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Broad-based cognitive deficits are an enduring and disabling symptom for many patients with severe mental illness, and these impairments are inadequately addressed by current medications. While novel drug targets for schizophrenia and depression have emerged from recent large-scale genome-wide association studies (GWAS) of these psychiatric disorders, GWAS of general cognitive ability can suggest potential targets for nootropic drug repurposing. Here, we (1) meta-analyze results from two recent cognitive GWAS to further enhance power for locus discovery; (2) employ several complementary transcriptomic methods to identify genes in these loci that are credibly associated with cognition; and (3) further annotate the resulting genes using multiple chemoinformatic databases to identify "druggable" targets. Using our meta-analytic data set (N = 373,617), we identified 241 independent cognition-associated loci (29 novel), and 76 genes were identified by 2 or more methods of gene identification. Actin and chromatin binding gene sets were identified as novel pathways that could be targeted via drug repurposing. Leveraging our transcriptomic and chemoinformatic databases, we identified 16 putative genes targeted by existing drugs potentially available for cognitive repurposing.

It has been suggested that we turn to solar geoengineering to counter global warming, which would consequently transform the relationship of terrestrial plant-life to the sun. This is an article not about geoengineering as such, but instead what is called photosynethics, or, thinking about our moral relationship to the light – in particular, as it is mediated by plants. Working from within but then extending the idea of responsibility found in the work of Emmanuel Levinas, it is argued here that, since the plant cultivates the conditions of life on earth by photosynthesis, its relationship to the sun is then a relation of giving to others that is properly moral. The plant's existence is an exposure so out of kilter with human ways of understanding existence that it interrupts our own and brings us into a relation of responsibility. It is concluded that rather than redirecting the sun's radiation, we should turn to plants to reconsider how we live with the light on a heating planet. This first means separating moral responsibility from human vision so that we might encounter light on its own terms, and not simply as an element of rationality or sentiment or discipline. [ABSTRACT FROM AUTHOR]

Purpose: Many athletes report consuming alcohol the day before their event, which might negatively affect their performance. However, the effects of previous-day alcohol ingestion on performance are equivocal, in part, due to no standardization of alcohol dose in previous studies. The purpose of this study was to examine the impact of a standardized previous-day alcohol dose and its corresponding impact on morning-after muscular strength, muscular power, and muscular fatigue in a short-duration test and on performance of severe-intensity exercise. Methods: On 2 occasions, 12 recreationally active individuals reported to the Applied Physiology Laboratory in the evening and ingested a beverage containing either 1.09 g ethanol·kg−1 fat-free body mass (ALC condition) or water (PLA condition). The following morning, they completed a hangover symptom questionnaire, vertical jumps, isometric midthigh pulls, biceps curls, and a constant-power cycle ergometer test to exhaustion. The responses from ALC and PLA were compared using paired-means t tests. Results: Time to exhaustion in the cycle ergometer tests was less (P =.03) in the ALC condition (181 [39] s vs 203 [34] s; –11%, Cohen d = 0.61). There was no difference in performance in vertical jump test, isometric midthigh pulls, and biceps curls tests between the ALC and PLA conditions. Conclusions: Previous-day alcohol consumption significantly reduces morning-after performance of severe-intensity exercise. Practitioners should educate their athletes, especially those whose events rely on anaerobic capacity and/or a rapid response of the aerobic pathways, of the adverse effect of previous-day alcohol consumption on performance. [ABSTRACT FROM AUTHOR]

This study aimed to examine the impact of 40-min and 90-min naps on performance in the 5-m shuttle run test (5mSRT) and on various physiological and perceptual measures. Sixteen male athletes (20 ± 3 years, 173 ± 7 cm, 67 ± 7 kg) performed the 5mSRT after a 40-min nap (N40), after a 90-min nap (N90), and in a no-nap, control condition (N0). The 5mSRT involves six repetitions of 30 s of all-out exercise. Total distance (in the six repetitions) and highest distance (in a single repetition) in the 5mSRT were greater after naps than in N0 (p < 0.001), and the total distance, which reflects the anaerobic capacity, was greater in N90 than in N40 (p < 0.05). Physiological and perceptual responses were favourable in both nap conditions (p < 0.01), more so in N90 than in N40 (p < 0.05). Together, the results support the contention that physiological/perceptual responses after napping contribute to improved exercise performance and that longer naps are more effective. [ABSTRACT FROM AUTHOR]

(101_0) GaN wafers grown on (100) face of y-LiAlO2 were studied using transmission electronmicroscopy. Despite good lattice matching in this heteroepitaxial system, high densities of planar structural defects in the form of stacking faults on the basal plane and networks of boundaries located on prism planes inclined to the layer/substrate interface were present in these GaN layers. In addition, significant numbers of threading dislocations were observed. High-resolution electron microscopy indicates that stacking faults present on the basal plane in these layers are of low-energy intrinsic I1 type. This is consistent with diffraction contrast experiments.

