1. More immune dysregulation: Sarcoidosis and chronic graft-versus-host disease after allogeneic stem cell transplant
- Author
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India A. Miller, Iviensan F. Manalo, and Loretta S. Davis
- Subjects
chronic graft-versus-host disease ,Cutaneous Sarcoidosis ,granulomatous dermatitis ,Case Report ,chemical and pharmacologic phenomena ,cutaneous sarcoidosis ,Dermatology ,Human leukocyte antigen ,GVHD, graft-versus-host disease ,medicine.disease_cause ,graft-versus-host-disease ,030207 dermatology & venereal diseases ,03 medical and health sciences ,HSCTs, hematopoietic stem cell transplants ,0302 clinical medicine ,human leukocyte antigen ,immune system diseases ,allogeneic hematopoietic stem cell transplant ,medicine ,Genetic predisposition ,sarcoidosis ,cutaneous manifestations of systemic disease ,HLA, human leukocyte antigen ,business.industry ,Hematopoietic stem cell ,Immune dysregulation ,medicine.disease ,noncaseating granulomas ,surgical procedures, operative ,Graft-versus-host disease ,medicine.anatomical_structure ,Immunology ,Sarcoidosis ,Stem cell ,business ,030215 immunology - Abstract
Approximately 25,000 allogeneic hematopoietic stem cell transplants (HSCTs) are performed annually. Cutaneous complications are common and include a spectrum of acute and chronic graft-versus-host disease (GVHD). Mechanisms implicated in the rare development of sarcoidosis after HSCT include specific pretransplant conditioning regimens, possible donor-to-recipient transmission, genetic predisposition of sarcoidosis, and post-HSCT immune dysregulation.
- Published
- 2016
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