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3. The immunopeptidomic landscape of ovarian carcinomas

Author

Schuster, Heiko, Peper, Janet K., Bösmüller, Hans-Christian, Röhle, Kevin, Backert, Linus, Bilich, Tatjana, Ney, Britta, Löffler, Markus W., Kowalewski, Daniel J., Trautwein, Nico, Rabsteyn, Armin, Engler, Tobias, Braun, Sabine, Haen, Sebastian P., Walz, Juliane S., Schmid-Horch, Barbara, Brucker, Sara Y., Wallwiener, Diethelm, Kohlbacher, Oliver, Fend, Falko, Rammensee, Hans-Georg, Stevanovic, Stefan, Staebler, Annette, and Wagner, Philipp

Published
2017

4. Supplementary Table 6 from Mapping the HLA Ligandome of Colorectal Cancer Reveals an Imprint of Malignant Cell Transformation

Author

Löffler, Markus W., primary, Kowalewski, Daniel J., primary, Backert, Linus, primary, Bernhardt, Jörg, primary, Adam, Patrick, primary, Schuster, Heiko, primary, Dengler, Florian, primary, Backes, Daniel, primary, Kopp, Hans-Georg, primary, Beckert, Stefan, primary, Wagner, Silvia, primary, Königsrainer, Ingmar, primary, Kohlbacher, Oliver, primary, Kanz, Lothar, primary, Königsrainer, Alfred, primary, Rammensee, Hans-Georg, primary, Stevanović, Stefan, primary, and Haen, Sebastian P., primary

Published
2023
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5. Supplementary Tables 1-5, 7, 9-12 from Mapping the HLA Ligandome of Colorectal Cancer Reveals an Imprint of Malignant Cell Transformation

Author

Löffler, Markus W., primary, Kowalewski, Daniel J., primary, Backert, Linus, primary, Bernhardt, Jörg, primary, Adam, Patrick, primary, Schuster, Heiko, primary, Dengler, Florian, primary, Backes, Daniel, primary, Kopp, Hans-Georg, primary, Beckert, Stefan, primary, Wagner, Silvia, primary, Königsrainer, Ingmar, primary, Kohlbacher, Oliver, primary, Kanz, Lothar, primary, Königsrainer, Alfred, primary, Rammensee, Hans-Georg, primary, Stevanović, Stefan, primary, and Haen, Sebastian P., primary

Published
2023
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6. Supplementary Table 8 from Mapping the HLA Ligandome of Colorectal Cancer Reveals an Imprint of Malignant Cell Transformation

Author

Löffler, Markus W., primary, Kowalewski, Daniel J., primary, Backert, Linus, primary, Bernhardt, Jörg, primary, Adam, Patrick, primary, Schuster, Heiko, primary, Dengler, Florian, primary, Backes, Daniel, primary, Kopp, Hans-Georg, primary, Beckert, Stefan, primary, Wagner, Silvia, primary, Königsrainer, Ingmar, primary, Kohlbacher, Oliver, primary, Kanz, Lothar, primary, Königsrainer, Alfred, primary, Rammensee, Hans-Georg, primary, Stevanović, Stefan, primary, and Haen, Sebastian P., primary

Published
2023
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7. Data from Mapping the HLA Ligandome of Colorectal Cancer Reveals an Imprint of Malignant Cell Transformation

Author

Löffler, Markus W., primary, Kowalewski, Daniel J., primary, Backert, Linus, primary, Bernhardt, Jörg, primary, Adam, Patrick, primary, Schuster, Heiko, primary, Dengler, Florian, primary, Backes, Daniel, primary, Kopp, Hans-Georg, primary, Beckert, Stefan, primary, Wagner, Silvia, primary, Königsrainer, Ingmar, primary, Kohlbacher, Oliver, primary, Kanz, Lothar, primary, Königsrainer, Alfred, primary, Rammensee, Hans-Georg, primary, Stevanović, Stefan, primary, and Haen, Sebastian P., primary

Published
2023
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8. Supplementary Figures 1-6 from Mapping the HLA Ligandome of Colorectal Cancer Reveals an Imprint of Malignant Cell Transformation

