46 results on '"HIROMI TAMURA"'
Search Results
2. Combined Intestinal Adenomas/Microcarcinoids
- Author
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Hiromi Tamura, Hiroka Ando, Reiko Doi, and Shiro Adachi
- Subjects
Combined intestinal adenoma-microcarcinoid ,Microcarcinoid ,Carcinoid ,Neuroendocrine tumor ,Large intestine ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
The combined colonic adenoma/microcarcinoid tumor is a rare intestinal neoplasm featuring intermingled adenomatous and carcinoid components. A few case reports and small case series have suggested that this entity exhibits an indolent clinical course. Here, we report two cases with these tumors, and describe the morphological features and clinical follow-up. A 61-year-old male and 78-year-old male presented with heme-positive stools at their medical checkups. Colonoscopy revealed masses in the colons; we performed endoscopic mucosal resection. Both lesions featured low-grade adenomas and low-grade neuroendocrine tumors. We diagnosed combined colonic adenomas/microcarcinoids. The clinical courses of both patients were benign at follow-up at 2.5 and 6 years. Awareness of this rare colonic tumor should prevent potential diagnostic pitfalls and may help clarify the natural history of these tumors and their possible relationships with composite glandular/carcinoid tumors.
- Published
- 2019
- Full Text
- View/download PDF
3. Alveolar Echinococcosis Mimicking a Hepatic Neoplasm with Lymph Node Metastasis: A Case Report
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Takahiro Amano, Shiro Hayashi, Tsutomu Nishida, Tokuhiro Matsubara, Kei Takahashi, Dai Nakamatsu, Yoshito Tomimaru, Masashi Yamamoto, Sachiko Nakajima, Koji Fukui, Hiromi Tamura, Shiro Adachi, Keizo Dono, and Masami Inada
- Subjects
Alveolar echinococcosis ,Echinococcus multilocularis ,Endoscopic ultrasonography fine-needle aspiration ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
A 37-year-old man had an asymptomatic 17-mm mass in the liver by health check with ultrasonography. Five years later, he was referred to our hospital because the mass was slightly enlarged with a peripancreatic lymph node. We performed endoscopic ultrasonography fine-needle aspiration (EUS-FNA) to evaluate a lymph node, but it showed amorphous eosinophilic material and eosinophilic infiltrate in necrotic tissue of toothpaste-like white specimen. However, we diagnosed as potentially malignant liver mass with lymph node metastasis because of 2-deoxy-2-(fluorine-18) fluorodeoxyglucose uptake. We then performed hepatectomy and enucleation of the pancreas. DNA polymerase chain reaction analysis revealed Echinococcus multilocularis infection. Retrospectively, we could find a part of Echinococcus in the specimens of EUS-FNA.
- Published
- 2018
- Full Text
- View/download PDF
4. A case of intraductal papillary-mucinous neoplasm of the pancreas penetrating into the stomach and spleen successfully treated by total pancreatectomy
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Takashi Harino, Yoshito Tomimaru, Kozo Noguchi, Hirotsugu Nagase, Takayuki Ogino, Masashi Hirota, Kazuteru Oshima, Tsukasa Tanida, Shingo Noura, Hiroshi Imamura, Takashi Iwazawa, Kenzo Akagi, Masashi Yamamoto, Tsutomu Nishida, Hiromi Tamura, Shiro Adachi, and Keizo Dono
- Subjects
Intraductal papillary-mucinous neoplasm ,Pancreas ,Penetration ,Fistula ,Surgery ,RD1-811 - Abstract
Abstract Background Intraductal papillary-mucinous neoplasms (IPMNs) are potentially malignant intraductal epithelial neoplasms that sometimes penetrate into other organs. To the best of our knowledge, no report has yet described a case with penetration into the spleen. We recently encountered a case of IPMN with penetration of the stomach and spleen that was successfully treated by total pancreatectomy. Case presentation A 70-year-old female visited our hospital with a complaint of fever and abdominal pain. Contrast-enhanced computed tomography (CT) revealed dilatation of the main pancreatic duct in the entire pancreas and penetration into the stomach and spleen. Upper gastrointestinal endoscopy revealed mucin extruding from four openings of the fistula in the stomach. No malignancy was detected based on cytology of the mucin. Inflammation markers and tumor markers (CEA, CA19–9) were elevated in the blood. The pre-operative diagnosis was IPMN of main pancreatic duct type penetrating into the stomach and spleen. A total pancreatectomy and splenectomy were performed, combined with distal gastrectomy including resection of the fistulas between the pancreas and stomach. No postoperative complications were noted. Histopathological examination of the resected specimen revealed atrophy of the pancreatic parenchyma, and the main duct of the pancreas was filled with mucin. Mucin-producing malignant tumor cells were detected in the epithelium of the main pancreatic duct with no signs of invasion. No malignancy was found at the fistulas between the pancreas and stomach or spleen. The patient was finally diagnosed with non-invasive intraductal papillary-mucinous carcinoma (IPMC) of main pancreatic duct type. Mechanical penetration was suspected as a mechanism of the penetration. The patient remained disease-free without evidence of recurrence more than 15 months after the operation. Conclusion Though IPMNs sometimes penetrate into other adjacent organs, penetration into two organs, including the spleen, is rare. The rare case of IPMC penetrating into the stomach and spleen presented here was treated successfully by total pancreatectomy.
- Published
- 2018
- Full Text
- View/download PDF
5. Extracranial meningiomas concurrently found in the lung and vertebral bone: a case report
- Author
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Hiromi Tamura, Yasushi Otani, Takashi Iwazawa, Masafumi Kashii, Hiroka Ando, Reiko Doi, and Shiro Adachi
- Subjects
Extracranial meningioma ,Lung ,Vertebral bone ,Medicine - Abstract
Abstract Background Primary pulmonary meningiomas are very rare, and primary intraosseous meningiomas outside the head and neck region have not yet been reported. We report an extremely unusual case of concurrent meningiomas arising in the pulmonary parenchyma and vertebral bone. Case presentation A 40-year-old Asian woman presented with a destructive lesion of the lumbar vertebral bone and a small nodule in the right lung. Five years later, both lesions slightly increased in size. To evaluate both the pulmonary and vertebral lesions, video-assisted thoracic surgery and curettage of the lytic lesion were performed. Both lesions showed similar histopathological findings corresponding to an intracranial meningioma of World Health Organization grade 1. The patient made good postoperative progress and remained free from disease at 41 months after the operation. Conclusions Our patient presented with almost synchronous pulmonary and lumbar vertebral intraosseous meningiomas. Regarding the relationship between the two lesions, there are two possibilities: Independent tumors occurred coincidentally or the primary pulmonary meningioma metastasized to the vertebral bone despite its bland morphology. It is important to keep in mind the exceptionally rare condition of extracranial meningioma.
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- 2018
- Full Text
- View/download PDF
6. Mesonephric adenocarcinoma of the uterine corpus with intracystic growth completely confined to the myometrium: a case report and literature review
- Author
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Hiroka Ando, Yuko Watanabe, Minori Ogawa, Hiromi Tamura, Tomomi Deguchi, Kayo Ikeda, Mayumi Fujitani, Mitsunori Shioji, Tomoko Tsujie, Reiko Doi, Akinori Wakimoto, and Shiro Adachi
- Subjects
Mesonephric adenocarcinoma ,Uterine corpus ,Intracystic growth ,Pathology ,RB1-214 - Abstract
Abstract Background Mesonephric adenocarcinoma (MA) is a rare tumor believed to arise from mesonephric remnants occurring mostly in the uterine cervix and, to a lesser extent, the corpus. Since the first case report of MA in the corpus in 1995, only 16 cases have been reported in the English literature. A recent report suggested that MA originates in Müllerian tissue and exhibits the mesonephric differentiation phenotype. Case presentation An asymptomatic 61-year-old woman was referred to our hospital because of elevated levels of tumor markers. Imaging revealed an intramural lesion of the uterine corpus exhibiting fluorodeoxyglucose uptake. A total hysterectomy and bilateral salpingo-oophorectomy were performed. The tumor was completely confined to the corpus wall and was composed of an intracystic bulky component and an invasive component in the myometrial layer. The tumor exhibited a variety of growth patterns, including a characteristic tubular pattern with dense eosinophilic secretion reminiscent of the thyroid, as well as a variety of morphologies, such as acinar, papillary, and ductal structures. The structures were immunoreactive for CK7, vimentin, CD10, calretinin, PAX8, and GATA3 and almost completely negative for ER/PgR. CA125 and CA19–9 antigen expression was also detected. Conclusion A case of MA with a unique growth pattern of an intracystic mass within the corpus wall is presented. The histogenesis and differential diagnoses are discussed. The histogenesis of MA is not yet clear. We hypothesize two different pathways involved: 1) direct development from the mesonephric remnants and/or 2) mesonephric transformation of Müllerian adenocarcinoma.
