Remote sensing satellite imagery consistently provides valuable and frequent information, enabling the exploration of mineral resources across immense, remote and harsh domains. Recent developments in spaceborne hyperspectral remote sensing have opened avenues to support diverse remote sensing applications, particularly in the realm of mineral exploration. This study evaluates the capabilities of the PRecursore IperSpettrale della Missione Applicativa (PRISMA) hyperspectral satellite data for mapping alteration minerals using the Matched Filtering Unmixing (MFU) approach in the Sar-e-châh-e-shur, Birjand, Iran. Minerals such as richterite, augite, psilomelane, ilmenite, kaolinite, smectite, mirabilite, muscovite, and chlorite were identified using the vertex component analysis (VCA) technique. Subsequently, alteration mineral maps of the study area were generated using a matched filtering technique. Additionally, through the integration of X-ray diffraction (XRD) analysis, thin section examination, geochemical study of stream sediments, and interpretation of geological maps, potential alteration mineralization zones were delineated in the study area. Ultimately, the validation process, which included comparing the maps with the findings derived from the PRISMA remote sensing study, was conducted using the normal score equation. Thus, our results yielded a normalized score of 3.42 out of 4, signifying an 85.71% agreement with the regional geological characteristics of the study area. The results of this investigation highlight the substantial potential of the PRISMA dataset for systematic alteration mineral mapping and consequent exploration of ore minerals, specifically in challenging and inaccessible terrains. [ABSTRACT FROM AUTHOR]