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651 results on '"Hadzidimitriou, A"'

2. 3D Protein-Structure-Oriented Discovery of Clinical Relation Across Chronic Lymphocytic Leukemia Patients

Author

Mochament, Konstantinos, Agathangelidis, Andreas, Polychronidou, Eleftheria, Palaskas, Christos, Kalamaras, Elias, Moschonas, Panagiotis, Stamatopoulos, Kostas, Chailyan, Anna, Overby, Nanna, Marcatili, Paolo, Hadzidimitriou, Anastasia, Tzovaras, Dimitrios, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Rojas, Ignacio, editor, and Ortuño, Francisco, editor

Published
2017
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3. First results from a Chandra survey of the 'Bar' region of the SMC

Author

Zezas, A., McDowell, J. C., Hadzidimitriou, D., Kalogera, V., Fabbiano, G., and Taylor, P.

Subjects
Astrophysics
Abstract

We present the first results from a Chandra survey of the central region of the Small Magellanic Cloud. We detect a total of 122 sources down to a limiting luminosity of ~4.3x10^{33} erg\s (corrected for Galactic N_{H}), which is ~10 times lower than in any previous survey of the SMC. We identify 20 candidate transient sources: eighteen previously known sources in this area which are not detected in our observations, and two new bright sources. The spectral parameters of the brightest sources indicate that they are X-ray binary pulsars. The high spatial resolution of Chandra allows us to initially identify optical counterparts for 35 sources, 13 of which are new identifications., Comment: Poster presented at the 2003 STScI Spring Symposium "The Local Group as an Astrophysical Laboratory"

Published
2003

4. AEGLE: A big bio-data analytics framework for integrated health-care services.

Author

Dimitrios Soudris, Sotirios Xydis, Christos Baloukas, Anastasia Hadzidimitriou, Ioanna Chouvarda, Kostas Stamatopoulos, Nicos Maglaveras, John Chang, Andreas Raptopoulos, David Manset, Barbara K. Pierscionek, Reem Kayyali, Nada Y. Philip, Tobias Becker, Katerina Vaporidi, Eumorphia Kondili, Dimitrios Georgopoulos, Lesley Ann Sutton, Richard Rosenquist, Lydia Scarfo, and Paolo Ghia

Published
2015
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5. Data from Implementation of HPV-based Cervical Cancer Screening Combined with Self-sampling Using a Midwifery Network Across Rural Greece: The GRECOSELF Study

Author

Agorastos, Theodoros, primary, Chatzistamatiou, Kimon, primary, Tsertanidou, Athena, primary, Mouchtaropoulou, Evangelia, primary, Pasentsis, Konstantinos, primary, Kitsou, Anastasia, primary, Moysiadis, Theodoros, primary, Moschaki, Viktoria, primary, Skenderi, Alkmini, primary, Katsiki, Evangelia, primary, Aggelidou, Stamatia, primary, Venizelos, Ioannis, primary, Ntoula, Maria, primary, Daponte, Alexandros, primary, Vanakara, Polyxeni, primary, Garas, Antonios, primary, Stefos, Theodoros, primary, Vrekoussis, Thomas, primary, Lymberis, Vasilis, primary, Kontomanolis, Emmanuel N., primary, Makrigiannakis, Antonis, primary, Manidakis, George, primary, Deligeoroglou, Efthimios, primary, Panoskaltsis, Theodoros, primary, Decavalas, George O., primary, Michail, George, primary, Kalogiannidis, Ioannis, primary, Koukoulis, George, primary, Zempili, Paraskevi, primary, Halatsi, Despina, primary, Truva, Theoni, primary, Piha, Vaia, primary, Agelena, Georgia, primary, Chronopoulou, Athanasia, primary, Vaitsi, Violetta, primary, Chatzaki, Ekaterini, primary, Paschopoulos, Minas, primary, Adonakis, George, primary, Kaufmann, Andreas M., primary, Hadzidimitriou, Anastasia, primary, and Stamatopoulos, Kostas, primary

Published
2023
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6. Supplementary Data from Implementation of HPV-based Cervical Cancer Screening Combined with Self-sampling Using a Midwifery Network Across Rural Greece: The GRECOSELF Study

Author

Agorastos, Theodoros, primary, Chatzistamatiou, Kimon, primary, Tsertanidou, Athena, primary, Mouchtaropoulou, Evangelia, primary, Pasentsis, Konstantinos, primary, Kitsou, Anastasia, primary, Moysiadis, Theodoros, primary, Moschaki, Viktoria, primary, Skenderi, Alkmini, primary, Katsiki, Evangelia, primary, Aggelidou, Stamatia, primary, Venizelos, Ioannis, primary, Ntoula, Maria, primary, Daponte, Alexandros, primary, Vanakara, Polyxeni, primary, Garas, Antonios, primary, Stefos, Theodoros, primary, Vrekoussis, Thomas, primary, Lymberis, Vasilis, primary, Kontomanolis, Emmanuel N., primary, Makrigiannakis, Antonis, primary, Manidakis, George, primary, Deligeoroglou, Efthimios, primary, Panoskaltsis, Theodoros, primary, Decavalas, George O., primary, Michail, George, primary, Kalogiannidis, Ioannis, primary, Koukoulis, George, primary, Zempili, Paraskevi, primary, Halatsi, Despina, primary, Truva, Theoni, primary, Piha, Vaia, primary, Agelena, Georgia, primary, Chronopoulou, Athanasia, primary, Vaitsi, Violetta, primary, Chatzaki, Ekaterini, primary, Paschopoulos, Minas, primary, Adonakis, George, primary, Kaufmann, Andreas M., primary, Hadzidimitriou, Anastasia, primary, and Stamatopoulos, Kostas, primary

Published
2023
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7. Supplemental Table 4 from An Immunogenetic Signature of Ongoing Antigen Interactions in Splenic Marginal Zone Lymphoma Expressing IGHV1-2*04 Receptors

Author

Bikos, Vasilis, primary, Karypidou, Maria, primary, Stalika, Evangelia, primary, Baliakas, Panagiotis, primary, Xochelli, Aliki, primary, Sutton, Lesley-Ann, primary, Papadopoulos, George, primary, Agathangelidis, Andreas, primary, Papadopoulou, Evdoxia, primary, Davis, Zadie, primary, Algara, Patricia, primary, Kanellis, George, primary, Traverse-Glehen, Alexandra, primary, Mollejo, Manuela, primary, Anagnostopoulos, Achilles, primary, Ponzoni, Maurilio, primary, Gonzalez, David, primary, Pospisilova, Sarka, primary, Matutes, Estella, primary, Piris, Miguel Angel, primary, Papadaki, Theodora, primary, Ghia, Paolo, primary, Rosenquist, Richard, primary, Oscier, David, primary, Darzentas, Nikos, primary, Tzovaras, Dimitrios, primary, Belessi, Chrysoula, primary, Hadzidimitriou, Anastasia, primary, and Stamatopoulos, Kostas, primary

Published
2023
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8. Supplemental Table 5 from An Immunogenetic Signature of Ongoing Antigen Interactions in Splenic Marginal Zone Lymphoma Expressing IGHV1-2*04 Receptors

Author

Bikos, Vasilis, primary, Karypidou, Maria, primary, Stalika, Evangelia, primary, Baliakas, Panagiotis, primary, Xochelli, Aliki, primary, Sutton, Lesley-Ann, primary, Papadopoulos, George, primary, Agathangelidis, Andreas, primary, Papadopoulou, Evdoxia, primary, Davis, Zadie, primary, Algara, Patricia, primary, Kanellis, George, primary, Traverse-Glehen, Alexandra, primary, Mollejo, Manuela, primary, Anagnostopoulos, Achilles, primary, Ponzoni, Maurilio, primary, Gonzalez, David, primary, Pospisilova, Sarka, primary, Matutes, Estella, primary, Piris, Miguel Angel, primary, Papadaki, Theodora, primary, Ghia, Paolo, primary, Rosenquist, Richard, primary, Oscier, David, primary, Darzentas, Nikos, primary, Tzovaras, Dimitrios, primary, Belessi, Chrysoula, primary, Hadzidimitriou, Anastasia, primary, and Stamatopoulos, Kostas, primary

