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554 results on '"HIROSE, Hiroshi"'

5. Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

Author

Demenais, Florence, Margaritte-Jeannin, Patricia, Barnes, Kathleen C., Cookson, William O. C., Altmüller, Janine, Ang, Wei, Barr, R. Graham, Beaty, Terri H., Becker, Allan B., Beilby, John, Bisgaard, Hans, Bjornsdottir, Unnur Steina, Bleecker, Eugene, Bønnelykke, Klaus, Boomsma, Dorret I., Bouzigon, Emmanuelle, Brightling, Christopher E., Brossard, Myriam, Brusselle, Guy G., Burchard, Esteban, Burkart, Kristin M., Bush, Andrew, Chan-Yeung, Moira, Chung, Kian Fan, Couto Alves, Alexessander, Curtin, John A., Custovic, Adnan, Daley, Denise, de Jongste, Johan C., Del-Rio-Navarro, Blanca E., Donohue, Kathleen M., Duijts, Liesbeth, Eng, Celeste, Eriksson, Johan G., Farrall, Martin, Fedorova, Yuliya, Feenstra, Bjarke, Ferreira, Manuel A., Freidin, Maxim B., Gajdos, Zofia, Gauderman, Jim, Gehring, Ulrike, Geller, Frank, Genuneit, Jon, Gharib, Sina A., Gilliland, Frank, Granell, Raquel, Graves, Penelope E., Gudbjartsson, Daniel F., Haahtela, Tari, Heckbert, Susan R., Heederik, Dick, Heinrich, Joachim, Heliövaara, Markku, Henderson, John, Himes, Blanca E., Hirose, Hiroshi, Hirschhorn, Joel N., Hofman, Albert, Holt, Patrick, Hottenga, Jouke, Hudson, Thomas J., Hui, Jennie, Imboden, Medea, Ivanov, Vladimir, Jaddoe, Vincent W. V., James, Alan, Janson, Christer, Jarvelin, Marjo-Riitta, Jarvis, Deborah, Jones, Graham, Jonsdottir, Ingileif, Jousilahti, Pekka, Kabesch, Michael, Kähönen, Mika, Kantor, David B., Karunas, Alexandra S., Khusnutdinova, Elza, Koppelman, Gerard H., Kozyrskyj, Anita L., Kreiner, Eskil, Kubo, Michiaki, Kumar, Rajesh, Kumar, Ashish, Kuokkanen, Mikko, Lahousse, Lies, Laitinen, Tarja, Laprise, Catherine, Lathrop, Mark, Lau, Susanne, Lee, Young-Ae, Lehtimäki, Terho, Letort, Sébastien, Levin, Albert M., Li, Guo, Liang, Liming, Loehr, Laura R., London, Stephanie J., Loth, Daan W., Manichaikul, Ani, Marenholz, Ingo, Martinez, Fernando J., Matheson, Melanie C., Mathias, Rasika A., Matsumoto, Kenji, Mbarek, Hamdi, McArdle, Wendy L., Melbye, Mads, Melén, Erik, Meyers, Deborah, Michel, Sven, Mohamdi, Hamida, Musk, Arthur W., Myers, Rachel A., Nieuwenhuis, Maartje A. E., Noguchi, Emiko, O’Connor, George T., Ogorodova, Ludmila M., Palmer, Cameron D., Palotie, Aarno, Park, Julie E., Pennell, Craig E., Pershagen, Göran, Polonikov, Alexey, Postma, Dirkje S., Probst-Hensch, Nicole, Puzyrev, Valery P., Raby, Benjamin A., Raitakari, Olli T., Ramasamy, Adaikalavan, Rich, Stephen S., Robertson, Colin F., Romieu, Isabelle, Salam, Muhammad T., Salomaa, Veikko, Schlünssen, Vivi, Scott, Robert, Selivanova, Polina A., Sigsgaard, Torben, Simpson, Angela, Siroux, Valérie, Smith, Lewis J., Solodilova, Maria, Standl, Marie, Stefansson, Kari, Strachan, David P., Stricker, Bruno H., Takahashi, Atsushi, Thompson, Philip J., Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tiesler, Carla M. T., Torgerson, Dara G., Tsunoda, Tatsuhiko, Uitterlinden, André G., van der Valk, Ralf J. P., Vaysse, Amaury, Vedantam, Sailaja, von Berg, Andrea, von Mutius, Erika, Vonk, Judith M., Waage, Johannes, Wareham, Nick J., Weiss, Scott T., White, Wendy B., Wickman, Magnus, Widén, Elisabeth, Willemsen, Gonneke, Williams, L. Keoki, Wouters, Inge M., Yang, James J., Zhao, Jing Hua, Moffatt, Miriam F., Ober, Carole, and Nicolae, Dan L.