Author

Löffler, Markus W., primary, Kowalewski, Daniel J., primary, Backert, Linus, primary, Bernhardt, Jörg, primary, Adam, Patrick, primary, Schuster, Heiko, primary, Dengler, Florian, primary, Backes, Daniel, primary, Kopp, Hans-Georg, primary, Beckert, Stefan, primary, Wagner, Silvia, primary, Königsrainer, Ingmar, primary, Kohlbacher, Oliver, primary, Kanz, Lothar, primary, Königsrainer, Alfred, primary, Rammensee, Hans-Georg, primary, Stevanović, Stefan, primary, and Haen, Sebastian P., primary

Published
2023
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9. Hematological Neoplasms

Author

Zierhut, Manfred, Haen, Sebastian P., Moehle, Robert, Chan, Chi-Chao, Zierhut, Manfred, editor, Pavesio, Carlos, editor, Ohno, Shigeaki, editor, Orefice, Fernando, editor, and Rao, Narsing A., editor

Published
2016
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10. Primary Intraocular Lymphoma

Author

Chan, Chi-Chao, Haen, Sebastian P., Möhle, Robert, Zierhut, Manfred, Zierhut, Manfred, editor, Pavesio, Carlos, editor, Ohno, Shigeaki, editor, Orefice, Fernando, editor, and Rao, Narsing A., editor

Published
2016
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12. A new synthetic toll-like receptor 1/2 ligand is an efficient adjuvant for peptide vaccination in a human volunteer

Author

Rammensee, Hans-Georg, Wiesmüller, Karl-Heinz, Chandran, P. Anoop, Zelba, Henning, Rusch, Elisa, Gouttefangeas, Cécile, Kowalewski, Daniel J., Di Marco, Moreno, Haen, Sebastian P., Walz, Juliane S., Gloria, Yamel Cardona, Bödder, Johanna, Schertel, Jill-Marie, Tunger, Antje, Müller, Luise, Kießler, Maximilian, Wehner, Rebekka, Schmitz, Marc, Jakobi, Meike, Schneiderhan-Marra, Nicole, Klein, Reinhild, Laske, Karoline, Artzner, Kerstin, Backert, Linus, Schuster, Heiko, Schwenck, Johannes, Weber, Alexander N. R., Pichler, Bernd J., Kneilling, Manfred, la Fougère, Christian, Forchhammer, Stephan, Metzler, Gisela, Bauer, Jürgen, Weide, Benjamin, Schippert, Wilfried, Stevanović, Stefan, and Löffler, Markus W.

Published
2019
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13. Multi-omics discovery of exome-derived neoantigens in hepatocellular carcinoma

Author

Löffler, Markus W., Mohr, Christopher, Bichmann, Leon, Freudenmann, Lena Katharina, Walzer, Mathias, Schroeder, Christopher M., Trautwein, Nico, Hilke, Franz J., Zinser, Raphael S., Mühlenbruch, Lena, Kowalewski, Daniel J., Schuster, Heiko, Sturm, Marc, Matthes, Jakob, Riess, Olaf, Czemmel, Stefan, Nahnsen, Sven, Königsrainer, Ingmar, Thiel, Karolin, Nadalin, Silvio, Beckert, Stefan, Bösmüller, Hans, Fend, Falko, Velic, Ana, Maček, Boris, Haen, Sebastian P., Buonaguro, Luigi, Kohlbacher, Oliver, Stevanović, Stefan, Königsrainer, Alfred, HEPAVAC Consortium, and Rammensee, Hans-Georg

Published
2019
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17. First case report of malignant peritoneal mesothelioma and oral verrucous carcinoma in a patient with a germline PTEN mutation: a combination of extremely rare diseases with probable further implications

Author

Löffler, Markus W., Steinhilber, Julia, Hilke, Franz J., Haen, Sebastian P., Bösmüller, Hans, Montes-Mojarro, Ivonne-Aidee, Bonzheim, Irina, Stäbler, Antje, Faust, Ulrike, Grasshoff, Ute, Königsrainer, Ingmar, Rammensee, Hans-Georg, Kanz, Lothar, Königsrainer, Alfred, Beckert, Stefan, Riess, Olaf, and Schroeder, Christopher

Published
2018
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21. Designing a SARS-CoV-2 T-Cell-Inducing Vaccine for High-Risk Patient Groups

Author

Rammensee, Hans-Georg, Gouttefangeas, Cécile, Heidu, Sonja, Klein, Reinhild, Preuß, Beate, Walz, Juliane Sarah, Nelde, Annika, Haen, Sebastian P., Reth, Michael, Yang, Jianying, Tabatabai, Ghazaleh, Bösmüller, Hans, Hoffmann, Helen, Schindler, Michael, Planz, Oliver, Wiesmüller, Karl-Heinz, and Löffler, Markus W.

