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6. Safety and efficacy of novel oblique-viewing scope for B2-endoscopic ultrasound-guided hepaticogastrostomy

Author

Ishikawa, Sho, primary, Hara, Kazuo, additional, Okuno, Nozomi, additional, Mizuno, Nobumasa, additional, Haba, Shin, additional, Kuwahara, Takamichi, additional, Kuraishi, Yasuhiro, additional, Yanaidani, Takafumi, additional, Yamada, Masanori, additional, Yasuda, Tsukasa, additional, Fukui, Toshitaka, additional, Kumagi, Teru, additional, and Hiasa, Yoichi, additional

Published
2024
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8. Clinical utility of endoscopic ultrasound-guided tissue acquisition for comprehensive genomic profiling of patients with biliary tract cancer, especially with intrahepatic cholangiocarcinoma

Author

Yanaidani, Takafumi, primary, Hara, Kazuo, additional, Okuno, Nozomi, additional, Haba, Shin, additional, Kuwahara, Takamichi, additional, Kuraishi, Yasuhiro, additional, Mizuno, Nobumasa, additional, Ishikawa, Sho, additional, Yamada, Masanori, additional, and Yasuda, Tsukasa, additional

Published
2024
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10. HOPS-R01 phase II trial evaluating neoadjuvant S-1 therapy for resectable pancreatic adenocarcinoma

Author

Nakamura, Toru, Hayashi, Tsuyoshi, Kimura, Yasutoshi, Kawakami, Hiroshi, Takahashi, Kuniyuki, Ishiwatari, Hirotoshi, Goto, Takuma, Motoya, Masayo, Yamakita, Keisuke, Sakuhara, Yusuke, Ono, Michihiro, Tanaka, Eiichi, Omi, Makoto, Murakawa, Katsuhiko, Iida, Tomoya, Sakurai, Tamaki, Haba, Shin, Abiko, Takehiro, Ito, Yoichi M., Maguchi, Hiroyuki, and Hirano, Satoshi

Published
2022
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11. EUS-guided Choledochoduodenostomy

Author

Hara, Kazuo, Okuno, Nozomi, Haba, Shin, Kuwahara, Takamichi, Teoh, Anthony Y.B., editor, Giovaninni, Marc, editor, Khashab, Mouen A., editor, and Itoi, Takao, editor

Published
2022
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14. Diagnostic performance and safety of endoscopic ultrasound‐guided fine‐needle aspiration/biopsy for gallbladder lesions.

Author

Kuraishi, Yasuhiro, Hara, Kazuo, Haba, Shin, Kuwahara, Takamichi, Okuno, Nozomi, Yanaidani, Takafumi, Ishikawa, Sho, Yasuda, Tsukasa, Yamada, Masanori, Fukui, Toshitaka, and Mizuno, Nobumasa

Subjects
ENDOSCOPIC ultrasonography, NEEDLE biopsy, GALLBLADDER, BIOPSY
Abstract

Objectives: Endoscopic ultrasound‐guided fine‐needle aspiration and fine‐needle biopsy (EUS‐FNA/FNB) is not fully established as a pathological sampling tool for gallbladder lesions due to limited evidence. We therefore aimed to clarify the effectiveness and safety of this procedure in a large‐population cohort. Methods: This study retrospectively evaluated the diagnostic yield of EUS‐FNA/FNB for accurately differentiating between benign and malignant gallbladder lesions. Puncture targets included the gallbladder mass, lymph node, and liver mass. Adverse events and factors associated with diagnostic accuracy were analyzed as well. Results: In 187 patients with gallbladder lesions undergoing EUS‐FNA/FNB, 18 benign lesions and 169 malignant lesions were identified. Overall sampling adequacy was 98% (184/187). The diagnostic accuracy of EUS‐FNA/FNB was 97% (182/187), sensitivity was 97% (164/169), and specificity was 100% (18/18). A single postprocedural complication (minor bleeding) was recorded in one patient. In the 169 cases of malignancy, 203 sites were punctured for pathological sampling of the primary mass (n = 94), lymph node (n = 79), and metastatic liver mass (n = 30). No significant difference was found for diagnostic accuracy among the puncture sites (P = 0.70). In cases having specimens obtained from the primary mass, the accuracy of those targeting liver invasion sites was significantly higher than that of other sites (98% vs. 83%, P < 0.01). Conclusion: EUS‐FNA/FNB demonstrated clinical usefulness and safety for the pathological diagnosis of gallbladder lesions, with high diagnostic yield and a low incidence of adverse events. Targeting the site of liver infiltration may improve the diagnostic rate of EUS‐FNA/FNB in the primary mass. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Effectiveness and Prognostic Factors of Everolimus in Patients with Pancreatic Neuroendocrine Neoplasms