This is a two-part study to determine one or more reliable physiological anchors for perception of effort. The purpose of Study 1 was to compare ratings of perceived exertion (RPE) at the ventilatory threshold (VT) in running, cycling, and upper body exercise with the premise that if RPE at VT did not differ across exercise modes, VT might provide a unique set of physiological inputs for perception of effort. For 27 participants, values for VT and for RPE at VT (Borg 6 to 20 scale) averaged 9.4 km⋅h−1 (SD = 0.7) and 11.9 km⋅h−1 (SD = 1.4) respectively in running, 135 W (SD = 24) and 12.1 W (SD = 1.6) in cycling, and 46 W (SD = 5) and 12.0 W (SD = 1.7) in upper body exercise. RPE did not differ, suggesting that VT may anchor effort perception. In Study 2, 10 participants performed cycle ergometer exercise for 30 minutes at their VT (M = 101 W, SD = 21), at their maximal lactate steady state (M = 143 W, SD = 22), and at their critical power (CP; M = 167 W, SD = 23). Mean end-exercise RPE were 12.1 (SD = 2.1), 15.0 (SD = 1.9), and 19.0 (SD = 0.5), respectively. The very close clustering of RPE during exercise at CP hints that the confluence of physiological responses at CP may (also) serve as a determinant in perception of effort. [ABSTRACT FROM AUTHOR]

The purpose was to investigate the effects of pedalling cadence on V̇o2 kinetics in severe-intensity cycling exercise. This question is pertinent to exercise testing, where cadence is an important (and often confounding) variable, and to performance, where V̇o2 kinetics determines the initial reliance upon anaerobic reserves. Eighteen university students performed tests to exhaustion at 241 ± 31 W, using cadences of 60, 80, and 100 rev·min-1. V̇o2 data were fitted to a 2-component model (primary phase + slow component). Responses during the 3 tests were compared using a repeated-measures analysis of variance, with significance at p < 0.05. The mean response time of the primary phase of the V̇o2 response (time to reach 63% of the response) was progressively smaller (response was faster) at higher cadences (37 ± 4 seconds at 60 rev·min-1, 32 ± 5 seconds at 80 rev·min-1, 27 ± 4 seconds at 100 rev·min-1), and there was a concomitantly faster heart rate response. In addition, the time delay before the slow component was shorter, the amplitude of the primary phase was greater, and the amplitude of the slow component was smaller at the higher cadence. The results suggest that pedalling cadence itself-and not just the higher metabolic demand associated with higher cadences-may be responsible for differences in temporal characteristics (time delays, time constants) of the primary and slow phases of the V̇o2 response. Exercise scientists must consider, and coaches might apply, the relationship between V̇o2 kinetics and pedalling cadence during exercise testing. [ABSTRACT FROM AUTHOR]

Love Island is a reality television series structured as a dating game, where participants compete to form romantic relationships. This article puts the show in conversation with theories and philosophies of love to draw between them an idea of love as a singular moral event that is constrained by cultural imperatives. What emerges is an existential phenomenology of love in three parts: first, romantic love is framed as an opening on to moral life; then, it is argued that moral life is enacted through a love for the neighbour that constitutes and animates our being in the world; and finally, it is shown that narcissism is not straightforwardly a negative condition but a balancing force in moral life. The article concludes with reflections on what this conceptual work might offer to analyses of relationships played out on reality television. [ABSTRACT FROM AUTHOR]

The purpose of this study was to explore the effect of rest redistribution with heavier loads (RR + L) on physiological and perceptual responses in resistance- trained men. Eight men who had back squat (BS) 1 repetition maximum (1RM) to body mass ratio; 1.8 ± 0.2 completed 2 BS exercise sessions in a counterbalanced and a randomized order; RR + L: 4 sets of (2 x 5) repetitions with 90-second interset rest and 30-second intraset rest using 75% BS 1RM and traditional sets (TS): 4 sets of 10 repetitions with 120-second interset rest using 70% BS 1RM. Blood samples were collected before exercise, immediately post exercise, and 5, 15, and 30 minutes post exercise for the analysis of growth hormone (GH), total testosterone (T7), cortisol (C), and blood lactate (BL), whereas rating of perceived exertion (RPE) and heart rate (HR) were measured immediately after each set of the BS exercise. While neither main effect of condition nor interaction existed, there was a significant (p < 0.05) main effect of time point (and set) for GH, TT, C, BL, RPE, and HR. Volume load was greater for RR + L compared with TS (4,074.9 ± 786.7 kg vs. 3,796.3 ± 714.8 kg). In conclusion, RR + L increases volume load by approximately 7% but does not seem to influence GH (g = —0.15), TT (g = —0.09), BL (g = —0.22), RPE (g = 0.14), and HR g = —0.08) responses. Practitioners may consider using RR + L to increase volume load without increasing acute fatigue responses. [ABSTRACT FROM AUTHOR]