Published
2023
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9. Supplemental Table 1 from An Immunogenetic Signature of Ongoing Antigen Interactions in Splenic Marginal Zone Lymphoma Expressing IGHV1-2*04 Receptors

Author

Bikos, Vasilis, primary, Karypidou, Maria, primary, Stalika, Evangelia, primary, Baliakas, Panagiotis, primary, Xochelli, Aliki, primary, Sutton, Lesley-Ann, primary, Papadopoulos, George, primary, Agathangelidis, Andreas, primary, Papadopoulou, Evdoxia, primary, Davis, Zadie, primary, Algara, Patricia, primary, Kanellis, George, primary, Traverse-Glehen, Alexandra, primary, Mollejo, Manuela, primary, Anagnostopoulos, Achilles, primary, Ponzoni, Maurilio, primary, Gonzalez, David, primary, Pospisilova, Sarka, primary, Matutes, Estella, primary, Piris, Miguel Angel, primary, Papadaki, Theodora, primary, Ghia, Paolo, primary, Rosenquist, Richard, primary, Oscier, David, primary, Darzentas, Nikos, primary, Tzovaras, Dimitrios, primary, Belessi, Chrysoula, primary, Hadzidimitriou, Anastasia, primary, and Stamatopoulos, Kostas, primary

Published
2023
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10. Figure S2B from Chronic Lymphocytic Leukemia with Mutated IGHV4-34 Receptors: Shared and Distinct Immunogenetic Features and Clinical Outcomes

Author

Xochelli, Aliki, primary, Baliakas, Panagiotis, primary, Kavakiotis, Ioannis, primary, Agathangelidis, Andreas, primary, Sutton, Lesley-Ann, primary, Minga, Eva, primary, Ntoufa, Stavroula, primary, Tausch, Eugen, primary, Yan, Xiao-Jie, primary, Shanafelt, Tait, primary, Plevova, Karla, primary, Boudjogra, Myriam, primary, Rossi, Davide, primary, Davis, Zadie, primary, Navarro, Alba, primary, Sandberg, Yorick, primary, Vojdeman, Fie Juhl, primary, Scarfo, Lydia, primary, Stavroyianni, Niki, primary, Sudarikov, Andrey, primary, Veronese, Silvio, primary, Tzenou, Tatiana, primary, Karan-Djurasevic, Teodora, primary, Catherwood, Mark, primary, Kienle, Dirk, primary, Chatzouli, Maria, primary, Facco, Monica, primary, Bahlo, Jasmin, primary, Pott, Christiane, primary, Pedersen, Lone Bredo, primary, Mansouri, Larry, primary, Smedby, Karin E., primary, Chu, Charles C., primary, Giudicelli, Véronique, primary, Lefranc, Marie-Paule, primary, Panagiotidis, Panagiotis, primary, Juliusson, Gunnar, primary, Anagnostopoulos, Achilles, primary, Vlahavas, Ioannis, primary, Antic, Darko, primary, Trentin, Livio, primary, Montillo, Marco, primary, Niemann, Carsten, primary, Döhner, Hartmut, primary, Langerak, Anton W., primary, Pospisilova, Sarka, primary, Hallek, Michael, primary, Campo, Elias, primary, Chiorazzi, Nicholas, primary, Maglaveras, Nikos, primary, Oscier, David, primary, Gaidano, Gianluca, primary, Jelinek, Diane F., primary, Stilgenbauer, Stephan, primary, Chouvarda, Ioanna, primary, Darzentas, Nikos, primary, Belessi, Chrysoula, primary, Davi, Frederic, primary, Hadzidimitriou, Anastasia, primary, Rosenquist, Richard, primary, Ghia, Paolo, primary, and Stamatopoulos, Kostas, primary

Published
2023
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11. Supplemental Table 3 from An Immunogenetic Signature of Ongoing Antigen Interactions in Splenic Marginal Zone Lymphoma Expressing IGHV1-2*04 Receptors

Author

Bikos, Vasilis, primary, Karypidou, Maria, primary, Stalika, Evangelia, primary, Baliakas, Panagiotis, primary, Xochelli, Aliki, primary, Sutton, Lesley-Ann, primary, Papadopoulos, George, primary, Agathangelidis, Andreas, primary, Papadopoulou, Evdoxia, primary, Davis, Zadie, primary, Algara, Patricia, primary, Kanellis, George, primary, Traverse-Glehen, Alexandra, primary, Mollejo, Manuela, primary, Anagnostopoulos, Achilles, primary, Ponzoni, Maurilio, primary, Gonzalez, David, primary, Pospisilova, Sarka, primary, Matutes, Estella, primary, Piris, Miguel Angel, primary, Papadaki, Theodora, primary, Ghia, Paolo, primary, Rosenquist, Richard, primary, Oscier, David, primary, Darzentas, Nikos, primary, Tzovaras, Dimitrios, primary, Belessi, Chrysoula, primary, Hadzidimitriou, Anastasia, primary, and Stamatopoulos, Kostas, primary

Published
2023
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13. Supplemental Table 2 from An Immunogenetic Signature of Ongoing Antigen Interactions in Splenic Marginal Zone Lymphoma Expressing IGHV1-2*04 Receptors

Author

Bikos, Vasilis, primary, Karypidou, Maria, primary, Stalika, Evangelia, primary, Baliakas, Panagiotis, primary, Xochelli, Aliki, primary, Sutton, Lesley-Ann, primary, Papadopoulos, George, primary, Agathangelidis, Andreas, primary, Papadopoulou, Evdoxia, primary, Davis, Zadie, primary, Algara, Patricia, primary, Kanellis, George, primary, Traverse-Glehen, Alexandra, primary, Mollejo, Manuela, primary, Anagnostopoulos, Achilles, primary, Ponzoni, Maurilio, primary, Gonzalez, David, primary, Pospisilova, Sarka, primary, Matutes, Estella, primary, Piris, Miguel Angel, primary, Papadaki, Theodora, primary, Ghia, Paolo, primary, Rosenquist, Richard, primary, Oscier, David, primary, Darzentas, Nikos, primary, Tzovaras, Dimitrios, primary, Belessi, Chrysoula, primary, Hadzidimitriou, Anastasia, primary, and Stamatopoulos, Kostas, primary

Published
2023
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14. Table S1 from Chronic Lymphocytic Leukemia with Mutated IGHV4-34 Receptors: Shared and Distinct Immunogenetic Features and Clinical Outcomes