- Published
- 2017
- Full Text
- View/download PDF
7. Insulinoma with Hyperprocalcitoninemia and Hypercalcitoninemia Showing Coexpression of Insulin and Calcitonin in Its Tumor Cells.
- Author
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Tomoko Kaketaka, Ikuo Mineo, Yu Kimura, Naohiko Ito, Yukiyoshi Okauchi, Hiromi Tamura, Shiro Adachi, and Hiromi Iwahashi
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- 2024
- Full Text
- View/download PDF
8. A Case Report of Endometriosis-induced Appendiceal Intussusception
- Author
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Koichi Jinushi, Yozo Suzuki, Hiroshi Takeyama, Shingo Noura, Masakazu Ikenaga, Junzo Shimizu, Hiromi Tamura, Shiro Adachi, and Naohiro Tomita
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Gastroenterology ,Surgery - Published
- 2023
9. Immunoglobulin G4-Hepatopathy with Acute Hepatitis-Like Onset and Marked Centrilobular Necrosis: Clinicopathologically Unique Pattern of Hepatic Injury Related to Immunoglobulin G4-Related Disease
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Kengo Matsumoto, Masami Inada, Tsutomu Nishida, Hiromi Tamura, Kaori Mukai, Masashi Yamamoto, Dai Nakamatsu, Aya Sugimoto, Koji Fukui, Naoto Osugi, and Shiro Adachi
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medicine.medical_specialty ,Anti-nuclear antibody ,Single Case ,Azathioprine ,Autoimmune hepatitis ,RC799-869 ,Gastroenterology ,Maintenance therapy ,Internal medicine ,medicine ,Acute hepatitis ,medicine.diagnostic_test ,biology ,business.industry ,Centrilobular necrosis ,Jaundice ,Diseases of the digestive system. Gastroenterology ,medicine.disease ,Liver biopsy ,biology.protein ,medicine.symptom ,Antibody ,business ,Immunoglobulin G4-hepatopathy ,medicine.drug - Abstract
A 69-year-old man presented with jaundice and appetite loss. Blood analyses showed elevated aminotransferase levels, hyperbilirubinemia, positivity for antinuclear antibody, elevated immunoglobulin (Ig) G4 levels, and negativity for hepatitis virus markers. Additionally, computed tomography revealed a focal enlargement of the pancreatic body and enhancement of the peripheral bile ducts. Liver biopsy showed interface hepatitis, supporting a clinical diagnosis of autoimmune hepatitis (AIH). Immunohistochemistry revealed that IgG4-bearing plasma cells accounted for more than 60% of the IgG-bearing plasma cells in the portal area. Then, we started oral prednisolone therapy. After tapering, serum transaminase levels became elevated again, and we had to adjust the dose. Azathioprine maintenance therapy was necessary to prevent relapse. We herein report a case of IgG4-hepatopathy with a clinical course similar to that of AIH with acute onset.
- Published
- 2021
10. Mechanical Thrombectomy for Acute Middle Cerebral Artery Occlusion Caused by Tumor Embolism: A Case Report
- Author
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Masami Nishio, Takuya Moriyama, Yuki Akazawa, Yuri Sugiura, Yuto Hayashi, Masayuki Moriya, Shiro Adachi, Ryohei Yamamura, Fukuaki Kinoshita, Chikao Tatsumi, Kazuyuki Nagatsuka, Masahiro Ishihara, and Hiromi Tamura
- Subjects
medicine.medical_specialty ,business.industry ,Tumor Embolism ,medicine.disease ,Mechanical thrombectomy ,Internal medicine ,medicine ,Cardiology ,Neurology (clinical) ,Middle cerebral artery occlusion ,Cardiology and Cardiovascular Medicine ,Lung cancer ,business ,Stroke - Published
- 2021
11. Perspective Chapter: Mountain Health Care Room
- Author
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Kuniyo, Maitani, Yoko, Takeuchi, Ayano, Miyazaki, Mitsue, Iso, Hiromi, Tamura, Katsumi, Yamase, Haruko, Ida, Yuki, Kamatani, Noriko, Suzuki, Kanae, Taniguchi, Kanako, Kawagata, and Takako, Kajii
- Abstract
The Kinjo University Faculty of Nursing has been running a project since 2017 as part of its community collaboration activities to help Hakusanroku residents maintain good health. First, we opened the Mountain Health Care Room for community salon participants and conducted a basic survey of Hakusanroku healthcare supporters and community residents. We then provided health education and recreational activities to help older adults maintain good health. Since 2020, we have been unable to hold community activities due to the COVID-19 pandemic, and have been attempting to determine the day-to-day circumstances of residents. In addition to in-person community activities, there is a need for new initiatives such as online activities to help people connect and help older adults living in Hakusanroku to maintain good health.
- Published
- 2022
12. Lymphangioleiomyoma of the Uterus and Pelvic Lymph Nodes
- Author
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Ryoko Takahashi, Minori Ogawa, Tomoko Tsujie, Shiro Adachi, Susumu Yoshida, Hiromi Tamura, Kanako Tsurunaga, Reina Nakajima, Kayo Ikeda, Akinori Wakimoto, Chie Nakamura, Hiroka Ando, Yuko Watanabe, and Reiko Doi
- Subjects
0301 basic medicine ,Pathology ,medicine.medical_specialty ,government.form_of_government ,medicine.medical_treatment ,Uterus ,Pathology and Forensic Medicine ,Metastasis ,03 medical and health sciences ,Tuberous sclerosis ,0302 clinical medicine ,medicine ,Humans ,Lymphangioleiomyomatosis ,Incidental Findings ,Hysterectomy ,business.industry ,Obstetrics and Gynecology ,Middle Aged ,medicine.disease ,Lymphatic Endothelium ,030104 developmental biology ,Lymphatic system ,medicine.anatomical_structure ,Lymphatic Metastasis ,030220 oncology & carcinogenesis ,Uterine Neoplasms ,government ,Female ,Lymph ,business - Abstract
We present 3 cases of extrapulmonary lymphangioleiomyomatosis (LAM) identified incidentally in the uterine corpus and pelvic nodes resected for other reasons. One patient, a 47-yr-old female with corpus cancer, underwent a total hysterectomy and nodal dissection; the other 2 patients, aged 44 and 49 yr, underwent simple hysterectomy for corpus leiomyomas. None of the patients had evidence of tuberous sclerosis complex or any significant lesions in other organs. An area of spindle cell proliferation, intimately associated with dilated and tortuous lymphatic vessels, was found in the myometrium of all 3 patients, and nodal involvement with spindle cell proliferation was observed in the patient with corpus cancer. The spindle cells had faintly eosinophilic cytoplasm and a bland appearance. They were immunoreactive for α-SMA, gp100 (HMB45), and Melan-A. Tumor cell clusters lined with a single layer of lymphatic endothelium were floating in the lymphatic vessel lumen. These lesions were diagnosed as lymphangioleiomyoma in the uterine corpus and associated lymph nodes. Two of the cases seemed to be the earliest manifestations of extrapulmonary LAM, and the other case represents early-phase metastasis of LAM from the uterus. The present cases support the speculation that the uterus is the primary source of LAM cells.
- Published
- 2020
13. A case of a huge mandibular tumor composed of ameloblastoma and high-grade sarcoma
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Hiroka Ando, Shusuke Okunaga, Shiro Adachi, Tetsuro Sumi, Hiromi Tamura, Ken Wakabayashi, Masakazu Hamada, and Yusei Fujita
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Pathology ,medicine.medical_specialty ,business.industry ,Mandible ,Autopsy ,030206 dentistry ,medicine.disease ,High-Grade Sarcoma ,Pathology and Forensic Medicine ,03 medical and health sciences ,MANDIBULAR TUMOR ,0302 clinical medicine ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,medicine ,Neoplasm ,Surgery ,Sarcoma ,Spindle cell sarcoma ,Oral Surgery ,Ameloblastoma ,business - Abstract
Ameloblastoma is a benign odontogenic tumor of the jaw. Sarcoma is a rare neoplasm that accounts for only about 1% of all tumors. Here, we report a quite rare case of simultaneous occurrence of an ameloblastoma and a high-grade sarcoma in the mandible of a 65-year-old man. He was referred to our hospital because of his difficulties in eating and drinking due to a remarkable swelling of the right mandible. He had first noticed the swelling about six years before and consulted a clinic one year before, but he had refused any examination or treatment. He underwent an incisional biopsy, and it revealed a high-grade spindle cell sarcoma with massive necrosis. Therefore, we suggested surgery, but he had never hoped any operation. His poor nutritional status gradually further declined, and he died due to massive hemorrhage from the tumor. In the autopsy, the histological findings revealed that the tumor was predominantly composed of high-grade spindle cell sarcoma and contained a small amount of epithelial component which was a granular cell variant of ameloblastoma. Metastatic tumors were seen in the bilateral lungs and the liver. They contained only the sarcomatous element.
