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15 results on '"Hachiya, Hiroki"'

9. Dulaglutide‐combined basal plus correction insulin therapy contributes to ideal glycemic control in non‐critical hospitalized patients.

Author

Fushimi, Nobutoshi, Shibuya, Takashi, Yoshida, Yohei, Ito, Shun, Hachiya, Hiroki, and Mori, Akihiro

Subjects
GLYCEMIC control, HOSPITAL patients, INSULIN, BLOOD sugar, TYPE 2 diabetes
Abstract

Aims/Introduction: We investigated whether dulaglutide (DU)‐combined conventional insulin therapy is beneficial for glycemic control in non‐critically ill hospitalized patients with type 2 diabetes. Materials and Methods: This study was a prospective, randomized controlled pilot study. Participants were randomized to either basal‐plus (BP) therapy, where basal insulin and corrective doses of regular insulin were administered before meals, or BP + DU therapy, where BP therapy was combined with DU. Blood glucose (BG) levels before and after every meal were measured for 7 days after assignment to groups. Because we consider the ideal BG during hospitalization to be within 100–180 mg/dL, we defined this range as the hospitalized ideal glucose range (hIGR). We compared the percentage of BG measurements within the hIGR among all BG measurements (%hIGR), mean BG, glucose variability and insulin dose between the two groups. Results: Of 54 patients, 27 were assigned to the BP group and 27 to the BP + DU group. The %hIGR was significantly higher (44% vs 56%, P < 0.001), and the frequency of BG >240 mg/dL and BG <70 mg/dL was significantly lower in the BP + DU group than in the BP group (both P < 0.001). The mean BG (183 ± 29 vs 162 ± 30 mg/dL, P < 0.05), standard deviation (P < 0.01), coefficient of variation (P < 0.01) and total regular insulin dose (P < 0.05) in the BP + DU group were significantly lower than those in the BP group. No significant side‐effects were observed in either group. Conclusions: BP + DU therapy reduced the frequency of hyperglycemia and hypoglycemia, and resulted in a lower glucose variability. [ABSTRACT FROM AUTHOR]

Published
2020
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10. Investigating the Relationship between Morning Glycemic Variability and Patient Characteristics Using Continuous Glucose Monitoring Data in Patients with Type 2 Diabetes

Author

Takeishi, Soichi, primary, Mori, Akihiro, additional, Kawai, Miyuka, additional, Yoshida, Yohei, additional, Hachiya, Hiroki, additional, Yumura, Takayuki, additional, Ito, Shun, additional, Shibuya, Takashi, additional, Fushimi, Nobutoshi, additional, Ohashi, Noritsugu, additional, and Kawai, Hiromi, additional

Published
2017
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12. Hypoglycemia and glycemic variability are associated with mortality in non‐intensive care unit hospitalized infectious disease patients with diabetes mellitus

Author

Takeishi, Soichi, primary, Mori, Akihiro, additional, Hachiya, Hiroki, additional, Yumura, Takayuki, additional, Ito, Shun, additional, Shibuya, Takashi, additional, Hayashi, Shintaro, additional, Fushimi, Nobutoshi, additional, Ohashi, Noritsugu, additional, and Kawai, Hiromi, additional

Published
2015
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