Subjects
adjuvant, lipopeptide, SARS-CoV-2, peptide vaccine, COVID-19, Medicine, high-risk patient, Article
Abstract

We describe the results of two vaccinations of a self-experimenting healthy volunteer with SARS-CoV-2-derived peptides performed in March and April 2020, respectively. The first set of peptides contained eight peptides predicted to bind to the individual's HLA molecules. The second set consisted of ten peptides predicted to bind promiscuously to several HLA-DR allotypes. The vaccine formulation contained the new TLR 1/2 agonist XS15 and was administered as an emulsion in Montanide as a single subcutaneous injection. Peripheral blood mononuclear cells isolated from blood drawn before and after vaccinations were assessed using Interferon-γ ELISpot assays and intracellular cytokine staining. We detected vaccine-induced CD4 T cell responses against six out of 11 peptides predicted to bind to HLA-DR after 19 days, following vaccination, for one peptide already at day 12. We used these results to support the design of a T-cell-inducing vaccine for application in high-risk patients, with weakened lymphocyte performance. Meanwhile, an according vaccine, incorporating T cell epitopes predominant in convalescents, is undergoing clinical trial testing.

Published
2021

23. Analysis of Coil Configurations for a Contactless Thermal Tumor Ablation With Implanted Devices.

Author

Prantner, Michael, Parspour, Nejila, Haen, Sebastian P., Bockeler, Michael, and Hetzel, Jurgen

Abstract

In the wide field of tumor treatment, thermal ablation procedures are very promising. Alternating magnetic fields are used to transfer the energy from outside the patient to the tumor area located anywhere in the body. This energy is converted to heat by implanted devices located in the tumor area. In this paper, the spatial distribution of the magnetic field of different circular coil configurations is analyzed and optimized with focus on patients’ safety and on coil configuration performance. The analysis is based on several performance criteria and is conducted with respect to the worst case scenario of a contactless thermal tumor ablation of deep-seated tumors, in which the energy has to be transferred over a considerably large distance. The magnetic field and the specific absorption rate (SAR) are calculated numerically and the performance criteria are evaluated based on a model of a human body including a tumor area. The most suitable coil configurations for different application scenarios are presented and a thermal analysis is done. Based on this, the minimum required heating power, coil current and number of coil windings, and the corresponding maximum SAR to achieve an adequate rise of tissue temperature are evaluated. For a heating power of 1.45 W, a minimum SAR of 130 mW/kg, a maximum power transfer efficiency of 1.05%, and a maximum coupling coefficient of 0.00695 is achieved. This paper shows the potential to enhance the safety of the patients significantly by choosing the appropriate coil configuration for a specific application scenario. [ABSTRACT FROM AUTHOR]

Published
2022
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25. Designing a therapeutic SARS-CoV-2 T-cell-inducing vaccine for high-risk patient groups

Author

Rammensee, Hans-Georg, primary, Stevanović, Stefan, additional, Gouttefangeas, Cécile, additional, Heidu, Sonja, additional, Klein, Reinhild, additional, Preuß, Beate, additional, Walz, Juliane Sarah, additional, Nelde, Annika, additional, Haen, Sebastian P., additional, Reth, Michael, additional, Yang, Jianying, additional, Tabatabai, Ghazaleh, additional, Bösmüller, Hans, additional, Hoffmann, Helen, additional, Schindler, Michael, additional, Planz, Oliver, additional, Wiesmüller, Karl-Heinz, additional, and Löffler, Markus W., additional

Published
2020
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26. A Non-interventional Clinical Trial Assessing Immune Responses After Radiofrequency Ablation of Liver Metastases From Colorectal Cancer

Author

Löffler, Markus W., primary, Nussbaum, Bianca, additional, Jäger, Günter, additional, Jurmeister, Philipp S., additional, Budczies, Jan, additional, Pereira, Philippe L., additional, Clasen, Stephan, additional, Kowalewski, Daniel J., additional, Mühlenbruch, Lena, additional, Königsrainer, Ingmar, additional, Beckert, Stefan, additional, Ladurner, Ruth, additional, Wagner, Silvia, additional, Bullinger, Florian, additional, Gross, Thorben H., additional, Schroeder, Christopher, additional, Sipos, Bence, additional, Königsrainer, Alfred, additional, Stevanović, Stefan, additional, Denkert, Carsten, additional, Rammensee, Hans-Georg, additional, Gouttefangeas, Cécile, additional, and Haen, Sebastian P., additional