- Published
- 2019
14. Combined Intestinal Adenomas/Microcarcinoids
- Author
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Shiro Adachi, Hiroka Ando, Hiromi Tamura, and Reiko Doi
- Subjects
medicine.medical_specialty ,business.industry ,Gastroenterology ,Carcinoid ,digestive system diseases ,Neuroendocrine tumor ,Internal medicine ,Medicine ,Combined intestinal adenoma-microcarcinoid ,Microcarcinoid ,Large intestine ,lcsh:Diseases of the digestive system. Gastroenterology ,lcsh:RC799-869 ,business - Abstract
The combined colonic adenoma/microcarcinoid tumor is a rare intestinal neoplasm featuring intermingled adenomatous and carcinoid components. A few case reports and small case series have suggested that this entity exhibits an indolent clinical course. Here, we report two cases with these tumors, and describe the morphological features and clinical follow-up. A 61-year-old male and 78-year-old male presented with heme-positive stools at their medical checkups. Colonoscopy revealed masses in the colons; we performed endoscopic mucosal resection. Both lesions featured low-grade adenomas and low-grade neuroendocrine tumors. We diagnosed combined colonic adenomas/microcarcinoids. The clinical courses of both patients were benign at follow-up at 2.5 and 6 years. Awareness of this rare colonic tumor should prevent potential diagnostic pitfalls and may help clarify the natural history of these tumors and their possible relationships with composite glandular/carcinoid tumors.
- Published
- 2019
15. Follicular cholangitis mimicking cholangiocarcinoma treated with right hepatectomy: A case report and review of published works
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Hiromi Tamura, Tsutomu Nishida, Shingo Noura, Hiroshi Imamura, Shiro Adachi, Keizo Dono, Li-Sa Chang, Tokuhiro Matsubara, Kozo Noguchi, Ryo Yoshioka, and Yoshito Tomimaru
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Pathology ,medicine.medical_specialty ,Hepatology ,business.industry ,Bile duct ,medicine.medical_treatment ,Germinal center ,Malignancy ,medicine.disease ,Infectious Diseases ,medicine.anatomical_structure ,Follicular phase ,medicine ,Differential diagnosis ,Hepatectomy ,business ,Intrahepatic Cholangiocarcinoma ,Rare disease - Abstract
Follicular cholangitis is a new, rare disease that causes severe biliary stricture. We herein describe the findings from a resected case of follicular cholangitis, suggesting a distinct disease entity that causes benign biliary stricture. A 60-year-old man who was referred to our hospital due to elevated γ-glutamyl transpeptidase levels and dilatation of the B8 bile duct. Although bile juice cytology and bile duct brushing cytology showed no malignancy, the dilatation was progressive. Therefore, right hepatectomy combined with caudate lobectomy was carried out on suspicion of intrahepatic cholangiocarcinoma. The wall of the resected bile duct was markedly thickened due to severe fibrosis under the mucosal layer. Histology of the mucosal epithelium indicated no malignancy. Infiltration of plasma cells characterized by remarkable formation of lymphoid follicles with germinal centers was observed around the bile ducts. The patient was diagnosed with follicular cholangitis based on histological findings. We thus observed a rare case of follicular cholangitis. This case and review of published reports suggest that, despite its rarity, follicular cholangitis should be considered at the differential diagnosis of biliary stricture. This case report could contribute to a better understanding of how to address this disease.
- Published
- 2019
16. [Long-Term Survival after Surgical Treatment of Neuroendocrine Carcinoma of the Ampulla of Vater-A Case Report]
- Author
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Ryo, Yoshioka, Yoshito, Tomimaru, Kozo, Noguchi, Hirotsugu, Nagase, Takayuki, Ogino, Masashi, Hirota, Kazuteru, Oshima, Tsukasa, Tanida, Shingo, Noura, Hiroshi, Imamura, Takashi, Iwazawa, Kenzo, Akagi, Hiromi, Tamura, Shiro, Adachi, and Keizo, Dono
- Subjects
Male ,Ampulla of Vater ,Time Factors ,Common Bile Duct Neoplasms ,Humans ,Neoplasm Recurrence, Local ,Carcinoma, Neuroendocrine ,Pancreaticoduodenectomy - Abstract
A 60s man underwent upper gastrointestinal endoscopy at a regular medical check-up without symptoms, which showed an ulcerative region in the duodenal ampulla, measuring 3 cm in diameter. He was diagnosed with poorly differentiated adenocarcinoma on biopsy and referred to our hospital. Abdominal contrast-enhanced CT scan revealed an enhanced-ulcerative tumor, measuring 3 cm, at the duodenal ampulla. After the preoperative diagnosis of adenocarcinoma of the duodenal ampulla, subtotal stomach-preserving pancreatoduodenectomy with regional lymph node dissection was performed. The final diagnosis was neuroendocrine carcinoma(NEC)of the duodenal ampulla. He has been alive for 9 years with no recurrences. NEC of the duodenal ampulla is rare, and its prognosis is poor. We report a case of long-term survival after resection of NEC of the duodenal ampulla.
- Published
- 2020
17. [A Rare Case of Adenosquamous Carcinoma in the Liver with Hepatolithiasis]
- Author
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Takashi, Harino, Yoshito, Tomimaru, Kozo, Noguchi, Hirotsugu, Nagase, Takayuki, Ogino, Masashi, Hirota, Kazuteru, Oshima, Tsukasa, Tanida, Shingo, Noura, Hiroshi, Imamura, Kenzo, Akagi, Takashi, Iwazawa, Hiromi, Tamura, Shiro, Adachi, and Keizo, Dono
- Subjects
Cholangiocarcinoma ,Male ,Carcinoma, Adenosquamous ,Bile Ducts, Intrahepatic ,Bile Duct Neoplasms ,Humans ,Aged - Abstract
This report describes a case of primary adenosquamous carcinoma of the liver with hepatolithiasis. A 70's man was followed up at a clinic for hepatolithiasis, gallbladder stone, and dilatation of the intrahepatic duct. He visited our hospital for computed tomography(CT)examination. CT showed a 30mm diameter low-density mass in the S2 liver and dilatation of the intrahe- patic duct filled with hepatolithiasis. Blood examination showed elevated levels of tumor markers(CEA 8.0 ng/mL, CA19-9 19,196 U/mL). We diagnosed the tumor as cholangiocellular carcinoma(cT2N1M0, cStage ⅣA)with hepatolithiasis and performed left hepatectomy and lymphadenectomy. In the specimen, a 39×22mm diameter solid tumor was detected and the intrahepatic duct was filled with haptolithiasis. Pathologically, a mixture of adenocarcinoma and squamous cell carcinoma was observed adjacent to the bile duct. Accordingly, a diagnosis of adenosquamous carcinoma was made(pT3N0M0, pStage Ⅲ). Multiple liver metastases were detected 8 months after the operation, and chemotherapy was started. He remains alive 11 months after the operation. We experienced a rare case of adenosquamous carcinoma in the liver with hepatolithiasis.
- Published
- 2019
18. [A Resected Case of Reactive Lymphoid Hyperplasia of the Liver Preoperatively Diagnosed as Hepatocellular Carcinoma]
- Author
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Ryo, Yoshioka, Yoshito, Tomimaru, Kozo, Noguchi, Hirotsugu, Nagase, Takayuki, Ogino, Masashi, Hirota, Kazuteru, Oshima, Tsukasa, Tanida, Shingo, Noura, Hiroshi, Imamura, Takashi, Iwazawa, Kenzo, Akagi, Hiromi, Tamura, Shiro, Adachi, and Keizo, Dono
- Subjects
Carcinoma, Hepatocellular ,Pseudolymphoma ,Liver Neoplasms ,Humans ,Female ,Neoplasm Recurrence, Local - Abstract
A60s woman was followed-up regularly for primary biliary cholangitis and a solitary enlarging hepatic mass in the S6 segment of her liver was discovered by ultrasonography. We diagnosed the mass as hepatocellular carcinoma by contrast ultrasonography, contrast computed tomography, and ethoxbenzyl magnetic resonance imaging and laparoscopic partial hepatectomy of S6 segment was performed. The resected specimen was histopathologicaly diagnosed as liver-reactive lymphoid hyperplasia(RLH). The patient is alive without recurrence 17 months after the surgery. Although liver RLH is a rare disease, it should be considered in the differential diagnosis of small liver tumors.