Published
2018
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18. Genome-wide association study identifies three novel loci for type 2 diabetes

Author

Hara, Kazuo, Fujita, Hayato, Johnson, Todd A., Yamauchi, Toshimasa, Yasuda, Kazuki, Horikoshi, Momoko, Peng, Chen, Hu, Cheng, Ma, Ronald C. W., Imamura, Minako, Iwata, Minoru, Tsunoda, Tatsuhiko, Morizono, Takashi, Shojima, Nobuhiro, So, Wing Yee, Leung, Ting Fan, Kwan, Patrick, Zhang, Rong, Wang, Jie, Yu, Weihui, Maegawa, Hiroshi, Hirose, Hiroshi, Kaku, Kohei, Ito, Chikako, Watada, Hirotaka, Tanaka, Yasushi, Tobe, Kazuyuki, Kashiwagi, Atsunori, Kawamori, Ryuzo, Jia, Weiping, Chan, Juliana C. N., Teo, Yik Ying, Shyong, Tai E., Kamatani, Naoyuki, Kubo, Michiaki, Maeda, Shiro, and Kadowaki, Takashi

Published
2014
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23. Genetic variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus

Author

Maeda, Shiro, Tsukada, Shuichi, Kanazawa, Akio, Sekine, Akihiro, Tsunoda, Tatsuhiko, Koya, Daisuke, Maegawa, Hiroshi, Kashiwagi, Atsunori, Babazono, Tetsuya, Matsuda, Masafumi, Tanaka, Yasushi, Fujioka, Tomoaki, Hirose, Hiroshi, Eguchi, Takashi, Ohno, Yoichi, Groves, Christopher J., Hattersley, Andrew T., Hitman, Graham A., Walker, Mark, Kaku, Kohei, Iwamoto, Yasuhiko, Kawamori, Ryuzo, Kikkawa, Ryuichi, Kamatani, Naoyuki, McCarthy, Mark I., and Nakamura, Yusuke

Published
2005
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26. Genome-Wide Association Study Identifies a Novel Locus Contributing to Type 2 Diabetes Susceptibility in Sikhs of Punjabi Origin From India

Author

Saxena, Richa, Saleheen, Danish, Been, Latonya F., Garavito, Martha L., Braun, Timothy, Bjonnes, Andrew, Young, Robin, Ho, Weang Kee, Rasheed, Asif, Frossard, Philippe, Sim, Xueling, Hassanali, Neelam, Radha, Venkatesan, Chidambaram, Manickam, Liju, Samuel, Rees, Simon D., Ng, Daniel Peng-Keat, Wong, Tien-Yin, Yamauchi, Toshimasa, Hara, Kazuo, Tanaka, Yasushi, Hirose, Hiroshi, McCarthy, Mark I., Morris, Andrew P., Basit, Abdul, Barnett, Anthony H., Katulanda, Prasad, Matthews, David, Mohan, Viswanathan, Wander, Gurpreet S., Singh, Jai Rup, Mehra, Narinder K., Ralhan, Sarju, Kamboh, M. Ilyas, Mulvihill, John J., Maegawa, Hiroshi, Tobe, Kazuyuki, Maeda, Shiro, Cho, Yoon S., Tai, E. Shyong, Kelly, M. Ann, Chambers, John C., Kooner, Jaspal S., Kadowaki, Takashi, Deloukas, Panos, Rader, Daniel J., Danesh, John, and Sanghera, Dharambir K.