Published
2019
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27. Short-term oxaliplatin exposure according to established hyperthermic intraperitoneal chemotherapy (HIPEC) protocols lacks effectivenessin vitroandex vivo

Author

Löffler, Markus W., primary, Seyfried, Nick, additional, Burkard, Markus, additional, Oswald, Benedikt, additional, Tolios, Alexander, additional, Yurttas, Can, additional, Herster, Franziska, additional, Kauer, Joseph, additional, Jäger, Tarkan, additional, Thiel, Karolin, additional, Haen, Sebastian P., additional, Rammensee, Hans-Georg, additional, Venturelli, Sascha, additional, Schwab, Matthias, additional, Königsrainer, Alfred, additional, and Beckert, Stefan, additional

Published
2019
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29. Mapping the HLA Ligandome of Colorectal Cancer Reveals an Imprint of Malignant Cell Transformation

Author

Löffler, Markus W., primary, Kowalewski, Daniel J., additional, Backert, Linus, additional, Bernhardt, Jörg, additional, Adam, Patrick, additional, Schuster, Heiko, additional, Dengler, Florian, additional, Backes, Daniel, additional, Kopp, Hans-Georg, additional, Beckert, Stefan, additional, Wagner, Silvia, additional, Königsrainer, Ingmar, additional, Kohlbacher, Oliver, additional, Kanz, Lothar, additional, Königsrainer, Alfred, additional, Rammensee, Hans-Georg, additional, Stevanović, Stefan, additional, and Haen, Sebastian P., additional

Published
2018
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32. Disease and Therapy Associated Complications of the Central Nervous System after Allogeneic Hematopoietic Cell Transplantation - a Significant Proportion of Patients Will Suffer from Permanent Damage

Author

Haen, Sebastian P., primary, Zierhut, Manfred, additional, Mirza, Nora, additional, Simon, Christoph M., additional, Korn, Andreas, additional, Faul, Christoph, additional, Vogel, Wichard, additional, Rammensee, Hans-Georg, additional, Kanz, Lothar, additional, and Bethge, Wolfgang, additional

Published
2016
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33. Unique Alterations in the Immunopeptidome of Colorectal Cancer Reflect Specific Transformations in Cancer-Associated Signaling Pathways and Reveal Tumor-Specific HLA-Ligand Modulations

Author

Haen, Sebastian P., primary, Kowalewski, Daniel J., additional, Bernhardt, Joerg, additional, Backert, Linus, additional, Backes, Daniel, additional, Dengler, Florian, additional, Beckert, Stefan, additional, Koenigsrainer, Ingmar, additional, Kopp, Hans-Georg, additional, Kohlbacher, Oliver, additional, Koenigsrainer, Alfred, additional, Kanz, Lothar, additional, Rammensee, Hans-Georg, additional, Stevanovic, Stefan, additional, and Loeffler, Markus W., additional

Published
2016
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34. Choroidal metastases from thymic carcinoma during pregnancy: Case Report

Author

Haen, Sebastian P., Stroebel, Philipp, Marx, Alexander, Suesskind, Daniela, Fend, Falko, Reichmann, Ursula, Kopp, Hans-Georg, Kanz, Lothar, and Mayer, Frank

Subjects
Adult, Cancer Research, Thymoma, Paraneoplastic Syndromes, Choroid Neoplasms, Vision Disorders, Case Report, Thymus Neoplasms, Dermatomyositis, Thymic carcinoma, Uveal metastasis, Oncology, Pregnancy, Genetics, Humans, Female, Pregnancy Complications, Neoplastic
Abstract

Background Rare sites of metastases, atypical symptoms and paraneoplastic syndromes are often neglected or misinterpreted, especially when they represent early symptoms of an underlying malignant disease. Hence, an interdisciplinary approach to these patients is essential to avoid tumor progression and metastatic spread in order to provide curative treatment options to the patients. We here report the case of a young woman presenting with visual loss which led to diagnosis of a thymic carcinoma. Case presentation A 28-year old white woman presented with subacute loss of vision in the last trimester of her first pregnancy which was first interpreted as an exacerbation of a pre-existing dermatomyositis and treated with steroids. After failure of steroid therapy choroidal metastases from an undifferentiated thymic carcinoma were diagnosed. This also shed a new light on the dermatomyositis the patient had been suffering from for seven years possibly representing a paraneoplastic syndrome from the tumor. Despite aggressive chemotherapy, the patient died from progressive disease eight years after first onset of dermatomyositis and 14 months after initial diagnosis of the thymic carcinoma. Conclusions Choroidal metastases from a thymic carcinoma have never been reported before but should be included into the differential diagnosis of choroidal masses. peerReviewed

