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ABSTRACT Transpirational cooling is crucial for plant thermal regulation to avoid overheating; however, during prolonged and/or acute heat stress it often necessitates stomatal closure to reduce the risk of hydraulic failure due to dehydration. The intricate interplay between thermal regulation, water transport and use may govern plant performance in water‐limited and simultaneously heat‐stressed environments, yet this remains inadequately understood. Here, in a common garden, we evaluated the functional associations among physiological characteristics related to leaf thermoregulation, heat tolerance, xylem water transport, and stomatal regulation in eight shrub species commonly used for fixing active sand dunes in northern China. Our study showed that traits associated with heat adaptation and xylem hydraulics were closely related to stomatal regulation. More isohydric shrub species with higher water transport efficiency possessed stronger transpirational cooling capacity; whereas the more anisohydric species demonstrated greater tolerance to overheating. Moreover, leaf heat tolerance was strongly coordinated with drought tolerance reflected by leaf turgor loss point. These results underscore the importance of stomatal regulation in shaping plant thermal adaptive strategies and provide valuable insights into the coupling of water and heat‐related physiological processes in plants adapted to sandy land environments prone to combined drought and heat stresses. [ABSTRACT FROM AUTHOR]

Background: Genomic structural variations (GSVs), notably copy number variations (CNVs), significantly shape genetic diversity and facilitate adaptation in cattle populations. Despite their importance, the genome-wide characterization of CNVs in indigenous Ethiopian cattle breeds—Abigar, Fellata, and Gojjam-Highland remains largely unexplored. In this study, we applied a read-depth approach to whole genome sequencing (WGS) data to conduct the first comprehensive analysis of CNVs in these populations. Results: We identified 3,893 CNV regions (CNVRs) covering 19.15 Mb (0.71% of the cattle genome). These CNVRs ranged from 1.60 kb to 488.0 kb, with an average size of 4.92 kb. These CNVRs included deletions (1713), duplications (1929), and mixed events (251) showing notable differences in distribution among the breeds. Four out of five randomly selected CNVRs were successfully validated using real time polymerase chain reaction (qPCR). Further analyses identified candidate genes associated with high-altitude adaptation (GBE1 and SOD1), heat stress adaptation (HSPA13, DNAJC18, and DNAJC8) and resistance to tick infestations (BoLA and KRT33A). In addition, variance stabilizing transformation (VST) statistics highlighted population-specific CNVRs, emphasizing the unique genetic signatures of high-altitude adaptation in the Gojjam-Highland cattle breed. Among the detected CNVRs, 4.93% (192 out of 3,893) overlapped with 520 quantitative traits loci (QTLs) associated with six economically important trait categories suggesting that these CNVRs may significantly contribute to the genetic variation underlying these traits. Conclusions: Our comprehensive analysis reveals significant CNVRs associated with key adaptive traits in Ethiopian cattle breeds highlighting their genetic diversity and resilience. These findings offer valuable insights into the genetic basis of adaptability and can inform sustainable breeding practices and conservation efforts. Future research should prioritize the functional validation of these CNVRs and their integration into breeding programs to enhance traits such as disease resistance and environmental adaptability. [ABSTRACT FROM AUTHOR]

Background: African cattle represent a unique resource of genetic diversity in response to adaptation to numerous environmental challenges. Characterising the genetic landscape of indigenous African cattle and identifying genomic regions and genes of functional importance can contribute to targeted breeding and tackle the loss of genetic diversity. However, pinpointing the adaptive variant and determining underlying functional mechanisms of adaptation remains challenging. Results: In this study, we use selection signatures from whole-genome sequence data of eight indigenous African cattle breeds in combination with gene expression and quantitative trait loci (QTL) databases to characterise genomic targets of artificial selection and environmental adaptation and to identify the underlying functional candidate genes. In general, the trait-association analyses of selection signatures suggest the innate and adaptive immune system and production traits as important selection targets. For example, a large genomic region, with selection signatures identified for all breeds except N'Dama, was located on BTA27, including multiple defensin DEFB coding-genes. Out of 22 analysed tissues, genes under putative selection were significantly enriched for those overexpressed in adipose tissue, blood, lung, testis and uterus. Our results further suggest that cis-eQTL are themselves selection targets; for most tissues, we found a positive correlation between allele frequency differences and cis-eQTL effect size, suggesting that positive selection acts directly on regulatory variants. Conclusions: By combining selection signatures with information on gene expression and QTL, we were able to reveal compelling candidate selection targets that did not stand out from selection signature results alone (e.g. GIMAP8 for tick resistance and NDUFS3 for heat adaptation). Insights from this study will help to inform breeding and maintain diversity of locally adapted, and hence important, breeds. [ABSTRACT FROM AUTHOR]

Despite its deadly nature, extreme heat has received fragmented and scattered responses in cities, often overlooking the crucial social and equity components. Dominant adaptation approaches have paid little attention to chronic socio-economic vulnerabilities to heat stress, resulting in a lack of strategic planning to address them. Building upon critical urban studies and adaptation scholarship, this article examines how the dynamics of urban climate adaptation in the Global North have sidestepped the root causes of heat vulnerability and their (re)production in past, present and future practices of uneven urban development and planning under austerity. We investigate this empirically in attending to the framing of adaptation, the instruments used and the biases they introduce in Montreal (Canada), as well the perception from planners and community groups regarding their agency in responding to extreme heat. We contribute to the literature in analysing how the urban governance of adaptation in urban planning tends to silence the social production of vulnerabilities by three intersecting processes: the biases of instruments used, the unacknowledged legacies of uneven urban development, and the lacking recognition and support for community organisations caring practices. [ABSTRACT FROM AUTHOR]

Despite the frequent occurrence of heat waves in the Middle East, there is a lack of evidence regarding the overall estimates for the effect of heat waves on mortality in this region. This study aimed to review the effect of exposure to heat and cold waves and daily cause-specific mortality. Four electronic databases were searched. The titles, abstracts, and full-texts of the articles were carefully reviewed by two researchers. Once eligible studies were identified, the required data were extracted. Separate meta-analyses were conducted based on gender, age group, and health endpoint combinations. According to the meta-analysis, heat waves had a statistically significant effect on all-cause mortality with an RR of 1.23 (CI 95%: 1.08, 1.39). Cardiovascular mortality significantly increased in heat waves with an RR of 1.08 (CI 95%: 1.05, 1.10). However, the increase in respiratory mortality was not statistically significant. Compared to young people (age < 65 years old) and women, elderly and men were more vulnerable to heat waves with RRs of 1.31 (95% CI: 1.05, 1.57) and 1.33 (95% CI: 1.08, 1.58), respectively. This study can be beneficial in developing response or adaptation plans for heat waves. Future studies should focus on other specific health endpoints like ischemic heart disease, chronic obstructive pulmonary diseases, etc., and other outcomes such as hospitalization and emergency visits. [ABSTRACT FROM AUTHOR]

To prepare for a hotter future, information on intra‐urban temperature distributions is crucial for cities worldwide. In recent years, different methods to compute high‐resolution temperature datasets have been developed. Such datasets commonly originate from downscaling techniques, which are applied to enhance the spatial resolution of existing data. In this study, we present an approach based on a fine‐scaled low‐cost urban temperature measurement network and a formerly developed land use regression approach. The dataset covers mean nocturnal temperatures of 16 summers (2007–2022) of a medium‐sized urban area with adapted land cover data for each year. It has a high spatial (50 m) and temporal (daily) resolution and performs well in validation (RMSEs of 0.70 and 0.69 K and mean biases of +0.41 and −0.19 K for two validation years). The dataset can be used to examine very detailed statistics in space and time, such as first heatwave per year, cumulative heat risks or inter‐annual variability. Here, we evaluate the dataset with two application cases regarding urban planning and heat risk assessment, which are of high interest for both researchers and practitioners. Due to potential biases of the low‐cost measurement devices during daytime, the dataset is currently limited to night‐time temperatures. With minor adaptions, the presented approach is transferable to cities worldwide in order to set a basis for researchers, city administrations and private stakeholders to address their heat mitigation and adaptation strategies. [ABSTRACT FROM AUTHOR]