- Published
- 2019
19. [A Case of Unresectable Advanced Gastric Neuroendocrine Cell Carcinoma Treated with Nivolumab]
- Author
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Ryo, Yoshioka, Hirotsugu, Nagase, Kozo, Noguchi, Atsushi, Hamabe, Masashi, Hirota, Kazuteru, Oshima, Tsukasa, Tanida, Takayuki, Ogino, Yoshito, Tomimaru, Tomono, Kawase, Shingo, Noura, Hiroshi, Imamura, Takashi, Iwasawa, Kenzo, Akagi, Hiroka, Ando, Hiromi, Tamura, Shiro, Adachi, and Keizo, Dono
- Subjects
Male ,Antineoplastic Agents, Immunological ,Fatal Outcome ,Nivolumab ,Stomach Neoplasms ,Humans ,Bone Neoplasms ,Combined Modality Therapy ,Aged ,Carcinoma, Neuroendocrine - Abstract
A 69-year-old man was administered S-1/oxaliplatin/trastuzumab as induction chemotherapy for advanced gastric cancer (cT4b[liver, pancreas], N2M1(H1P0CYX), cStage IV). After 4 courses, because contrast-enhanced computed tomography showed remarkable reduction of the tumor, distal gastrectomy, partial hepatectomy, and radiofrequency ablation for the liver metastasis were performed. The patient was histopathologically diagnosed with gastric neuroendocrine carcinoma(NEC). S- 1/oxaliplatin/trastuzumab was continued after surgery; however, recurrence in the remnant liver was observed after 4 cours- es. For recurrence, cisplatin/irinotecan as first-line and paclitaxel/ramucirumab as second-line treatment were administered, but progression of liver metastasis and ascites due to peritoneal dissemination were observed. As third-line treatment, nivolumab was initiated. Ascites decreased after 3 courses, but after 2 more courses, progression of ascites, liver recurrence, and multiple metastasis in the lumbar vertebra were observed.
- Published
- 2018
20. A case of intraductal papillary-mucinous neoplasm of the pancreas penetrating into the stomach and spleen successfully treated by total pancreatectomy
- Author
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Yoshito Tomimaru, Takayuki Ogino, Tsutomu Nishida, Hiromi Tamura, Kazuteru Oshima, Masashi Hirota, Hiroshi Imamura, Takashi Harino, Masashi Yamamoto, Keizo Dono, Takashi Iwazawa, Kozo Noguchi, Hirotsugu Nagase, Shiro Adachi, Kenzo Akagi, Tsukasa Tanida, and Shingo Noura
- Subjects
Pathology ,medicine.medical_specialty ,Abdominal pain ,Fistula ,medicine.medical_treatment ,Splenectomy ,lcsh:Surgery ,Intraductal papillary-mucinous neoplasm ,Penetration ,Malignancy ,03 medical and health sciences ,0302 clinical medicine ,Carcinoma ,Medicine ,Pancreas ,Pancreatic duct ,Intraductal papillary mucinous neoplasm ,business.industry ,Stomach ,lcsh:RD1-811 ,medicine.disease ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,medicine.symptom ,business - Abstract
Background Intraductal papillary-mucinous neoplasms (IPMNs) are potentially malignant intraductal epithelial neoplasms that sometimes penetrate into other organs. To the best of our knowledge, no report has yet described a case with penetration into the spleen. We recently encountered a case of IPMN with penetration of the stomach and spleen that was successfully treated by total pancreatectomy. Case presentation A 70-year-old female visited our hospital with a complaint of fever and abdominal pain. Contrast-enhanced computed tomography (CT) revealed dilatation of the main pancreatic duct in the entire pancreas and penetration into the stomach and spleen. Upper gastrointestinal endoscopy revealed mucin extruding from four openings of the fistula in the stomach. No malignancy was detected based on cytology of the mucin. Inflammation markers and tumor markers (CEA, CA19–9) were elevated in the blood. The pre-operative diagnosis was IPMN of main pancreatic duct type penetrating into the stomach and spleen. A total pancreatectomy and splenectomy were performed, combined with distal gastrectomy including resection of the fistulas between the pancreas and stomach. No postoperative complications were noted. Histopathological examination of the resected specimen revealed atrophy of the pancreatic parenchyma, and the main duct of the pancreas was filled with mucin. Mucin-producing malignant tumor cells were detected in the epithelium of the main pancreatic duct with no signs of invasion. No malignancy was found at the fistulas between the pancreas and stomach or spleen. The patient was finally diagnosed with non-invasive intraductal papillary-mucinous carcinoma (IPMC) of main pancreatic duct type. Mechanical penetration was suspected as a mechanism of the penetration. The patient remained disease-free without evidence of recurrence more than 15 months after the operation. Conclusion Though IPMNs sometimes penetrate into other adjacent organs, penetration into two organs, including the spleen, is rare. The rare case of IPMC penetrating into the stomach and spleen presented here was treated successfully by total pancreatectomy.
- Published
- 2018
21. Polypoid extrahepatic bile duct carcinoma morphologically indistinguishable from benign giant cell tumor
- Author
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Reiko Doi, Hiromi Tamura, and Shiro Adachi
- Subjects
Pathology ,medicine.medical_specialty ,business.industry ,General Medicine ,Bile Duct Neoplasm ,Jaundice ,medicine.disease ,Pathology and Forensic Medicine ,03 medical and health sciences ,0302 clinical medicine ,Giant cell ,030220 oncology & carcinogenesis ,Calcium-binding protein ,medicine ,Carcinoma ,030211 gastroenterology & hepatology ,Giant Cell Tumors ,Differential diagnosis ,medicine.symptom ,business ,Extrahepatic bile duct carcinoma - Published
- 2015
22. Mesonephric adenocarcinoma of the uterine corpus with intracystic growth completely confined to the myometrium: a case report and literature review
- Author
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Akinori Wakimoto, Mitsunori Shioji, Tomoko Tsujie, Reiko Doi, Mayumi Fujitani, Kayo Ikeda, Hiromi Tamura, Minori Ogawa, Yuko Watanabe, Tomomi Deguchi, Shiro Adachi, and Hiroka Ando
- Subjects
0301 basic medicine ,Pathology ,medicine.medical_specialty ,Histology ,Mesonephric Adenocarcinoma ,Case Report ,Histogenesis ,Biology ,Adenocarcinoma ,Tubular Pattern ,Pathology and Forensic Medicine ,Mesonephric duct ,03 medical and health sciences ,0302 clinical medicine ,Uterine corpus ,lcsh:Pathology ,medicine ,Mesonephroma ,Humans ,Mesonephric Remnants ,Intracystic growth ,Myometrium ,General Medicine ,Anatomy ,Middle Aged ,medicine.disease ,030104 developmental biology ,030220 oncology & carcinogenesis ,Uterine Neoplasms ,Female ,Mesonephric adenocarcinoma ,PAX8 ,lcsh:RB1-214 - Abstract
Background Mesonephric adenocarcinoma (MA) is a rare tumor believed to arise from mesonephric remnants occurring mostly in the uterine cervix and, to a lesser extent, the corpus. Since the first case report of MA in the corpus in 1995, only 16 cases have been reported in the English literature. A recent report suggested that MA originates in Müllerian tissue and exhibits the mesonephric differentiation phenotype. Case presentation An asymptomatic 61-year-old woman was referred to our hospital because of elevated levels of tumor markers. Imaging revealed an intramural lesion of the uterine corpus exhibiting fluorodeoxyglucose uptake. A total hysterectomy and bilateral salpingo-oophorectomy were performed. The tumor was completely confined to the corpus wall and was composed of an intracystic bulky component and an invasive component in the myometrial layer. The tumor exhibited a variety of growth patterns, including a characteristic tubular pattern with dense eosinophilic secretion reminiscent of the thyroid, as well as a variety of morphologies, such as acinar, papillary, and ductal structures. The structures were immunoreactive for CK7, vimentin, CD10, calretinin, PAX8, and GATA3 and almost completely negative for ER/PgR. CA125 and CA19–9 antigen expression was also detected. Conclusion A case of MA with a unique growth pattern of an intracystic mass within the corpus wall is presented. The histogenesis and differential diagnoses are discussed. The histogenesis of MA is not yet clear. We hypothesize two different pathways involved: 1) direct development from the mesonephric remnants and/or 2) mesonephric transformation of Müllerian adenocarcinoma.
