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23 results on '"Haagdorens, Michel"'

2. Collagen analogs with phosphorylcholine are inflammation-suppressing scaffolds for corneal regeneration from alkali burns in mini-pigs

Author

Simpson, Fiona C., McTiernan, Christopher D., Islam, Mohammad Mirazul, Buznyk, Oleksiy, Lewis, Philip N., Meek, Keith M., Haagdorens, Michel, Audiger, Cindy, Lesage, Sylvie, Gueriot, François-Xavier, Brunette, Isabelle, Robert, Marie-Claude, Olsen, David, Koivusalo, Laura, Liszka, Aneta, Fagerholm, Per, Gonzalez-Andrades, Miguel, and Griffith, May

Published
2021
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7. Plant Recombinant Human Collagen Type I Hydrogels for Corneal Regeneration

Author

Haagdorens, Michel, primary, Edin, Elle, additional, Fagerholm, Per, additional, Groleau, Marc, additional, Shtein, Zvi, additional, Ulčinas, Artūras, additional, Yaari, Amit, additional, Samanta, Ayan, additional, Cepla, Vytautas, additional, Liszka, Aneta, additional, Tassignon, Marie-José, additional, Simpson, Fiona, additional, Shoseyov, Oded, additional, Valiokas, Ramūnas, additional, Pintelon, Isabel, additional, Ljunggren, Monika Kozak, additional, and Griffith, May, additional

Published
2021
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8. Pterygium—The Good, the Bad, and the Ugly

Author

Van Acker, Sara I., primary, Van den Bogerd, Bert, additional, Haagdorens, Michel, additional, Siozopoulou, Vasiliki, additional, Ní Dhubhghaill, Sorcha, additional, Pintelon, Isabel, additional, and Koppen, Carina, additional

Published
2021
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9. New Technologies in Clinical Trials in Corneal Diseases and Limbal Stem Cell Deficiency: Review from the European Vision Institute Special Interest Focus Group Meeting

Author

Schlereth, Simona L., Hos, Deniz, Matthaei, Mario, Hamrah, Pedram, Schmetterer, Leopold, O'Leary, Olivia, Ullmer, Christoph, Horstmann, Jens, Bock, Felix, Wacker, Katrin, Schroder, Hannes, Notara, Maria, Haagdorens, Michel, Nuijts, Rudy M. M. A., Dunker, Suryan, Dickman, Mor, Fauser, Sascha, Scholl, Hendrik P. N., Wheeler-Schilling, Thomas, Cursiefen, Claus, Schlereth, Simona L., Hos, Deniz, Matthaei, Mario, Hamrah, Pedram, Schmetterer, Leopold, O'Leary, Olivia, Ullmer, Christoph, Horstmann, Jens, Bock, Felix, Wacker, Katrin, Schroder, Hannes, Notara, Maria, Haagdorens, Michel, Nuijts, Rudy M. M. A., Dunker, Suryan, Dickman, Mor, Fauser, Sascha, Scholl, Hendrik P. N., Wheeler-Schilling, Thomas, and Cursiefen, Claus

Abstract

To discuss and evaluate new technologies for a better diagnosis of corneal diseases and limbal stem cell deficiency, the outcomes of a consensus process within the European Vision Institute (and of a workshop at the University of Cologne) are outlined. Various technologies are presented and analyzed for their potential clinical use also in defining new end points in clinical trials. The disease areas which are discussed comprise dry eye and ocular surface inflammation, imaging, and corneal neovascularization and corneal grafting/stem cell and cell transplantation. The unmet needs in the abovementioned disease areas are discussed, and realistically achievable new technologies for better diagnosis and use in clinical trials are outlined. To sum up, it can be said that there are several new technologies that can improve current diagnostics in the field of ophthalmology in the near future and will have impact on clinical trial end point design.