Plants generate a range of physiological and molecular responses to sustain their growth and development when suffering heat stress. Avocado is a type of tropical fruit tree with high economic value. Most avocado cultivars delete, wither, or even die when exposed to heat stress for a long time, which seriously restricts the introduction and cultivation of avocados. In this study, samples of a heat-intolerant variety ('Hass') were treated under heat stress, and the transcriptomics and metabolomics were analyzed, with the expectation of providing information on the variety improvement and domestication of avocados. The differentially expressed genes identified using transcriptome analysis mainly involved metabolic pathways such as plant hormone signal transduction, plant–pathogen interaction, and protein processing in the endoplasmic reticulum. Combined transcriptome and metabolome analysis indicated that the down-regulation of Hass.g03.10206 and Hass.g03.10205 in heat shock-like proteins may result in the reduced Trehalose and Sinapoyl aldehyde content. Metabolomics analysis results indicated that the decrease in Trehalose and Sinapoyl aldehyde content may be an important factor for heat intolerance. These results provide important clues for understanding the physiological mechanisms of adaptation to heat stress in avocados. [ABSTRACT FROM AUTHOR]

As the risk of extreme heat in urban centres becomes more frequent and intense, a comparative case study of New York City, New York's and New Orleans, Louisiana's policy responses to dangerous heat highlights past approaches to protecting vulnerable populations, where improvements can be made to best suit local needs, and the areas where solutions may still be implemented. Two cities at the forefront of the climate crisis in the United States, their policy approaches are guided by their histories, their existing adaptations and behaviours, and the harsh reality the changing climate has wrought. New York City has prioritised cooling centres as a safety measure, as the city is regularly seeing hundreds of heat-related deaths per year, often in unairconditioned homes. New Orleans has prioritised the installation of back-up energy generation following mass blackouts caused by Hurricane Ida in 2021 and deaths of at least 10 residents in the resulting excessive heat exposure. In New York, census tracts with the highest percentage of Black, elderly, and foreign-born populations were most likely to have reduced access to a cooling centre. In New Orleans, tracts with the highest percentage of Black, elderly, unemployed, and impoverished populations were most likely to have reduced access to a cooling centre. Comparing both city's codes, regulations, and policies, reviewing their emergency management communication strategies on social media, and performing GIS analysis on cooling centre locations against vulnerability criteria paints a clear picture of where heat policy stands in both cities and where it could potentially expand. [ABSTRACT FROM AUTHOR]

Purpose: To assess elite racewalkers' preparation strategies, knowledge, and general practices for competition in the heat and their health status during the World Athletics Race Walking Teams Championships (WRW) Muscat 2022. Methods: Sixty-six elite racewalkers (male: n = 42; mean age = 25.8 y) completed an online survey prior to WRW Muscat 2022. Athletes were grouped by sex (males vs females) and climate (self-reported) they live/trained in (hot vs temperate/cold), with differences/relationships between groups assessed. Relationships between ranking (medalist/top 10 vs nonmedalist/nontop 10) and precompetition use of heat acclimation/acclimatization (HA) were assessed. Results: All surveyed medalists (n = 4) implemented, and top 10 finishers were more likely to report using (P =.049; OR = 0.25; 95% CI, 0.06%–1%), HA before the championships. Forty-three percent of athletes did not complete specific HA training. Females (8% [males 31%]) were less likely to have measured core temperature (P =.049; OR = 0.2; 95% CI, 0.041–0.99) and more likely to not know expected conditions in Muscat (42% vs 14%; P =.016; OR = 4.3; 95% CI, 1%–14%) or what wet bulb globe temperature is (83% vs 55%; P =.024; OR = 4.1; 95% CI, 1%–14%). Conclusions: Athletes who implemented HA before the championships tended to place better than those who did not. Forty-three percent of athletes did not prepare for the expected hot conditions at the WRW Muscat 2022, primarily attributed to challenges in accessing and/or cost of equipment/facilities for HA strategies. Further efforts to bridge the gap between research and practice in this elite sport are needed, particularly in female athletes. [ABSTRACT FROM AUTHOR]

Abstract Since the early 1900s, repeated heat exposure has been used as a method to induce physiological adaptations that enhance our ability to tolerate heat stress during athletic and occupational pursuits. Much of this work has been dedicated to quantifying the time course of adaptation and identifying the minimum duration of acclimation required to optimise performance or enhance safety. To achieve this, investigators have typically applied classical (constant load) heat acclimation, whereby 60–90 min exercise is performed at the same absolute or relative intensity in a hot environment for 3–24 days, with adaptations evaluated using an identical forcing function test before and after. This approach has provided a foundation from which to develop our understanding of changes in thermoregulatory function, but it has several, frequently overlooked shortcomings, which have resulted in misconceptions concerning the time course of adaptation. It is frequently suggested that most of the thermoregulatory adaptations during heat acclimation occur within a week, but this is an oversimplification and a predictable artefact of the experimental designs used. Consequently, the time course of complete human adaptation to heat remains poorly understood and appears to vary considerably due to numerous individual factors. The purpose of this communication is to highlight the key methodological considerations required when interpreting the existing literature documenting adaptation over time. We also propose potential means by which to improve the way we induce and quantify the magnitude of adaptation to expedite discovery.

Global warming poses a significant threat to plant ecosystems and agricultural productivity, primarily through heat stress (HS), which disrupts photosynthesis, respiration, and overall plant metabolism. Epigenetic modifications, including DNA methylation, histone modifications, and RNA modifications, enable plants to dynamically and heritably adjust gene expression in response to environmental stressors. These mechanisms not only help plants survive immediate stress but also confer stress memory, enhancing their resilience to future HS events. This review explores the mechanisms underlying plant thermotolerance, emphasizing the critical role of epigenetic regulation in adapting to HS. It also highlights how DNA methylation modulates stress-responsive genes, histone modifications facilitate transcriptional memory, and RNA modifications influence mRNA stability and translation. Recent advancements in genome editing technologies, such as CRISPR-Cas9, have enabled precise modifications of epigenetic traits, offering new avenues for breeding climate-resilient crops. The integration of these modern tools with traditional breeding methods holds significant promise for developing crops with enhanced thermotolerance. Despite the potential, challenges such as the stability and heritability of epigenetic marks and the complex interplay between different epigenetic modifications need to be addressed. Future research should focus on elucidating these interactions and identifying reliable epigenetic markers for selection. By leveraging the insights gained from epigenetic studies, we can develop innovative breeding strategies to improve crop resilience and ensure sustainable agricultural productivity in the face of global warming. This review underscores the importance of epigenetic regulation in plant adaptation to heat stress and its potential to revolutionize crop breeding, offering a pathway to secure food production and sustainability under changing climatic conditions. [ABSTRACT FROM AUTHOR]

This study aimed to investigate seasonal heat acclimatization in active adolescents following summer. Fifteen (5 females) active adolescents (14.6 ± 1.0 y) completed a 45-min heat response test (HRT) walking at 60% $\dot {\rm V}$ V ˙ O2peak in 40°C and 30% relative humidity before and after summer (i.e. November 2022 and March 2023). During the HRT, gastro-intestinal temperature (Tgi), skin temperature (Tsk), heart rate, local sweat rate (LSR) and whole-body sweat loss (WBSL) were recorded. Carbon monoxide rebreathing and dual-energy X-ray absorptiometry scans determined resting hematological measures and body composition. Participants completed physical activity (PA) diaries and wore an accelerometer for two one-week periods (pre- and post-summer). Daytime wet-bulb globe temperature (WBGT) was calculated for each summer day. Data are presented as posterior mean and 90% credible intervals. Participants reported 7 ± 4 h·wk−1 of outdoor PA, and daytime WBGT was 21.2 ± 4.6°C. Following summer, resting Tgi and heart rate were reduced by 0.2°C [−0.3, −0.1; probability of direction = 99%] and 7 beats·min−1 [−10, −3; 100%], respectively. During the HRT, there was an earlier onset of sweating (−0.2°C [−0.3, −0.0; 98%]), an attenuated rise of Tgi (0.2°C [−0.5, 0.0; 92%]) and mean Tsk changed by −0.2°C [−0.5, 0.1; 86%]. There was minimal evidence for heat adaptations in LSR or WBSL, hematological parameters or perceptual measures. This is the first study to demonstrate seasonal heat adaptations in active adolescents. Reductions in resting Tgi and exercising Tsk and a lower Tgi at the onset of sweating were associated with a smaller rise in Tgi during the HRT following summer. [ABSTRACT FROM AUTHOR]