- Published
- 2017
23. Pancreatic intraductal tubulopapillary neoplasm with associated invasive cancer successfully treated by total pancreatectomy: A case report
- Author
-
Takashi Iwazawa, Hiroshi Imamura, Shiro Adachi, Keizo Dono, Yoshito Tomimaru, Tsutomu Nishida, Kenzo Akagi, Atsushi Hamabe, Tsukasa Tanida, Kazuteru Oshima, Tomono Kawase, Masashi Yamamoto, Masashi Hirota, Yuji Fujimoto, Hiromi Tamura, Hirotsugu Nagase, Shunji Morita, and Kozo Noguchi
- Subjects
Pancreatic duct ,Cancer Research ,Pathology ,medicine.medical_specialty ,intraductal tubulopapillary neoplasm ,Pancreatic Intraductal Tubulopapillary Neoplasm ,intraductal neoplasm ,pancreatic cancer ,Articles ,Biology ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Oncology ,Accessory pancreatic duct ,Dysplasia ,Pancreatic tumor ,030220 oncology & carcinogenesis ,Pancreatic cancer ,medicine ,Adenocarcinoma ,030211 gastroenterology & hepatology ,pancreas ,Pancreas - Abstract
A 74-year-old male was admitted to Departments of Surgery, Toyonaka Municipal Hospital (Osaka, Japan) for treatment of a pancreatic tumor. Contrast enhanced computed tomography (CT) revealed a mass with small cystic lesions in the pancreatic head and body. Fluorodeoxyglucose-positron emission tomography/CT revealed an abnormal uptake of fluorodeoxyglucose, corresponding to the mass lesions. Upper gastrointestinal endoscopy revealed rough mucosa near the opening of the accessory pancreatic duct, and the mucosa biopsy exhibited adenocarcinoma with no mucin observed. The preoperative diagnosis was pancreatic intraductal tubulopapillary neoplasm (ITPN) with cancerous lesions, and a total pancreatectomy with splenectomy was performed. The resected tissue specimen revealed a solid tumor occupying the entire pancreas with intraductal growth into the main pancreatic duct. Histological examination revealed high-grade dysplastic cells in a tubulopapillary growth pattern without overt mucin production beyond the pancreatic duct. Immunohistochemical staining analysis of the tumor was positive for cytokeratin (CK)7, CK19 and mucin (MUC)1, and negative for MUC2, MUC5AC, MUC6 and caudal type homeobox 2. The tumor was finally diagnosed as pancreatic ITPN with associated invasive cancer. The patient remains well without evident recurrence nine months post-surgery. ITPN is a rare type of epithelial neoplasm of the pancreas, and is characterized by intraductal tubulo-papillary growth, ductal differentiation, limited intracellular mucin production, and cellular dysplasia. The present case report may contribute to improved understanding of how to effectively treat patients with ITPN.
- Published
- 2016
24. GVHD PROPHYLAXIS USING TACROLIMUS ALONE FOLLOWING REDUCED-INTENSITY CORD BLOOD TRANSPLANTATION IN ADULT PATIENTS: RETROSPECTIVE ANALYSIS OF 39 PATIENTS WITH SPECIAL ATTENTION TO SERUM CONCENTRATION OF TACROLIMUS
- Author
-
Atsushi Wake, Naofumi Matsuno, Tadaaki Ito, Yuki Mori, Shinsuke Takagi, Hiromi Tamura, Shinobu Hasebe, Masahiro Hayashi, Masako Furusawa, Kanako Ino, Shuichi Taniguchi, Hisashi Yamamoto, Yuri Okuno, Yumiko Uchida, Izumi Nasu, Masanori Tuji, Kazuhiro Masuoka, Mayumi Minowa, Shigesaburo Miyakoshi, Shigeyoshi Makino, and Naoyuki Uchida
- Subjects
Adult patients ,business.industry ,Anesthesia ,Retrospective analysis ,Medicine ,Gvhd prophylaxis ,Reduced intensity ,Serum concentration ,business ,Cord blood transplantation ,Tacrolimus - Published
- 2010
25. Relationships between the Molecular Structure of Lignins and the Performance of the Negative Plates of Lead-Acid Batteries
- Author
-
Masayuki Terada, Masamitsu Funaoka, Takayuki Kimura, and Hiromi Tamura
- Subjects
Chemical engineering ,Chemistry ,Molecule ,Lead–acid battery - Published
- 2007
26. Identification of genes whose expressions are enhanced or reduced in baker's yeast during fed-batch culture process using molasses medium by DNA microarray analysis
- Author
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Seigo Kuwazaki, Hiromi Tamura, Ryoichi Nakajima, Yamamoto Hideki, Jun Shima, Tadaaki Tokashiki, Hajime Watanabe, and Fumiko Tanaka
- Subjects
Saccharomyces cerevisiae ,Formate dehydrogenase ,Microbiology ,chemistry.chemical_compound ,Gene Expression Regulation, Fungal ,Molasses ,Sugar ,Oligonucleotide Array Sequence Analysis ,biology ,Fungal genetics ,RNA, Fungal ,General Medicine ,Maltose ,Hydrogen-Ion Concentration ,biology.organism_classification ,Yeast ,Culture Media ,Fed-batch culture ,chemistry ,Biochemistry ,Fermentation ,Food Microbiology ,Food Technology ,Food Science - Abstract
Genes whose expression levels are enhanced or reduced during the cultivation process that uses cane molasses in baker's yeast production were identified in this study. The results showed that baker's yeast grown in molasses medium had higher fermentation ability and stress tolerance compared with baker's yeast grown in synthetic medium. Molasses apparently provided not only sugar as a carbon source but also provided functional components that enhanced or reduced expression of genes involved in fermentation ability and stress tolerance. To identify the genes whose expression is enhanced or reduced during cultivation in molasses medium, DNA microarray analysis was then used to compare the gene expression profile of cells grown in molasses with that of cells grown in synthetic medium. To simulate the commercial baker's yeast production process, cells were cultivated using a fed-batch culture system. In molasses medium, genes involved in the synthesis or uptake of vitamins (e.g., biotin, pyridoxine and thiamine) showed enhanced expression, suggesting that vitamin concentrations in molasses medium were lower than those in synthetic medium. Genes involved in formate dehydrogenase and maltose assimilation showed enhanced expression in molasses medium. In contrast, genes involved in iron utilization (e.g., siderophore, iron transporter and ferroxidase) showed enhanced expression in synthetic medium, suggesting that iron starvation occurred. The genes involved in the metabolism of amino acids also showed enhanced expression in synthetic medium. This identification of genes provides information that will help improve the baker's yeast production process.
- Published
- 2005
27. Esophageal carcinoma originating in the surface epithelium with immunohistochemically proven esophageal gland duct differentiation: A case report
- Author
-
Hiroka Ando, Reiko Doi, Hiromi Tamura, Shiro Adachi, Tsutomu Nishida, Hirotsugu Saiki, Takahiro Amano, Katsumi Yamamoto, Shiro Hayashi, and Masashi Yamamoto
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Esophageal Mucosa ,Esophageal Neoplasms ,Bilayered structure ,Biopsy ,Case Report ,Adenocarcinoma ,Epithelium ,Endosonography ,03 medical and health sciences ,0302 clinical medicine ,Keratinizing Squamous Cell Carcinoma ,medicine ,Carcinoma ,Humans ,Esophagus ,Esophageal glands ,medicine.diagnostic_test ,business.industry ,Gastroenterology ,Cell Differentiation ,Chemoradiotherapy, Adjuvant ,General Medicine ,Middle Aged ,medicine.disease ,Immunohistochemistry ,Carcinoembryonic Antigen ,medicine.anatomical_structure ,Esophageal gland duct ,030220 oncology & carcinogenesis ,Carcinoma, Squamous Cell ,030211 gastroenterology & hepatology ,Esophagoscopy ,Esophageal adenocarcinoma ,business ,Duct (anatomy) - Abstract
A case of esophageal carcinoma exclusively composed of adenocarcinoma simulating an esophageal gland duct in a 61-year-old man is presented. The tumor arose as a slightly elevated lesion in the middle intrathoracic esophagus. It was almost completely overlaid with non-neoplastic stratified squamous epithelial cells. Beneath the overlying surface epithelium, an adenocarcinoma that was bilayered in structure diffusely invaded both the mucosal and submucosal layers. Although the tumor consisted exclusively of adenocarcinomatous cells, a keratinizing squamous cell carcinoma component was focally observed. The invasive carcinoma was focally continuous with the small area of the surface squamous epithelial layer, which was confirmed to be neoplastic by immunohistochemistry. Morphological and immunohistochemical examinations suggested that the adenocarcinomatous component arose from the esophageal surface epithelium and clearly differentiated into an esophageal gland duct. It is important to consider the possibility of this type of adenocarcinoma when diagnosing a ductal or glandular lesion of the esophagus in small biopsy specimens.
