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This paper presents a psychology professor's account of his experiences teaching a course on Acquired Immune Deficiency Syndrome/Human Immunodeficiency Virus (AIDS/HIV) to college students. The first section discusses how to introduce and market the course on campus, and anticipate students' and colleagues' questions about one's motivations for teaching the course, one's sexual preference, and one's expertise. The second part discusses how to deal with religion, values, and morality, by asserting the objective from the outset (to stop the spread of AIDS by whatever means possible), and how to deal with the likelihood that terminology used in the course will offend some students. Also discussed are the problems of teaching students from diverse cultures and value systems. The third section addresses how to comment on current events and new potential cures, and how to address students' questions and concerns. The remaining sections discuss: how to resolve conflict among sources of information; how to find an appropriate level of knowledge and sophistication; topical coverage; pedagogical devices; audiovisual materials; and experiential exercises. The concluding sections discuss the distribution of activities across class periods and the problem of AIDS burnout. (TE)