Published
2013
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27. Combination therapy with PPAR[gamma] and PPAR[alpha] agonists increases glucose-stimulated insulin secretion in db/db mice

Author

Yajima, Ken, Hirose, Hiroshi, Fujita, Haruhisa, Seto, Yoshiko, Fujita, Hiroshi, Ukeda, Kaname, Miyashita, Kiichi, Kawai, Toshihide, Yamamoto, Yukihiro, Ogawa, Takeo, Yamada, Taketo, and Saruta Takao

Subjects
Insulin resistance -- Physiological aspects, Obesity -- Physiological aspects, Type 2 diabetes -- Physiological aspects, Biological sciences
Abstract

Although peroxisome proliferator-activated receptor (PPAR)[gamma] agonists ameliorate insulin resistance, they sometimes cause body weight gain, and the effect of PPAR agonists on insulin secretion is unclear. We evaluated the effects of combination therapy with a PPAR[gamma] agonist, pioglitazone, and a PPAR[alpha] agonist, bezafibrate, and a dual agonist, KRP-297, for 4 wk in male C57BL/6J mice and db/db mice, and we investigated glucose-stimulated insulin secretion (GSIS) by in situ pancreatic perfusion. Body weight gain in db/db mice was less with KRP-297 treatment than with pioglitazone or pioglitazone + bezafibrate treatment. Plasma glucose, insulin, triglyceride, and nonesterified fatty acid levels were elevated in untreated db/db mice compared with untreated C57BL/6J mice, and these parameters were significantly ameliorated in the PPAR[gamma] agonist-treated groups. Also, PPAR[gamma] agonists ameliorated the diminished GSIS and insulin content, and they preserved insulin and GLUT2 staining in db/db mice. GSIS was further increased by PPAR[gamma] and -[alpha] agonists. We conclude that combination therapy with PPAR[gamma] and PPAR[alpha] agonists may be more useful with respect to body weight and pancreatic GSIS in type 2 diabetes with obesity. peroxisome proliferator-activated receptor; glucose-stimulated insulin secretion; glucolipotoxicity; insulin resistance; type 2 diabetes with obesity

Published
2003

28. A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations

Author

Imamura, Minako, Maeda, Shiro, Yamauchi, Toshimasa, Hara, Kazuo, Yasuda, Kazuki, Morizono, Takashi, Takahashi, Atsushi, Horikoshi, Momoko, Nakamura, Masahiro, Fujita, Hayato, Tsunoda, Tatsuhiko, Kubo, Michiaki, Watada, Hirotaka, Maegawa, Hiroshi, Okada-Iwabu, Miki, Iwabu, Masato, Shojima, Nobuhiro, Ohshige, Toshihiko, Omori, Shintaro, Iwata, Minoru, Hirose, Hiroshi, Kaku, Kohei, Ito, Chikako, Tanaka, Yasushi, Tobe, Kazuyuki, Kashiwagi, Atsunori, Kawamori, Ryuzo, Kasuga, Masato, Kamatani, Naoyuki, Nakamura, Yusuke, and Kadowaki, Takashi

Published
2012
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37. Association of polymorphisms in the MTH1 gene with small cell lung carcinoma risk

Author

Kohno, Takashi, Sakiyama, Tokuki, Kunitoh, Hideo, Goto, Koichi, Nishiwaki, Yutaka, Saito, Daizo, Hirose, Hiroshi, Eguchi, Takashi, Yanagitani, Noriko, Saito, Ryusei, Sasaki-Matsumura, Rumie, Mimaki, Sachiyo, Toyama, Kaoru, Yamamoto, Seiichiro, Kuchiba, Aya, Sobue, Tomotaka, Ohta, Tsutomu, Ohki, Misao, and Yokota, Jun

