH detected by HUTT was higher than that detected by AST [62.96% (34/54) vs. 24.07% (13/54); χ2=19.048, P=0.000]. Logistic regression analysis showed that the levodopa equivalent daily dose (LEDD) of dopamine receptor agonists increased (OR=1.029, 95%CI: 1.007-1.051; P=0.010), constipation (OR=16.268, 95%CI: 1.213-227.972; P=0.035), the lower MMSE score (OR=0.606, 95%CI: 0.418-0.880; P=0.008), the higher UPDRS total scores (OR=1.303, 95%CI: 1.034-1.643; P=0.025) and the higher UPDRSⅢ score (OR=1.438, 95%CI: 1.041-1.986; P=0.027) were risk factors for OH in PD. Conclusions The incidence of OH detected by HUTT was significantly higher than that detected by AST in PD patients. The higher dosage of dopamine receptor agonist LEDD, constipation, the higher total UPDRS score, the higher UPDRSⅢ score and the lower MMSE score were risk factors for the development of OH in PD patients.

Abstract Photodynamic therapy emerged in the 1900s and recently, it has been developed as a novel modality for treating tumors, precancerous lesions, hypertrophic skin diseases, vascular diseases and so on. We aimed to compare the efficacy and adverse effects of surgery combined with photodynamic therapy or triamcinolone acetonide injection for keloid treatment. This self‐controlled study included nine patients with keloids. Two keloid sites were selected for each patient: one site received photodynamic therapy (PDT group) and the other site received local triamcinolone acetonide injections (TA group). All the keloids were surgically excised. The Vancouver Scar Scale and pruritus and pain scores were assessed at 3 and 6 months, respectively. At 3 and 6 months postoperatively, the pruritus and pain scores decreased significantly (P .05). At 6 months postoperatively, the PDT group showed the following results: complete cure, one patient; significantly effective, four patients; effective, four patients; and ineffective, no patient (efficacy, 100%). The TA group showed the following results: complete cure, one patient; significantly effective, three patients; effective, four patients; and ineffective, one patient (efficacy, 88.9%). Between‐group differences were not significant (P > .05). Hyperpigmentation was observed (n = 2) in the experimental group, whereas menstrual disorders (n = 2), local capillary dilation (n = 1) and subcutaneous atrophy (n = 1) were observed in the TA group. Photodynamic therapy and local triamcinolone acetonide are equally and highly effective in treating keloids with few side effects and when combined with surgery.

A novel composite phase change materials (PCMs) of paraffin/TiO2/active-carbon was prepared by a microemulsion method, where paraffin acted as a PCM and titanium dioxide (TiO2) as matrix material, and a small amount of active carbon was added to improve the thermal conductivity. The compositions, morphology and thermal properties of the paraffin/TiO2/active-carbon composite PCMs were characterized by XRD, SEM, TGA and DSC respectively. The shape stability during phase change process of this composite was also tested. The results show that paraffin is well encapsulated by TiO2 matrix, and thus exhibiting excellent shape-stabilized phase change feature. Besides, this composite PCM also presents superhydrophobic property. Therefore, these multifunctional features will endow PCMs with important application potential in energy efficient buildings.

AIMS: The clinical correlates and outcomes of asymptomatic atrial fibrillation (AF) in hospitalized patients are largely unknown. We aimed to investigate the clinical correlates and in-hospital outcomes of asymptomatic AF in hospitalized Chinese patients. METHODS AND RESULTS: We conducted a cross-sectional registry study of inpatients with AF enrolled in the Improving Care for Cardiovascular Disease in China-Atrial Fibrillation Project between February 2015 and December 2019. We investigated the clinical characteristics of asymptomatic AF and the association between the clinical correlates and the in-hospital outcomes of asymptomatic AF. Asymptomatic and symptomatic AF were defined according to the European Heart Rhythm Association score. Asymptomatic patients were more commonly males (56.3%) and had more comorbidities such as hypertension (57.4%), diabetes mellitus (18.6%), peripheral artery disease (PAD; 2.3%), coronary artery disease (55.5%), previous history of stroke/transient ischaemic attack (TIA; 17.9%), and myocardial infarction (MI; 5.4%); however, they had less prevalent heart failure (9.6%) or left ventricular ejection fractions ≤40% (7.3%). Asymptomatic patients were more often hospitalized with a non-AF diagnosis as the main diagnosis and were more commonly first diagnosed with AF (23.9%) and long-standing persistent/permanent AF (17.0%). The independent determinants of asymptomatic presentation were male sex, long-standing persistent AF/permanent AF, previous history of stroke/TIA, MI, PAD, and previous treatment with anti-platelet drugs. The incidence of in-hospital clinical events such as all-cause death, ischaemic stroke/TIA, and acute coronary syndrome (ACS) was higher in asymptomatic patients than in symptomatic patients, and asymptomatic clinical status was an independent risk factor for in-hospital all-cause death, ischaemic stroke/TIA, and ACS. CONCLUSION: Asymptomatic AF is common among hospitalized patients with AF. Asymptomatic clinical status is associated with male sex, comorbidities, and a higher risk of in-hospital outcomes. The adoption of effective management strategies for patients with AF should not be solely based on clinical symptoms.

Combined with the Dingxi-Lintao Expressway, this paper discusses the method of strengthening the collapsible loess foundation, and conducts the indoor California Bearing Ratio (CBR) test research according to the characteristics of the highway project. Under the optimal water content, through the comparison analysis of the test results of the plain soil California Bearing Ratio test and the lime soil California Bearing Ratio test after the ash mixing ratio reaches 5%, it can be found that under the condition that the compaction degree reaches 96%, the test result after ash mixing is 5% The CBR value of this kind has been greatly improved, and the expansion amount has been drastically reduced. It is proved that this treatment method can eliminate the adverse effects of collapsible loess, significantly increase the bearing capacity of the foundation, and provide good guidance for the subsequent roadbed treatment design and construction.

ObjectiveCardiogenic shock (CS) is the leading cause of death in patients with acute myocardial infarction (AMI) despite advances in care. This study aims to derive and validate a risk score for in-hospital development of CS in patients with AMI.MethodsIn this study, we used the Improving Care for Cardiovascular Disease in China-Acute Coronary Syndrome (CCC-ACS) registry of 76,807 patients for model development and internal validation. These patients came from 158 tertiary hospitals and 82 secondary hospitals between 2014 and 2019, presenting AMI without CS upon admission. The eligible patients with AMI were randomly assigned to derivation (n = 53,790) and internal validation (n = 23,017) cohorts. Another cohort of 2,205 patients with AMI between 2014 and 2016 was used for external validation. Based on the identified predictors for in-hospital CS, a new point-based CS risk scheme, referred to as the CCC-ACS CS score, was developed and validated.ResultsA total of 866 (1.1%) and 39 (1.8%) patients subsequently developed in-hospital CS in the CCC-ACS project and external validation cohort, respectively. The CCC-ACS CS score consists of seven variables, including age, acute heart failure upon admission, systolic blood pressure upon admission, heart rate, initial serum creatine kinase-MB level, estimated glomerular filtration rate, and mechanical complications. The area under the curve for in-hospital development of CS was 0.73, 0.71, and 0.85 in the derivation, internal validation and external validation cohorts, respectively.ConclusionThis newly developed CCC-ACS CS score can quantify the risk of in-hospital CS for patients with AMI, which may help in clinical decision making.Clinical trial registrationwww.ClinicalTrials.gov, identifier: NCT02306616.