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12. Noninvasive detection of clinically occult lymph-node metastases in prostate cancer.

Author

Harisinghani, M.G., Barentsz, J.O., Hahn, P.F., Deserno, W.M.L.L.G., Tabatabaei, S., Hulsbergen-van de Kaa, C.A., Rosette, J.J.M.H.C. de la, Weissleder, R., Harisinghani, M.G., Barentsz, J.O., Hahn, P.F., Deserno, W.M.L.L.G., Tabatabaei, S., Hulsbergen-van de Kaa, C.A., Rosette, J.J.M.H.C. de la, and Weissleder, R.

Abstract

Item does not contain fulltext, BACKGROUND: Accurate detection of lymph-node metastases in prostate cancer is an essential component of the approach to treatment. We investigated whether highly lymphotropic superparamagnetic nanoparticles, which gain access to lymph nodes by means of interstitial-lymphatic fluid transport, could be used in conjunction with high-resolution magnetic resonance imaging (MRI) to reveal small nodal metastases. METHODS: Eighty patients with presurgical clinical stage T1, T2, or T3 prostate cancer who underwent surgical lymph-node resection or biopsy were enrolled. All patients were examined by MRI before and 24 hours after the intravenous administration of lymphotropic superparamagnetic nanoparticles (2.6 mg of iron per kilogram of body weight). The imaging results were correlated with histopathological findings. RESULTS: Of the 334 lymph nodes that underwent resection or biopsy, 63 (18.9 percent) from 33 patients (41 percent) had histopathologically detected metastases. Of these 63 nodes, 45 (71.4 percent) did not fulfill the usual imaging criteria for malignancy. MRI with lymphotropic superparamagnetic nanoparticles correctly identified all patients with nodal metastases, and a node-by-node analysis had a significantly higher sensitivity than conventional MRI (90.5 percent vs. 35.4 percent, P<0.001) or nomograms. CONCLUSIONS: High-resolution MRI with magnetic nanoparticles allows the detection of small and otherwise undetectable lymph-node metastases in patients with prostate cancer.

Published
2003

14. MR lymphangiography for detection of minimal nodal disease in patients with prostate cancer.

Author

Harisinghani, M.G., Barentsz, J.O., Hahn, P.F., Deserno, W.M.L.L.G., Rosette, J.J.M.H.C. de la, Saini, S., Marten, K., Weissleder, R., Harisinghani, M.G., Barentsz, J.O., Hahn, P.F., Deserno, W.M.L.L.G., Rosette, J.J.M.H.C. de la, Saini, S., Marten, K., and Weissleder, R.

Abstract

Contains fulltext : 130072.pdf (publisher's version ) (Closed access)

Published
2002

27. Iron metabolism in human pregnancy as studied with the radioactive isotope, Fe59

Author

Hahn, P.F., Carothers, E.L., Darby, W.J., Martin, M., Sheppard, C.W., Cannon, R.O., Beam, A.S., Densen, P.M., Peterson, J.C., and McClellan, G.S.

Abstract

1.1. Iron tagged with the radioactive isotope Fe59was fed in single doses, ranging from 1.8 to 120 mg., to 466 women at various stages of pregnancy, and the uptake of iron determined.2.2. As the dosage was increased from 9 to 18 mg. and beyond, the percentage of the total dose of iron found in the maternal red cells decreased, while the amount of iron taken up increased from the lowest to the highest dose.3.3. As gestation progressed, the uptake of iron increased to the extent that at thirty weeks' gestation and over, three or more times as much iron was absorbed as during the period before the fifteenth week of gestation.4.4. The therapeutic implications of these findings are discussed. The inefficiency of absorption of large doses of iron for normal pregnant women is noted.5.5. The variation in uptake of the fetus with varying dosage does not appear to be greatly different from that of the mother. Relatively little variation in the amount of radioactive iron in the red cells of the infant at birth was observed for iron administered at different periods of gestation. The red blood cell mass of the newborn infant contained on the average about 10 per cent as much of the administered iron as that of the mother. The ratio of fetal to maternal radioactive iron per milliliter of red blood cells was not greatly different from one.6.6. The relation between parity and iron uptake is discussed.

Published
1951
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32. FERRITIN

Author

Hahn, P.F., primary, Granick, S., additional, Bale, William F., additional, and Michaelis, Leonor, additional

Published
1943
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