Published
2021

10. New Technologies in Clinical Trials in Corneal Diseases and Limbal Stem Cell Deficiency: Review from the European Vision Institute Special Interest Focus Group Meeting

Author

Schlereth, Simona L., primary, Hos, Deniz, additional, Matthaei, Mario, additional, Hamrah, Pedram, additional, Schmetterer, Leopold, additional, O’Leary, Olivia, additional, Ullmer, Christoph, additional, Horstmann, Jens, additional, Bock, Felix, additional, Wacker, Katrin, additional, Schröder, Hannes, additional, Notara, Maria, additional, Haagdorens, Michel, additional, Nuijts, Rudy M.M.A., additional, Dunker, Suryan L., additional, Dickman, Mor M., additional, Fauser, Sascha, additional, Scholl, Hendrik P.N., additional, Wheeler-Schilling, Thomas, additional, and Cursiefen, Claus, additional

Published
2020
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11. LiQD Cornea: Pro-regeneration collagen mimetics as patches and alternatives to corneal transplantation

Author

McTiernan, Christopher D., primary, Simpson, Fiona C., additional, Haagdorens, Michel, additional, Samarawickrama, Chameen, additional, Hunter, Damien, additional, Buznyk, Oleksiy, additional, Fagerholm, Per, additional, Ljunggren, Monika K., additional, Lewis, Philip, additional, Pintelon, Isabel, additional, Olsen, David, additional, Edin, Elle, additional, Groleau, Marc, additional, Allan, Bruce D., additional, and Griffith, May, additional

Published
2020
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12. LiQD Cornea: Pro-regeneration collagen mimetics as patches and alternatives to corneal transplantation

Author

McTiernan, Christopher D., Simpson, Fiona C., Haagdorens, Michel, Samarawickrama, Chameen, Hunter, Damien, Buznyk, Oleksiy, Fagerholm, Per, Kozak Ljunggren, Monika, Lewis, Philip, Pintelon, Isabel, Olsen, David, Edin, Elle, Groleau, Marc, Allan, Bruce D., Griffith, May, McTiernan, Christopher D., Simpson, Fiona C., Haagdorens, Michel, Samarawickrama, Chameen, Hunter, Damien, Buznyk, Oleksiy, Fagerholm, Per, Kozak Ljunggren, Monika, Lewis, Philip, Pintelon, Isabel, Olsen, David, Edin, Elle, Groleau, Marc, Allan, Bruce D., and Griffith, May

Abstract

Transplantation with donor corneas is the mainstay for treating corneal blindness, but a severe worldwide shortage necessitates the development of other treatment options. Corneal perforation from infection or inflammation is sealed with cyanoacrylate glue. However, the resulting cytotoxicity requires transplantation. LiQD Cornea is an alternative to conventional corneal transplantation and sealants. It is a cell-free, liquid hydrogel matrix for corneal regeneration, comprising short collagen-like peptides conjugated with polyethylene glycol and mixed with fibrinogen to promote adhesion within tissue defects. Gelation occurs spontaneously at body temperature within 5 min. Light exposure is not required-particularly advantageous because patients with corneal inflammation are typically photophobic. The self-assembling, fully defined, synthetic collagen analog is much less costly than human recombinant collagen and reduces the risk of immune rejection associated with xenogeneic materials. In situ gelation potentially allows for clinical application in outpatient clinics instead of operating theaters, maximizing practicality, and minimizing health care costs., Funding Agencies|Euronanomed II-Swedish Research Council [IKE-2014-00597]; Euronanomed III-FRQS [278653]; Quebec Vision Health Research Network-FRQS [2017-3]; Caroline Foundation Research Chair for Cellular Therapy in the Eye; NIHR Biomedical Research Centre at the Moorfields Eye Hospital NHS Foundation Trust [BRC-1215-20002]; UCL Institute of Ophthalmology; Westmead Charitable Trust Early Career Research Fellowship [CC368629-8245]; Faculte des etudes superieures et postdoctorales de lUniversite de Montreal; Fonds de recherche en ophtalmologie de lUniversite de Montreal (FROUM); Fonds de recherche du Quebec-Nature et technologies (FRQNT); Natural Sciences and Engineering Research Council of Canada (NSERC)Natural Sciences and Engineering Research Council of Canada