The purpose of this study was to examine mechanical responses to rest redistribution with heavier loads (RR + L) in resistance-trained men. Eight men (23.0 ± 4.8 years, 1.76 ±0.06 m, 78.5 6 8.6 kg, back squat [BS] one-repetition maximum [1RM] of 138.7± 27.9 kg) completed 2 BS exercise sessions in a counterbalanced and a randomized order; RR + L: 4 sets of (2 3 5) repetitions with 90-second interset rest and 30-second intraset rest using 75% BS 1RM and traditional sets (TS): 4 sets of 10 repetitions with 120-second interset rest using 70% BS 1RM. During the concentric phase, mean force ( x̅F), velocity ( x̅V), and power ( x̅P) were collected for each repetition using a linear position transducer and analyzed the first 3 sets. Compared with TS, RR + L resulted in significantly greater x̅F (1820 ± 260 N vs. 1753 ± 248 N; p < 0.001; g = 0.25) and lower x̅V (0.47 ± 0.07 m·s-1 vs. 0.50 ± 0.09 m·s-1 ; p = 0.005; g = -0.35). However, no significant difference in x̅P (836±165 W vs. 871 ± 197 W; p = 0.082; g = -0.18) was found between RR + L and TS. In conclusion, the lack of difference in x̅P might be the result of the combination of greater x̅F and lower x̅V for RR + L compared with TS. Therefore, practitioners may consider using RR + L to augment x̅F without compromising x̅P and increasing total rest time. However, given the approximate 4% difference in x̅F, the effect of RR + L training on chronic strength adaptation is expected to be small. [ABSTRACT FROM AUTHOR]

To identify rates and factors associated with timely prenatal care (PNC) initiation, HIV test counseling, test offering, and test offer acceptance, we conducted a semistructured survey of a convenience sample of pregnant/recently delivered Hispanic women (n = 453, 418 with analyzable data) in four California counties in 2000. Only 68.4% and 43.5% of Hispanic women reported receiving an HIV test offer and counseling, respectively, though 88.8% of those offered a test accepted. After controlling for the effects of age, education, years lived in the United States, health insurance coverage, delivery status, and parity, Hispanic women who initiated prenatal care in the first trimester were 1.7 times more likely to be offered an HIV test and almost 3 times more likely to receive counseling than women with a later prenatal care start or no prenatal care. Factors associated with timely PNC initiation on multivariate analysis were private/HMO insurance (OR = 10.7, p less than 0.001), Medi-Cal insurance (OR = 4.32, p less than 0.001), being 25-30 years old (OR = 3.0, p = 0.008), and completion of high school (OR = 2.07, p = 0.01). Key opportunities to prevent perinatal HIV transmission are being lost for Hispanic women in California. Interventions to increase timely PNC initiation, and to improve test offering by health care providers, may help to improve counseling and testing rates for this population.

The effect of a 40-min nap opportunity was investigated during the day following a late evening simulated soccer match. Twelve male amateur soccer players (23 ± 3 years; 77.3 ± 5.3 kg; 1.76 ± 0.04 m) performed the Loughborough-intermittent-shuttle test at 21h00 and the following day they completed the sleepiness scale after either a nonap (N0) or 40-min nap (N40) opportunity that began at 14h00. At 17h00, participants performed the 5-m shuttle run test (5mSRT) (6 × 30-s with 35-s in-between; best distance (BD) and total distance (TD) were calculated). After performing the 5mSRT, they provided their rating of the perceived exertion (RPE) and rated their muscle soreness. Sleepiness scores were significantly lower in N40 in comparison with N0 (P < 0.05). A significant increase of TD (+64.5 m) and BD (+9.6 m) after N40 compared to N0 was observed (P < 0.05). The improved performance was associated with reduced levels of muscle soreness and lower RPE. In conclusion, a daytime 40-min nap opportunity after a late evening simulated soccer match improves short-term repetitive maximal performance in soccer players, and has positive effects on perception of sleepiness, muscle soreness, and RPE. [ABSTRACT FROM AUTHOR]