Streptococcus suis is an important zoonotic pathogen, causing cytokine storms of Streptococcal toxic shock‐like syndrome amongst humans after a wound infection into the bloodstream. To overcome the challenges of fever and leukocyte recruitment, invasive S. suis must deploy multiple stress responses forming a network and utilize proteases to degrade short‐lived regulatory and misfolded proteins induced by adverse stresses, thereby adapting and evading host immune responses. In this study, we found that S. suis encodes multiple ATP‐dependent proteases, including single‐chain FtsH and double‐subunit Clp protease complexes ClpAP, ClpBP, ClpCP, and ClpXP, which were activated as the fever of infected mice in vivo. The expression of genes ftsH, clpA/B/C, and clpP, but not clpX, were significantly upregulated in S. suis in response to heat stress, while were not changed notably under the treatments with several other stresses, including oxidative, acidic, and cold stimulation. FtsH and ClpP were required for S. suis survival within host blood under heat stress in vitro and in vivo. Deletion of ftsH or clpP attenuated the tolerance of S. suis to heat, oxidative and acidic stresses, and significantly impaired the bacterial survival within macrophages. Further analysis identified that repressor CtsR directly binds and controls the clpA/B/C and clpP operons and is relieved by heat stress. In summary, the deployments of multiple ATP‐dependent proteases form a flexible heat stress response network that appears to allow S. suis to fine‐tune the degradation or refolding of the misfolded proteins to maintain cellular homeostasis and optimal survival during infection. [ABSTRACT FROM AUTHOR]

The aim of this study is to synthesise the scientific evidence on the implications of urban and rural environments on older adults' adaptation strategies to heatwaves. Methods: The methodology follows PRISMA guidelines, which involves a systematic search of the scientific literature in selected electronic databases, including Web of Science and Scopus, to assist in the selection, identification and retention of studies. Results: The search identified 4991 potentially eligible articles, of which 17 met the criteria, mainly from developed countries, emphasising a multidisciplinary approach and moderate to low quality. Urban and rural environments influence older adults' adaptation strategies to heatwaves through the adequacy of the physical environment of the dwelling (design, materials, equipment) and the neighbourhood (green spaces, residential density, land use), the social environment (support network and type of assistance) and risk management (protective measures and heat warning systems). At the individual level, adaptation to heatwaves is determined by age, gender, health status, socio-economic status and social isolation. Discussion and conclusions: Differences in perceptions of heat adaptation were found according to location, typology and environmental characteristics, especially in developing countries. The findings contribute to promoting the adoption of protective measures, the design of heat warning systems, and the planning of friendly and resilient cities and rural communities to support the adaptation of an ageing society to the climate warming. [ABSTRACT FROM AUTHOR]

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Metropolitan areas have diverse land uses (LUs), which can also cause significant differences in land surface temperature (LST), leading to the formation of micro-urban heat islands (MUHIs). Measuring the MUHIs is significant for heat mitiga-tion and adaptation measures and requires high spatial-temporal resolution, which is not feasible through coarser satellite observations (CSOs). Thermal cameras onboard unmanned aerial vehicles (UAVs) can detect such MUHIs because of their high spatial and desired temporal resolution. This study used the Zenmuse H20T onboard a UAV providing LST at ∼8 cm resolution to evaluate MUHIs in an area with diverse and contiguous LUs including three urban built-up LUs: 1) residential high cost (RHC), 2) residential low cost (RLC), 3) industrial area (IA) and one natural area (i.e. park area (PA)). The LST and MUHI were estimated in two seasons: fall (October 2022) and summer (June-July 2023). In each season, six flights were conducted at similar times of day. The findings were compared with Landsat in each season to examine the loss of information between coarser and finer spatial resolution. Using UAV, a maximum MUHI of 25.54◦C and 15.85◦C was identified in the summer and fall seasons, respectively, between 15:30 and 16:20. The maximum LST was observed in RHC, and PA showed the minimum LST in both seasons. Notably, dark-coloured roofs with asphalt shingle coating reported up to 25.78◦C and 27.37◦C higher LST (UAV-estimated) than light-coloured roofs in the fall and summer, respectively. Landsat significantly underestimated MUHI hotspots in the summer and fall seasons. The on-ground validation of the UAV showed better results in the summer season. The study shows the pragmatic use of UAVs to detect localized MUHIs. The findings are useful to devise strategies to mitigate MUHIs utilizing UAVs in the face of climatic and environmental changes. [ABSTRACT FROM AUTHOR]

Simple Summary: Positive natural selection increases the frequency of beneficial genetic variations, promoting an organism's adaptability and survival in specific environments. In this study, we conducted whole-genome resequencing and population genetic structure analysis to investigate the genetic diversity of Zaobei cattle, local yellow cattle from China. By comparing Zaobei cattle with Simmental cattle, we identified several genomic regions exhibiting positive selection. Gene annotation of these regions revealed key traits of Zaobei cattle, such as heat tolerance, fertility, and superior meat quality. These findings not only help understand the characteristics of Zaobei cattle but also provide valuable genetic information for future breeding programs, thereby improving their production efficiency and economic value. This investigation provides a comprehensive analysis of genomic diversity and selection signatures in Zaobei beef cattle, an indigenous breed known for its adaptation to hot and humid climates and superior meat quality. Whole-genome resequencing was conducted on 23 Zaobei cattle, compared with 46 Simmental cattle to highlight genetic distinctions. Population structure analysis confirmed the genetic uniqueness of Zaobei cattle. Using methods such as DASDC v1.01, XPEHH, and θπ ratio, we identified 230, 232, and 221 genes through DASDC, including hard sweeps, soft sweeps, and linkage sweeps, respectively. Coincidentally, 109 genes were identified when using XPEHH and θπ ratio methods. Together, these analyses revealed eight positive selection genes (ARHGAP15, ZNF618, USH2A, PDZRN4, SPATA6, ROR2, KCNIP3, and VWA3B), which are linked to critical traits such as heat stress adaptation, fertility, and meat quality. Moreover, functional enrichment analyses showed pathways related to autophagy, immune response, energy metabolism, and muscle development. The comprehensive genomic insights gained from this study provide valuable knowledge for breeding programs aimed at enhancing the beneficial traits in Zaobei cattle. [ABSTRACT FROM AUTHOR]

The article discusses the need for standardized definitions in the field of applied physiology to improve understanding of adaptive mechanisms. The authors highlight the inconsistent use of terminology and propose a set of definitions for key terms related to adaptation. They argue that these definitions will enhance clarity and consensus in the field. The article also briefly mentions the relevance of evolutionary biology to the study of adaptation. Another article titled "The Biology of the Colonizing Ape" explores the biological factors contributing to the success of ape colonization, such as diet, locomotion, and reproductive strategies. It provides valuable insights into the evolutionary history and behavior of apes, making it a useful resource for researchers in this field. [Extracted from the article]

Individual heating systems, such as the air-source heat pump (ASHP) air-conditioner or floor heating (FH), are usually used by people living in the hot summer and cold winter (HSCW) zone of China to heat indoor climates in the winter. However, little research has been conducted in the HSCW zone on the thermal comfort difference between indoor climates heated by ASHP air-conditioners and those heated by floor heating, as well as how occupants adapt to different indoor climates. We conducted a comparative field experiment in ASHP-heated and FH-heated apartments in Nanjing to investigate how different types of heating systems influence the thermal sensation of occupants, and we conducted a comparative field experiment in ASHP-heated office buildings and naturally ventilated teaching buildings in Shanghai to investigate how occupants adapt to different indoor thermal environments. Indoor environmental parameters and body surface temperatures were measured using instruments, and occupants' thermal sensation, activity level, and clothing were evaluated using the questionnaire. The results show that floor heating improves thermal comfort by raising foot temperature compared to the ASHP air-conditioner, and that occupants become acclimatized to different indoor climates by adjusting neutral operative temperature. According to the findings, there is no need to overheat the indoor environment in the HSCW zone because occupants can adapt to their experienced thermal environment and it is critical to maintain warm foot temperature in the cool/cold indoor environment. [ABSTRACT FROM AUTHOR]