- Published
- 2017
28. A STUDY ON THE EVALUATION STRUCTURE OF THE ENVIRONMENTAL RESOURCES : The method of the town planning to succeed 'the context of the community'
- Author
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Susumu Tago and Hiromi Tamura
- Subjects
Structure (mathematical logic) ,Engineering ,business.industry ,Environmental resource management ,Context (language use) ,business ,Environmental resource ,Town planning - Published
- 2001
29. A Practical Study of the Town Reconstruction Based on the Context of the Pre-Earthquake Community
- Author
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Hiromi Tamura and Kohhei Doi
- Published
- 1999
30. THE ESTABLISHMENT OF THE URBAN DESIGN SYSTEM IN THE CENTER OF SHANGHAI : The international collaboration between Japan and China to draw up the general planning of roadside landscape along Nanjingxilu
- Author
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Hiromi TAMURA, Ming FANG, Takue SAKAI, Mugi TERAYAMA, Kohhei DOI, and Yosisada HISAMOTO
- Subjects
Architecture ,Building and Construction - Published
- 1999
31. Evaluation of contrast-enhanced ultrasonography using perfluorobutane (Sonazoid®) in patients with small hepatocellular carcinoma: comparison with dynamic computed tomography
- Author
-
Satoshi Hidaka, Akihiro Kodama, Masanori Abe, Miki Kan, Hiromasa Nakahara, Tomoyuki Ninomiya, Atsushi Hiraoka, Misa Ichiryu, Yasuyuki Miyamoto, Morikazu Onji, Hironori Ochi, Kojiro Michitaka, Takahide Uehara, Yoichi Hiasa, Chieko Kameoka, Keizou Furuya, Hiromi Tamura, Atsushi Tanabe, Aki Hasebe, Shigekazu Doi, Yuki Shinbata, and Bunzo Matsuura
- Subjects
Cancer Research ,medicine.medical_specialty ,medicine.diagnostic_test ,Perfluorobutane ,business.industry ,Cancer ,Computed tomography ,Articles ,HCCS ,medicine.disease ,Chronic liver disease ,digestive system diseases ,chemistry.chemical_compound ,Oncology ,chemistry ,Hepatocellular carcinoma ,medicine ,Atypical adenomatous hyperplasia ,Radiology ,Ultrasonography ,business ,neoplasms - Abstract
This study aimed to elucidate the efficacy of contrast-enhanced ultrasonography (CEUS) with perfluorobutane (Sonazoid(®)) in the diagnosis of hepatocellular carcinomas (HCCs), particularly small HCCs, by comparing the results with dynamic computed tomography (Dy-CT). Seventy-nine nodules in 69 patients with chronic liver disease, suspected as HCCs were studied. The nodules were selected based on the results of B-mode ultrasonography and/or Dy-CT conducted between January and August 2007. The nodules were divided into two groups: the S-group with tumors ≤2 cm (49 nodules), and the L-group with tumors >2 cm (30 nodules). Typical HCCs were defined, and the nodules were enhanced and shown as defects in the arterial and late phase of Dy-CT, respectively. Target lesions were scanned using CEUS, and the results were compared with those of Dy-CT. The L-group nodules diagnosed as HCCs using Dy-CT were also diagnosed as HCCs using CEUS. In the S-group, the diagnostic sensitivity of CEUS was 94.7% and the specificity was 81.8%. We diagnosed two liver tumors that were detected by CEUS but not by Dy-CT; biopsies revealed one tumor to be a well-differentiated HCC and the other to be an atypical adenomatous hyperplasia. The sensitivity and specificity of CEUS against HCC were high even in the small-size HCCs. Thus, Sonazoid is useful in the screening for small HCCs.
- Published
- 2010
32. [Analysis of blood concentrations following oral administration of beclomethasone dipropionate for gut GVHD]
- Author
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Tadaaki, Ito, Kaori, Watanabe, Izumi, Nasu, Kanako, Ino, Mayumi, Minowa, Masako, Furusawa, Yuri, Okuno, Yumiko, Uchida, Yoko, Miyazaki, Hiromi, Tamura, Shinobu, Hasebe, Shinsuke, Takagi, Hisashi, Yamamoto, Naofumi, Matsuno, Naoyuki, Uchida, Kazuhiro, Masuoka, Atsushi, Wake, Shigeyoshi, Makino, Shuichi, Taniguchi, and Masahiro, Hayashi
- Subjects
Adult ,Male ,Intestinal Diseases ,Intestinal Absorption ,Anti-Inflammatory Agents ,Beclomethasone ,Administration, Oral ,Graft vs Host Disease ,Humans ,Female ,Middle Aged ,Aged - Abstract
In this study, we investigated the level of gut absorption following oral beclomethasone dipropionate (BDP) administration by measuring the blood concentration of its metabolites measured by LC-MS/MS using the HPLC method. Five patients who were administered BDP orally for gut GVHD were included. The blood concentrations of beclomethasone-17-monopropionate (17BMP), which is one of the active metabolites of BDP, were 618 approximately 1, 749 pg/mL in 4 of the studied 5 patients, which was comparable to that after inhalation of BDP; however, it was relatively higher in one patient (2,439+/-161 pg/mL). As the blood concentration of 17BMP in this study patient was higher compared with healthy volunteers administered a single oral BDP 4 mg, GVHD patients might have a higher concentration than healthy volunteers. Given that a higher grade of gut GVHD was associated with a higher blood level of 17BMP, BDP absorption might be associated with gut mucosal injury. Thus, the systemic adverse effect following oral BDP administration might not be negligible especially in gut GVHD patients.
- Published
- 2010
33. Primitive neuroectodermal tumor of the pancreas
- Author
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Hirokazu Doi, Hiromasa Nakahara, Yasunao Miyamoto, Akihiro Kodama, Tomoyuki Ninomiya, Norio Horiike, Tadashi Hasegawa, Miki Kan, Atsushi Tanabe, Atsushi Hiraoka, Chieko Kameoka, Toshiharu Maeda, Hideki Kawasaki, Aki Hasebe, Seijin Seno, Yoshiko Soga, Soichi Ichikawa, Hiromi Tamura, Akinori Asaki, Misa Ichiryu, Kazuhito Takamura, Haruo Iguchi, Hironori Ochi, and Shigekazu Doi
- Subjects
Adult ,Male ,Vincristine ,Pathology ,medicine.medical_specialty ,CD99 ,EWING SARCOMA BREAKPOINT REGION 1 ,Drug Therapy ,Pancreatic tumor ,Internal Medicine ,medicine ,Humans ,Neuroectodermal Tumors, Primitive ,Etoposide ,Ifosfamide ,biology ,business.industry ,RNA-Binding Proteins ,General Medicine ,medicine.disease ,Pancreatic Neoplasms ,Primitive neuroectodermal tumor ,Positron-Emission Tomography ,Calmodulin-Binding Proteins ,Sarcoma ,biology.gene ,RNA-Binding Protein EWS ,business ,medicine.drug - Abstract
The primitive neuroectodermal tumor (PNET) of the pancreas, a member of Ewing's sarcoma family of tumors, is extremely rare. We treated a 37-year-old Japanese man who had a solitary pancreatic tumor 40 mm in diameter and multiple hepatic tumors with surgical resection. The PNET was positive for CD99 on immunohistochemical staining. Fluorescence in situ hybridization (FISH) was also performed, which revealed a Ewing sarcoma breakpoint region 1 (EWSR1) 22q12 rearrangement. According to the Japan-Ewing protocol, chemotherapy with Ifomide (ifosfamide), etoposide, vincristine, and cyclophosphamide was given after surgery. To the best of our knowledge, to date 13 PNET cases have been reported with a mean age for all patients of 19.3 years old. Surgical resection was performed in most cases and some patients received postoperative chemotherapy. The clinicopathologic characteristics and management of this extremely rare disease are also discussed.
- Published
- 2009
34. Chromosome deletions associated with hepatitis B virus integration
- Author
-
Kenichi Matsubara, Naohiro Hori, Takashi Tokino, and Hiromi Tamura
- Subjects
Hepatitis B virus ,Virus Integration ,Molecular Sequence Data ,Restriction Mapping ,medicine.disease_cause ,Genome ,chemistry.chemical_compound ,Restriction map ,Virology ,medicine ,Humans ,Gene ,Recombination, Genetic ,Genetics ,Base Sequence ,biology ,Chromosome ,biology.organism_classification ,Blotting, Southern ,Hepadnaviridae ,chemistry ,DNA, Viral ,Chromosome Deletion ,DNA - Abstract
Integrated hepatitis B virus (HBV) DNA is often found in hepatocellular carcinomas which develop in HBV carriers. We previously found that chromosomal abnormalities such as translocations and inversions are often associated with HBV integration. Here we report deletions that were found with three integrants, by comparing the physical maps of the flanking cellular DNA of the integrants with those of the unoccupied cellular sequences. The sizes of the deletions were 25, 12, and 11 kb, respectively. Each integrant carried only a small fragment of the viral genome, from which the cohesive end region, the preferred site of integration, was deleted. We speculate that these deletions were made from primary integrants by recombination of regions between the viral DNA and the flanking cellular sequence.