Published
2020
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14. Corrigendum to “Short peptide analogs as alternatives to collagen in pro-regenerative corneal implants” [Acta Biomater. 69 (2018) 120–130]

Author

Jangamreddy, Jaganmohan R., primary, Haagdorens, Michel K.C., additional, Islam, M. Mirazul, additional, Lewis, Philip, additional, Samanta, Ayan, additional, Fagerholm, Per, additional, Liszka, Aneta, additional, Ljunggren, Monika K., additional, Buznyk, Oleksiy, additional, Alarcon, Emilio I., additional, Zakaria, Nadia, additional, Meek, Keith M., additional, and Griffith, May, additional

Published
2019
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18. Corrigendum to “Short peptide analogs as alternatives to collagen in pro-regenerative corneal implants” [Acta Biomaterialia 69 (2018) 120–130]

Author

Jangamreddy, Jaganmohan R., primary, Haagdorens, Michel K.C., additional, Islam, M. Mirazul, additional, Lewis, Philip, additional, Samanta, Ayan, additional, Fagerholm, Per, additional, Liszka, Aneta, additional, Ljunggren, Monika K., additional, Buznyk, Oleksiy, additional, Alarcon, Emilio I., additional, Zakaria, Nadia, additional, Meek, Keith M., additional, and Griffith, May, additional

Published
2018
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19. Recombinant human collagen type I hydrogels as superior cell carriers for corneal epithelial stem cells

Author

Zakaria, Nadia, Haagdorens, Michel, Liszka, Aneta, Ulcinas, Arturas, Cepla, Vytautas, Valiokas, Ramunas, Ljunggren, Monika Kozak, Samanta, Ayan, Tassignon, Marie-Jose B. R., Tal, Yeheil, Orr, Nadav, Shoseyov, Oded, Pintelon, Isabel, Griffith, May, Zakaria, Nadia, Haagdorens, Michel, Liszka, Aneta, Ulcinas, Arturas, Cepla, Vytautas, Valiokas, Ramunas, Ljunggren, Monika Kozak, Samanta, Ayan, Tassignon, Marie-Jose B. R., Tal, Yeheil, Orr, Nadav, Shoseyov, Oded, Pintelon, Isabel, and Griffith, May

Published
2018

22. Limbal Stem Cell Deficiency: Current Treatment Options and Emerging Therapies.

Author

Haagdorens, Michel, Van Acker, Sara Ilse, Van Gerwen, Veerle, Ní Dhubhghaill, Sorcha, Koppen, Carina, Tassignon, Marie-José, and Zakaria, Nadia

Subjects
*CORNEAL limbus, *STEM cells, *VISUAL acuity, *STEM cell transplantation, *EPITHELIAL cells, *PATHOLOGICAL physiology
Abstract

Severe ocular surface disease can result in limbal stem cell deficiency (LSCD), a condition leading to decreased visual acuity, photophobia, and ocular pain. To restore the ocular surface in advanced stem cell deficient corneas, an autologous or allogenic limbal stem cell transplantation is performed. In recent years, the risk of secondary LSCD due to removal of large limbal grafts has been significantly reduced by the optimization of cultivated limbal epithelial transplantation (CLET). Despite the great successes of CLET, there still is room for improvement as overall success rate is 70% and visual acuity often remains suboptimal after successful transplantation. Simple limbal epithelial transplantation reports higher success rates but has not been performed in as many patients yet. This review focuses on limbal epithelial stem cells and the pathophysiology of LSCD. State-of-the-art therapeutic management of LSCD is described, and new and evolving techniques in ocular surface regeneration are being discussed, in particular, advantages and disadvantages of alternative cell scaffolds and cell sources for cell based ocular surface reconstruction. [ABSTRACT FROM AUTHOR]

Published
2015
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