Author

Xochelli, Aliki, primary, Baliakas, Panagiotis, primary, Kavakiotis, Ioannis, primary, Agathangelidis, Andreas, primary, Sutton, Lesley-Ann, primary, Minga, Eva, primary, Ntoufa, Stavroula, primary, Tausch, Eugen, primary, Yan, Xiao-Jie, primary, Shanafelt, Tait, primary, Plevova, Karla, primary, Boudjogra, Myriam, primary, Rossi, Davide, primary, Davis, Zadie, primary, Navarro, Alba, primary, Sandberg, Yorick, primary, Vojdeman, Fie Juhl, primary, Scarfo, Lydia, primary, Stavroyianni, Niki, primary, Sudarikov, Andrey, primary, Veronese, Silvio, primary, Tzenou, Tatiana, primary, Karan-Djurasevic, Teodora, primary, Catherwood, Mark, primary, Kienle, Dirk, primary, Chatzouli, Maria, primary, Facco, Monica, primary, Bahlo, Jasmin, primary, Pott, Christiane, primary, Pedersen, Lone Bredo, primary, Mansouri, Larry, primary, Smedby, Karin E., primary, Chu, Charles C., primary, Giudicelli, Véronique, primary, Lefranc, Marie-Paule, primary, Panagiotidis, Panagiotis, primary, Juliusson, Gunnar, primary, Anagnostopoulos, Achilles, primary, Vlahavas, Ioannis, primary, Antic, Darko, primary, Trentin, Livio, primary, Montillo, Marco, primary, Niemann, Carsten, primary, Döhner, Hartmut, primary, Langerak, Anton W., primary, Pospisilova, Sarka, primary, Hallek, Michael, primary, Campo, Elias, primary, Chiorazzi, Nicholas, primary, Maglaveras, Nikos, primary, Oscier, David, primary, Gaidano, Gianluca, primary, Jelinek, Diane F., primary, Stilgenbauer, Stephan, primary, Chouvarda, Ioanna, primary, Darzentas, Nikos, primary, Belessi, Chrysoula, primary, Davi, Frederic, primary, Hadzidimitriou, Anastasia, primary, Rosenquist, Richard, primary, Ghia, Paolo, primary, and Stamatopoulos, Kostas, primary

Published
2023
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15. Supplemental Figure 1 from An Immunogenetic Signature of Ongoing Antigen Interactions in Splenic Marginal Zone Lymphoma Expressing IGHV1-2*04 Receptors

Author

Bikos, Vasilis, primary, Karypidou, Maria, primary, Stalika, Evangelia, primary, Baliakas, Panagiotis, primary, Xochelli, Aliki, primary, Sutton, Lesley-Ann, primary, Papadopoulos, George, primary, Agathangelidis, Andreas, primary, Papadopoulou, Evdoxia, primary, Davis, Zadie, primary, Algara, Patricia, primary, Kanellis, George, primary, Traverse-Glehen, Alexandra, primary, Mollejo, Manuela, primary, Anagnostopoulos, Achilles, primary, Ponzoni, Maurilio, primary, Gonzalez, David, primary, Pospisilova, Sarka, primary, Matutes, Estella, primary, Piris, Miguel Angel, primary, Papadaki, Theodora, primary, Ghia, Paolo, primary, Rosenquist, Richard, primary, Oscier, David, primary, Darzentas, Nikos, primary, Tzovaras, Dimitrios, primary, Belessi, Chrysoula, primary, Hadzidimitriou, Anastasia, primary, and Stamatopoulos, Kostas, primary

Published
2023
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16. Data from Molecular Subsets of Mantle Cell Lymphoma Defined by the IGHV Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features

Author

Navarro, Alba, primary, Clot, Guillem, primary, Royo, Cristina, primary, Jares, Pedro, primary, Hadzidimitriou, Anastasia, primary, Agathangelidis, Andreas, primary, Bikos, Vasilis, primary, Darzentas, Nikos, primary, Papadaki, Theodora, primary, Salaverria, Itziar, primary, Pinyol, Magda, primary, Puig, Xavier, primary, Palomero, Jara, primary, Vegliante, Maria Carmela, primary, Amador, Virgina, primary, Martinez-Trillos, Alejandra, primary, Stefancikova, Lenka, primary, Wiestner, Adrian, primary, Wilson, Wyndham, primary, Pott, Christiane, primary, Calasanz, Maria Jose, primary, Trim, Nicola, primary, Erber, Wendy, primary, Sander, Birgitta, primary, Ott, German, primary, Rosenwald, Andreas, primary, Colomer, Dolors, primary, Giné, Eva, primary, Siebert, Reiner, primary, Lopez-Guillermo, Armando, primary, Stamatopoulos, Kostas, primary, Beà, Sílvia, primary, and Campo, Elías, primary

Published
2023
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17. Supplementary Table 4 from Molecular Subsets of Mantle Cell Lymphoma Defined by the IGHV Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features

Author

Navarro, Alba, primary, Clot, Guillem, primary, Royo, Cristina, primary, Jares, Pedro, primary, Hadzidimitriou, Anastasia, primary, Agathangelidis, Andreas, primary, Bikos, Vasilis, primary, Darzentas, Nikos, primary, Papadaki, Theodora, primary, Salaverria, Itziar, primary, Pinyol, Magda, primary, Puig, Xavier, primary, Palomero, Jara, primary, Vegliante, Maria Carmela, primary, Amador, Virgina, primary, Martinez-Trillos, Alejandra, primary, Stefancikova, Lenka, primary, Wiestner, Adrian, primary, Wilson, Wyndham, primary, Pott, Christiane, primary, Calasanz, Maria Jose, primary, Trim, Nicola, primary, Erber, Wendy, primary, Sander, Birgitta, primary, Ott, German, primary, Rosenwald, Andreas, primary, Colomer, Dolors, primary, Giné, Eva, primary, Siebert, Reiner, primary, Lopez-Guillermo, Armando, primary, Stamatopoulos, Kostas, primary, Beà, Sílvia, primary, and Campo, Elías, primary

Published
2023
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18. Supplementary Figure 3 from Molecular Subsets of Mantle Cell Lymphoma Defined by the IGHV Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features

Author

Navarro, Alba, primary, Clot, Guillem, primary, Royo, Cristina, primary, Jares, Pedro, primary, Hadzidimitriou, Anastasia, primary, Agathangelidis, Andreas, primary, Bikos, Vasilis, primary, Darzentas, Nikos, primary, Papadaki, Theodora, primary, Salaverria, Itziar, primary, Pinyol, Magda, primary, Puig, Xavier, primary, Palomero, Jara, primary, Vegliante, Maria Carmela, primary, Amador, Virgina, primary, Martinez-Trillos, Alejandra, primary, Stefancikova, Lenka, primary, Wiestner, Adrian, primary, Wilson, Wyndham, primary, Pott, Christiane, primary, Calasanz, Maria Jose, primary, Trim, Nicola, primary, Erber, Wendy, primary, Sander, Birgitta, primary, Ott, German, primary, Rosenwald, Andreas, primary, Colomer, Dolors, primary, Giné, Eva, primary, Siebert, Reiner, primary, Lopez-Guillermo, Armando, primary, Stamatopoulos, Kostas, primary, Beà, Sílvia, primary, and Campo, Elías, primary

Published
2023
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19. Supplementary Table 1 from Molecular Subsets of Mantle Cell Lymphoma Defined by the IGHV Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features

Author

Navarro, Alba, primary, Clot, Guillem, primary, Royo, Cristina, primary, Jares, Pedro, primary, Hadzidimitriou, Anastasia, primary, Agathangelidis, Andreas, primary, Bikos, Vasilis, primary, Darzentas, Nikos, primary, Papadaki, Theodora, primary, Salaverria, Itziar, primary, Pinyol, Magda, primary, Puig, Xavier, primary, Palomero, Jara, primary, Vegliante, Maria Carmela, primary, Amador, Virgina, primary, Martinez-Trillos, Alejandra, primary, Stefancikova, Lenka, primary, Wiestner, Adrian, primary, Wilson, Wyndham, primary, Pott, Christiane, primary, Calasanz, Maria Jose, primary, Trim, Nicola, primary, Erber, Wendy, primary, Sander, Birgitta, primary, Ott, German, primary, Rosenwald, Andreas, primary, Colomer, Dolors, primary, Giné, Eva, primary, Siebert, Reiner, primary, Lopez-Guillermo, Armando, primary, Stamatopoulos, Kostas, primary, Beà, Sílvia, primary, and Campo, Elías, primary

Published
2023
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20. Supplementary Figure 2 from Molecular Subsets of Mantle Cell Lymphoma Defined by the IGHV Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features