- Published
- 1991
35. Therapeutic Drug Monitoring
- Author
-
Tadaaki ITO, Yumiko UCHIDA, Hiromi TAMURA, Shinobu HASEBE, Masahiro IGARASHI, and Masahiro HAYASHI
- Subjects
Pharmacology ,Patient Care Team ,Pharmaceutical Science ,General Medicine ,Pharmacists ,Drug Administration Schedule ,Anti-Bacterial Agents ,Professional Role ,Risk Factors ,Vancomycin ,Pharmaceutical Services ,Antineoplastic Combined Chemotherapy Protocols ,Humans ,Clinical Competence ,Drug Monitoring - Abstract
Practicing pharmaceutical care is necessary to promote the appropriate use of medicines. In the practice of pharmaceutical care, monitoring the efficacy and safety of drugs from the pharmacists' point of view is an important role for clinical pharmacists and it is necessary to standardize clinical skills. We would like to introduce the monitoring skills of pharmacotherapy of clinical pharmacists by taking vancomycin injection and injectable anticancer drugs that have different monitoring points as examples.
- Published
- 2007
36. The Spread of Methicillin-ResistantStaphylococcus aureus in a Rural community: Will It Become a Common Microorganism Colonizing among the General Population?
- Author
-
Koh Kodama, Yoshiyuki Fujiwara, Hiromi Tamura, and Hiroyuki Kayaba
- Subjects
Rural Population ,Cross Infection ,Staphylococcus aureus ,medicine.medical_specialty ,education.field_of_study ,Rural community ,Isolation (health care) ,business.industry ,Population ,Hospitals, Community ,General Medicine ,medicine.disease_cause ,Methicillin-resistant Staphylococcus aureus ,Community hospital ,Japan ,Internal medicine ,Ambulatory Care ,medicine ,Humans ,Methicillin Resistance ,Surgery ,Intensive care medicine ,education ,business - Abstract
At Fujiwara Memorial Hospital (FMH), a community hospital with 140 beds located near a large agricultural area in Akita prefecture, the annual number of patients colonized with methicillin-resistant Staphylococcus aureus (MRSA) has been increasing in recent years. To elucidate the current status of MRSA spread, the frequency of its isolation among a total of 10598 bacteriological specimens obtained from patients treated at FMH between July 1989 and December 1994 was evaluated. The frequency increased from 3.8% in 1990 to 9.6% in 1994, and of all the patients colonized with MRSA, outpatients accounted for 4.5% in 1990 and 34.9% in 1994. These outpatients included patients from long-term care facilities, those cared for at home with chronic diseases, and those who had been hospitalized in tertiary general hospitals. This remarkable increase in the percentage of outpatients colonized with MRSA may suggest the spread of MRSA in our community.
- Published
- 1997
37. Pancreatic intraductal tubulopapillary neoplasm with associated invasive cancer successfully treated by total pancreatectomy: A case report.
- Author
-
YUJI FUJIMOTO, YOSHITO TOMIMARU, KOZO NOGUCHI, HIROTSUGU NAGASE, ATSUSHI HAMABE, MASASHI HIROTA, KAZUTERU OSHIMA, TSUKASA TANIDA, TOMONO KAWASE, SHUNJI MORITA, HIROSHI IMAMURA, TAKASHI IWAZAWA, KENZO AKAGI, KEIZO DONO, HIROMI TAMURA, SHIRO ADACHI, MASASHI YAMAMOTO, and TSUTOMU NISHIDA
- Subjects
PANCREATIC tumors ,PANCREATECTOMY ,CANCER invasiveness ,TUBULAR carcinoma ,IMMUNOSTAINING ,TUMOR treatment - Abstract
A 74‑year‑old male was admitted to Departments of Surgery, Toyonaka Municipal Hospital (Osaka, Japan) for treatment of a pancreatic tumor. Contrast enhanced computed tomography (CT) revealed a mass with small cystic lesions in the pancreatic head and body. Fluorodeoxyglucose‑positron emission tomography/CT revealed an abnormal uptake of fluorodeoxyglucose, corresponding to the mass lesions. Upper gastrointestinal endoscopy revealed rough mucosa near the opening of the accessory pancreatic duct, and the mucosa biopsy exhibited adenocarcinoma with no mucin observed. The preoperative diagnosis was pancreatic intraductal tubulopapillary neoplasm (ITPN) with cancerous lesions, and a total pancreatectomy with splenectomy was performed. The resected tissue specimen revealed a solid tumor occupying the entire pancreas with intraductal growth into the main pancreatic duct. Histological examination revealed high‑grade dysplastic cells in a tubulopapillary growth pattern without overt mucin production beyond the pancreatic duct. Immunohistochemical staining analysis of the tumor was positive for cytokeratin (CK)7, CK19 and mucin (MUC)1, and negative for MUC2, MUC5AC, MUC6 and caudal type homeobox 2. The tumor was finally diagnosed as pancreatic ITPN with associated invasive cancer. The patient remains well without evident recurrence nine months post‑surgery. ITPN is a rare type of epithelial neoplasm of the pancreas, and is characterized by intraductal tubulo‑papillary growth, ductal differentiation, limited intracellular mucin production, and cellular dysplasia. The present case report may contribute to improved understanding of how to effectively treat patients with ITPN. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
38. Analysis of Shape and Retractability of the Prepuce in 603 Japanese Boys
- Author
-
Hiroyuki Kayaba, Hiromi Tamura, Seiichi Kitajima, Yoshiyuki Fujiwara, and Tetsuo Kato
- Subjects
Male ,medicine.medical_specialty ,Adolescent ,business.industry ,Incidence (epidemiology) ,Urinary system ,Urology ,Preputial gland ,Infant, Newborn ,Infant ,medicine.disease ,Surgery ,medicine.anatomical_structure ,El Niño ,Japan ,Balanoposthitis ,Child, Preschool ,Penile Diseases ,Medicine ,Humans ,business ,Child ,Penis - Abstract
Purpose: We evaluated preputial development in Japanese boys.Materials and Methods: Preputial retractability and formation of a tight ring were evaluated in 603 Japanese boys 0 to 15 years old.Results: The incidence of a completely retractable prepuce gradually increased from 0 percent at age 6 months to 62.9 percent by 11 to 15 years, while that of a tight ring decreased with age from 84.3 to 8.6 percent. Nine boys had balanoposthitis but none had a symptomatic urinary tract infection.Conclusions: Incomplete separation of the prepuce is common and normal in neonates and infants, and preputial separation progresses until adolescence. Awareness of these findings will eliminate unnecessary circumcision in boys.
- Published
- 1996
39. The position and size of radiological nephrogram in Japanese preschool children
- Author
-
Yoshimi Kobayashi, Kohei Honda, Hiroaki Yoshino, Yoshiyuki Fujiwara, Hiromi Tamura, Hiroyuki Kayaba, Tetsuo Kato, Junichi Chihara, Osamu Urayama, Norihiro Saitoh, and Tatsuzou Hebiguchi
- Subjects
medicine.medical_specialty ,Aging ,Early detection ,Age dependent ,Kidney ,General Biochemistry, Genetics and Molecular Biology ,Age groups ,Japan ,Reference Values ,medicine ,Humans ,Child ,Hydronephrosis ,business.industry ,Infant ,General Medicine ,Nomogram ,medicine.disease ,Spine ,Surgery ,Radiography ,Position (obstetrics) ,medicine.anatomical_structure ,Radiological weapon ,Child, Preschool ,Kidney Diseases ,business - Abstract
The early detection of retroperitoneal masses in children, such as neuroblastoma, Wilm's tumor, hydronephrosis and cystic renal diseases, has a great clinical importance for the improvement of their prognosis. The kidney is often affected in its size or position by these lesions, and occasionally allows clinicians to find a clue to reach the correct diagnosis before the patient become symptomatic. Since we had no clinically available nomogram on the position and the size of the kidney in Japanese children, we measured the size and position of the kidneys on plain abdominal x-rays in 347 Japanese children in preschool years with a special attention to their relationship with the spine. As a result, the nomogram showed age dependent growth of the kidneys keeping almost the same ratio with the spine, while the distance between the upper pole of the kidney and the spine remained less than 10 mm in all age groups. Our nomogram may be useful not only for picking up the malposition of the kidneys but also for the follow up of the patients with chronic renal diseases affecting the growth of the kidneys.
- Published
- 1999
40. Hemorrhagic ovarian cyst in childhood: a case report
- Author
-
Jyunzi Murata, Hiromi Tamura, Hiroyuki Kayaba, Kimiyuki Shirayama, and Yoshiyuki Fujiwara
- Subjects
medicine.medical_specialty ,media_common.quotation_subject ,Ovary ,Hemorrhage ,Adnexal mass ,Diagnosis, Differential ,medicine ,Humans ,Cyst ,Hemoperitoneum ,Girl ,Child ,media_common ,Rupture ,Vascular disease ,business.industry ,General Medicine ,medicine.disease ,Surgery ,Abdominal Pain ,Ovarian Cysts ,medicine.anatomical_structure ,Adnexal Diseases ,Pediatrics, Perinatology and Child Health ,Etiology ,Female ,medicine.symptom ,Differential diagnosis ,business - Abstract
A 12-year-old girl with massive hemoperitoneum caused by a ruptured hemorrhagic ovarian cyst (HOC) is described. Although HOC is not common in early adolescence, it should be included in the differential diagnosis of any adnexal mass or lower abdominal pain in a girl.
