1. Dose-dependent effects of anthocyanin supplementation on platelet function in subjects with dyslipidemia: A randomized clinical trial
- Author
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Zezhong Tian, Xiaoli Gao, Yimin Zhao, Ping Wang, Yan Yang, Kongyao Li, Lin Xu, Wenhua Ling, Yuheng Mao, Xilin Ma, Fuli Ya, Die Fan, Jinchao Zou, and Yilin Shi
- Subjects
Male ,BP, blood pressure ,Medicine (General) ,Platelet Aggregation ,Apolipoprotein B ,IPAQ, International Physical Activity Questionnaire ,Fib, fibrinogen ,PRP, platelet-rich plasma ,HDL-C, high-density lipoprotein cholesterol ,Anthocyanins ,EDTA, ethylene diamine tetraacetic acid ,chemistry.chemical_compound ,WC, waist circumference ,TT, thrombin clotting time ,Platelet ,ANOVA, analysis of variance ,HR, heart rate ,TG, triglyceride ,biology ,BW, body weight ,food and beverages ,General Medicine ,Middle Aged ,Malondialdehyde ,Dose-dependent effects ,UA, uric acid ,P-Selectin ,Randomized controlled trial ,8-iso-PGF2α, 8-iso-prostaglandin F2α ,Medicine ,Female ,Platelet function ,ASCVD, atherosclerotic cardiovascular disease ,Research Paper ,WHR, waist-hip ratio ,Adult ,medicine.medical_specialty ,ApoA-1, apolipoprotein A-1 ,FBG, fasting blood glucose ,HOMA-IR, insulin resistance ,Platelet Glycoprotein GPIIb-IIIa Complex ,SEM, standard error of the mean ,Placebo ,General Biochemistry, Genetics and Molecular Biology ,ROS, reactive oxygen species ,Insulin resistance ,R5-920 ,PT, prothrombin time ,Internal medicine ,HC, hip circumference ,medicine ,Humans ,ApoB, apolipoprotein B ,APTT, activated partial thromboplastin time ,Aged ,Dyslipidemias ,MDA, malondialdehyde ,Dose-Response Relationship, Drug ,business.industry ,FINS, fasting insulin ,BH, body height ,medicine.disease ,TC, total cholesterol ,Endocrinology ,TSOD, total superoxide dismutase ,chemistry ,Oxidative stress ,Platelet-rich plasma ,Dietary Supplements ,biology.protein ,Uric acid ,LDL-C, low-density lipoprotein cholesterol ,ACN, anthocyanin ,Reactive Oxygen Species ,business ,NC, neck circumference ,Platelet Aggregation Inhibitors ,Dyslipidemia - Abstract
BACKGROUND Dyslipidemia induces platelet hyperactivation and hyper-aggregation, which are linked to thrombosis. Anthocyanins could inhibit platelet function in vitro and in mice fed high-fat diets with their effects on platelet function in subjects with dyslipidemia remained unknown. This study aimed to investigate the effects of different doses of anthocyanins on platelet function in individuals with dyslipidemia. METHODS A double-blind, randomized, controlled trial was conducted. Ninety-three individuals who were initially diagnosed with dyslipidemia were randomly assigned to placebo or 40, 80, 160 or 320 mg/day anthocyanin groups. The supplementations were anthocyanin capsules (Medox, Norway). Platelet aggregation by light aggregometry of platelet-rich plasma, P-selectin, activated GPⅡbⅢa, reactive oxygen species (ROS), and mitochondrial membrane potential were tested at baseline, 6 weeks and 12 weeks. FINDINGS Compared to placebo group, anthocyanins at 80 mg/day for 12 weeks reduced collagen-induced platelet aggregation (-3.39±2.36%) and activated GPⅡbⅢa (-8.25±2.45%) (P
- Published
- 2021