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30 results on '"Haase, Daniela"'

1. 60 Years of Open‐Celled Ceramics Based on Replica Technique: Applications, Obstacles, and Opportunities.

Author

Haase, Daniela, Füssel, Alexander, Adler, Jörg, and Petasch, Uwe

Subjects
CRYSTAL filters, CATALYST supports, LIGHTWEIGHT construction, BONE substitutes, LIQUID metals
Abstract

Open‐celled ceramics look back on a remarkable history of development and innovation spanning around 60 years. Starting with the first patents to produce ceramic foams in the 1960s, the Schwartzwalder process became established industrially for manufacturing molten metal filters. Since then, a wide range of potential applications for these specific structured materials has been identified and discussed in the literature, such as porous burners, direct heaters, structured catalyst supports, filters, bone substitute materials, energy absorbers, preforms, and lightweight or acoustic construction components. For such high‐performance applications, ceramic foams require high quality in terms of purity, mechanical strength, high temperature, and chemical resistance or structural design. On this account, production technologies and material variety of ceramic foams have developed rapidly over the past few decades, and there are numerous applications in the industrial sector. This article gives an overview of the current state of development of open‐celled ceramic foams for various applications. Based on selected examples, it is demonstrated for which applications an industrial implementation is successfully realized and why some applications will never get beyond the proof‐of‐concept stage in research. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Skeletal Muscle Function, Structure, and Metabolism in Patients With Heart Failure With Reduced Ejection Fraction and Heart Failure With Preserved Ejection Fraction

Author

Bekfani, Tarek, Bekhite Elsaied, Mohamed, Derlien, Steffen, Nisser, Jenny, Westermann, Martin, Nietzsche, Sandor, Hamadanchi, Ali, Fröb, Elisabeth, Westphal, Julian, Haase, Daniela, Kretzschmar, Tom, Schlattmann, Peter, Smolenski, Ulrich C., Lichtenauer, Michael, Wernly, Bernhard, Jirak, Peter, Lehmann, Gabriele, Möbius-Winkler, Sven, and Schulze, P. Christian

Published
2020
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8. Metabolomic Profiling in Patients with Heart Failure and Exercise Intolerance: Kynurenine as a Potential Biomarker

Author

Bekfani, Tarek, primary, Bekhite, Mohamed, additional, Neugebauer, Sophie, additional, Derlien, Steffen, additional, Hamadanchi, Ali, additional, Nisser, Jenny, additional, Hilse, Marion S., additional, Haase, Daniela, additional, Kretzschmar, Tom, additional, Wu, Mei-Fang, additional, Lichtenauer, Michael, additional, Kiehntopf, Michael, additional, von Haehling, Stephan, additional, Schlattmann, Peter, additional, Lehmann, Gabriele, additional, Franz, Marcus, additional, Möbius-Winkler, Sven, additional, and Schulze, Christian, additional

Published
2022
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16. The C. elegans GATA transcription factor elt-2 mediates distinct transcriptional responses and opposite infection outcomes towards different Bacillus thuringiensis strains

Author

Zárate-Potes, Alejandra, primary, Yang, Wentao, additional, Pees, Barbara, additional, Schalkowski, Rebecca, additional, Segler, Philipp, additional, Andresen, Bentje, additional, Haase, Daniela, additional, Nakad, Rania, additional, Rosenstiel, Philip, additional, Tetreau, Guillaume, additional, Colletier, Jacques-Philippe, additional, Schulenburg, Hinrich, additional, and Dierking, Katja, additional

Published
2020
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20. Loss of the Protein‐Tyrosine Phosphatase DEP‐1/PTPRJ Drives Meningioma Cell Motility

Author

Petermann, Astrid, Haase, Daniela, Wetzel, Andrea, Balavenkatraman, Kamal K., Tenev, Tencho, Gührs, Karl‐Heinz, Friedrich, Sabrina, Nakamura, Makoto, Mawrin, Christian, and Böhmer, Frank‐D.

Subjects
Immunoblotting, Receptor-Like Protein Tyrosine Phosphatases, Class 3, Loss of Heterozygosity, Mice, Nude, respiratory system, Transfection, complex mixtures, Immunohistochemistry, Polymerase Chain Reaction, respiratory tract diseases, Mice, Cell Movement, Cell Line, Tumor, Gene Knockdown Techniques, Cell Adhesion, Meningeal Neoplasms, Animals, Humans, Neoplasm Invasiveness, Paxillin, RNA, Small Interfering, Meningioma, Research Articles, Signal Transduction
Abstract

DEP-1/PTPRJ is a transmembrane protein-tyrosine phosphatase which has been proposed as a suppressor of epithelial tumors. We have found loss of heterozygosity (LOH) of the PTPRJ gene and loss of DEP-1 protein expression in a subset of human meningiomas. RNAi-mediated suppression of DEP-1 in DEP-1 positive meningioma cell lines caused enhanced motility and colony formation in semi-solid media. Cells devoid of DEP-1 exhibited enhanced signaling of endogenous platelet-derived growth factor (PDGF) receptors, and reduced paxillin phosphorylation upon seeding. Moreover, DEP-1 loss caused diminished adhesion to different matrices, and impaired cell spreading. DEP-1-deficient meningioma cells exhibited invasive growth in an orthotopic xenotransplantation model in nude mice, indicating that elevated motility translates into a biological phenotype in vivo. We propose that negative regulation of PDGF receptor signaling and positive regulation of adhesion signaling by DEP-1 cooperate in inhibition of meningioma cell motility, and possibly tumor invasiveness. These phenotypes of DEP-1 loss reveal functions of DEP-1 in adherent cells, and may be more generally relevant for tumorigenesis.