- Published
- 1996
41. Evaluation of the therapy for streptococcal pharyngitis using Abbott Test Pack strep A
- Author
-
Hiromi Tamura, Hiroyuki Kayaba, and Yoshiyuki Fujiwara
- Subjects
Male ,medicine.medical_specialty ,Recurrent infections ,Adolescent ,Streptococcus pyogenes ,Treatment failure ,Predictive Value of Tests ,Recurrence ,Throat ,Internal medicine ,Streptococcal Infections ,medicine ,Initial treatment ,Humans ,Child ,Bacteriological Techniques ,business.industry ,Infant ,Pharyngitis ,Surgery ,medicine.anatomical_structure ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Pharynx ,Female ,Reagent Kits, Diagnostic ,medicine.symptom ,business - Abstract
A total of 953 children (511 boys and 442 girls) with streptococcal pharyngitis diagnosed with Abbott Test Pack® Strep A (ATPSA) or throat cultures were analyzed. ATPSA specimens were repeatedly obtained until ATPSA turned negative during or after the treatment. The percentage of positive ATPSA specimens reached the lowest value (9.2%) on the fourth day of the course of the treatment, which indicates the acquisition from an infected individual is probably uncommon after the initial treatment. Bacteriological treatment failure (positive ATPSA after 14 days of treatment) occurred in 4.1% of the children. Out of 953 subjects studied, 216 (22.7%) had recurrent infections. More than 30% of the recurrent infections occurred within 2 months after initial infection. ATPSA is useful for establishing a rapid diagnosis and confirming the bacteriological success of the treatment.
- Published
- 1996
42. Chylothorax, splenic lymphangiomatosis, and consumptive coagulopathy after surgical treatment of primary chylopericardium
- Author
-
Hiroaki Yoshino, Masamichi Tamura, Tadahiko Ito, Kyoji Okada, Terukazu Shiota, Kenji Harada, Tatsuzo Hebiguchi, Goro Takada, Tetsuo Kato, and Hiromi Tamura
- Subjects
medicine.medical_specialty ,Chyle ,Bone Neoplasms ,Chylothorax ,Thoracic duct ,Thoracic Duct ,Pleural disease ,Postoperative Complications ,Consumptive Coagulopathy ,medicine ,Humans ,Lymphangiomatosis ,Ligation ,Lymphangioma ,business.industry ,Splenic Neoplasms ,Disseminated Intravascular Coagulation ,Humerus ,medicine.disease ,Surgery ,medicine.anatomical_structure ,Effusion ,Child, Preschool ,Chylopericardium ,Female ,Radiology ,Cardiology and Cardiovascular Medicine ,business ,Pericardium - Published
- 1994
43. A giant periosteal chondroma of the distal femur successfully reconstructed with synthetic bone grafts and a bioresorbable plate: a case report.
- Author
-
Yoshinori Imura, Atsuo Shigi, Hidetatsu Outani, Kenichiro Hamada, Hiromi Tamura, Eiichi Morii, Akira Myoui, Hideki Yoshikawa, and Norifumi Naka
- Subjects
CHONDROMALACIA ,FEMUR surgery ,BONE grafting ,PERIOSTEUM diseases ,SURGICAL excision - Abstract
Periosteal chondromas are rare benign cartilaginous tumors that arise adjacent to the cortex beneath the periosteum. These lesions are usually slow-growing and rarely exceed 3 cm in the greatest dimension. Here, we describe a 17-year-old boy who had a giant periosteal chondroma of the right distal femur, which was treated with intralesional resection and intensive curettage. In addition, we report a novel application of a bioresorbable plate in the management of the large bone defect after resection of a benign bone tumor. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
44. Influence of H2O pretreatment on hydrogen absorption property of LaNi5-hydrogen storage alloy
- Author
-
Hiromi Tamura, K. Suzuki, Haru-Hisa Uchida, and Yuka Ozu
- Subjects
Energy carrier ,Materials science ,Hydrogen ,Cryo-adsorption ,Inorganic chemistry ,Alloy ,chemistry.chemical_element ,Sorption ,engineering.material ,complex mixtures ,Hydrogen storage ,chemistry ,engineering ,Water treatment ,Hydrogen absorption - Abstract
The hydrogen storage alloy is an important element in hydrogen system as energy carrier. Unfortunately by contacting with air the hydrogen storage alloy becomes to be deactivated and usually does not absorb any hydrogen more. Recently we found the effect of alkaline treatment and subsequent water rinsing process on the H2 sorption characteristics, where the H2 sorption is improved even after a significant oxidation. In this study we investigated the effect of only by the treatment at the water treatment on the H2 sorption characteristics. We found the preferred effect only at adequate temperature and with treatment duration.
- Published
- 1999
45. A giant periosteal chondroma of the distal femur successfully reconstructed with synthetic bone grafts and a bioresorbable plate: a case report
- Author
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Hiromi Tamura, Kenichiro Hamada, Atsuo Shigi, Hideki Yoshikawa, Akira Myoui, Hidetatsu Outani, Yoshinori Imura, Norifumi Naka, and Eiichi Morii
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Male ,medicine.medical_specialty ,Adolescent ,medicine.medical_treatment ,Bone Neoplasms ,Case Report ,Resection ,intensive curettage ,Distal femur ,Periosteum ,medicine ,Humans ,Femur ,Bone Transplantation ,business.industry ,Periosteal Chondroma ,bioresorbable plate ,Synthetic bone ,intralesional resection ,periosteal chondroma ,Anatomy ,Prostheses and Implants ,Plastic Surgery Procedures ,medicine.disease ,Prognosis ,Curettage ,Surgery ,medicine.anatomical_structure ,Oncology ,synthetic bone grafts ,distal femur ,business ,Chondroma - Abstract
Periosteal chondromas are rare benign cartilaginous tumors that arise adjacent to the cortex beneath the periosteum. These lesions are usually slow-growing and rarely exceed 3 cm in the greatest dimension. Here, we describe a 17-year-old boy who had a giant periosteal chondroma of the right distal femur, which was treated with intralesional resection and intensive curettage. In addition, we report a novel application of a bioresorbable plate in the management of the large bone defect after resection of a benign bone tumor.
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- View/download PDF
46. Esophageal carcinoma originating in the surface epithelium with immunohistochemically proven esophageal gland duct differentiation: A case report.
- Author
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Tamura H, Saiki H, Amano T, Yamamoto M, Hayashi S, Ando H, Doi R, Nishida T, Yamamoto K, and Adachi S
- Subjects
- Adenocarcinoma blood, Adenocarcinoma diagnostic imaging, Adenocarcinoma therapy, Biopsy, Carcinoembryonic Antigen blood, Carcinoma, Squamous Cell blood, Carcinoma, Squamous Cell diagnostic imaging, Carcinoma, Squamous Cell therapy, Cell Differentiation, Chemoradiotherapy, Adjuvant, Endosonography, Epithelium diagnostic imaging, Esophageal Mucosa diagnostic imaging, Esophageal Mucosa pathology, Esophageal Neoplasms blood, Esophageal Neoplasms diagnostic imaging, Esophageal Neoplasms therapy, Esophagoscopy, Humans, Immunohistochemistry, Male, Middle Aged, Adenocarcinoma pathology, Carcinoma, Squamous Cell pathology, Epithelium pathology, Esophageal Neoplasms pathology
- Abstract
A case of esophageal carcinoma exclusively composed of adenocarcinoma simulating an esophageal gland duct in a 61-year-old man is presented. The tumor arose as a slightly elevated lesion in the middle intrathoracic esophagus. It was almost completely overlaid with non-neoplastic stratified squamous epithelial cells. Beneath the overlying surface epithelium, an adenocarcinoma that was bilayered in structure diffusely invaded both the mucosal and submucosal layers. Although the tumor consisted exclusively of adenocarcinomatous cells, a keratinizing squamous cell carcinoma component was focally observed. The invasive carcinoma was focally continuous with the small area of the surface squamous epithelial layer, which was confirmed to be neoplastic by immunohistochemistry. Morphological and immunohistochemical examinations suggested that the adenocarcinomatous component arose from the esophageal surface epithelium and clearly differentiated into an esophageal gland duct. It is important to consider the possibility of this type of adenocarcinoma when diagnosing a ductal or glandular lesion of the esophagus in small biopsy specimens., Competing Interests: Conflict-of-interest statement: We have no conflict of interest in reporting the present case.
- Published
- 2017
- Full Text
- View/download PDF
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