Author

Navarro, Alba, primary, Clot, Guillem, primary, Royo, Cristina, primary, Jares, Pedro, primary, Hadzidimitriou, Anastasia, primary, Agathangelidis, Andreas, primary, Bikos, Vasilis, primary, Darzentas, Nikos, primary, Papadaki, Theodora, primary, Salaverria, Itziar, primary, Pinyol, Magda, primary, Puig, Xavier, primary, Palomero, Jara, primary, Vegliante, Maria Carmela, primary, Amador, Virgina, primary, Martinez-Trillos, Alejandra, primary, Stefancikova, Lenka, primary, Wiestner, Adrian, primary, Wilson, Wyndham, primary, Pott, Christiane, primary, Calasanz, Maria Jose, primary, Trim, Nicola, primary, Erber, Wendy, primary, Sander, Birgitta, primary, Ott, German, primary, Rosenwald, Andreas, primary, Colomer, Dolors, primary, Giné, Eva, primary, Siebert, Reiner, primary, Lopez-Guillermo, Armando, primary, Stamatopoulos, Kostas, primary, Beà, Sílvia, primary, and Campo, Elías, primary

Published
2023
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21. Supplementary Figure 1 from Molecular Subsets of Mantle Cell Lymphoma Defined by the IGHV Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features

Author

Navarro, Alba, primary, Clot, Guillem, primary, Royo, Cristina, primary, Jares, Pedro, primary, Hadzidimitriou, Anastasia, primary, Agathangelidis, Andreas, primary, Bikos, Vasilis, primary, Darzentas, Nikos, primary, Papadaki, Theodora, primary, Salaverria, Itziar, primary, Pinyol, Magda, primary, Puig, Xavier, primary, Palomero, Jara, primary, Vegliante, Maria Carmela, primary, Amador, Virgina, primary, Martinez-Trillos, Alejandra, primary, Stefancikova, Lenka, primary, Wiestner, Adrian, primary, Wilson, Wyndham, primary, Pott, Christiane, primary, Calasanz, Maria Jose, primary, Trim, Nicola, primary, Erber, Wendy, primary, Sander, Birgitta, primary, Ott, German, primary, Rosenwald, Andreas, primary, Colomer, Dolors, primary, Giné, Eva, primary, Siebert, Reiner, primary, Lopez-Guillermo, Armando, primary, Stamatopoulos, Kostas, primary, Beà, Sílvia, primary, and Campo, Elías, primary

Published
2023
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22. Supplementary Table 2 from Molecular Subsets of Mantle Cell Lymphoma Defined by the IGHV Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features

Author

Navarro, Alba, primary, Clot, Guillem, primary, Royo, Cristina, primary, Jares, Pedro, primary, Hadzidimitriou, Anastasia, primary, Agathangelidis, Andreas, primary, Bikos, Vasilis, primary, Darzentas, Nikos, primary, Papadaki, Theodora, primary, Salaverria, Itziar, primary, Pinyol, Magda, primary, Puig, Xavier, primary, Palomero, Jara, primary, Vegliante, Maria Carmela, primary, Amador, Virgina, primary, Martinez-Trillos, Alejandra, primary, Stefancikova, Lenka, primary, Wiestner, Adrian, primary, Wilson, Wyndham, primary, Pott, Christiane, primary, Calasanz, Maria Jose, primary, Trim, Nicola, primary, Erber, Wendy, primary, Sander, Birgitta, primary, Ott, German, primary, Rosenwald, Andreas, primary, Colomer, Dolors, primary, Giné, Eva, primary, Siebert, Reiner, primary, Lopez-Guillermo, Armando, primary, Stamatopoulos, Kostas, primary, Beà, Sílvia, primary, and Campo, Elías, primary

Published
2023
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23. Supplementary Table 3 from Molecular Subsets of Mantle Cell Lymphoma Defined by the IGHV Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features

Author

Navarro, Alba, primary, Clot, Guillem, primary, Royo, Cristina, primary, Jares, Pedro, primary, Hadzidimitriou, Anastasia, primary, Agathangelidis, Andreas, primary, Bikos, Vasilis, primary, Darzentas, Nikos, primary, Papadaki, Theodora, primary, Salaverria, Itziar, primary, Pinyol, Magda, primary, Puig, Xavier, primary, Palomero, Jara, primary, Vegliante, Maria Carmela, primary, Amador, Virgina, primary, Martinez-Trillos, Alejandra, primary, Stefancikova, Lenka, primary, Wiestner, Adrian, primary, Wilson, Wyndham, primary, Pott, Christiane, primary, Calasanz, Maria Jose, primary, Trim, Nicola, primary, Erber, Wendy, primary, Sander, Birgitta, primary, Ott, German, primary, Rosenwald, Andreas, primary, Colomer, Dolors, primary, Giné, Eva, primary, Siebert, Reiner, primary, Lopez-Guillermo, Armando, primary, Stamatopoulos, Kostas, primary, Beà, Sílvia, primary, and Campo, Elías, primary

Published
2023
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24. Tailored approaches grounded on immunogenetic features for refined prognostication in chronic lymphocytic leukemia

Author

Panagiotis Baliakas, Theodoros Moysiadis, Anastasia Hadzidimitriou, Aliki Xochelli, Sabine Jeromin, Andreas Agathangelidis, Mattias Mattsson, Lesley-Ann Sutton, Eva Minga, Lydia Scarfò, Davide Rossi, Zadie Davis, Neus Villamor, Helen Parker, Jana Kotaskova, Evangelia Stalika, Karla Plevova, Larry Mansouri, Diego Cortese, Alba Navarro, Julio Delgado, Marta Larrayoz, Emma Young, Achilles Anagnostopoulos, Karin E. Smedby, Gunnar Juliusson, Oonagh Sheehy, Mark Catherwood, Jonathan C. Strefford, Niki Stavroyianni, Chrysoula Belessi, Sarka Pospisilova, David Oscier, Gianluca Gaidano, Elias Campo, Claudia Haferlach, Paolo Ghia, Richard Rosenquist, and Kostas Stamatopoulos

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Abstract

Chronic lymphocytic leukemia (CLL) patients with differential somatic hypermutation status of the immunoglobulin heavy variable genes, namely mutated or unmutated, display fundamental clinico-biological differences. Considering this, we assessed prognosis separately within mutated (M-CLL) and unmutated (U-CLL) CLL in 3015 patients, hypothesizing that the relative significance of relevant indicators may differ between these two categories. Within Binet A M-CLL patients, besides TP53 abnormalities, trisomy 12 and stereotyped subset #2 membership were equivalently associated with the shortest time-to-first-treatment and a treatment probability at five and ten years after diagnosis of 40% and 55%, respectively; the remaining cases exhibited 5-year and 10-year treatment probability of 12% and 25%, respectively. Within Binet A U-CLL patients, besides TP53 abnormalities, del(11q) and/or SF3B1 mutations were associated with the shortest time-to-first-treatment (5- and 10-year treatment probability: 78% and 98%, respectively); in the remaining cases, males had a significantly worse prognosis than females. In conclusion, the relative weight of indicators that can accurately risk stratify early-stage CLL patients differs depending on the somatic hypermutation status of the immunoglobulin heavy variable genes of each patient. This finding highlights the fact that compartmentalized approaches based on immunogenetic features are necessary to refine and tailor prognostication in CLL.