Since the early 1900s, repeated heat exposure has been used as a method to induce physiological adaptations that enhance our ability to tolerate heat stress during athletic and occupational pursuits. Much of this work has been dedicated to quantifying the time course of adaptation and identifying the minimum duration of acclimation required to optimise performance or enhance safety. To achieve this, investigators have typically applied classical (constant load) heat acclimation, whereby 60–90 min exercise is performed at the same absolute or relative intensity in a hot environment for 3–24 days, with adaptations evaluated using an identical forcing function test before and after. This approach has provided a foundation from which to develop our understanding of changes in thermoregulatory function, but it has several, frequently overlooked shortcomings, which have resulted in misconceptions concerning the time course of adaptation. It is frequently suggested that most of the thermoregulatory adaptations during heat acclimation occur within a week, but this is an oversimplification and a predictable artefact of the experimental designs used. Consequently, the time course of complete human adaptation to heat remains poorly understood and appears to vary considerably due to numerous individual factors. The purpose of this communication is to highlight the key methodological considerations required when interpreting the existing literature documenting adaptation over time. We also propose potential means by which to improve the way we induce and quantify the magnitude of adaptation to expedite discovery. [ABSTRACT FROM AUTHOR]

Clothing adjustment by building occupants is a highly effective and prevalent thermal adaptation behavior aimed at achieving thermal comfort. This paper aims to quantify the impact of climate-responsive indoor clothing adaptation on heating/cooling energy consumption. A climate-responsive indoor temperature control strategy based on rural residents' indoor clothing adaptation was proposed and integrated into building energy simulations. Indoor clothing insulations were obtained using a predictive model from the author's prior research. These values were used to calculate indoor setpoint temperatures in terms of the PMV model, which were then input into the building energy simulations. The simulations were conducted using "Ladybug Tools" in Grasshopper. Four simulation scenarios were proposed for winter and summer, respectively, to compare heating/cooling energy use with different indoor clothing strategies (constant and dynamic) and thermal comfort requirements (neutral and 80% acceptable). The results indicated that indoor clothing adaptation significantly reduced indoor setpoint temperatures by 5.0–6.7 °C in winter. In contrast, the impacts on summer indoor setpoint temperatures were not significant. The impacts of indoor clothing adaptation on energy use were evident in both seasons and more pronounced in winter. With a neutral thermal comfort requirement (PMV = 0), total heating and cooling energy use decreased by 35.6% and 20.2%, respectively. The influence was further enhanced with lower indoor thermal comfort requirements. With an 80% acceptable thermal comfort requirement ( P M V = ± 0.85 ), total heating and cooling energy use decreased by 63.1% and 34.4%, respectively. The climate-responsive indoor temperature control strategy based on indoor clothing adaptation and its impact on heating/cooling energy consumption suggested a viable approach for improving building energy efficiency in China's rural area and similar cost-sensitive and fuel-poverty contexts. [ABSTRACT FROM AUTHOR]

Extreme heat poses severe health threats, as the increased numbers of hospitalizations and fatalities during heat waves show, though little is known about adaptive behavior toward heat. We conducted a household survey on individual perceptions of heat stress and individual heat protection in the summer and autumn of 2019. In total, 1417 people from three medium‐sized German cities participated via telephone or online. Based on the Protective Action Decision Model (PADM), which we adapted to heat stress, we analyzed links between risk perception, environmental and demographic factors, perceptions of stakeholders, different heat warning messages, as well as actual and intended adaptive behavior. Overall, the PADM constructs explained around 16% of the variance in protection motivation, 19% in protective response, and 23% in emotion‐focused coping. Context factors (i.e., temperature, risk communication, gender, age, and homeownership) were significant predictors of the addressed outcome variables as were psychological factors (i.e., perceived personal vulnerability, response efficacy, response costs, preparedness, and perceived external responsibility). We further explored the effect of different warning messages on situational knowledge and intended behavioral adaptation in an experimental setting. Results showed that respondents felt significantly better informed after receiving a warning with action recommendations and reported more intended specific behaviors. Our research gives insights into individual protective action decision‐making processes. Based on our findings, we recommend tailoring risk communication strategies and combining heat warnings with action recommendations whenever possible to increase understanding and individual adaptation. [ABSTRACT FROM AUTHOR]

Starting from the relationship between urban planning and mobility management, TeMA has gradually expanded the view of the covered topics, always remaining in the groove of rigorous scientific in-depth analysis. This section of the Journal, Review Notes, is the expression of continuously updating emerging topics concerning relationships between urban planning, mobility and environment, through a collection of short scientific papers written by young researchers. The Review Notes are made of four parts. Each section examines a specific aspect of the broader information storage within the main interests of TeMA Journal. In particular, the Urban Practices section aims at presenting recent advancements on relevant topics that underline the challenges that the cities have to face. This note provides an overview of the challenges that global warming poses and the risks in terms of climate change that it generates for territories and cities, with a specific focus on the extreme heat phenomenon. The challenges that adaptation to extreme heat events commonly faces are outlined, and a brief review of international case studies is carried out. Finally, the results of the review are discussed highlighting some key threads of extreme heat events adaptation practices and three significant examples of adaptation in urban areas are reported, within a perspective of integration and sharing of know-how on the topic. [ABSTRACT FROM AUTHOR]

Comprehensive studies comparing impacts of building and street levels interventions on air temperature at metropolitan scales are still lacking despite increased urban heat‐related mortality and morbidity. We therefore model the impact of 9 interventions on air temperatures at 2 m during 2 hot days from the summer 2018 in the Greater London Authority area using the WRF BEP‐BEM climate model. We find that on average cool roofs most effectively reduce temperatures (∼−1.2°C), outperforming green roofs (∼0°C), solar panels (∼−0.5°C) and street level vegetation (∼−0.3°C). Application of air conditioning across London (United Kingdom) increases air temperatures by ∼+0.15°C. A practicable deployment of solar panels could cover its related energetic consumption. Current practicable deployments of green roofs and solar panels are ineffective at large scale reduction of temperatures. We provide a detailed decomposition of the surface energy balance to explain changes in air temperature and guide future decision‐making. Plain Language Summary: Multiple common city scale passive and active interventions exist to reduce urban population's exposure to extreme heat during hot spells. Nonetheless, a proper comparison of the effect that each of these interventions may have on the temperatures experienced within large cities is missing. Additionally, the radiative and thermal mechanisms that lead to outdoor temperature changes are often not detailed and could lead to detrimental effects for local populations, such as indirect increase of water vapor or reflection of solar radiation. Our study, focusing over London, compares several common interventions through a modeling experiment and finds that cool roofs largely outperform other interventions during the two hottest days of the summer 2018. We also find that green roofs are ineffective on average and that solar panels and tree vegetation would only marginally change temperature exposures. Large scale deployment of air conditioning would lead to increased temperature in the core of London. Solar panels could potentially provide sufficient energy for running air conditioning all over London, creating comfortable indoor environments, and green roofs could reduce temperatures during the day. We argue that such inter‐comparisons should guide future decision making. Key Points: City scale deployment of cool roofs leads to the greatest reduction in 2 m air temperatureGreen roofs do not decrease daily average temperature but have a daytime cooling effectSolar photovoltaic panels can reduce temperatures in London by capturing sensible heat flux and generate electrical power [ABSTRACT FROM AUTHOR]