Author

Kurita, Yusuke, primary, Kobayashi, Noritoshi, additional, Hara, Kazuo, additional, Mizuno, Nobumasa, additional, Kuwahara, Takamichi, additional, Okuno, Nozomi, additional, Haba, Shin, additional, Tokuhisa, Motohiko, additional, Hasegawa, Sho, additional, Sato, Takamitsu, additional, Hosono, Kunihiro, additional, Kato, Shingo, additional, Kessoku, Takaomi, additional, Endo, Itaru, additional, Shimizu, Yasuhiro, additional, Kubota, Kensuke, additional, Nakajima, Atsushi, additional, Ichikawa, Yasushi, additional, and Niwa, Yasumasa, additional

Published
2023
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26. Clinical Outcomes of Everolimus Rechallenge in Patients with Pancreatic Neuroendocrine Neoplasms with No Other Treatment Options

Author

Kurita, Yusuke, primary, Kobayashi, Noritoshi, additional, Hara, Kazuo, additional, Mizuno, Nobumasa, additional, Kuwahara, Takamichi, additional, Okuno, Nozomi, additional, Haba, Shin, additional, Tokuhisa, Motohiko, additional, Hasegawa, Sho, additional, Kubota, Kensuke, additional, Nakajima, Atsushi, additional, and Ichikawa, Yasushi, additional

Published
2022
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28. Endoscopic ultrasound-guided drainage for an abscess cavity

Author

Okuno, Nozomi, primary, Hara, Kazuo, additional, Mizuno, Nobumasa, additional, Haba, Shin, additional, Kuwahara, Takamichi, additional, Kuraishi, Yasuhiro, additional, Yanaidani, Takafumi, additional, Ishikawa, Sho, additional, Yasuda, Tsukasa, additional, Yamada, Masanori, additional, and Fukui, Toshitaka, additional

Published
2022
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30. Endoscopic Management of Adenomas in the Ileal Pouch and the Rectal Remnant after Surgical Treatment in Familial Adenomatous Polyposis

Author

Tajika, Masahiro, primary, Tanaka, Tsutomu, additional, Oonishi, Sachiyo, additional, Yamada, Keisaku, additional, Kamiya, Tomoyasu, additional, Mizuno, Nobumasa, additional, Kuwahara, Takamichi, additional, Okuno, Nozomi, additional, Haba, Shin, additional, Kuraishi, Yasuhiro, additional, Ouchi, Akira, additional, Sato, Yusuke, additional, Kinoshita, Takashi, additional, Komori, Koji, additional, Hara, Kazuo, additional, Hosoda, Waki, additional, and Niwa, Yasumasa, additional

Published
2022
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31. Artificial intelligence using deep learning analysis of endoscopic ultrasonography images for the differential diagnosis of pancreatic masses

Author

Kuwahara, Takamichi, additional, Hara, Kazuo, additional, Mizuno, Nobumasa, additional, Haba, Shin, additional, Okuno, Nozomi, additional, Kuraishi, Yasuhiro, additional, Fumihara, Daiki, additional, Yanaidani, Takafumi, additional, Ishikawa, Sho, additional, Yasuda, Tsukasa, additional, Yamada, Masanori, additional, Onishi, Sachiyo, additional, Yamada, Keisaku, additional, Tanaka, Tsutomu, additional, Tajika, Masahiro, additional, Niwa, Yasumasa, additional, Yamaguchi, Rui, additional, and Shimizu, Yasuhiro, additional

Published
2022
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33. Novel drill dilator facilitates endoscopic ultrasound‐guided hepaticogastrostomy.