Published
2019
Full Text
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25. Data from Implementation of HPV-based Cervical Cancer Screening Combined with Self-sampling Using a Midwifery Network Across Rural Greece: The GRECOSELF Study

Author

Kostas Stamatopoulos, Anastasia Hadzidimitriou, Andreas M. Kaufmann, George Adonakis, Minas Paschopoulos, Ekaterini Chatzaki, Violetta Vaitsi, Athanasia Chronopoulou, Georgia Agelena, Vaia Piha, Theoni Truva, Despina Halatsi, Paraskevi Zempili, George Koukoulis, Ioannis Kalogiannidis, George Michail, George O. Decavalas, Theodoros Panoskaltsis, Efthimios Deligeoroglou, George Manidakis, Antonis Makrigiannakis, Emmanuel N. Kontomanolis, Vasilis Lymberis, Thomas Vrekoussis, Theodoros Stefos, Antonios Garas, Polyxeni Vanakara, Alexandros Daponte, Maria Ntoula, Ioannis Venizelos, Stamatia Aggelidou, Evangelia Katsiki, Alkmini Skenderi, Viktoria Moschaki, Theodoros Moysiadis, Anastasia Kitsou, Konstantinos Pasentsis, Evangelia Mouchtaropoulou, Athena Tsertanidou, Kimon Chatzistamatiou, and Theodoros Agorastos

Abstract

Self-sampling for human papillomavirus (HPV) testing is an alternative to physician sampling particularly for cervical cancer screening nonattenders. The GRECOSELF study is a nationwide observational cross-sectional study aiming to suggest a way to implement HPV-DNA testing in conjunction with self-sampling for cervical cancer screening in Greece, utilizing a midwifery network. Women residing in remote areas of Greece were approached by midwives, of a nationwide network, and were provided with a self-collection kit (dry swab) for cervicovaginal sampling and asked to answer a questionnaire about their cervical cancer screening history. Each sample was tested for high-risk (hr) HPV with the Cobas HPV test. HrHPV-Positive women were referred to undergo colposcopy and, if needed, treatment according to colposcopy/biopsy results. Between May 2016 and November 2018, 13,111 women were recruited. Of these, 12,787 women gave valid answers in the study questionnaire and had valid HPV-DNA results; hrHPV prevalence was 8.3%; high-grade cervical/vaginal disease or cancer prevalence was 0.6%. HrHPV positivity rate decreased with age from 20.7% for women aged 25–29 years to 5.1% for women aged 50–60 years. Positive predictive value for hrHPV testing and for HPV16/18 genotyping ranged from 5.0% to 11.6% and from 11.8% to 27.0%, respectively, in different age groups. Compliance to colposcopy referral rate ranged from 68.6% (for women 25–29) to 76.3% (for women 40–49). For women residing in remote areas of Greece, the detection of hrHPV DNA with the Cobas HPV test, on self-collected cervicovaginal samples using dry cotton swabs, which are provided by visiting midwives, is a promising method for cervical cancer secondary prevention.

Published
2023

26. Supplementary Data from Implementation of HPV-based Cervical Cancer Screening Combined with Self-sampling Using a Midwifery Network Across Rural Greece: The GRECOSELF Study

Author

Kostas Stamatopoulos, Anastasia Hadzidimitriou, Andreas M. Kaufmann, George Adonakis, Minas Paschopoulos, Ekaterini Chatzaki, Violetta Vaitsi, Athanasia Chronopoulou, Georgia Agelena, Vaia Piha, Theoni Truva, Despina Halatsi, Paraskevi Zempili, George Koukoulis, Ioannis Kalogiannidis, George Michail, George O. Decavalas, Theodoros Panoskaltsis, Efthimios Deligeoroglou, George Manidakis, Antonis Makrigiannakis, Emmanuel N. Kontomanolis, Vasilis Lymberis, Thomas Vrekoussis, Theodoros Stefos, Antonios Garas, Polyxeni Vanakara, Alexandros Daponte, Maria Ntoula, Ioannis Venizelos, Stamatia Aggelidou, Evangelia Katsiki, Alkmini Skenderi, Viktoria Moschaki, Theodoros Moysiadis, Anastasia Kitsou, Konstantinos Pasentsis, Evangelia Mouchtaropoulou, Athena Tsertanidou, Kimon Chatzistamatiou, and Theodoros Agorastos

Abstract

Suppl. 1. Comparison of different storage and transportation conditions

Published
2023

27. Supplemental Table 5 from An Immunogenetic Signature of Ongoing Antigen Interactions in Splenic Marginal Zone Lymphoma Expressing IGHV1-2*04 Receptors

Author

Kostas Stamatopoulos, Anastasia Hadzidimitriou, Chrysoula Belessi, Dimitrios Tzovaras, Nikos Darzentas, David Oscier, Richard Rosenquist, Paolo Ghia, Theodora Papadaki, Miguel Angel Piris, Estella Matutes, Sarka Pospisilova, David Gonzalez, Maurilio Ponzoni, Achilles Anagnostopoulos, Manuela Mollejo, Alexandra Traverse-Glehen, George Kanellis, Patricia Algara, Zadie Davis, Evdoxia Papadopoulou, Andreas Agathangelidis, George Papadopoulos, Lesley-Ann Sutton, Aliki Xochelli, Panagiotis Baliakas, Evangelia Stalika, Maria Karypidou, and Vasilis Bikos

Abstract

Recurrent amino acid replacements. Counts and distribution per IGHV gene and V-subregion. Respective physicochemical characteristics of the substitutions

Published
2023

28. Supplemental Table 2 from An Immunogenetic Signature of Ongoing Antigen Interactions in Splenic Marginal Zone Lymphoma Expressing IGHV1-2*04 Receptors

Author

Kostas Stamatopoulos, Anastasia Hadzidimitriou, Chrysoula Belessi, Dimitrios Tzovaras, Nikos Darzentas, David Oscier, Richard Rosenquist, Paolo Ghia, Theodora Papadaki, Miguel Angel Piris, Estella Matutes, Sarka Pospisilova, David Gonzalez, Maurilio Ponzoni, Achilles Anagnostopoulos, Manuela Mollejo, Alexandra Traverse-Glehen, George Kanellis, Patricia Algara, Zadie Davis, Evdoxia Papadopoulou, Andreas Agathangelidis, George Papadopoulos, Lesley-Ann Sutton, Aliki Xochelli, Panagiotis Baliakas, Evangelia Stalika, Maria Karypidou, and Vasilis Bikos

Abstract

IGH rearrangements'intraclonal diversification characteristics. Counts, distribution, hotspot targeting of confirmed/unconfirmed mutations and respective amino acid changes across gene groups and IGHV subregions.

Published
2023

30. Figure S1 from Chronic Lymphocytic Leukemia with Mutated IGHV4-34 Receptors: Shared and Distinct Immunogenetic Features and Clinical Outcomes

Author

Kostas Stamatopoulos, Paolo Ghia, Richard Rosenquist, Anastasia Hadzidimitriou, Frederic Davi, Chrysoula Belessi, Nikos Darzentas, Ioanna Chouvarda, Stephan Stilgenbauer, Diane F. Jelinek, Gianluca Gaidano, David Oscier, Nikos Maglaveras, Nicholas Chiorazzi, Elias Campo, Michael Hallek, Sarka Pospisilova, Anton W. Langerak, Hartmut Döhner, Carsten Niemann, Marco Montillo, Livio Trentin, Darko Antic, Ioannis Vlahavas, Achilles Anagnostopoulos, Gunnar Juliusson, Panagiotis Panagiotidis, Marie-Paule Lefranc, Véronique Giudicelli, Charles C. Chu, Karin E. Smedby, Larry Mansouri, Lone Bredo Pedersen, Christiane Pott, Jasmin Bahlo, Monica Facco, Maria Chatzouli, Dirk Kienle, Mark Catherwood, Teodora Karan-Djurasevic, Tatiana Tzenou, Silvio Veronese, Andrey Sudarikov, Niki Stavroyianni, Lydia Scarfo, Fie Juhl Vojdeman, Yorick Sandberg, Alba Navarro, Zadie Davis, Davide Rossi, Myriam Boudjogra, Karla Plevova, Tait Shanafelt, Xiao-Jie Yan, Eugen Tausch, Stavroula Ntoufa, Eva Minga, Lesley-Ann Sutton, Andreas Agathangelidis, Ioannis Kavakiotis, Panagiotis Baliakas, and Aliki Xochelli

Abstract

Distribution of IGHV4-34 CLL according to IGHV mutational status and subset membership.