SUMMARY: Much progress has been made in understanding the molecular mechanisms of plant adaptation to heat stress. However, the great diversity of models and stress conditions, and the fact that analyses are often limited to a small number of approaches, complicate the picture. We took advantage of a liquid culture system in which Arabidopsis seedlings are arrested in their development, thus avoiding interference with development and drought stress responses, to investigate through an integrative approach seedlings' global response to heat stress and acclimation. Seedlings perfectly tolerate a noxious heat shock (43°C) when subjected to a heat priming treatment at a lower temperature (38°C) the day before, displaying a thermotolerance comparable to that previously observed for Arabidopsis. A major effect of the pre‐treatment was to partially protect energy metabolism under heat shock and favor its subsequent rapid recovery, which was correlated with the survival of seedlings. Rapid recovery of actin cytoskeleton and mitochondrial dynamics were another landmark of heat shock tolerance. The omics confirmed the role of the ubiquitous heat shock response actors but also revealed specific or overlapping responses to priming, heat shock, and their combination. Since only a few components or functions of chloroplast and mitochondria were highlighted in these analyses, the preservation and rapid recovery of their bioenergetic roles upon acute heat stress do not require extensive remodeling of the organelles. Protection of these organelles is rather integrated into the overall heat shock response, thus allowing them to provide the energy required to elaborate other cellular responses toward acclimation. Significance Statement: With increasing heat waves, we need to understand the mechanisms of acclimation. Using Arabidopsis seedlings, we show that the partial protection of respiration and photosynthesis and their rapid recovery upon heat shock induced by heat priming are primordial for survival. This does not require extensive remodeling in mitochondria and chloroplasts, the energy‐transducing organelles. It is rather integrated within the ubiquitous heat shock response, allowing energy production for other mechanisms required to fulfill acclimation. [ABSTRACT FROM AUTHOR]

Background: Livestock productivity and health are adversely affected by heat stress (HS). The aim of this study was to determine the effects of HS on the thermoregulation and hormonal profile in Assam Hill Goats reared in the subtropical hilly regions of Meghalaya so as to arrive at a conclusion on its heat adaptation abilities. Methods: An experiment was conducted during the year 2022 for 120 days with twelve (12) Assam Hill Goats, aged between 3-5 months, randomly divided into 2 groups (n= 6 per group). The goats in group I were exposed to HS through natural exposure to sunlight during the extreme summer months (May to August) for 07 hours (8 AM to 3 PM) during grazing. The control animals (CON, group II) were maintained under shade with no exposure to sunlight. Thermoregulatory responses viz., rectal temperature, respiratory rate and pulse rate and body weight data were recorded every 15 days interval of the sampling period. The hormonal profile viz., serum T3 (nmol/L), T4 (nmol/L) and Cortisol (ng/mL) were also determined. Result: Results revealed a significant (p<0.05) increase in rectal temperature, pulse rate (day 45 onwards to day 120) and respiratory rate in HS group in comparison to CON. A significantly (p<0.05) lower average daily gain was recorded in HS group. Serum T3 and T4 concentrations were significantly (p<0.05) reduced and cortisol concentration was significantly (p<0.05) elevated in HS group in comparison to CON. In conclusion, Assam Hill Goats exposed to environmental HS shows elevated thermoregulatory responses, decreased thyroid hormone activity and increased cortisol activity to reduce production to support life sustaining activities in the hilly regions. [ABSTRACT FROM AUTHOR]

This study systematically investigated the physiological and molecular responses of the wheat mutant 'XC-MU201' under high-temperature stress through comprehensive transcriptome analysis and physiological measurements. RNA sequencing of 21 samples across seven different treatment groups revealed, through Weighted Gene Co-expression Network Analysis (WGCNA), 13 modules among 9071 genes closely related to high-temperature treatments. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses showed significant enrichment of lignin biosynthesis-related modules under high-temperature conditions, especially at the H-10DAT, H-20DAT, and H-30DAT time points. Experimental results demonstrated a significant increase in lignin content in high-temperature-treated samples, confirmed by tissue staining methods, indicating wheat's adaptation to heat damage through lignin accumulation. The phenylalanine ammonia-lyase gene (TaPAL33) was significantly upregulated under high-temperature stress, peaking at H-30DAT, suggesting its critical role in cellular defense mechanisms. Overexpression of TaPAL33 in the wheat variety 'Xinchun 11' enhanced lignin synthesis but inhibited growth. Subcellular localization of GFP-labeled TaPAL33 in tobacco cells showed its distribution mainly in the cytoplasm and cell membrane. Transgenic wheat exhibited higher PAL enzyme activity, enhanced antioxidant defense, and reduced oxidative damage under high-temperature stress, outperforming wild-type wheat. These results highlight TaPAL33's key role in improving wheat heat tolerance and provide a genetic foundation for future research and applications. [ABSTRACT FROM AUTHOR]

Background: Using genetic enhancement techniques has led to the development of poultry capable of fulfilling significant portions of human dietary requirements through meat and egg production. Maximizing genetic potential necessitates the provision of conducive environmental conditions. Heat stress poses a substantial challenge within the poultry sector, detrimentally impacting poultry production and growth, there by diminishing breeders' economic returns. Adaptation to heat stress is contingent upon a multitude of factors. The capacity to establish homeostasis through alterations in gene expression serves to mitigate extracellular damage and restore physiological equilibrium upon reversion to favorable temperature ranges. Domestic birds thrive within a temperature spectrum of 18-24 °C, with any deviation beyond this range precipitating elevated mortality rates. Elevated mortality is attributed to heat-induced suppression of the immune system and compromised resilience. Moreover, heat stress amplifies the secretion of the corticotropin-releasing hormone, subsequently elevating blood corticosterone levels, thereby instigating molecular alterations under stress conditions. Hence, a comprehensive examination of this challenge from diverse perspectives holds significant promise. Consequently, the present study endeavors to delineate protein complexes and pivotal signaling pathways regulated by distinct genes expressed in response to heat stress within the hypothalamus of broiler chickens. Methods: The systemic response of chickens' hypothalamus transcripts to heat stress was comprehensively examined in this investigation. Transcript expression profiles from eight chicken hypothalamus tissues, including four subjected to thermal stress and four under non-stress conditions, were retrieved from the GEO database (accession number GSE37400). The raw microarray data underwent rigorous quality control measures and normalization using GEO2R software to ensure reliability and consistency. Genes with discernible expression changes were identified based on a stringent criterion of P-value > 0.05 and (LogFC < 0.5-0.5). Subsequently, a gene expression regulatory network was constructed to elucidate the interplay among genes implicated in broiler heat stress, employing Cytoscape software in conjunction with the STRING database. The network visualization facilitated the identification of protein clusters, representing areas of high density, which were further analyzed using the CytoCluster plugin renowned for its efficacy in detecting such densely interconnected regions. Following the delineation and characterization of genes within these clusters, the DAVID database was utilized to elucidate the relevant biological pathways associated with the identified genes. This comprehensive approach enabled a detailed exploration of the molecular mechanisms underlying the hypothalamic response to heat stress in chickens. Results: The analysis of microarray data unveiled a comprehensive portrait of the molecular response to heat stress in chickens. Among the 43,607 initially examined probes, 593 differentially expressed genes were identified after rigorous curation involving the elimination of duplicate genes and application of a significance threshold. A network encompassing 149 genes with a minimum interaction score of 0.4 was constructed utilizing the STRING software, shedding light on the intricate interplay among these genes. Subsequent investigations honed in on genes exerting significant regulatory effects in response to heat stress, elucidating their pivotal roles in orchestrating physiological processes. Functional assessment of the networked genes revealed their involvement in diverse biological activities, including the positive regulation of T cell- mediated immunity, WNT and MAPK signaling pathways, as well as phagocytosis and natural killer (NK) cell activity. Particularly noteworthy was the observation of suppressed NK cell activity in broilers under heat stress, likely influenced by heightened corticosterone levels and subsequent inhibition of thyroid hormone secretion, thereby impacting temperature regulation and metabolism. Moreover, the elevation in blood glucose levels observed in stressed chicks may contribute to their adaptive survival response. Importantly, heat stress was observed to disrupt cellular homeostasis and molecular pathways, manifesting in alterations in biological processes such as the cell cycle. This disruption in the cell cycle may signify a novel mechanism of stress resistance in vertebrates, further underscoring the complexity of the physiological response to thermal stress in chickens. Conclusion: The analysis of gene functionality within the network underscores the intricate nature of the innate immune response and cellular demise elicited by heat stress. Notably, certain genes identified in this analysis participate in positively regulating T cell-mediated immunity, vascular endothelial growth factor (VEGF), WNT signaling, and mitogen-activated protein kinase (MAPK) pathways. Introducing a biomarker panel comprising genes, such as MAPK14, NT3, SOX2, YAP1, FGF2, LRRK1, LEF1, and TLE1, holds promise for advancing our understanding of the underlying molecular mechanisms governing stress responses in poultry. Furthermore, this approach may facilitate the discovery of novel genes whose modulation could mitigate the effects of thermal stress. [ABSTRACT FROM AUTHOR]

