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20 results on '"Hagikura, Kazuhiro"'

4. Intravenous Semaphorin 3A Administration Maintains Cardiac Contractility and Improves Electrical Remodeling in a Mouse Model of Isoproterenol-Induced Heart Failure

Author

Kurokawa, Sayaka, primary, Kashimoto, Miwa, additional, Hagikura, Kazuhiro, additional, Shimodai-Yamada, Sayaka, additional, Otsuka, Naoto, additional, Wakamatsu, Yuji, additional, Nagashima, Koichi, additional, Matsumoto, Taro, additional, Hao, Hiroyuki, additional, and Okumura, Yasuo, additional

Published
2023
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11. Effect of the dipeptidyl peptidase-4 inhibitor linagliptin on atherosclerotic lesions in Watanabe heritable hyperlipidemic rabbits: iMap-IVUS and pathological analysis

Author

Kurosawa, Takafumi, primary, Li, Yuxin, additional, Sudo, Mitsumasa, additional, Haruta, Hironori, additional, Hagikura, Kazuhiro, additional, Takayama, Tadateru, additional, Hiro, Takafumi, additional, Shiomi, Masashi, additional, Hao, Hiroyuki, additional, Matsumoto, Taro, additional, Hirayama, Atsushi, additional, and Okumura, Yasuo, additional

Published
2020
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14. Soluble factors released by dedifferentiated fat cells reduce the functional activity of iPS cell‐derived cardiomyocytes.

Author

Watanabe, Hirofumi, Kanemaru, Kazunori, Hagikura, Kazuhiro, Matsumoto, Taro, Ayusawa, Mamoru, and Morioka, Ichiro

Subjects
FAT cells, PLURIPOTENT stem cells, MACROPHAGE migration inhibitory factor, ADIPOSE tissues, GRANULOCYTE-colony stimulating factor, CARDIAC contraction, PLASMINOGEN activator inhibitors, CYTOKINES
Abstract

Interactions between tissues such as epicardial adipose (EAT), and myocardial tissues is important in the pathogenesis of heart failure. Changes in adipose tissues in obesity or diabetes impair preadipocyte differentiation. Furthermore, proinflammatory cytokine secretion is higher in preadipocytes than in mature adipocytes in diabetes and obesity. However, how undifferentiated cells committed to the adipose lineage directly influence cardiomyocytes is not yet understood. We used human‐derived dedifferentiated fat (DFAT) cells as models of undifferentiated cells committed to an adipose lineage. Here, we evaluated the effects of soluble factor interactions in indirect cocultures of DFAT cells and induced pluripotent stem cell‐derived cardiomyocytes. Our RNA sequencing findings showed that these interactions were predominantly inflammatory responses. Furthermore, proinflammatory cytokines secreted by DFAT cells reduced myocardial functions such as contraction frequency and catecholamine sensitivity, and simultaneously increased apoptosis, decreased antioxidative stress tolerance, and reduced oxygen consumption rates in cardiomyocytes. These adverse effects might be attributable to monocyte chemoattractant protein‐1, chemokine (C‐X‐C motif) ligands 1 (CXCL1), and 12, granulocyte colony‐stimulating factor, interleukins 6 and 8, macrophage migration inhibitory factor (MIF), and plasminogen activator inhibitor 1‐A among the proinflammatory mediators secreted by DFAT cells. Our results could be useful for understanding the pathogenesis of EAT‐related heart failure in terms of the involvement of undifferentiated cells committed to the adipose lineage. Furthermore, we suggest the importance of focusing on surrounding adipose tissues as a strategy with which to maximize the survival and function of transplanted stem cell‐derived cardiomyocytes. [ABSTRACT FROM AUTHOR]

Published
2021
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17. The Sphingosine-1-Phosphate Receptor S1PR1 Restricts Sprouting Angiogenesis by Regulating the Interplay between VE-Cadherin and VEGFR2