Author

Okuno, Nozomi, Hara, Kazuo, Haba, Shin, Kuwahara, Takamichi, Kuraishi, Yasuhiro, Yanaidani, Takafumi, Ishikawa, Sho, Yasuda, Tsukasa, Yamada, Masanori, and Fukui, Toshitaka

Subjects
ENDOSCOPIC ultrasonography, TIME dilation
Abstract

Tract dilation is one of the most difficult stages of endoscopic ultrasound‐guided hepaticogastrostomy (EUS‐HGS), especially for beginners. To overcome this problem, we applied a special dedicated dilator. Herein, we retrospectively evaluate the safety and usefulness of a novel drill dilator in EUS‐HGS. This single‐center retrospective study included 20 consecutive patients who underwent EUS‐HGS with a novel drill dilator. The tip is 0.77 mm, and it becomes 7F at 3 cm from tip. The track is dilated to 7F by simple clockwise rotation. The technical success rate of both initial tract dilation and stent placement was 20/20 (100%). No cases required additional dilation such as balloon or electric cautery. In 13/20 cases (65.0%), EUS‐HGS was performed by beginner endoscopists. Median time required for dilation was 62.5 s (range, 30–144 s). Median procedure time was 13 min (range, 7–25 min). Early adverse events were two cases of mild fever. There was no bile leakage or bleeding. The novel drill dilator appears to be safe and useful for EUS‐HGS. As it is not necessary to press the device strongly, there is no pushback during dilation and the scope position is stable. These characteristics facilitate EUS‐HGS even for beginners. This device may enable the further development and increased dissemination of EUS intervention. [ABSTRACT FROM AUTHOR]

Published
2023
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34. Artificial intelligence using deep learning analysis of endoscopic ultrasonography images for the differential diagnosis of pancreatic masses.

Author

Kuwahara, Takamichi, Hara, Kazuo, Mizuno, Nobumasa, Haba, Shin, Okuno, Nozomi, Kuraishi, Yasuhiro, Fumihara, Daiki, Yanaidani, Takafumi, Ishikawa, Sho, Yasuda, Tsukasa, Yamada, Masanori, Onishi, Sachiyo, Yamada, Keisaku, Tanaka, Tsutomu, Tajika, Masahiro, Niwa, Yasumasa, Yamaguchi, Rui, and Shimizu, Yasuhiro

Subjects
ENDOSCOPIC ultrasonography, DEEP learning, ARTIFICIAL intelligence, DIFFERENTIAL diagnosis, NEUROENDOCRINE tumors, CHRONIC pancreatitis, PANCREATIC duct
Abstract

Background There are several types of pancreatic mass, so it is important to distinguish between them before treatment. Artificial intelligence (AI) is a mathematical technique that automates learning and recognition of data patterns. This study aimed to investigate the efficacy of our AI model using endoscopic ultrasonography (EUS) images of multiple types of pancreatic mass (pancreatic ductal adenocarcinoma [PDAC], pancreatic adenosquamous carcinoma [PASC], acinar cell carcinoma [ACC], metastatic pancreatic tumor [MPT], neuroendocrine carcinoma [NEC], neuroendocrine tumor [NET], solid pseudopapillary neoplasm [SPN], chronic pancreatitis, and autoimmune pancreatitis [AIP]). Methods Patients who underwent EUS were included in this retrospective study. The included patients were divided into training, validation, and test cohorts. Using these cohorts, an AI model that can distinguish pancreatic carcinomas from noncarcinomatous pancreatic lesions was developed using a deep-learning architecture and the diagnostic performance of the AI model was evaluated. Results 22 000 images were generated from 933 patients. The area under the curve, sensitivity, specificity, and accuracy (95 %CI) of the AI model for the diagnosis of pancreatic carcinomas in the test cohort were 0.90 (0.84–0.97), 0.94 (0.88–0.98), 0.82 (0.68–0.92), and 0.91 (0.85–0.95), respectively. The per-category sensitivities (95 %CI) of each disease were PDAC 0.96 (0.90–0.99), PASC 1.00 (0.05–1.00), ACC 1.00 (0.22–1.00), MPT 0.33 (0.01–0.91), NEC 1.00 (0.22–1.00), NET 0.93 (0.66–1.00), SPN 1.00 (0.22–1.00), chronic pancreatitis 0.78 (0.52–0.94), and AIP 0.73 (0.39–0.94). Conclusions Our developed AI model can distinguish pancreatic carcinomas from noncarcinomatous pancreatic lesions, but external validation is needed. [ABSTRACT FROM AUTHOR]

