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7 results on '"Ha, Seokjun"'

1. Integrated proteogenomic characterization of glioblastoma evolution

Author

Kim, Kyung-Hee, Migliozzi, Simona, Koo, Harim, Hong, Jun-Hee, Park, Seung Min, Kim, Sooheon, Kwon, Hyung Joon, Ha, Seokjun, Garofano, Luciano, Oh, Young Taek, D'Angelo, Fulvio, Kim, Chan Il, Kim, Seongsoo, Lee, Ji Yoon, Kim, Jiwon, Hong, Jisoo, Jang, Eun-Hae, Mathon, Bertrand, Di Stefano, Anna-Luisa, Bielle, Franck, Laurenge, Alice, Nesvizhskii, Alexey I., Hur, Eun-Mi, Yin, Jinlong, Shi, Bingyang, Kim, Youngwook, Moon, Kyung-Sub, Kwon, Jeong Taik, Lee, Shin Heon, Lee, Seung Hoon, Gwak, Ho Shin, Lasorella, Anna, Yoo, Heon, Sanson, Marc, Sa, Jason K., Park, Chul-Kee, Nam, Do-Hyun, Iavarone, Antonio, and Park, Jong Bae

Published
2024
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4. Fam20C Kinase as A Key Regulator of Bevacizumab Resistance in Mesenchymal Glioblastoma

Author

Kim, Chan Il, primary, Kim, Sooheon, additional, Park, Seong‐Min, additional, Kim, Sung Soo, additional, Kwon, Hyung Joon, additional, Lin, Weiwei, additional, Park, Saewhan, additional, Ha, Seokjun, additional, Ha, Kyung Hee, additional, Park, Sanha, additional, Park, Seung Min, additional, Kim, Tae Hoon, additional, Kim, Kyung‐Hee, additional, Kim, Yun‐Hee, additional, Kim, Jong Heon, additional, and Park, Jong Bae, additional

Published
2023
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7. HLH-30/TFEB mediates sexual dimorphism in immunity in <italic>caenorhabditis elegans</italic>.

Author

Sohn, Jooyeon, Kwon, Sujeong, Lee, Gee-Yoon, Kim, Sieun S., Lee, Yujin, Lee, Jongsun, Jung, Yoonji, Ham, Seokjin, Park, Hae-Eun H., Park, Sangsoon, Ha, Seokjun G., Lee, Daehan, and Lee, Seung-Jae V.

Abstract

Sexual dimorphism affects various biological functions, including immune responses. However, the mechanisms by which sex alters immunity remain largely unknown. Using Caenorhabditis elegans as a model species, we showed that males exhibit enhanced immunity against various pathogenic bacteria through the upregulation of HLH-30 (Helix Loop Helix 30/TFEB (transcription factor EB), a transcription factor crucial for macroautophagy/autophagy. Compared with hermaphroditic C. elegans, males displayed increased activity of HLH-30/TFEB, which contributed to enhanced antibacterial immunity. atg-2 (AuTophaGy (yeast Atg homolog) 2) upregulated by HLH-30/TFEB mediated increased immunity in male C. elegans. Thus, the males appear to be equipped with enhanced HLH-30/TFEB-mediated autophagy, which increases pathogen resistance, and this may functionally prolong mate-searching ability with reduced risk of infection. [ABSTRACT FROM AUTHOR]

Published
2024
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