Author

Gaengel, Konstantin, primary, Niaudet, Colin, additional, Hagikura, Kazuhiro, additional, Laviña, Bàrbara, additional, Muhl, Lars, additional, Hofmann, Jennifer J., additional, Ebarasi, Lwaki, additional, Nyström, Staffan, additional, Rymo, Simin, additional, Chen, Long Long, additional, Pang, Mei-Fong, additional, Jin, Yi, additional, Raschperger, Elisabeth, additional, Roswall, Pernilla, additional, Schulte, Dörte, additional, Benedito, Rui, additional, Larsson, Jimmy, additional, Hellström, Mats, additional, Fuxe, Jonas, additional, Uhlén, Per, additional, Adams, Ralf, additional, Jakobsson, Lars, additional, Majumdar, Arindam, additional, Vestweber, Dietmar, additional, Uv, Anne, additional, and Betsholtz, Christer, additional

Published
2012
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18. Stent-Based Delivery of Antisense Oligodeoxynucleotides Targeted to the PDGF A-Chain Decreases In-Stent Restenosis of the Coronary Artery

Author

Li, Yuxin, primary, Fukuda, Noboru, additional, Kunimoto, Satoshi, additional, Yokoyama, Shin-ichiro, additional, Hagikura, Kazuhiro, additional, Kawano, Taro, additional, Takayama, Tadateru, additional, Honye, Junko, additional, Kobayashi, Naohiko, additional, Mugishima, Hideo, additional, Saito, Satoshi, additional, and Serie, Kazuo, additional

Published
2006
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19. Mismatch Between Results of Myocardial Fractional Flow Reserve (FFR) Measurements and Myocardial Perfusion SPECT for Identification of the Severity of Ischemia: Pitfall of FFR in Patients With Prior Myocardial Infarction

Author

Tani, Shigemasa, primary, Watanabe, Ikuyoshi, additional, Kobari, Chikara, additional, Matsumoto, Michiaki, additional, Miyazawa, Takuya, additional, Iwamoto, Yasuhito, additional, Tsutsui, Akihito, additional, Hagikura, Kazuhiro, additional, Furuichi, Tomohiro, additional, Matsumoto, Naoya, additional, Sato, Yuichi, additional, Kushiro, Toshio, additional, Nagao, Ken, additional, and Kanmatsuse, Katsuo, additional

Published
2004
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20. [Bronchoesophageal fistula in a patient with untreated malignant lymphoma].

Author

Uenogawa K, Hatta Y, Oshiro S, Hagikura K, Takahashi N, Kura Y, Yamazaki T, Akashiba T, Sawada U, and Horie T

Subjects
Aged, Bronchial Fistula therapy, Esophageal Fistula therapy, Fatal Outcome, Humans, Male, Pneumonia, Aspiration etiology, Pneumonia, Aspiration therapy, Stents adverse effects, Bronchial Fistula etiology, Esophageal Fistula etiology, Lymphoma, B-Cell complications, Lymphoma, Large B-Cell, Diffuse complications
Abstract

Bronchoesophageal fistulae associated with lymphomas are generally associated with chemo-radiotherapy. We report here an unusual case of lymphoma with a therapy-unrelated bronchoesophageal fistula. Previously, only 10 similar cases have been reported. A 70-year-old male was diagnosed as having gastric diffuse large B-cell lymphoma in May 1998. In January 1999, he noted a cough after eating and drinking. Because of the presence of a febrile temperature, productive cough and dyspnea, he was referred to our hospital and diagnosed as having aspiration pneumonia. Antibiotics did not improve his symptoms. When tracheal intubation was performed with bronchoscopy, a bronchoesophageal fistula was revealed. Malignant lymphoma cells were found around the fistula in the biopsy specimen. The patient died of pneumonia after treatment with airway stenting and chemotherapy. Induction of necrosis by chemotherapy or low blood flow with stenting and dopamine probably caused enlargement of the fistula.

Published
2005

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