Published
2015

37. Interplay Between the Immune System and Colorectal Carcinoma - Towards Tumor-Specific Peptide-Based Vaccination for Any HLA-Type

Author

Haen, Sebastian P., primary, Kowalewski, Daniel Johannes, additional, Stevanovic, Stefan, additional, Backert, Linus, additional, Dengler, Florian, additional, Backes, Daniel, additional, Beckert, Stefan, additional, Silvia, Wagner, additional, Koenigsrainer, Ingmar, additional, Kopp, Hans-Georg, additional, Kohlbacher, Oliver, additional, Koenigsrainer, Alfred, additional, Kanz, Lothar, additional, Rammensee, Hans-Georg, additional, and Loeffler, Markus W., additional

Published
2015
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38. Induction of NK Cell Reactivity Against Myeloid Leukemia By a Novel Fc-Optimized CD133 Antibody

Author

Rothfelder, Kathrin, primary, Koerner, Samuel, additional, Andre, Maya, additional, Leibold, Julia, additional, Kousis, Philaretos, additional, Bühring, Hans-Jörg, additional, Haen, Sebastian P., additional, Kuebler, Ayline, additional, Kanz, Lothar, additional, Grosse-Hovest, Ludger, additional, Jung, Gundram, additional, and Salih, Helmut R, additional

Published
2015
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40. More Than Just Tumor Destruction: Immunomodulation by Thermal Ablation of Cancer

Author

Haen, Sebastian P., Pereira, Philippe L., Salih, Helmut R., Rammensee, Hans-Georg, and Gouttefangeas, Cécile

Subjects
Article Subject
Abstract

Over the past decades, thermoablative techniques for the therapy of localized tumors have gained importance in the treatment of patients not eligible for surgical resection. Anecdotal reports have described spontaneous distant tumor regression after thermal ablation, indicating a possible involvement of the immune system, hence an induction of antitumor immunity after thermoinduced therapy. In recent years, a growing body of evidence for modulation of both adaptive and innate immunity, as well as for the induction of danger signals through thermoablation, has emerged. Induced immune responses, however, are mostly weak and not sufficient for the complete eradication of established tumors or durable prevention of disease progression, and combination therapies with immunomodulating drugs are being evaluated with promising results. This article aims to summarize published findings on immune modulation through radiofrequency ablation, cryoablation, microwave ablation therapy, high-intensity focused ultrasound, and laser-induced thermotherapy.

Published
2011
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42. Graft versus self (GvS) against T-cell autoantigens is a mechanism of graft--host interaction.

Author

Vogel, Wichard, Bethge, Wolfgang A., Kanz, Lothar, Mirza, Nora, Haen, Sebastian P., Salih, Helmut R., Stevanović, Stefan, Rammensee, Hans-Georg, Zierhut, Manfred, Korn, Andreas, Bornemann, Antje, and Schmid-Horch, Barbara

Subjects
T cells, AUTOANTIGENS, TRANSPLANTATION of organs, tissues, etc., HOMOGRAFTS, HEMATOPOIETIC stem cells, CELL transplantation
Abstract

Graft-versus-host disease (GVHD) represents the major nonrelapse complication of allogeneic hematopoietic cell transplantation. Although rare, the CNS and the eye can be affected. In this study, manifestation in the retina as part of the CNS and T-cell epitopes recognized by the allogeneic T cells were evaluated. In 2 of 6 patients with posttransplantation retina diseases and 6 of 22 patients without ocular symptoms, antigen-specific T-cell responses against retinaspecific epitopes were observed. No genetic differences between donor and recipient could be identified indicating T-cell activation against self-antigens (graft versus self). Transplantation of a preexisting immunity and cross-reactivity with ubiquitous epitopes was excluded in family donors and healthy individuals. In summary, an immunological reaction against retina cells represents a mechanism of graft-versus-host interaction following hematopoietic cell transplantation. [ABSTRACT FROM AUTHOR]

Published
2016
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