ABSTRACT: The wide distribution and diverse varieties of chickens make them important models for studying genetic adaptation. The aim of this study was to identify genes that alter heat adaptation in commercial chicken breeds by comparing genetic differences between tropical and cold-resistant chickens. We analyzed whole-genome resequencing data of 186 chickens across various regions in Asia, including the following breeds: Bian chickens (B), Dagu chickens (DG), Beijing-You chickens (BY), and Gallus gallus jabouillei from China; Gallus gallus murghi from India; Vietnam native chickens (VN); Thailand native chickens (TN) and Gallus gallus spadiceus from Thailand; and Indonesia native chickens (IN), Gallus gallus gallus, and Gallus gallus bankiva from Indonesia. In total, 5,454,765 SNPs were identified for further analyses. Population genetic structure analysis revealed that each local chicken breed had undergone independent evolution. Additionally, when K = 5, B, BY, and DG chickens shared a common ancestor and exhibited high levels of inbreeding, suggesting that northern cold-resistant chickens are likely the result of artificial selection. In contrast, the runs of homozygosity (ROH) and the ROH-based genomic inbreeding coefficient (FROH) results for IN, TN, and VN chickens showed low levels of inbreeding. Low population differentiation index values indicated low differentiation levels, suggesting low genetic diversity in tropical chickens, implying increased vulnerability to environmental changes, decreased adaptability, and disease resistance. Whole-genome selection sweep analysis revealed 69 candidate genes, including LGR4, G6PC, and NBR1, between tropical and cold-resistant chickens. The genes were further subjected to GO and KEGG enrichment analyses, revealing that most of the genes were primarily enriched in biological synthesis processes, metabolic processes, central nervous system development, ion transmembrane transport, and the Wnt signaling pathway. Our study identified heat adaptation genes and their functions in chickens that primarily affect chickens in high-temperature environments through metabolic pathways. These heat-resistance genes provide a theoretical basis for improving the heat-adaptation capacity of commercial chicken breeds.

Strawberry production is facing a serious decline with the increase in global temperature as a result of climate change. Improving the heat tolerance is imperative for the strawberry plants to remain productive under high temperature conditions. The present work aimed to study the effect of heat acclimation on the thermotolerance of strawberry plants subjected to severe heat stress. Tissue cultured Fragaria ‘Taoyuan No. 1’ plantlets were subjected to four heat-acclimation treatments with gradual increase of temperatures from 30°C to 42°C for 1.25 hr to 10 hr before exposing them to the lethal temperature of 48°C for 4 hr. Survival, new leaf emergence and root growth, electrolyte leakage, chlorophyll and proline contents, as well as antioxidant enzyme activities were compared between the control, acclimated and non-acclimated plantlets. Results indicated that heat acclimation was required for the strawberry plantlets to survive under lethal temperature conditions. The acclimated plantlets registered a lower degree of electrolyte leakage and chlorophyll degradation, and a higher proline content compared to the non-acclimated plantlets. The activities of the antioxidant enzymes increased with the elevation of acclimation temperature and peaked at 42°C except for ascorbate peroxidase (APX) whose activity peaked at 39°C. Higher activities of superoxide dismutase (SOD), APX, glutathione reductase (GR), catalase (CAT) and peroxidase (POD) were observed in the acclimated plantlets compared to the non-acclimated plantlets. This study demonstrates that heat acclimation improved the thermotolerance of in vitro strawberry plantlets by reducing electrolyte leakage and chlorophyll degradation, as well as by enhancing proline content and antioxidant enzyme activities under severe heat stress.

This document provides summaries of various research studies related to potato breeding, genetics, cultivation, disease management, and storage. The studies cover topics such as optimizing photosynthesis in potato plants, detecting potato virus Y using hyperspectral reflectance analysis, managing pathogens in potato fields, developing CPB-resistant potato varieties, suppressing Fusarium dry rot using biological control agents, analyzing flavor profiles of different potato genotypes, breeding heat-tolerant potato varieties, identifying genomic regions associated with heat tolerance, and using deep learning models for PVY detection. The document also includes information on new potato varieties, disease resistance, insecticide resistance in Colorado potato beetles, molecular detection of P. infestans, and the impact of soil organic matter on potato productivity. These studies provide valuable insights and potential solutions for improving potato production, disease management, and storage practices. [Extracted from the article]

Heat stress represents a significant environmental challenge that restricts maize (Zea mays) growth and yield on a global scale. Within the plant kingdom, the AGC gene family, encoding a group of protein kinases, has emerged as crucial players in various stress responses. Nevertheless, a comprehensive understanding of AGC genes in Z. mays under heat-stress conditions remains elusive. A genome-wide analysis was done using bioinformatics techniques to identify 39 AGC genes in Z. mays , categorising them into three subfamilies based on their conserved domains. We investigated their phylogenetic relationships, gene structures (including intron-exon configurations), and expression patterns. These genes are likely involved in diverse signalling pathways, fulfilling distinct roles when exposed to heat stress conditions. Notably, most ZmAGC1.5, ZmAGC1.9, ZmNDR3, ZmNDR5 and ZmIRE3 exhibited significant changes in expression levels under heat stress, featuring a high G-box ratio. Furthermore, we pinpointed a subset of AGC genes displaying highly coordinated expression, implying their potential involvement in the heat stress response pathway. Our study offers valuable insights into the contribution of AGC genes to Z. mays 's heat stress response, thus facilitating the development of heat-tolerant Z. mays varieties. Rising global temperature is negatively affecting maize yield. Current genome-wide analysis identified and characterised AGC genes, one of the major contributors of plant stress response. Heat stress mediated differential expression of AGCs (using RNA-seq and real time qPCR) underscore the potential for developing heat-tolerant maize varieties by understanding the intricate workings of these genes. This article belongs to the Collection Functional Genomics for Developing Climate Resilient Crops. [ABSTRACT FROM AUTHOR]

The article focuses on integrating thermal physiology and biometeorology research to address heat-related illnesses among elite athletes. Topics include the physiological challenges posed by climate change on athletes, the relevance of understanding heat-related issues in sports for broader applications, and the necessity for collaborative strategies involving stakeholders like sports organizations, and medical professionals.

Forests overlap with large parts of the northern hemisphere permafrost area, and representing canopy processes is therefore crucial for simulating thermal and hydrological conditions in these regions. Forests impact permafrost through the modulation of radiative fluxes and exchange of turbulent fluxes, precipitation interception and regulation of transpiration. Forests also feature distinct soil layers of litter and organic matter, which play central roles for the infiltration and evaporation of water, while also providing thermal insulation for deeper ground layers. In this study, we present a new module within the CryoGrid community model to simulate forest ecosystems and their impact on the surface water and energy balance. The module includes a big‐leaf vegetation scheme with adaptations for canopy heat storage and transpiration. Furthermore, we account for the effect of surface litter layers on water and energy transfer. We show that the model is capable of simulating radiation, snow cover and ground temperatures below a deciduous needleleaf forest on a north‐facing slope in the Khentii Mountains in Central Mongolia. A sensitivity analysis of topographic aspect and ecosystem configuration confirms the important role of the litter layers for the energy and water balance of the ground. Furthermore, it suggests that the presence of permafrost is primarily linked to topographic aspect rather than the presence of forest at this site. The presented model scheme can be used to study the development of the ground thermal regime in forests, including the state of permafrost, under different climate, ecosystem, and land use scenarios. Plain Language Summary: Large parts of the permafrost in the Northern Hemisphere are covered by forest, which impact the transfer of water and energy between the atmosphere and the ground. In this study we include single‐layer vegetation scheme in an established permafrost model, and test this for a site in Mongolia at the southern limit of Eurasian permafrost and boreal forest. We find that forest soils have smaller variations in ground temperature than on the nearby steppe, and that surface litter layers provide substantial insulation and soil water retention. Our simulations also suggest that the local distribution of permafrost in our study area is linked to topography rather than forest cover. The vegetation scheme is based on a global land surface model and represents a new modeling tool that readily can be used for further studies of permafrost‐ecosystem interactions. Key Points: Novel developments in the CryoGrid Community Model reproduce how forests dampen the seasonal ground surface temperature signalSurface litter layers are essential for forest ground hydrothermal regime as they provide thermal insulation and retain soil moisturePermafrost in our simulations is confined to north‐facing slopes in the study region regardless of ecosystem setup [ABSTRACT FROM AUTHOR]

