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23 results on '"Habigt, Moriz A."'

2. Coronary Microvascular Dysfunction in Acute Cholestasis-Induced Liver Injury

Author

Billig, Sebastian, primary, Hein, Marc, additional, Kirchner, Celine, additional, Schumacher, David, additional, Habigt, Moriz Aljoscha, additional, Mechelinck, Mare, additional, Fuchs, Dieter, additional, Klinge, Uwe, additional, Theißen, Alexander, additional, Beckers, Christian, additional, Bleilevens, Christian, additional, Kramann, Rafael, additional, and Uhlig, Moritz, additional

Published
2024
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15. In VivoEvaluation of a Novel Control Algorithm for Left Ventricular Assist Devices Based Upon Ventricular Stroke Work

Author

Habigt, Moriz A., Hein, Marc, Gesenhues, Jonas, Abel, Dirk, Rossaint, Rolf, and Mechelinck, Mare

Abstract

The physical fitness of patients with terminal heart failure and an implanted left ventricular assist device (LVAD) might be improved by load-adaptive control of the LVAD. In this study, three control strategies for LVAD were compared in eight pigs: (1) a constant stroke work (CSW) control strategy that ensures a constant ventricular load using ventricular stroke work as the control variable; (2) a work ratio (WR) controller that maintains a constant ratio of ventricular work to hydraulic pump work; and (3) a controller that maintains the pump pace at a constant speed (CS). Biventricular heart insufficiency was induced by increased isoflurane application, and preload, afterload, and contractility alterations were performed. LVAD speed changes were significantly more pronounced in all load interventions with the CSW control strategy (preload: P< 0.001 vs.CS and P= 0.004 vs.WR; afterload: P< 0.001 vs.CS and P< 0.001 vs.WR; contractility: P< 0.001 vs.CS and P< 0.001 vs.WR). However, a significant difference in systemic flow only became evident in the experiments upon afterload increase (P< 0.001 vs.CS and P= 0.004 vs.WR). An implementation of an evolved version of the CSW control strategy that dispenses with invasively measured parameters might be feasible for clinical use.

Published
2023
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21. Benefits of object-oriented models and ModeliChart: modern tools and methods for the interdisciplinary research on smart biomedical technology

Author

Gesenhues, Jonas, primary, Hein, Marc, additional, Ketelhut, Maike, additional, Habigt, Moriz, additional, Rüschen, Daniel, additional, Mechelinck, Mare, additional, Albin, Thivaharan, additional, Leonhardt, Steffen, additional, Schmitz-Rode, Thomas, additional, Rossaint, Rolf, additional, Autschbach, Rüdiger, additional, and Abel, Dirk, additional

Published
2017
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23. In vivo evaluation of two adaptive Starling-like control algorithms for left ventricular assist devices.

Author

Habigt MA, Gesenhues J, Ketelhut M, Hein M, Duschner P, Rossaint R, and Mechelinck M

Subjects
Algorithms, Animals, Computer Simulation, Equipment Design, Heart-Assist Devices, Humans, Swine, Heart Failure physiopathology, Heart Ventricles physiopathology, Pulsatile Flow physiology, Starlings, Stroke physiopathology
Abstract

The implantation of a left ventricular assist device (LVAD) is often the only therapy in terminal heart failure (HF). However, despite technical advancements, the physical fitness of the patients is still limited. One strategy to improve the benefits of ventricular assist device therapy might be the implementation of load adaptive control strategies. Two control strategies and a constant speed controller (CS) were implemented in an acute animal model where four healthy pigs received LVAD implantations. In the first strategy (preload recruitable stroke work [SW] controller, PRS), the desired pump work was computed in relation to the end-diastolic volume. In the second strategy, the controller was programmed to keep a fixed ratio of the mean hydraulic power of the assist device to the mean hydraulic power of the left ventricle (power relation controller, PR). Preload reduction, afterload increase experiments and short-term coronary artery occlusions were conducted to test the behavior of the control strategies under variable conditions. Within the experiments, the PR controller demonstrated the best preload sensitivity. The PRS controller had the best response to an increased afterload and to a reduced ventricular contractility in terms of effectively preventing ventricular overloading and increasing VAD support. No significant differences in systemic flow were observed., (© 2020 Walter de Gruyter GmbH, Berlin/Boston.)

Published
2020
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