Published
2023

31. Data from Chronic Lymphocytic Leukemia with Mutated IGHV4-34 Receptors: Shared and Distinct Immunogenetic Features and Clinical Outcomes

Author

Kostas Stamatopoulos, Paolo Ghia, Richard Rosenquist, Anastasia Hadzidimitriou, Frederic Davi, Chrysoula Belessi, Nikos Darzentas, Ioanna Chouvarda, Stephan Stilgenbauer, Diane F. Jelinek, Gianluca Gaidano, David Oscier, Nikos Maglaveras, Nicholas Chiorazzi, Elias Campo, Michael Hallek, Sarka Pospisilova, Anton W. Langerak, Hartmut Döhner, Carsten Niemann, Marco Montillo, Livio Trentin, Darko Antic, Ioannis Vlahavas, Achilles Anagnostopoulos, Gunnar Juliusson, Panagiotis Panagiotidis, Marie-Paule Lefranc, Véronique Giudicelli, Charles C. Chu, Karin E. Smedby, Larry Mansouri, Lone Bredo Pedersen, Christiane Pott, Jasmin Bahlo, Monica Facco, Maria Chatzouli, Dirk Kienle, Mark Catherwood, Teodora Karan-Djurasevic, Tatiana Tzenou, Silvio Veronese, Andrey Sudarikov, Niki Stavroyianni, Lydia Scarfo, Fie Juhl Vojdeman, Yorick Sandberg, Alba Navarro, Zadie Davis, Davide Rossi, Myriam Boudjogra, Karla Plevova, Tait Shanafelt, Xiao-Jie Yan, Eugen Tausch, Stavroula Ntoufa, Eva Minga, Lesley-Ann Sutton, Andreas Agathangelidis, Ioannis Kavakiotis, Panagiotis Baliakas, and Aliki Xochelli

Abstract

Purpose: We sought to investigate whether B cell receptor immunoglobulin (BcR IG) stereotypy is associated with particular clinicobiological features among chronic lymphocytic leukemia (CLL) patients expressing mutated BcR IG (M-CLL) encoded by the IGHV4-34 gene, and also ascertain whether these associations could refine prognostication.Experimental Design: In a series of 19,907 CLL cases with available immunogenetic information, we identified 339 IGHV4-34–expressing cases assigned to one of the four largest stereotyped M-CLL subsets, namely subsets #4, #16, #29 and #201, and investigated in detail their clinicobiological characteristics and disease outcomes.Results: We identified shared and subset-specific patterns of somatic hypermutation (SHM) among patients assigned to these subsets. The greatest similarity was observed between subsets #4 and #16, both including IgG-switched cases (IgG-CLL). In contrast, the least similarity was detected between subsets #16 and #201, the latter concerning IgM/D-expressing CLL. Significant differences between subsets also involved disease stage at diagnosis and the presence of specific genomic aberrations. IgG subsets #4 and #16 emerged as particularly indolent with a significantly (P < 0.05) longer time-to-first-treatment (TTFT; median TTFT: not yet reached) compared with the IgM/D subsets #29 and #201 (median TTFT: 11 and 12 years, respectively).Conclusions: Our findings support the notion that BcR IG stereotypy further refines prognostication in CLL, superseding the immunogenetic distinction based solely on SHM load. In addition, the observed distinct genetic aberration landscapes and clinical heterogeneity suggest that not all M-CLL cases are equal, prompting further research into the underlying biological background with the ultimate aim of tailored patient management. Clin Cancer Res; 23(17); 5292–301. ©2017 AACR.

Published
2023

32. Data from An Immunogenetic Signature of Ongoing Antigen Interactions in Splenic Marginal Zone Lymphoma Expressing IGHV1-2*04 Receptors

Author

Kostas Stamatopoulos, Anastasia Hadzidimitriou, Chrysoula Belessi, Dimitrios Tzovaras, Nikos Darzentas, David Oscier, Richard Rosenquist, Paolo Ghia, Theodora Papadaki, Miguel Angel Piris, Estella Matutes, Sarka Pospisilova, David Gonzalez, Maurilio Ponzoni, Achilles Anagnostopoulos, Manuela Mollejo, Alexandra Traverse-Glehen, George Kanellis, Patricia Algara, Zadie Davis, Evdoxia Papadopoulou, Andreas Agathangelidis, George Papadopoulos, Lesley-Ann Sutton, Aliki Xochelli, Panagiotis Baliakas, Evangelia Stalika, Maria Karypidou, and Vasilis Bikos

Abstract

Purpose: Prompted by the extensive biases in the immunoglobulin (IG) gene repertoire of splenic marginal-zone lymphoma (SMZL), supporting antigen selection in SMZL ontogeny, we sought to investigate whether antigen involvement is also relevant post-transformation.Experimental Design: We conducted a large-scale subcloning study of the IG rearrangements of 40 SMZL cases aimed at assessing intraclonal diversification (ID) due to ongoing somatic hypermutation (SHM).Results: ID was identified in 17 of 21 (81%) rearrangements using the immunoglobulin heavy variable (IGHV)1-2*04 gene versus 8 of 19 (40%) rearrangements utilizing other IGHV genes (P = 0.001). ID was also evident in most analyzed IG light chain gene rearrangements, albeit was more limited compared with IG heavy chains. Identical sequence changes were shared by subclones from different patients utilizing the IGHV1-2*04 gene, confirming restricted ongoing SHM profiles. Non-IGHV1-2*04 cases displayed both a lower number of ongoing SHMs and a lack of shared mutations (per group of cases utilizing the same IGHV gene).Conclusions: These findings support ongoing antigen involvement in a sizable portion of SMZL and further argue that IGHV1-2*04 SMZL may represent a distinct molecular subtype of the disease. Clin Cancer Res; 22(8); 2032–40. ©2015 AACR.

Published
2023

33. Table S1 from Chronic Lymphocytic Leukemia with Mutated IGHV4-34 Receptors: Shared and Distinct Immunogenetic Features and Clinical Outcomes

Author

Kostas Stamatopoulos, Paolo Ghia, Richard Rosenquist, Anastasia Hadzidimitriou, Frederic Davi, Chrysoula Belessi, Nikos Darzentas, Ioanna Chouvarda, Stephan Stilgenbauer, Diane F. Jelinek, Gianluca Gaidano, David Oscier, Nikos Maglaveras, Nicholas Chiorazzi, Elias Campo, Michael Hallek, Sarka Pospisilova, Anton W. Langerak, Hartmut Döhner, Carsten Niemann, Marco Montillo, Livio Trentin, Darko Antic, Ioannis Vlahavas, Achilles Anagnostopoulos, Gunnar Juliusson, Panagiotis Panagiotidis, Marie-Paule Lefranc, Véronique Giudicelli, Charles C. Chu, Karin E. Smedby, Larry Mansouri, Lone Bredo Pedersen, Christiane Pott, Jasmin Bahlo, Monica Facco, Maria Chatzouli, Dirk Kienle, Mark Catherwood, Teodora Karan-Djurasevic, Tatiana Tzenou, Silvio Veronese, Andrey Sudarikov, Niki Stavroyianni, Lydia Scarfo, Fie Juhl Vojdeman, Yorick Sandberg, Alba Navarro, Zadie Davis, Davide Rossi, Myriam Boudjogra, Karla Plevova, Tait Shanafelt, Xiao-Jie Yan, Eugen Tausch, Stavroula Ntoufa, Eva Minga, Lesley-Ann Sutton, Andreas Agathangelidis, Ioannis Kavakiotis, Panagiotis Baliakas, and Aliki Xochelli

Abstract

Univariable and multivariable analysis for TTFT within M-CLL.