Background: As the greenhouse effect intensifies, global temperatures are steadily increasing, posing a challenge to bread wheat (Triticum aestivum L.) production. It is imperative to comprehend the mechanism of high temperature tolerance in wheat and implement breeding programs to identify and develop heat-tolerant wheat germplasm and cultivars. Results: To identify quantitative trait loci (QTL) related to heat stress tolerance (HST) at seedling stage in wheat, a panel of 253 wheat accessions which were re-sequenced used to conduct genome-wide association studies (GWAS) using the factored spectrally transformed linear mixed models (FaST-LMM). For most accessions, the growth of seedlings was found to be inhibited under heat stress. Analysis of the phenotypic data revealed that under heat stress conditions, the main root length, total root length, and shoot length of seedlings decreased by 47.46%, 49.29%, and 15.19%, respectively, compared to those in normal conditions. However, 17 varieties were identified as heat stress tolerant germplasm. Through GWAS analysis, a total of 115 QTLs were detected under both heat stress and normal conditions. Furthermore, 15 stable QTL-clusters associated with heat response were identified. By combining gene expression, haplotype analysis, and gene annotation information within the physical intervals of the 15 QTL-clusters, two novel candidate genes, TraesCS4B03G0152700/TaWRKY74-B and TraesCS4B03G0501400/TaSnRK3.15-B, were responsive to temperature and identified as potential regulators of HST in wheat at the seedling stage. Conclusions: This study conducted a detailed genetic analysis and successfully identified two genes potentially associated with HST in wheat at the seedling stage, laying a foundation to further dissect the regulatory mechanism underlying HST in wheat under high temperature conditions. Our finding could serve as genomic landmarks for wheat breeding aimed at improving adaptation to heat stress in the face of climate change. [ABSTRACT FROM AUTHOR]

Decreased production of crops due to climate change has been predicted scientifically. While climate-resilient crops are necessary to ensure food security and support sustainable agriculture, predicting crop growth under future global warming is challenging. Therefore, we aimed to assess the impact of realistic global warming conditions on rice cultivation. We developed a crop evaluation platform, the agro-environment (AE) emulator, which generates diverse environments by implementing the complexity of natural environmental fluctuations in customized, fully artificial lighting growth chambers. We confirmed that the environmental responsiveness of rice obtained in the fluctuation of artificial environments is similar to those exhibited in natural environments by validating our AE emulator using publicly available meteorological data from multiple years at the same location and multiple locations in the same year. Based on the representative concentration pathway, real-time emulation of severe global warming unveiled dramatic advances in the rice life cycle, accompanied by a 35% decrease in grain yield and an 85% increase in quality deterioration, which is higher than the recently reported projections. The transcriptome dynamism showed that increasing temperature and CO2 concentrations synergistically changed the expression of various genes and strengthened the induction of flowering, heat stress adaptation, and CO2 response genes. The predicted severe global warming greatly alters rice environmental adaptability and negatively impacts rice production. Our findings offer innovative applications of artificial environments and insights for enhancing varietal potential and cultivation methods in the future. [ABSTRACT FROM AUTHOR]

This study aimed to determine whether heat acclimation could induce adaptations in exercise performance, thermoregulation, and the expression of proteins associated with heat stress in the skeletal muscles of Thoroughbreds. Thirteen trained Thoroughbreds performed 3 weeks of training protocols, consisting of cantering at 90% maximal oxygen consumption (VO2max) for 2 min 2 days/week and cantering at 7 m/s for 3 min 1 day/week, followed by a 20‐min walk in either a control group (CON; Wet Bulb Globe Temperature [WBGT] 12–13°C; n = 6) or a heat acclimation group (HA; WBGT 29–30°C; n = 7). Before and after heat acclimation, standardized exercise tests (SET) were conducted, cantering at 7 m/s for 90 s and at 115% VO2max until fatigue in hot conditions. Increases in run time (p = 0.0301), peak cardiac output (p = 0.0248), and peak stroke volume (p = 0.0113) were greater in HA than in CON. Pulmonary artery temperature at 7 m/s was lower in HA than in CON (p = 0.0332). The expression of heat shock protein 70 (p = 0.0201) and 90 (p = 0.0167) increased in HA, but not in CON. These results suggest that heat acclimation elicits improvements in exercise performance and thermoregulation under hot conditions, with a protective adaptation to heat stress in equine skeletal muscles. [ABSTRACT FROM AUTHOR]

Extreme high temperature has deleterious impact on the yield and quality of tea production, which has aroused the attention of growers and breeders. However, the mechanisms by which tea plant varieties respond to extreme environmental heat is not clear. In this study, we analyzed physiological indices, metabolites and transcriptome differences in three different heat-tolerant tea plant F1 hybrid progenies. Results showed that the antioxidant enzyme activity, proline, and malondialdehyde were significantly decreased in heat-sensitive 'FWS' variety, and the accumulation of reactive oxygen molecules such as H2O2 and O2− was remarkably increased during heat stress. Metabolomic analysis was used to investigate the metabolite accumulation pattern of different varieties in response to heat stress. The result showed that a total of 810 metabolites were identified and more than 300 metabolites were differentially accumulated. Transcriptional profiling of three tea varieties found that such genes encoding proteins with chaperon domains were preferentially expressed in heat-tolerant varieties under heat stress, including universal stress protein (USP32, USP-like), chaperonin-like protein 2 (CLP2), small heat shock protein (HSP18.1), and late embryogenesis abundant protein (LEA5). Combining metabolomic with transcriptomic analyses discovered that the flavonoids biosynthesis pathway was affected by heat stress and most flavonols were up-regulated in heat-tolerant varieties, which owe to the preferential expression of key FLS genes controlling flavonol biosynthesis. Take together, molecular chaperons, or chaperon-like proteins, flavonols accumulation collaboratively contributed to the heat stress adaptation in tea plant. The present study elucidated the differences in metabolite accumulation and gene expression patterns among three different heat-tolerant tea varieties under extreme ambient high temperatures, which helps to reveal the regulatory mechanisms of tea plant adaptation to heat stress, and provides a reference for the breeding of heat-tolerant tea plant varieties. [ABSTRACT FROM AUTHOR]

Megacities, such as Lagos, Nigeria, face significant challenges due to rapid urbanization and climate change, resulting in a higher intensity of the urban heat island effect, coupled with high population density, making the city fall under the category of moderate to high heat stress/risk. Despite this, very few studies have analyzed the urban impact on heat stress over the coastal city, albeit with poor resolution data. In this study, we assessed the performance of an integrated high-resolution WRF-urban scheme driven by the readily available urban canopy information of the local climate zone (LCZ) to simulate local meteorological data for analyzing the spatiotemporal pattern of heat stress over the megacity. Our results show that the WRF-BEP scheme outperformed the other evaluated urban schemes, reducing the normalized root mean squared error by 25%. Furthermore, using humidex, we found a generally high incidence of intense discomfort in highly urbanized areas and noted the significant influence of urban morphology on the pattern of heat stress, particularly at night due to the combined effect of urban warming and higher relative humidity. The most socioeconomically disadvantaged urban areas, LCZ7, were most affected, with "hot" heat stress conditions observed over 90% of the time. However, during the afternoon, we found reduced heat stress in the core urban areas which might be due to the shading effect and/or cold air advection. Our findings would be relevant in the development of the urgently needed climate/heat adaptation plans for the city and other sub-Saharan African cities. [ABSTRACT FROM AUTHOR]