Published
2023
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35. Detection rate of endoscopic ultrasound and computed tomography in diagnosing pancreatic neuroendocrine neoplasms including small lesions: A multicenter study

Author

Kurita, Yusuke, primary, Hara, Kazuo, additional, Kobayashi, Noritoshi, additional, Kuwahara, Takamichi, additional, Mizuno, Nobumasa, additional, Okuno, Nozomi, additional, Haba, Shin, additional, Yagi, Shin, additional, Hasegawa, Sho, additional, Sato, Takamitsu, additional, Hosono, Kunihiro, additional, Endo, Itaru, additional, Shimizu, Yasuhiro, additional, Niwa, Yasumasa, additional, Utsunomiya, Daisuke, additional, Inaba, Yoshitaka, additional, Nakajima, Atsushi, additional, Kubota, Kensuke, additional, and Ichikawa, Yasushi, additional

Published
2022
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38. Neoadjuvant S-1 Therapy for Resectable Pancreatic Adenocarcinoma: Findings from Phase II of the HOPS-R01 Trial

Author

Nakamura, Toru, primary, Hayashi, Tsuyoshi, additional, Kimura, Yasutoshi, additional, Kawakami, Hiroshi, additional, Takahashi, Kuniyuki, additional, Ishiwatari, Hirotoshi, additional, Goto, Takuma, additional, Motoya, Masayo, additional, Yamakita, Keisuke, additional, Sakuhara, Yusuke, additional, Ono, Michihiro, additional, Tanaka, Eiichi, additional, Omi, Makoto, additional, Murakawa, Katsuhiko, additional, Iida, Tomoya, additional, Sakurai, Tamaki, additional, Haba, Shin, additional, Abiko, Takehiro, additional, ITO, Yoichi, additional, Maguchi, Hiroyuki, additional, and Hirano, Satoshi, additional

Published
2022
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40. B2 puncture with forward-viewing EUS simplifies EUS-guided hepaticogastrostomy (with video)

Author

Hara, Kazuo, primary, Okuno, Nozomi, additional, Mizuno, Nobumasa, additional, Haba, Shin, additional, Kuwahara, Takamichi, additional, Kuraishi, Yasuhiro, additional, Tajika, Masahiro, additional, Tanaka, Tsutomu, additional, Onishi, Sachiyo, additional, Yamada, Keisaku, additional, Fumihara, Daiki, additional, Yanaidani, Takafumi, additional, Ishikawa, Sho, additional, Yamada, Masanori, additional, Yasuda, Tsukasa, additional, and Elshair, Moaz, additional

Published
2022
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46. Outcomes of Endoscopic Ultrasound-Guided Biliary Drainage in Patients Undergoing Antithrombotic Therapy

Author

Okuno, Nozomi, primary, Hara, Kazuo, additional, Mizuno, Nobumasa, additional, Haba, Shin, additional, Kuwahara, Takamichi, additional, Koda, Hiroki, additional, Tajika, Masahiro, additional, Tanaka, Tsutomu, additional, Onishi, Sachiyo, additional, Yamada, Keisaku, additional, Miyano, Akira, additional, Fumihara, Daiki, additional, and Elshair, Moaz, additional

Published
2021
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