Published
2023

34. Supplemental Table 1 from An Immunogenetic Signature of Ongoing Antigen Interactions in Splenic Marginal Zone Lymphoma Expressing IGHV1-2*04 Receptors

Author

Kostas Stamatopoulos, Anastasia Hadzidimitriou, Chrysoula Belessi, Dimitrios Tzovaras, Nikos Darzentas, David Oscier, Richard Rosenquist, Paolo Ghia, Theodora Papadaki, Miguel Angel Piris, Estella Matutes, Sarka Pospisilova, David Gonzalez, Maurilio Ponzoni, Achilles Anagnostopoulos, Manuela Mollejo, Alexandra Traverse-Glehen, George Kanellis, Patricia Algara, Zadie Davis, Evdoxia Papadopoulou, Andreas Agathangelidis, George Papadopoulos, Lesley-Ann Sutton, Aliki Xochelli, Panagiotis Baliakas, Evangelia Stalika, Maria Karypidou, and Vasilis Bikos

Abstract

Analyzed IGH, IGK/L rearrangements. Annotation characteristics

Published
2023

35. Supplemental Figure 1 from An Immunogenetic Signature of Ongoing Antigen Interactions in Splenic Marginal Zone Lymphoma Expressing IGHV1-2*04 Receptors

Author

Kostas Stamatopoulos, Anastasia Hadzidimitriou, Chrysoula Belessi, Dimitrios Tzovaras, Nikos Darzentas, David Oscier, Richard Rosenquist, Paolo Ghia, Theodora Papadaki, Miguel Angel Piris, Estella Matutes, Sarka Pospisilova, David Gonzalez, Maurilio Ponzoni, Achilles Anagnostopoulos, Manuela Mollejo, Alexandra Traverse-Glehen, George Kanellis, Patricia Algara, Zadie Davis, Evdoxia Papadopoulou, Andreas Agathangelidis, George Papadopoulos, Lesley-Ann Sutton, Aliki Xochelli, Panagiotis Baliakas, Evangelia Stalika, Maria Karypidou, and Vasilis Bikos

Abstract

Network of the aligned IGVH1-2*04 CDR3 sub-regions, depicting the emerging patterns

Published
2023

36. Supplemental Table 3 from An Immunogenetic Signature of Ongoing Antigen Interactions in Splenic Marginal Zone Lymphoma Expressing IGHV1-2*04 Receptors

Author

Kostas Stamatopoulos, Anastasia Hadzidimitriou, Chrysoula Belessi, Dimitrios Tzovaras, Nikos Darzentas, David Oscier, Richard Rosenquist, Paolo Ghia, Theodora Papadaki, Miguel Angel Piris, Estella Matutes, Sarka Pospisilova, David Gonzalez, Maurilio Ponzoni, Achilles Anagnostopoulos, Manuela Mollejo, Alexandra Traverse-Glehen, George Kanellis, Patricia Algara, Zadie Davis, Evdoxia Papadopoulou, Andreas Agathangelidis, George Papadopoulos, Lesley-Ann Sutton, Aliki Xochelli, Panagiotis Baliakas, Evangelia Stalika, Maria Karypidou, and Vasilis Bikos

Abstract

IGK/L rearrangements'intraclonal diversification characteristics. Counts, distribution, hotspot targeting of confirmed/unconfirmed mutations and respective amino acid changes across gene groups and IGLV subregions.

Published
2023

37. Data from Antigen Selection Shapes the T-cell Repertoire in Chronic Lymphocytic Leukemia

Author

Kostas Stamatopoulos, Lesley-Ann Sutton, Paolo Ghia, Anastasia Hadzidimitriou, Richard Rosenquist, Achilles Anagnostopoulos, Alexandra Siorenta, Maria Karypidou, Evangelia Stalika, Andreas Agathangelidis, and Anna Vardi

Abstract

Purpose: The role of antigen(s) in shaping the T-cell repertoire in chronic lymphocytic leukemia, although relevant for understanding malignant cell interactions with cognate T cells, is largely unexplored.Experimental Design: Here we profiled the T-cell receptor β chain gene repertoire in 58 chronic lymphocytic leukemia patients, focusing on cases assigned to well-characterized subsets with stereotyped clonotypic B-cell receptor immunoglobulins, therefore those cases most evidently selected by antigen (subsets #1, #2, and #4).Results: Remarkable repertoire skewing and oligoclonality were observed, and differences between subsets were noted regarding both T-cell receptor β chain gene usage and the extent of clonality, with subset #2 being the least oligoclonal. Longitudinal analysis of subset #4 cases revealed that although the repertoire may fluctuate over time, certain clonotypes persist, thus alluding to persistent antigenic stimulation. Shared (“stereotyped”) clonotypes were found between different patients, reflecting selection by common antigenic elements. Cross-comparison of our dataset with public databases showed that some T-cell clonotypes may have expanded secondary to common viral infections; however, the majority of clonotypes proved to be disease-specific.Conclusions: Overall, the T-cell receptor β chain repertoire in chronic lymphocytic leukemia is likely shaped by antigen selection and the implicated antigenic elements may concern epitopes that also select the malignant B-cell progenitors or, more intriguingly, chronic lymphocytic leukemia–derived epitopes. Clin Cancer Res; 22(1); 167–74. ©2015 AACR.

Published
2023

38. Supplementary Table 4 from Molecular Subsets of Mantle Cell Lymphoma Defined by the IGHV Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features

Author

Elías Campo, Sílvia Beà, Kostas Stamatopoulos, Armando Lopez-Guillermo, Reiner Siebert, Eva Giné, Dolors Colomer, Andreas Rosenwald, German Ott, Birgitta Sander, Wendy Erber, Nicola Trim, Maria Jose Calasanz, Christiane Pott, Wyndham Wilson, Adrian Wiestner, Lenka Stefancikova, Alejandra Martinez-Trillos, Virgina Amador, Maria Carmela Vegliante, Jara Palomero, Xavier Puig, Magda Pinyol, Itziar Salaverria, Theodora Papadaki, Nikos Darzentas, Vasilis Bikos, Andreas Agathangelidis, Anastasia Hadzidimitriou, Pedro Jares, Cristina Royo, Guillem Clot, and Alba Navarro

Abstract

PDF file - 105K, Biological processes and genes differentially expressed among M-MCL (M) and U-MCL (U) validated genes by qPCR

Published
2023

39. Supplementary Table 1 from Molecular Subsets of Mantle Cell Lymphoma Defined by the IGHV Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features

Author

Elías Campo, Sílvia Beà, Kostas Stamatopoulos, Armando Lopez-Guillermo, Reiner Siebert, Eva Giné, Dolors Colomer, Andreas Rosenwald, German Ott, Birgitta Sander, Wendy Erber, Nicola Trim, Maria Jose Calasanz, Christiane Pott, Wyndham Wilson, Adrian Wiestner, Lenka Stefancikova, Alejandra Martinez-Trillos, Virgina Amador, Maria Carmela Vegliante, Jara Palomero, Xavier Puig, Magda Pinyol, Itziar Salaverria, Theodora Papadaki, Nikos Darzentas, Vasilis Bikos, Andreas Agathangelidis, Anastasia Hadzidimitriou, Pedro Jares, Cristina Royo, Guillem Clot, and Alba Navarro

Abstract

PDF file - 105K, Normal B-cell types signatures used in the GSEA analysis

Published
2023

40. Supplementary Figure 3 from Molecular Subsets of Mantle Cell Lymphoma Defined by the IGHV Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features

