1. Association between hyperuricemia and acute kidney injury in critically ill patients with sepsis
- Author
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Yuan-Xia Jiang, Chun-Lei Gong, Yan Tang, Yang Yi, Fu-Gang Liu, Jing-Wen Zhou, Ying-Long Shi, Hong-Wei Zhou, and Kai-Qing Xie
- Subjects
Hyperuricemia ,Sepsis ,Acute renal insufficiency ,Risk-factors ,Acute kidney injury ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Abstract Background Sepsis-related AKI is related to short-term mortality and poor long-term prognoses, such as chronic renal insufficiency, late development of end-stage renal disease, and long-term mortality. In this study, we aimed to investigate the association of hyperuricemia with acute kidney injury (AKI) in patients with sepsis. Methods The retrospective cohort study included 634 adult sepsis patients hospitalized in the intensive care unit (ICU) of the First Affiliated Hospital of Guangxi Medical University from March 2014 to June 2020 and the ICU of the Second Affiliated Hospital of Guangxi Medical University from January 2017 to June 2020. Based on the first serum uric acid level within 24 h of admission to the ICU, patients were divided into groups with or without hyperuricemia, and the incidence of AKI within seven days of ICU admission was compared between the two groups. The univariate analysis analyzed the effect of hyperuricemia on sepsis-related AKI, and the multivariable logistic regression model analysis was used. Results Among the 634 patients with sepsis, 163 (25.7%) developed hyperuricemia, and 324 (51.5%) developed AKI. The incidence of AKI in the groups with and without hyperuricemia was 76.7% and 42.3%, respectively, with statistically significant differences (2 = 57.469, P
- Published
- 2023
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