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This study examined the impact of the COVID-19 pandemic on men's ice hockey in Kanagawa prefecture. We investigated the number and type of penalties and injuries that occurred in men's ice hockey league games in Kanagawa between September 2018 and March 2023. In total, data from 734 games were analyzed, and data were compared between seasons. The average number of penalties per game was 5.93 in the 2018-2019 season, 5.66 in the 2019-2020 season, 4.96 in 2020-2021, and 4.40 in 2021-2022, 4.64 in the 2022-2023 season, indicating that the number of penalties decreased during the COVID-19 pandemic. However, the number of penalties involving the stick increased. Injuries during games also increased during the COVID-19 pandemic, from 0 in the 20182019 (175 games) and 2019-2020 (191 games) seasons to 1 case in the 2020-2021 (73 games) season, 6 cases in the 2021-2022 (119 games) season and 2 cases in the 2022-2023 (176 games) season. The increased number of injuries observed may have been due to the closure of ice rinks by the state of emergency, which restricted on-ice training. As players avoided contact to prevent the spread of COVID-19, penalties caused by contact play decreased, whereas those involving sticks increased. [ABSTRACT FROM AUTHOR]

Urea is an important reutilizable nitrogen source for the ruminant and is mainly synthesized through the urea cycle in the liver. The cycle is undertaken by 5 enzymes: carbamoyl phosphate synthetase (CPS), ornithine transcarbamoylase (OTC), arginino-succinate synthetase (AS), argininosuccinate lyase (AL), and arginase. The purpose of this study was to investigate changes in the activity of the enzymes and mRNA expression, given that previous observations have indicated an increase in plasma urea concentrations with age in Holstein calves. First, plasma concentrations of metabolites and hormones were determined in calves at 1, 3, 8, 13, and 19 wk of age (n = 4, weaned at 6 wk of age). The plasma concentration of urea drastically increased after weaning (P < 0.001). The plasma concentration of glucose was lowest at 8 wk. The plasma concentration of IGF-I gradually increased with age, although those of NEFA, glucagon, and cortisol decreased (P < 0.001). Concentrations of triglyceride, [alpha]-amino nitrogen, growth hormone, and insulin did not change significantly with age of the calf. Next, using the liver tissues taken from calves at 2, 13, and 19 wk of age (n = 4 to 6 at each time point, weaned at 6 wk of age), we measured the activity and mRNA expression of the enzymes by biochemical methods and quantitative reverse transcription-PCR, respectively. The activities of CPS (P < 0.001), OTC (P = 0.001), and AS -(P = 0.015) increased with age, whereas AL (P = 0.003) decreased. Although mRNA expression was decreased with age for AL (P = 0.002) and arginase (P = 0.007), no significant change was observed for CPS, OTC, or AS mRNA expression. We conclude that the increased urea production in the liver may be explained not only by an increase in the activities of the urea cycle enzymes, but also by increased ammonia production by rumen fermentation and gluconeogenesis from amino acids around weaning time. Key words: calf, development, liver, mRNA, urea cycle enzyme, weaning

Sarah J Bond,1 Nathan Parikh,1 Shrey Majmudar,1 Sabrina Pin,1 Christine Wang,1 Lauren Willis,1 Susanne B Haga1,2 1Duke University, Durham, NC, 27708, USA; 2Duke University School of Medicine, Durham, NC, 27708, USACorrespondence: Susanne B HagaDuke University, 101 Science Drive, Box 3382, Durham, NC, 27708, USA, Tel +1 919 684 0325, Fax +1 919 681 8973, Email susanne.haga@duke.eduBackground: Despite the purported advantages and potential efficacy of mHealth interventions to promote wellness in children, adolescents, and young adults, it is not clear what areas have been explored and the challenges reported in the biomedical literature.Methods: We conducted a scoping review of publications between 2015 and 2019.Results: We identified 54 papers that met our inclusion criteria. Studies were conducted in 21 countries and ranged in size from six to 9851 participants (median: 184). A total of 41% of studies enrolled adolescents only (n = 19). Of the seven types of mHealth interventions identified, apps were the most common intervention (59%; n = 32) evaluated and 44% of the studies evaluated two or more interventions. The most common topic of the studies reviewed was sexual and reproductive health (24%; n = 13).Conclusion: Most pediatric mHealth intervention studies are conducted in adolescents in large part, and sexual and reproductive health is the most commonly studied topic. With the easy and widespread accessibility to smartphone technology, the use of mobile apps for wellness interventions will likely continue to expand to other wellness topics.Keywords: mHealth, wellness, children, adolescents, young adults