Genomic regions related to tropical adaptability are of paramount importance for animal breeding nowadays, especially in the context of global climate change. Moreover, understanding the genomic architecture of these regions may be very relevant for aiding breeding programs in choosing the best selection scheme for tropical adaptation and/or implementing a crossbreeding scheme. The composite MONTANA TROPICAL® population was developed by crossing cattle of four different biological types to improve production in harsh environments. Pedigree and genotype data (51962 SNPs) from 3215 MONTANA TROPICAL® cattle were used to i) characterize the population structure; ii) identify signatures of selection with complementary approaches, i.e. Integrated Haplotype Score (iHS) and Runs of Homozygosity (ROH); and iii) understand genes and traits related to each selected region. The population structure based on principal components had a weak relationship with the genetic contribution of the different biological types. Clustering analyses (ADMIXTURE) showed different clusters according to the number of generations within the composite population. Considering results of both selection signatures approaches, we identified only one consensus region on chromosome 20 (35399405–40329703 bp). Genes in this region are related to immune function, regulation of epithelial cell differentiation, and cell response to ionizing radiation. This region harbors the slick locus which is related to slick hair and epidermis anatomy, both of which are related to heat stress adaptation. Also, QTLs in this region were related to feed intake, milk yield, mastitis, reproduction, and slick hair coat. The signatures of selection detected here arose in a few generations after crossbreeding between contrasting breeds. Therefore, it shows how important this genomic region may be for these animals to thrive in tropical conditions. Further investigations on sequencing this region can identify candidate genes for animal breeding and/or gene editing to tackle the challenges of climate change. [ABSTRACT FROM AUTHOR]

Domestication has shaped the diverse characteristics of rabbits, including coat color, fur structure, body size, and various physiological traits. Utilizing whole-genome resequencing (DNBSEQ-T7), we analyzed the genetic diversity, population structure, and genomic selection across 180 rabbits from 17 distinct breeds to uncover the genetic basis of these traits. We conducted whole-genome sequencing on 17 rabbit breeds, identifying 17,430,184 high-quality SNPs and analyzing genomic diversity, patterns of genomic variation, population structure, and selection signatures related to coat color, coat structure, long hair, body size, reproductive capacity, and disease resistance. Through PCA and NJ tree analyses, distinct clusters emerged among Chinese indigenous rabbits, suggesting varied origins and domestication histories. Selective sweep testing pinpointed regions and genes linked to domestication and key morphological and economic traits, including those affecting coat color (TYR, ASIP), structure (LIPH), body size (INSIG2, GLI3), fertility (EDNRA, SRD5A2), heat stress adaptation (PLCB1), and immune response (SEC31A, CD86, LAP3). Our study identified key genomic signatures of selection related to traits such as coat color, fur structure, body size, and fertility; these findings highlight the genetic basis underlying phenotypic diversification in rabbits and have implications for breeding programs aiming to improve productive, reproductive, and adaptive traits. The detected genomic signatures of selection also provide insights into rabbit domestication and can aid conservation efforts for indigenous breeds. [ABSTRACT FROM AUTHOR]

Abstract Comprehensive studies comparing impacts of building and street levels interventions on air temperature at metropolitan scales are still lacking despite increased urban heat‐related mortality and morbidity. We therefore model the impact of 9 interventions on air temperatures at 2 m during 2 hot days from the summer 2018 in the Greater London Authority area using the WRF BEP‐BEM climate model. We find that on average cool roofs most effectively reduce temperatures (∼−1.2°C), outperforming green roofs (∼0°C), solar panels (∼−0.5°C) and street level vegetation (∼−0.3°C). Application of air conditioning across London (United Kingdom) increases air temperatures by ∼+0.15°C. A practicable deployment of solar panels could cover its related energetic consumption. Current practicable deployments of green roofs and solar panels are ineffective at large scale reduction of temperatures. We provide a detailed decomposition of the surface energy balance to explain changes in air temperature and guide future decision‐making.

A recent study published in the journal PAIN explores the use of low-intensity focused ultrasound (LIFU) to modulate neuronal activity in different subregions of the insula cortex, a brain region involved in the perception of pain. The study suggests that LIFU may have the potential to selectively target deep tissues and determine the causal role of the insula in pain perception. However, the study has some methodological concerns that should be considered when interpreting the findings. The authors caution against solely attributing the reduction in pain ratings to the effects of LIFU and highlight inconsistencies in the nomenclature used and the interpretation of the results. Despite these concerns, the study provides important evidence for the potential of LIFU in modulating the insula and calls for further research in this area. [Extracted from the article]

Thermal management systems utilizing fixed-area extended surfaces for thermal enhancement have been extensively investigated. Unlike these systems, in nature, few creatures display the ability to control heat dissipation in adaptation to changes in environmental conditions by controlling their exposed surface area of the body. Motivated by this, the primary objective of this research is the design, development, numerical and experimental evaluation of an adaptive variable area smart fin system for intelligent thermal management using a high-strain SMA spring actuator. Unlike most thermal management devices and techniques that involve a fixed surface area, a smart fin controlled by Pennate structure-based SMA (PeSMA) actuator is proposed for large actuation and compact arrangement. The capabilities of the smart fin to adaptively enhance heat transfer are experimentally demonstrated and numerically modeled. The proposed fin design can deliver improved thermal performance in terms of reduced operating temperature and pressure drop, which is an indicator of operational cost when the application involves variable and uncertain thermal load conditions. We envisage one of the future applications of this technology in the battery thermal management of Electric Vehicles (EVs) where deployable compact heat transfer system is highly desirable. [ABSTRACT FROM AUTHOR]

Marine heat waves are having unprecedented impacts on reef-building corals worldwide. Corals within the same species have different sensitivity to heat stress, and part of this variation is due to genetic adaptation. Finding coral genotypes that underpin heat adaptation would allow the identification of adapted populations so that reef managers could protect and promote the spread of these adapted populations. Seascape genomics identifies candidate adaptive genotypes by associating variation in genotype frequencies across a reef system with historical thermal conditions. CRISPR/Cas9-based gene editing could assess and validate the functional roles of putative adaptive genotypes, and validated genotypes could then be used in conservation. Mass coral bleaching is one of the clearest threats of climate change to the persistence of marine biodiversity. Despite the negative impacts of bleaching on coral health and survival, some corals may be able to rapidly adapt to warming ocean temperatures. Thus, a significant focus in coral research is identifying the genes and pathways underlying coral heat adaptation. Here, we review state-of-the-art methods that may enable the discovery of heat-adaptive loci in corals and identify four main knowledge gaps. To fill these gaps, we describe an experimental approach combining seascape genomics with CRISPR/Cas9 gene editing to discover and validate heat-adaptive loci. Finally, we discuss how information on adaptive genotypes could be used in coral reef conservation and management strategies. [ABSTRACT FROM AUTHOR]

Plants monitor day length and memorize changes in temperature signals throughout the day, creating circadian rhythms that support the timely control of physiological and metabolic processes. The DEHYDRATION-RESPONSE ELEMENT-BINDING PROTEIN 1/C-REPEAT BINDING FACTOR (DREB1/CBF) transcription factors are known as master regulators for the acquisition of cold stress tolerance, whereas PHYTOCHROME INTERACTING FACTOR 4 (PIF4) is involved in plant adaptation to heat stress through thermomorphogenesis. Recent studies have shown that circadian clock genes control plant responses to temperature. Temperature-responsive transcriptomes show a diurnal cycle and peak expression levels at specific times of throughout the day. Circadian clock genes play essential roles in allowing plants to maintain homeostasis by accommodating temperature changes within the normal temperature range or by altering protein properties and morphogenesis at the cellular level for plant survival and growth under temperature stress conditions. Recent studies revealed that the central oscillator genes CIRCADIAN CLOCK ASSOCIATED 1/LATE ELONGATED HYPOCOTYL (CCA1/LHY) and PSEUDO-RESPONSE REGULATOR5/7/9 (PRR5/7/9), as well as the EVENING COMPLEX (EC) genes REVEILLE4/REVEILLE8 (REV4/REV8), were involved in the DREB1 pathway of the cold signaling transcription factor and regulated the thermomorphogenesis gene PIF4. Further studies showed that another central oscillator, TIMING OF CAB EXPRESSION 1 (TOC1), and the regulatory protein ZEITLUPE (ZTL) are also involved. These studies led to attempts to utilize circadian clock genes for the acquisition of temperature-stress resistance in crops. In this review, we highlight circadian rhythm regulation and the clock genes involved in plant responses to temperature changes, as well as strategies for plant survival in a rapidly changing global climate. [ABSTRACT FROM AUTHOR]