Published
2006

41. Changes in Knowledge Levels through Lectures on Radiotherapy to Nursing Students in Japan

Author

Tanaka, Osamu, Saito, Minako, Sugano, Naoko, Hirose, Hiroshi, Tomita, Eiichi, Ono, Kousei, Taniguchi, Takuya, Matsuo, Masayuki, Department of Radiotherapy, Gifu Municipal Hospital, Gifu City Medical Association Nursing School, Director of Gifu Municipal Hospital, Department of Radiation Oncology, Murakami Memorial Hospital, Department of Radiology, Gifu University School of Medicine, Tanaka, Osamu, Saito, Minako, Sugano, Naoko, Hirose, Hiroshi, Tomita, Eiichi, Ono, Kousei, Taniguchi, Takuya, Matsuo, Masayuki, Department of Radiotherapy, Gifu Municipal Hospital, Gifu City Medical Association Nursing School, Director of Gifu Municipal Hospital, Department of Radiation Oncology, Murakami Memorial Hospital, and Department of Radiology, Gifu University School of Medicine

Abstract

Background:Recently, the number of patients choosing radiotherapy is increasing in Japan. It is necessary for even nurses to have knowledge of radiotherapy. We measured the degree of awareness with a lecture on how a nursing student can obtain knowledge of radiotherapy.Materials and methods: Forty nursing students who were in their third year and preparing for their national nursing certification in two months were recruited. The 90-min lecture covered a range of topics from general theories to specific concepts. The students were not informed that they would be required to fill a survey at the end of the lecture. This was to avoid bias that could occur from knowing in advance that a survey would be conducted.Results: The following items below were particularly remarkable. The distinction between the radiologist and the radiation oncologist. The radiotherapy is a local therapy. The pain from bone metastasis could be relieved.Conclusion: Students had very little knowledge on radiotherapy before the lecture. the results of this study indicated the need to increase the number of lectures on radiotherapy for nursing as well medical students. As the number of radiotherapy patients increases., source:https://www.longdom.org/cancer-research-immuno-oncology.html

Published
2019

46. Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte- beta-cell relationships

Author

Lee, Young, Hirose, Hiroshi, Ohneda, Makoto, Johnson, J.H., McGarry, J. Denis, and Unger, Roger H.

Subjects
Type 2 diabetes -- Causes of, Pancreatic beta cells -- Physiological aspects, Science and technology
Abstract

A study of the involvement of free fatty acids (FFA) in the pathogenesis of non-insulin dependent diabetes mellitus (NIDDM) in obese Zucker diabetic fatty (ZDF-drt) rats from 5 weeks of age until 14 weeks reveals a continuous increase in plasma FFA levels two weeks prior to hyperglycemia, absence of GSIS and reduced levels of the beta-cell GLUT-2 glucose transporter. Reducing hyperlipacidemia by pair feeding with lean littermates minimizes all beta-cell defects and inhibits hyperglycemia, suggesting the involvement of hyperlipacidemia in the pathogenesis of NIDDM.

Published
1994

48. Open Access

Author

Tanaka, Osamu, Saito, Minako, Sugano, Naoko, Hirose, Hiroshi, Tomita, Eiichi, Ono, Kousei, Taniguchi, Takuya, Matsuo, Masayuki, Department of Radiotherapy, Gifu Municipal Hospital, Gifu City Medical Association Nursing School, Director of Gifu Municipal Hospital, Department of Radiation Oncology, Murakami Memorial Hospital, and Department of Radiology, Gifu University School of Medicine

Subjects
Radiotherapy, Japan, Nurse, education, Education
Abstract

Background:Recently, the number of patients choosing radiotherapy is increasing in Japan. It is necessary for even nurses to have knowledge of radiotherapy. We measured the degree of awareness with a lecture on how a nursing student can obtain knowledge of radiotherapy.Materials and methods: Forty nursing students who were in their third year and preparing for their national nursing certification in two months were recruited. The 90-min lecture covered a range of topics from general theories to specific concepts. The students were not informed that they would be required to fill a survey at the end of the lecture. This was to avoid bias that could occur from knowing in advance that a survey would be conducted.Results: The following items below were particularly remarkable. The distinction between the radiologist and the radiation oncologist. The radiotherapy is a local therapy. The pain from bone metastasis could be relieved.Conclusion: Students had very little knowledge on radiotherapy before the lecture. the results of this study indicated the need to increase the number of lectures on radiotherapy for nursing as well medical students. As the number of radiotherapy patients increases.

Published
2017

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