Author

Elías Campo, Sílvia Beà, Kostas Stamatopoulos, Armando Lopez-Guillermo, Reiner Siebert, Eva Giné, Dolors Colomer, Andreas Rosenwald, German Ott, Birgitta Sander, Wendy Erber, Nicola Trim, Maria Jose Calasanz, Christiane Pott, Wyndham Wilson, Adrian Wiestner, Lenka Stefancikova, Alejandra Martinez-Trillos, Virgina Amador, Maria Carmela Vegliante, Jara Palomero, Xavier Puig, Magda Pinyol, Itziar Salaverria, Theodora Papadaki, Nikos Darzentas, Vasilis Bikos, Andreas Agathangelidis, Anastasia Hadzidimitriou, Pedro Jares, Cristina Royo, Guillem Clot, and Alba Navarro

Abstract

PDF file - 332K, Determination of the best cut-off for the percentage of identity of IGHV gene in relation to overall survival. Two cut-offs, 96.6 and 97%, were selected according to a maximally log-rank statistic

Published
2023

41. Supplementary Table 2 from Molecular Subsets of Mantle Cell Lymphoma Defined by the IGHV Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features

Author

Elías Campo, Sílvia Beà, Kostas Stamatopoulos, Armando Lopez-Guillermo, Reiner Siebert, Eva Giné, Dolors Colomer, Andreas Rosenwald, German Ott, Birgitta Sander, Wendy Erber, Nicola Trim, Maria Jose Calasanz, Christiane Pott, Wyndham Wilson, Adrian Wiestner, Lenka Stefancikova, Alejandra Martinez-Trillos, Virgina Amador, Maria Carmela Vegliante, Jara Palomero, Xavier Puig, Magda Pinyol, Itziar Salaverria, Theodora Papadaki, Nikos Darzentas, Vasilis Bikos, Andreas Agathangelidis, Anastasia Hadzidimitriou, Pedro Jares, Cristina Royo, Guillem Clot, and Alba Navarro

Abstract

PDF file - 75K, IGHV, IGHD and IGHJ gene frequencies according to mutational status

Published
2023

42. Supplementary Table 3 from Molecular Subsets of Mantle Cell Lymphoma Defined by the IGHV Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features

Author

Elías Campo, Sílvia Beà, Kostas Stamatopoulos, Armando Lopez-Guillermo, Reiner Siebert, Eva Giné, Dolors Colomer, Andreas Rosenwald, German Ott, Birgitta Sander, Wendy Erber, Nicola Trim, Maria Jose Calasanz, Christiane Pott, Wyndham Wilson, Adrian Wiestner, Lenka Stefancikova, Alejandra Martinez-Trillos, Virgina Amador, Maria Carmela Vegliante, Jara Palomero, Xavier Puig, Magda Pinyol, Itziar Salaverria, Theodora Papadaki, Nikos Darzentas, Vasilis Bikos, Andreas Agathangelidis, Anastasia Hadzidimitriou, Pedro Jares, Cristina Royo, Guillem Clot, and Alba Navarro

Abstract

PDF file - 108K, P-values of the 518 genes differentially expressed between M-MCL and U-MCL

Published
2023

43. Supplementary Figure 2 from Molecular Subsets of Mantle Cell Lymphoma Defined by the IGHV Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features

Author

Elías Campo, Sílvia Beà, Kostas Stamatopoulos, Armando Lopez-Guillermo, Reiner Siebert, Eva Giné, Dolors Colomer, Andreas Rosenwald, German Ott, Birgitta Sander, Wendy Erber, Nicola Trim, Maria Jose Calasanz, Christiane Pott, Wyndham Wilson, Adrian Wiestner, Lenka Stefancikova, Alejandra Martinez-Trillos, Virgina Amador, Maria Carmela Vegliante, Jara Palomero, Xavier Puig, Magda Pinyol, Itziar Salaverria, Theodora Papadaki, Nikos Darzentas, Vasilis Bikos, Andreas Agathangelidis, Anastasia Hadzidimitriou, Pedro Jares, Cristina Royo, Guillem Clot, and Alba Navarro

Abstract

PDF file - 198K, Recurrent mutations in rearrangements utilizing the six most frequent IGHV genes. Individual codons are represented in the X-axis. Each color represents a different amino acid (AA) change. CDR: complementary determining region, FR: framework region

Published
2023

44. Supplementary Figure 1 from Molecular Subsets of Mantle Cell Lymphoma Defined by the IGHV Mutational Status and SOX11 Expression Have Distinct Biologic and Clinical Features

Author

Elías Campo, Sílvia Beà, Kostas Stamatopoulos, Armando Lopez-Guillermo, Reiner Siebert, Eva Giné, Dolors Colomer, Andreas Rosenwald, German Ott, Birgitta Sander, Wendy Erber, Nicola Trim, Maria Jose Calasanz, Christiane Pott, Wyndham Wilson, Adrian Wiestner, Lenka Stefancikova, Alejandra Martinez-Trillos, Virgina Amador, Maria Carmela Vegliante, Jara Palomero, Xavier Puig, Magda Pinyol, Itziar Salaverria, Theodora Papadaki, Nikos Darzentas, Vasilis Bikos, Andreas Agathangelidis, Anastasia Hadzidimitriou, Pedro Jares, Cristina Royo, Guillem Clot, and Alba Navarro

Abstract

PDF file - 73K, SOX11 expression evaluated by three different techniques. One-hundred-sixty-one MCL patients were studied, 64 by immunohistochemistry (IHC), 143 by quantitative PCR (qPCR) and 50 by gene expression profiling (GEP). Several samples were evaluated with more than one technique, and 8 patients were assessed by all three methodologies. The results were concordant in all cases

Published
2023

47. Molecular Evidence for Antigen Drive in the Natural History of Mantle Cell Lymphoma

Author

Xochelli, Aliki, Sutton, Lesley-Ann, Agathangelidis, Andreas, Stalika, Evangelia, Karypidou, Maria, Marantidou, Fotini, Lopez, Alba Navarro, Papadopoulos, Giorgos, Supikova, Jana, Groenen, Patricia, Boudjogra, Myriam, Sundstrom, Christer, Ponzoni, Maurilio, Francova, Hana Skuhrova, Anagnostopoulos, Achilles, Pospisilova, Sarka, Papadaki, Theodora, Tzovaras, Dimitris, Ghia, Paolo, Pott, Christiane, Davi, Frederic, Campo, Elias, Rosenquist, Richard, Hadzidimitriou, Anastasia, Belessi, Chrysoula, and Stamatopoulos, Kostas

Published
2015
Full Text
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50. No improvement in long-term survival over time for chronic lymphocytic leukemia patients in stereotyped subsets #1 and #2 treated with chemo(immuno)therapy

Author

Panagiotis Baliakas, Mattias Mattsson, Anastasia Hadzidimitriou, Eva Minga, Andreas Agathangelidis, Lesley-Ann Sutton, Lydia Scarfo, Zadie Davis, Xiao-Jie Yan, Karla Plevova, Yorick Sandberg, Fie J. Vojdeman, Tatiana Tzenou, Charles C. Chu, Silvio Veronese, Larry Mansouri, Karin E Smedby, Véronique Giudicelli, Florence Nguyen-Khac, Panagiotis Panagiotidis, Gunnar Juliusson, Achilles Anagnostopoulos, Marie-Paule Lefranc, Livio Trentin, Mark Catherwood, Marco Montillo, Carsten U. Niemann, Anton W. Langerak, Sarka Pospisilova, Niki Stavroyianni, Nicholas Chiorazzi, David Oscier, Diane F Jelinek, Tait Shanafelt, Nikos Darzentas, Chrysoula Belessi, Frederic Davi, Paolo Ghia, Richard Rosenquist, and Kostas Stamatopoulos

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Published
2018
Full Text
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