Published
2010

22. Reduced Activity of CD13/Aminopeptidase N (APN) in Aggressive Meningiomas Is Associated with Increased Levels of SPARC

Author

Mawrin, Christian, Wolke, Carmen, Haase, Daniela, Krüger, Sabine, Firsching, Raimund, Keilhoff, Gerburg, Paulus, Werner, Gutmann, David H., Lal, Anita, and Lendeckel, Uwe

Subjects
Adult, animal structures, Reverse Transcriptase Polymerase Chain Reaction, Blotting, Western, Glyceraldehyde-3-Phosphate Dehydrogenases, CD13 Antigens, Immunohistochemistry, nervous system diseases, Gene Expression Regulation, Neoplastic, Cell Line, Tumor, otorhinolaryngologic diseases, Humans, Neoplasm Invasiveness, Osteonectin, RNA, Small Interfering, Meningioma, neoplasms, hormones, hormone substitutes, and hormone antagonists, Research Articles, Cell Proliferation
Abstract

Meningiomas are the second most common brain tumors in adults, and meningiomas exhibit a tendency to invade adjacent structures. Compared with high-grade gliomas, little is known about the molecular changes that potentially underlie the invasive behavior of meningiomas. In this study, we examined the expression and function of the membrane alanyl-aminopeptidase [mAAP, aminopeptidase N (APN), CD13, EC3.4.11.2] zinc-dependent ectopeptidase in meningiomas and meningioma cell lines, based on its prior association with tumor invasion in colorectal and renal carcinomas. We found a significant reduction of APNmRNA and protein expression, as well as enzymatic activity, in high-grade meningiomas. While meningioma tumor cell proliferation was not affected by either pharmacologic APN inhibition or siRNA-mediated APN silencing, APN pharmacologic and siRNA knockdown significantly reduced meningioma cell invasion in vitro. Next, we employed pathway-specific cDNA microarray analyses to identify extracellular matrix and adhesion molecules regulated by APN, and found that APN-siRNA knockdown substantially increased the expression of secreted protein, acidic and rich in cysteine (SPARC)/osteonectin. Finally, we demonstrated that SPARC, which has been previously associated with meningioma invasiveness, was increased in aggressive meningiomas. Collectively, these results suggest that APN expression and enzymatic function is reduced in aggressive meningiomas, and that alterations in the balance between APN and SPARC might favor meningioma invasion.

Published
2009

25. Fatty acid synthase as a novel target for meningioma therapy

Author

Haase, Daniela, primary, Schmidl, Stefan, additional, Ewald, Christian, additional, Kalff, Rolf, additional, Huebner, Christian, additional, Firsching, Raimund, additional, Keilhoff, Gerburg, additional, Evert, Matthias, additional, Paulus, Werner, additional, Gutmann, David H., additional, Lal, Anita, additional, and Mawrin, Christian, additional

Published
2010
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30. Reduced Morg1 expression in ischemic human brain

Author

Haase, Daniela, Keiner, Silke, Mawrin, Christian, and Wolf, Gunter

Subjects
*CEREBRAL ischemia, *MYELIN gene expression, *BRAIN diseases, *IMMUNOHISTOCHEMISTRY, *CEREBRAL anoxia, *GENETIC regulation, *POLYMERASE chain reaction
Abstract

Abstract: The mitogen-activated protein kinase organizer 1 (Morg1) has been recently identified as modular scaffold regulating ERK signaling. Morg1 also attenuates expression of the hypoxia-inducible factor-1α (HIF-1α) by activating or stabilizing of prolyl-hydroxylase 3 (PHD3). Here we demonstrate for the first time that Morg1 is expressed in the human brain in neurons, glial cells, and blood vessel walls. Immunohistochemistry, RT real-time PCR and western blotting indicated that Morg1 expression is reduced in human brain tissue with ischemic damage. Moreover, reactive astrocytes in the surrounding brain tissue showed strong Morg1 expression. Since hypoxic adaptation with enhancing HIF-1α expression can engage a genetic program leading to profound sparing of brain tissue and enhanced recovery of function, down-regulation of Morg1 expression in the ischemic brain may be viewed as an intrinsic mechanism to stimulate this response. On the other hand, upregulation of Morg1 in astrocytes surrounding the penumbra may counteract this hypoxic adaptation. [Copyright &y& Elsevier]

Published
2009
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